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https://www.readbyqxmd.com/read/29782930/all-atom-four-body-knowledge-based-statistical-potential-to-distinguish-native-tertiary-rna-structures-from-nonnative-folds
#1
Majid Masso
Scientific breakthroughs in recent decades have uncovered the capability of RNA molecules to fulfill a wide array of structural, functional, and regulatory roles in living cells, leading to a concomitantly significant increase in both the number and diversity of experimentally determined RNA three-dimensional (3D) structures. Atomic coordinates from a representative training set of solved RNA structures, displaying low sequence and structure similarity, facilitate derivation of knowledge-based energy functions...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782906/influence-of-second-outcome-on-monetary-discounting
#2
David J Cox, Jesse Dallery
The rates that an outcome (e.g., money) loses value as delay increases or probability decreases are called delay and probability discounting, respectively. Discounting is typically studied by asking participants to make choices between two options that vary in amount and delay (e.g., $50 now vs. $100 in 3 months) or probability (e.g., 100% chance of $50 vs. 60% chance of $100). Little is known about how more complex options affect discounting. We asked participants (N = 56) to choose between two options that each resulted in two outcomes (e...
May 18, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29782495/molecular-immunological-and-neurophysiological-evaluations-for-early-diagnosis-of-neural-impairment-in-seropositive-leprosy-household-contacts
#3
Diogo Fernandes Dos Santos, Matheus Rocha Mendonça, Douglas Eulálio Antunes, Elaine Fávaro Pípi Sabino, Raquel Campos Pereira, Luiz Ricardo Goulart, Isabela Maria Bernardes Goulart
BACKGROUND: Household contacts constitute the highest risk group for leprosy development, and despite significant progress in the disease control, early diagnosis remains the primary goals for leprosy management programs. METHODS: We have recruited 175 seropositive and 35 seronegative household contacts from 2014 to 2016, who were subjected to an extensive protocol that included clinical, molecular (peripheral blood qPCR, slit-skin smear qPCR, skin biopsy qPCR) and electroneuromyographic evaluations...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782396/risk-factors-for-delays-in-adjuvant-chemotherapy-following-immediate-breast-reconstruction
#4
Oriana Cohen, Gretl Lam, Mihye Choi, Daniel Ceradini, Nolan Karp
BACKGROUND: Concerns exist that immediate breast reconstruction may delay adjuvant chemotherapy initiation, impacting oncologic outcomes. Here, we determine how post-operative complications impact chemotherapy timing, and identify factors associated with greater risk for delays. METHODS: Retrospective chart review identified patients undergoing immediate breast reconstruction and adjuvant chemotherapy at a single institution from 2010 to 2015. Patients were analyzed based on occurrence of post-operative complications and time to chemotherapy...
May 15, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29782184/the-growth-of-preantral-follicles-and-the-impact-of-different-supplementations-and-circumstances-a-review-study-with-focus-on-bovine-and-human-preantral-follicles
#5
Zahra Rajabi, Zunair Khokhar, Hossein Yazdekhasti
One of the most important concerns cancer survivors face is fertility. Current treatment modalities often result in damage to the reproductive system. Different options have been proposed to preserve the fertility of affected women, and many attempts have been made to improve their chance of childbearing after therapy. Cryopreservation of ovarian tissue and follicles before the onset of cancer treatment and then either transplantation of ovarian tissue or culture of ovarian tissue and individual follicles in vitro is a commonly cited approach...
May 21, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29781808/tensor-driven-extraction-of-developmental-features-from-varying-paediatric-eeg-datasets
#6
Eli Kinney-Lang, Loukianos Spyrou, Ahmed Ebied, Richard Fm Chin, Javier Escudero
Constant changes in developing children's brains can pose a challenge in EEG dependant technologies. Advancing signal processing methods to identify developmental differences in paediatric populations could help improve function and usability of such technologies. Taking advantage of the multi-dimensional structure of EEG data through tensor analysis may offer a framework for extracting relevant developmental features of paediatric datasets. A proof of concept is demonstrated through identifying latent developmental features in resting-state EEG...
