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https://www.readbyqxmd.com/read/28944878/gene-expression-analysis-regulation-of-key-genes-associated-with-mycophenolate-mofetil-treatment-of-symptomatic-carotid-artery-stenosis
#1
Feng Jin, Kai Wang, Xiaochuan Sun, Zhanpu Zhang, Ping Han
The present study analyzed gene expression arrays to identify differentially-expressed genes (DEGs) between mycophenolate mofetil (MMF)‑treated and placebo‑treated patients with symptomatic carotid artery stenosis (SCAS). In addition, the key genes involved in the pharmacology of MMF treatment in patients with SCAS were identified. The gene expression dataset was obtained from a Gene Expression Omnibus database, which included 9 MMF‑treated and 11 placebo‑treated samples. The DEGs were identified between MMF and placebo groups using R software...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943539/leptomeningeal-collaterals-strongly-correlate-with-reduced-cerebrovascular-reactivity-measured-by-acetazolamide-challenged-single-photon-emission-computed-tomography-using-a-stereotactic-extraction-estimation-analysis-in-patients-with-unilateral-internal-carotid
#2
Takenobu Kunieda, Kosuke Miyake, Hiroki Sakamoto, Yuko Iwasaki, Shin Iida, Satoshi Morise, Kengo Fujita, Masataka Nakamura, Satoshi Kaneko, Hirofumi Kusaka
Objective To assess the correlation between the angiographic appearance of cerebral collateral pathways or the degree of internal carotid artery stenosis (ICAS) and reduced cerebrovascular reactivity (CVR) estimated by single-photon emission computed tomography (SPECT) image analysis in patients with unilateral ICAS. Methods A retrospective analysis was performed in 42 patients with unilateral ICAS who underwent cerebral angiography and acetazolamide-challenged SPECT of the brain. Cerebral blood flow quantitation was performed using the quantitative SPECT/dual-table autoradiography method...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943008/development-and-validation-of-a-score-to-predict-life-expectancy-after-carotid-endarterectomy-in-asymptomatic-patients
#3
Michele Carmo, Iacopo Barbetta, Daniele Bissacco, Santi Trimarchi, Vincenzo Catanese, Matteo Bonzini, Stefano Bonardelli, Piergiorgio G Settembrini
OBJECTIVE: Recent improvement of best medical treatment for carotid stenosis has sparked a debate on the role of surgery identification of patients who may benefit from carotid endarterectomy (CEA) is crucial to avoid overtreatment. An expected 5-year postoperative survival is one of the main selection criteria. The aim of this study was the development of a score for predicting survival of asymptomatic patients after CEA. METHODS: Our score was derived from a retrospective analysis of 648 consecutive asymptomatic patients from a single hospital...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28943006/outcomes-of-mini-incision-eversion-carotid-endarterectomy-combined-with-nontouch-isolation-technique-of-the-internal-carotid-artery
#4
Kota Shukuzawa, Takao Ohki, Yuji Kanaoka, Makoto Sumi, Koji Maeda, Naoki Toya, Hirotsugu Ozawa
OBJECTIVE: We developed a mini-incision eversion carotid endarterectomy (CEA) procedure (the Jikei method CEA) to prevent perioperative embolic stroke. The aim of this study was to retrospectively analyze perioperative and midterm outcomes after the Jikei method CEA. METHODS: We evaluated patients with the Jikei method CEA at our institution between January 2006 and June 2014. The primary end point was a major adverse event, which included death, stroke, intracranial hemorrhage, and myocardial infarction, within 30 days of CEA...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28937045/carotid-atherosclerosis-and-cognitive-impairment-in-nonstroke-patients
#5
REVIEW
Wei-Hong Chen, Wei Jin, Pei-Yuan Lyu, Yang Liu, Rui Li, Ming Hu, Xiang-Jian Xiao
OBJECTIVE: As a vascular risk factor, carotid atherosclerosis is crucial to cognitive impairment. While carotid intima-media thickness, carotid artery plaque, and carotid stenosis can reflect carotid atherosclerosis in different stages, this review aimed to explore researches on the role of carotid intima-media thickness, carotid artery plaque, and carotid stenosis in the progress of cognitive impairment in nonstroke patients and tried to illustrate the possible mechanisms. DATA SOURCES: We searched the PubMed database for recently published research articles up to July 2017, with the key words of "carotid atherosclerosis," "carotid intima-media thickness," "carotid plaque," "carotid stenosis," "nonstroke," and "cognitive impairment...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28935292/clinical-significance-of-reversal-of-flow-in-the-vertebral-artery-identified-on-cerebrovascular-duplex-ultrasound
