Gordon F Schwartz, Kevin S Hughes, Henry T Lynch, Carol J Fabian, Ian S Fentiman, Mark E Robson, Susan M Domchek, Lynn C Hartmann, Roland Holland, David J Winchester, Benjamin O Anderson, Banu K Arun, Harry Bartelink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B Clough, Stephen A Feig, Sylvia H Heywang-Köbrunner, Anthony Howell, Claudine Isaacs, Daniel B Kopans, Robert E Mansel, Shahla Masood, Juan P Palazzo, Peter I Pressman, Lawrence J Solin, Michael Untch
A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups...
January 2009: Breast Journal