May 21, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29781807/word-recognition-re-thinking-prosthetic-vision-evaluation
#7
Shui'Er Han, Cheng Qiu, Kassandra R Lee, JaeHyun Jung, Eli Peli
Evaluations of vision prostheses and sensory substitution devices have frequently relied on repeated training and testing with the same small set of items. These multiple forced-choice tasks have been shown to produce above chance performance in blind patients, but it is unclear if the observed performance represents restoration of vision that transfers to novel, untrained items. Here, we tested the generalizability of the forced-choice paradigm on the discrimination of low-resolution word images. Extensive visual training was conducted with the same 10 words used in previous BrainPort tongue stimulating studies...
May 21, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29781783/clinical-and-radiological-outcome-of-non-surgical-management-of-thoracic-and-lumbar-spinal-fracture-dislocations-a-historical-analysis-in-the-era-of-modern-spinal-surgery
#8
Andrei Fernandes Joaquim, Gregory D Schroeder, Alpesh A Patel, Alexander R Vaccaro
CONTEXT: It is well established that traumatic spinal dislocations (AO Type C injuries) should be surgically treated. However, no recent comparative study of surgical versus non-surgical management of type C injuries was found attesting the superiority of surgical treatment. OBJECTIVE: Due to the lack of information about the natural history of non-surgical management of type C injuries, we evaluated the outcome of historical conservative treatment of type C injuries...
May 21, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29781416/the-risk-of-rabies-spread-in-japan-a-mathematical-modelling-assessment
#9
H Kadowaki, K Hampson, K Tojinbara, A Yamada, K Makita
Rabies was eliminated from Japan in 1957. In the 60 years since elimination, vaccination coverage has declined and dog ownership habits have changed. The purpose of this study was to assess the current risk of rabies spread in Japan. A spatially explicit transmission model was developed at the 1 km2 grid scale for Hokkaido and Ibaraki Prefectures. Parameters associated with dog movement and bite injuries were estimated using historical records from Japan, and were used with previously published epidemiological parameters...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29781100/factors-associated-with-breast-mri-use-among-women-with-a-family-history-of-breast-cancer
#10
Mary C White, Ashwini Soman, Clarice R Weinberg, Juan L Rodriguez, Susan A Sabatino, Lucy A Peipins, Lisa DeRoo, Hazel B Nichols, M Elizabeth Hodgson, Dale P Sandler
Although annual breast magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer as an adjunct to screening mammography, breast MRI use remains low. We examined factors associated with breast MRI use in a cohort of women with a family history of breast cancer but no personal cancer history. Study participants came from the Sister Study cohort, a nationwide, prospective study of women with at least 1 sister who had been diagnosed with breast cancer but who themselves had not ever had breast cancer (n = 17 894)...
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29780755/ovarian-teratoma-associated-anti-n-methyl-d-aspartate-receptor-encephalitis-a-difficult-diagnosis-with-a-favorable-prognosis
#11
Ananya Datta Mitra, Alaa Afify
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a recently described auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations affecting young adults with ovarian teratoma. The availability of a novel assay to measure these antibodies might suggest an etiology for this potentially life-threatening disease, which if early recognized can be treated promptly with surgery with chances of a good clinical outcome. Reported prognostic indicators for a good outcome depend on the presence of a tumor, prompt treatment and no admission to an intensive care unit...