#6
Aleksandra Policha, Melissa Baldwin, Victoria Lee, Mark A Adelman, Caron Rockman, Todd Berland, Neal S Cayne, Thomas S Maldonado
BACKGROUND: Reversal of flow in the vertebral artery (RFVA) is an uncommon finding on cerebrovascular duplex ultrasound examination. The clinical significance of RFVA and the natural history of patients presenting with it are poorly understood. Our objective was to better characterize the symptoms and outcomes of patients presenting with RFVA. METHODS: A retrospective review was performed of all cerebrovascular duplex ultrasound studies performed at our institution between January 2010 and January 2016 (N = 2927 patients)...
September 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28925313/hemodynamics-and-oxygen-extraction-in-chronic-large-artery-steno-occlusive-disease-clinical-applications-for-predicting-stroke-risk
#7
Colin P Derdeyn
Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined compensatory mechanisms to reduced pressure or flow - autoregulatory vasodilation and increased oxygen extraction fraction. Other changes, such as metabolic downregulation, are likely. The positive identification of autoregulatory vasodilation and increased oxygen extraction fraction in humans is an established risk factor for future ischemic stroke in some disease states such as atherosclerotic carotid stenosis and occlusion...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28919313/periprocedural-outcomes-of-carotid-artery-stenting-in-elderly-patients
#8
Masataka Nanto, Yudai Goto, Hiroyuki Yamamoto, Seisuke Tanigawa, Michiko Takado, Takahiro Ogawa, Yoshikazu Nakahara
BACKGROUND: Carotid artery stenting has emerged as an alternative to carotid endarterectomy especially in patients with high risk of carotid endarterectomy. Older age (≥80 years old) was recognized as one of the high risk factors of carotid endarterectomy. However, the association between older age and increased risk of adverse events for carotid artery stenting has been reported. The purpose of this study was to evaluate the association between age and periprocedural outcomes after carotid artery stenting...
September 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28917828/a-model-of-blood-supply-to-the-brain-via-the-carotid-arteries-effects-of-obstructive-vs-sclerotic-changes
#9
O Onaizah, T L Poepping, M Zamir
The carotid artery is one of the major supply routes of blood to the brain and a common site of vascular disease. Obstructive and sclerotic disorders within the carotid artery impact local blood flow patterns as well as overall impedance and blood supply to the brain. A lumped parameter model and an experimental in-vitro flow loop were used to study the effects of local stenosis and stiffness in the carotid artery based on a family of phantoms with different degrees of stenosis and compliance. The model also allows independent examination of the effects of downstream resistance and compliance...
September 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28916863/intracerebral-hemorrhage-as-a-manifestation-of-cerebral-hyperperfusion-syndrome-after-carotid-revascularization-systematic-review-and-meta-analysis
#10
REVIEW
Pedro Abreu, Jerina Nogueira, Filipe Brogueira Rodrigues, Ana Nascimento, Mariana Carvalho, Ana Marreiros, Hipólito Nzwalo
BACKGROUND: Intracerebral hemorrhage (ICH) in the context of cerebral hyperperfusion syndrome (CHS) is an uncommon but potentially lethal complication after carotid revascularization for carotid occlusive disease. Information about its incidence, risk factors and fatality is scarce. Therefore, we aimed to perform a systematic review and meta-analysis focusing on the incidence, risk factors and outcomes of ICH in the context of CHS after carotid revascularization. METHODS: We searched the PubMed and EBSCO hosts for all studies published in English about CHS in the context of carotid revascularization...
