Xiaofan Yuan, Chuan Jiang, Yuzhou Xue, Fuqiang Guo, Minghao Luo, Lei Guo, Yang Gao, Tongling Yuan, Hui Xu, Hong Chen
Krüppel-like factor 13 (KLF13), a zinc finger transcription factor, is considered as a potential regulator of cardiomyocyte differentiation and proliferation during heart morphogenesis. However, its precise role in the dedifferentiation of vascular smooth muscle cells (VSMCs) during atherosclerosis and neointimal formation after injury remains poorly understood. In this study, we investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE-/- mice...
April 18, 2024: Journal of Cellular Physiology