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https://www.readbyqxmd.com/read/29350490/chronic-exposure-to-high-doses-of-selenium-in-the-first-trimester-of-pregnancy-case-report-and-brief-literature-review
#1
Luisa D'Oria, Massimo Apicella, Carmen De Luca, Angelo Licameli, Caterina Neri, Marcella Pellegrino, Daniela Simeone, Marco De Santis
BACKGROUND: Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE: A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestational week (g.w.) 7 to 12, due to a prescription error. The patient experienced nausea, vomiting, hand and foot paresthesia, followed by fatigue, loss of fingernails and hair...
January 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29350246/data-driven-quality-improvement-project-to-increase-the-value-of-the-congenital-echocardiographic-report
#2
Pei-Ni Jone, Ruthanne Gould, Cindy Barrett, Adel K Younoszai, Brian Fonseca
Echocardiography is the primary diagnostic modality for congenital heart disease patients. The written report is used to communicate with the care team and organization is often divided into the body with detailed findings and the conclusions with important findings summarized. Strategies to increase workflow efficiency include batch writing of reports after performance of multiple echocardiograms and the use of report templates which may contribute to discrepancies within report leading to potential downstream medical errors...
January 19, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29349248/association-of-financial-hardship-with-poor-sleep-health-outcomes-among-men-who-have-sex-with-men
#3
Dustin T Duncan, Su Hyun Park, Yazan A Al-Ajlouni, Lauren Hale, Girardin Jean-Louis, William C Goedel, Basile Chaix, Brian Elbel
Previous studies have identified an association between socioeconomic status and sleep health. While some research has studied this association among sexual minority groups, including men who have sex with men (MSM), they exclusively focused on US-based populations. The interplay between the two in shaping sleep health has not been previously examined on populations residing outside the US. This study considers both determinants, by investigating whether financial hardship is associated with sleep health among a sample of MSM in Paris, France...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29348092/prescribing-pattern-of-angiotensin-receptor-blocker-a-study-of-errors-and-drug-drug-interactions
#4
Shagufta Nesar, Muhammad Harris Shoaib, Kiran Rafiq, Najia Rahim, Iyad Naeem Muhammad, Wajiha Iffat
Prescriptions comprising multi-drug therapy mostly illustrate the prescribing error. The phenomenon of error is bonded with human inaccuracy. The erroneous practice is observed in under developed countries like Pakistan, Bangladesh and also in developed ones. Consequently drug-drug interaction is one of the most common error associated with potentially serious adverse response even death. Accordingly the present study was conducted to assess the prevalence of prescribing errors and drug-drug interactions in out-patients receiving angiotensin receptor blockers...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347405/revisiting-universality-of-the-liquid-gas-critical-point-in-two-dimensions
#5
Max Yarmolinsky, Anatoly Kuklov
Critical point of liquid-gas (LG) transition does not conform with the paradigm of spontaneous symmetry breaking because there is no broken symmetry in both phases. We revisit the conjecture that this critical point belongs to the Ising class by performing large scale Monte Carlo simulations in two-dimensional free space in combination with the numerical flowgram method. Our main result is that the critical indices do agree with the Onsager values within the error of 1%-2%. This significantly improves the accuracy reported in the literature...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346210/significance-errors-power-and-sample-size-the-blocking-and-tackling-of-statistics
#6
Edward J Mascha, Thomas R Vetter
Inferential statistics relies heavily on the central limit theorem and the related law of large numbers. According to the central limit theorem, regardless of the distribution of the source population, a sample estimate of that population will have a normal distribution, but only if the sample is large enough. The related law of large numbers holds that the central limit theorem is valid as random samples become large enough, usually defined as an n ≥ 30. In research-related hypothesis testing, the term "statistically significant" is used to describe when an observed difference or association has met a certain threshold...
February 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29346175/long-term-impacts-faced-by-patients-and-families-after-harmful-healthcare-events
#7
Madelene J Ottosen, Emily W Sedlock, Aitebureme O Aigbe, Sigall K Bell, Thomas H Gallagher, Eric J Thomas
BACKGROUND: Patients and families report experiencing a multitude of harms from medical errors resulting in physical, emotional, and financial hardships. Little is known about the duration and nature of these harms and the type of support needed to promote patient and family healing after such events. We sought to describe the long-term impacts (LTIs) reported by patients and family members who experienced harmful medical events 5 or more years ago. METHODS: We performed a content analysis on 32 interviews originally conducted with 72 patients or family members about their views of the factors contributing to their self-reported harmful event...