September 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28916669/asymptomatic-carotid-stenosis-in-cardiac-surgery-patients-is-less-more
#11
EDITORIAL
Rebecca F Gottesman
No abstract text is available yet for this article.
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28916664/safety-of-simultaneous-coronary-artery-bypass-grafting-and-carotid-endarterectomy-versus-isolated-coronary-artery-bypass-grafting-a-randomized-clinical-trial
#12
Christian Weimar, Konstantinos Bilbilis, Jan Rekowski, Torulv Holst, Friedhelm Beyersdorf, Martin Breuer, Manfred Dahm, Anno Diegeler, Arne Kowalski, Sven Martens, Friedrich W Mohr, Jiri Ondrášek, Beate Reiter, Peter Roth, Ralf Seipelt, Markus Siggelkow, Gustav Steinhoff, Anton Moritz, Mathias Wilhelmi, Gerhard Wimmer-Greinecker, Hans-Christoph Diener, Heinz Jakob, Claudia Ose, Andre Scherag, Stephan C Knipp
BACKGROUND AND PURPOSE: The optimal operative strategy in patients with severe carotid artery disease undergoing coronary artery bypass grafting (CABG) is unknown. We sought to investigate the safety and efficacy of synchronous combined carotid endarterectomy and CABG as compared with isolated CABG. METHODS: Patients with asymptomatic high-grade carotid artery stenosis ≥80% according to ECST (European Carotid Surgery Trial) ultrasound criteria (corresponding to ≥70% NASCET [North American Symptomatic Carotid Endarterectomy Trial]) who required CABG surgery were randomly assigned to synchronous carotid endarterectomy+CABG or isolated CABG...
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28915102/acceleration-selective-arterial-spin-labeling-mr-angiography-used-to-visualize-distal-cerebral-arteries-and-collateral-vessels-in-moyamoya-disease
#13
Osamu Togao, Akio Hiwatashi, Makoto Obara, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei, Ataru Nishimura, Koichi Arimura, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda
Purpose To evaluate and compare the performance of acceleration-selective arterial spin labeling (AccASL) magnetic resonance (MR) angiography in the visualization of cerebral arteries and collateral vessels in patients with Moyamoya disease with that of time-of-flight (TOF) MR angiography, with digital subtraction angiography (DSA) as the reference standard. Materials and Methods Thirty-six cerebral hemispheres from 22 patients with Moyamoya disease underwent TOF and AccASL MR angiography and DSA. Qualitative evaluations included imaging of the terminal internal carotid artery (ICA), distal middle cerebral arteries (MCAs), Moyamoya vessels, and leptomeningeal anastomosis (LMA) collaterals with reference to DSA...
September 15, 2017: Radiology
https://www.readbyqxmd.com/read/28912200/development-and-validation-of-electronic-quality-measures-to-assess-care-for-patients-with-transient-ischemic-attack-and-minor-ischemic-stroke
#14
Dawn M Bravata, Laura J Myers, Eric Cheng, Mathew Reeves, Fitsum Baye, Zhangsheng Yu, Teresa Damush, Edward J Miech, Jason Sico, Michael Phipps, Alan Zillich, Jason Johanning, Seemant Chaturvedi, Curt Austin, Jared Ferguson, Bailey Maryfield, Kathy Snow, Susan Ofner, Glenn Graham, Rachel Rhude, Linda S Williams, Greg Arling
BACKGROUND: Despite interest in using electronic health record (EHR) data to assess quality of care, the accuracy of such data is largely unknown. We sought to develop and validate transient ischemic attack and minor ischemic stroke electronic quality measures (eQMs) using EHR data. METHODS AND RESULTS: A random sample of patients with transient ischemic attack or minor ischemic stroke, cared for in Veterans Health Administration facilities (fiscal year 2011), was identified...