January 17, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29345744/land-surveys-show-regional-variability-of-historical-fire-regimes-and-structure-of-dry-forests-of-the-western-usa
#8
William L Baker, Mark A Williams
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western USA remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration programs are underway. We used General Land Office survey reconstructions from the late-1800s across 11 landscapes covering ∼1.9 million ha in four states to analyze spatial variation in fire regimes and forest structure. We first synthesized the state of validation of our methods using 20 modern validations, 53 historical cross-validations, and corroborating evidence...
January 18, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29345499/disrupted-behaviour-in-grammatical-morphology-in-french-speakers-with-autism-spectrum-disorders
#9
Marie-Thérèse Le Normand, Romuald Blanc, Simona Caldani, Frédérique Bonnet-Brilhault
Mixed and inconsistent findings have been reported across languages concerning grammatical morphology in speakers with Autism Spectrum Disorders (ASD). Some researchers argue for a selective sparing of grammar whereas others claim to have identified grammatical deficits. The present study aimed to investigate this issue in 26 participants with ASD speaking European French who were matched on age, gender and SES to 26 participants with typical development (TD). The groups were compared regarding their productivity and accuracy of syntactic and agreement categories using the French MOR part-of-speech tagger available from the CHILDES...
January 18, 2018: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/29343761/a-high-throughput-approach-for-the-generation-of-orthogonally-interacting-protein-pairs
#10
Justin Lawrie, Xi Song, Wei Niu, Jiantao Guo
In contrast to the nearly error-free self-assembly of protein architectures in nature, artificial assembly of protein complexes with pre-defined structure and function in vitro is still challenging. To mimic nature's strategy to construct pre-defined three-dimensional protein architectures, highly specific protein-protein interacting pairs are needed. Here we report an effort to create an orthogonally interacting protein pair from its parental pair using a bacteria-based in vivo directed evolution strategy...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343627/risk-ratios-for-contagious-outcomes
#11
Olga Morozova, Ted Cohen, Forrest W Crawford
Epidemiologists commonly use the risk ratio to summarize the relationship between a binary covariate and outcome, even when outcomes may be dependent. Investigations of transmissible diseases in clusters-households, villages or small groups-often report risk ratios. Epidemiologists have warned that risk ratios may be misleading when outcomes are contagious, but the nature of this error is poorly understood. In this study, we assess the meaning of the risk ratio when outcomes are contagious. We provide a mathematical definition of infectious disease transmission within clusters, based on the canonical stochastic susceptible-infective model...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29343542/clinical-validation-of-the-sensitest%C3%A2-colistin-a-broth-microdilution-based-method-to-evaluate-colistin-mics
#12
Edoardo Carretto, Flavia Brovarone, Giuseppe Russello, Paola Nardini, Maisra El-Bouseary, Ali Aboklaish, Timothy R Walsh, Jonathan M Tyrrell
The global spread of multi-drug resistant Gram negative has led to the return of colistin for treating severe infections. Recently, different plasmid-mediated genes conferring resistance to this drug were described and reported worldwide. International committees (EUCAST/CLSI) re-evaluated inconsistencies surrounding colistin antimicrobial susceptibility testing (AST), concluding that broth microdilution (BMD) should serve as the reference method for AST. The development of an accurate, reproducible commercial test based on BMD is therefore highly desirable...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29342848/a-voltammetric-electronic-tongue-for-the-resolution-of-ternary-nitrophenol-mixtures
#13
Andreu González-Calabuig, Xavier Cetó, Manel Del Valle
This work reports the applicability of a voltammetric sensor array able to quantify the content of 2,4-dinitrophenol, 4-nitrophenol, and picric acid in artificial samples using the electronic tongue (ET) principles. The ET is based on cyclic voltammetry signals, obtained from an array of metal disk electrodes and a graphite epoxy composite electrode, compressed using discrete wavelet transform with chemometric tools such as artificial neural networks (ANNs). ANNs were employed to build the quantitative prediction model...
January 13, 2018: Sensors
https://www.readbyqxmd.com/read/29341203/food-specific-inhibitory-control-under-negative-mood-in-binge-eating-disorder-evidence-from-a-multimethod-approach
#14
Elisabeth J Leehr, Kathrin Schag, Thomas Dresler, Moritz Grosse-Wentrup, Martin Hautzinger, Andreas J Fallgatter, Stephan Zipfel, Katrin E Giel, Ann-Christine Ehlis
OBJECTIVE: Inhibitory control has been discussed as a developmental and maintenance factor in binge-eating disorder (BED). The current study is the first aimed at investigating inhibitory control in a negative mood condition on a psychophysiological and behavioral level in BED with a combination of electroencephalography (EEG) and eye tracking (ET). METHOD: We conducted a combined EEG and ET study with overweight individuals with BED (BED+, n = 24, mean age = 31, mean BMI = 35 kg/m2 ) and without BED (BED-, n = 23, mean age = 28, mean BMI = 35 kg/m2 ) and a normal-weight (NWC, n = 26, mean age 28, mean BMI = 22 kg/m2 ) control group...
January 17, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29340523/a-case-of-severe-glutathione-synthetase-deficiency-with-novel-gss-mutations
#15
H Xia, J Ye, L Wang, J Zhu, Z He
Glutathione synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism with autosomal recessive inheritance. The severe form of the disease is characterized by acute metabolic acidosis, usually present in the neonatal period with hemolytic anemia and progressive encephalopathy. A case of a male newborn infant who had severe metabolic acidosis with high anion gap, hemolytic anemia, and hyperbilirubinemia is reported. A high level of 5-oxoproline was detected in his urine and a diagnosis of generalized GSSD was made...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29340268/out-with-the-old-in-with-the-new-assessing-change-in-screen-time-when-measurement-changes-over-time
#16
Katie E Gunnell, Jennifer Brunet, Mathieu Bélanger
We examined if screen time can be assessed over time when the measurement protocol has changed to reflect advances in technology. Beginning in 2011, 929 youth (9-12 years at time one) living in in New Brunswick (Canada) self-reported the amount of time spent watching television (cycles 1-13), using computers (cycles 1-13), and playing video games (cycles 3-13). Using longitudinal invariance to test a shifting indicators model of screen time, we found that the relationships between the latent variable reflecting overall screen time and the indicators used to assess screen time were invariant across cycles (weak invariance)...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29339346/user-centered-design-of-learn-to-quit-a-smoking-cessation-smartphone-app-for-people-with-serious-mental-illness
#17
Roger Vilardaga, Javier Rizo, Emily Zeng, Julie A Kientz, Richard Ries, Chad Otis, Kayla Hernandez
BACKGROUND: Smoking rates in the United States have been reduced in the past decades to 15% of the general population. However, up to 88% of people with psychiatric symptoms still smoke, leading to high rates of disease and mortality. Therefore, there is a great need to develop smoking cessation interventions that have adequate levels of usability and can reach this population. OBJECTIVE: The objective of this study was to report the rationale, ideation, design, user research, and final specifications of a novel smoking cessation app for people with serious mental illness (SMI) that will be tested in a feasibility trial...
January 16, 2018: JMIR Serious Games
https://www.readbyqxmd.com/read/29338470/measurement-error-in-the-liebowitz-social-anxiety-scale-results-from-a-general-adult-population-in-japan
#18
Koki Takada, Kana Takahashi, Kazuki Hirao
OBJECTIVE: Although the self-report version of Liebowitz Social Anxiety Scale (LSAS) is frequently used to measure social anxiety, data is lacking on the smallest detectable change (SDC), an important index of measurement error. We therefore aimed to determine the SDC of LSAS. METHODS: Japanese adults aged 20-69 years were invited from a panel managed by a nationwide internet research agency. We then conducted a test-retest internet survey with a two-week interval to estimate the SDC at the individual (SDCind) and group (SDCgroup) levels...
January 17, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29338273/adverse-drug-reactions-of-non-opioid-and-opioid-analgesics-reported-to-croatian-national-authority-from-2007-to-2014
#19
Petra Sunara, Darko Krnic, Livia Puljak
OBJECTIVE: Adverse drug reactions (ADRs) are commonly observed in the health services because of system weaknesses and individual errors. Analgesics are widely used and it can be expected that with the increased use one can expect increased number of ADRs of analgesics. The aim of this study was to analyze ADRs of non-opioid and opioid analgesics reported to the Croatian Agency for Medicinal Products and Medical Devices (HALMED) from 2007 to 2014. METHODS: HALMED provided data on generic drug name, year of the ADR report, type of report, institution, reporting person, patient's age, sex and ADR type...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29338107/how-often-is-the-diagnosis-of-the-permanent-vegetative-state-incorrect-a-review-of-the-evidence
#20
Derick T Wade
BACKGROUND: Some research suggests that 40% of people in the vegetative state are misdiagnosed. This review investigates the frequency, nature and causes of reported misdiagnosis of patients in the vegetative state, focusing on the nature of the error. METHOD: A systematic review of all relevant literature, using references from key papers identified. Data summarised in tables. RESULTS: Five clinical studies of rate of misdiagnosis in practice were identified, encompassing 236 patients in the vegetative state of whom 80 (34%) were reclassified has having some awareness, often minimal...
January 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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