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28910807/cerebral-infarct-topography-and-early-outcome-after-surgery-for-symptomatic-carotid-stenosis-a-multicentre-study
#15
Caroline Kazandjian, Nicla Settembre, Fabien Lareyre, Benjamin Kretz, Agnès Soudry-Faure, Yannick Béjot, Sergueï Malikov, Reda Hassen-Khodja, Elixene Jean-Baptiste, Eric Steinmetz
INTRODUCTION: Although carotid stenosis can cause both territorial and border-zone (BZ) cerebral infarcts (CI), the influence of CI topography on postoperative complications after surgery remains unclear. We compared early outcomes after endarterectomy on the basis of CI location: territorial (T group) or BZ group. MATERIAL AND METHODS: During the period between 2009 and 2013, ischaemic stroke patients who had undergone surgery for symptomatic carotid stenosis were identified from prospective databases from 3 French centres...
September 15, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28910449/carotid-artery-stenosis-causing-choroidal-infarction
#16
Gerald Seidel, Laura Pertl, Franz Hafner
No abstract text is available yet for this article.
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28904796/endovascular-management-of-symptomatic-cerebral-aneurysm-thromboembolism-due-to-pre-aneurysmal-arterial-stenosis
#17
Torin Karsonovich, Ajeet Gordhan
BACKGROUND: Pre-aneurysmal internal carotid steno-occlusive disease resulting in cerebral intra-aneurysmal thrombosis and subsequent embolic infarction has not been previously described. CONCLUSION: Antithrombotic treatment for dissolution of the thrombus and pre-aneurysmal stent angioplasty followed by Pipeline embolization flow diverter placement through the aneurysm is a safe and feasible management option.
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28904464/clinical-features-risk-factors-and-short-term-outcome-of-ischemic-stroke-in-patients-with-atrial-fibrillation-data-from-a-population-based-study
#18
William G Akanksha, Kaur Paramdeep, Singh Gagandeep, Bansal Rajinder, S Paul Birinder, Singla Monika, Singh Shavinder, J Samuel Clarence, J Verma Shweta, Meenakshi Sharma, D Pandian Jeyaraj
OBJECTIVES: Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder associated with stroke. This study was done to describe risk factors, clinical features, and short-term outcomes of stroke patients with AF. MATERIALS AND METHODS: This study was a part of the Indian Council of Medical Research funded "Ludhiana urban population based Stroke Registry." Data were collected using WHO STEPS stroke method. All patients ≥18 years of age, who developed ischemic stroke between March 26, 2011, and March 25, 2013, were included in this study...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28903431/detection-of-specific-chlamydia-pneumoniae-and-cytomegalovirus-antigens-in-human-carotid-atherosclerotic-plaque-in-a-chinese-population
#19
Jiachao Cao, Yumin Mao, Bo Dong, Wei Guan, Jia Shi, Suinuan Wang
To explore the relationship between certain pathogens, such as chlamydia pneumonia (Cpn) and cytomegalovirus (CMV), and carotid atherosclerosis (AS) in a Chinese population.Twenty-five carotid atherosclerotic stenosis patients from the Beijing Tiantan Hospital (affiliated with Capital Medical University) participated in the study. After undergoing digital subtraction angiography (DSA) and/or computed tomography angiography (CTA), the degree of carotid artery stenosis was over 70% in all cases, and the patients underwent carotid endarterectomy...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902827/-repeat-prosthetic-repair-of-the-internal-carotid-artery
#20
K S Zamskiĭ, A D Shatokhina, A Iu Zavarzin, G V Mashtanov
Described herein is a clinical case report regarding reoperation on carotid arteries for thrombosis of a synthetic graft of the internal carotid artery in a patient presenting with a multifocal atherosclerotic lesion. Despite medicamentous treatment carried out after the primary operation, the presence of major risk factors had unfavourably contributed to progression of the disseminated atherosclerotic process. During eight years, the patient had endured reconstructive interventions on the brachiocephalic and coronary arteries, as well as on the vessels of the iliac-femoral-popliteal segment...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
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