April 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29780742/caries-risk-assessment-of-12-13-year-old-government-and-private-school-going-children-of-mysore-city-using-cariogram-a-comparative-study
#12
Sandhya P Naik, Shabna Moyin, Bhakti Patel, Lata Prabhu Warad, Sameer Punathil, C B Sudeep
Aim: The aim of this study is to assess the caries risk assessment of 12-13-year-old government and private school going children of Mysore city using Cariogram. Materials and Methods: A cross-sectional examination was carried out on a total of 104 government and private schoolchildren aged 12-13 years. Ten factors from the Cariogram software(D Bratthall, Computer software, Malmo, Sweden) were included from study participant's records to complete the Cariogram. The percentage of "chances of avoiding new lesions" (caries risk) among government and private school study participants were obtained from Cariogram, and the participants were classified into five risk groups...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29780601/a-comparison-of-apache-ii-bisap-ranson-s-score-and-modified-ctsi-in-predicting-the-severity-of-acute-pancreatitis-based-on-the-2012-revised-atlanta-classification
#13
Anubhav Harshit Kumar, Mahavir Singh Griwan
Objective: Our aim was to prospectively compare the Accuracy of Acute Physiology and Chronic Health Evaluation (APACHE) II, Bedside Index of Severity in Acute Pancreatitis (BISAP), Ranson's score and modified Computed Tomography Severity Index (CTSI) in predicting the severity of acute pancreatitis based on Atlanta 2012 definitions in a tertiary care hospital in northern India. Methods: Fifty patients with acute pancreatitis admitted to our hospital during the period of March 2015 to September 2016 were included in the study...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780431/mathematical-modelling-of-bacterial-meningitis-transmission-dynamics-with-control-measures
#14
Joshua Kiddy K Asamoah, Farai Nyabadza, Baba Seidu, Mehar Chand, Hemen Dutta
Vaccination and treatment are the most effective ways of controlling the transmission of most infectious diseases. While vaccination helps susceptible individuals to build either a long-term immunity or short-term immunity, treatment reduces the number of disease-induced deaths and the number of infectious individuals in a community/nation. In this paper, a nonlinear deterministic model with time-dependent controls has been proposed to describe the dynamics of bacterial meningitis in a population. The model is shown to exhibit a unique globally asymptotically stable disease-free equilibrium ℰ 0 , when the effective reproduction number ℛ VT ≤ 1, and a globally asymptotically stable endemic equilibrium ℰ 1 , when ℛ VT > 1; and it exhibits a transcritical bifurcation at ℛ VT = 1...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29780240/feasibility-of-visual-aids-for-risk-evaluation-by-hospitalized-patients-with-coronary-artery-disease-results-from-face-to-face-interviews
#15
Carlos Alberto da Silva Magliano, Andrea Liborio Monteiro, Bernardo Rangel Tura, Claudia Silvia Rocha Oliveira, Amanda Rebeca de Oliveira Rebelo, Claudia Cristina de Aguiar Pereira
Purpose: Communicating information about risk and probability to patients is considered a difficult task. In this study, we aim to evaluate the use of visual aids representing perioperative mortality and long-term survival in the communication process for patients diagnosed with coronary artery disease at the National Institute of Cardiology, a Brazilian public hospital specializing in cardiology. Patients and methods: One-on-one interviews were conducted between August 1 and November 20, 2017...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29780028/induced-endometrial-trauma-endometrial-scratch-in-the-mid-luteal-menstrual-cycle-phase-preceding-first-cycle-ivf-icsi-versus-usual-ivf-icsi-therapy-study-protocol-for-a-randomised-controlled-trial
#16
Clare Pye, Robin Chatters, Judith Cohen, Kate Brian, Ying C Cheong, Susan Laird, Lamiya Mohiyiddeen, Jonathan Skull, Stephen Walters, Tracey Young, Mostafa Metwally
INTRODUCTION: Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracytoplasmic sperm injection (ICSI). However, the procedure has not yet been fully explored in women having IVF/ICSI for the first time. This study aims to examine the effect of performing an ES in the mid-luteal phase prior to a first-time IVF/ICSI cycle on the chances of achieving a clinical pregnancy and live birth...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779878/a-role-for-mouse-primary-visual-cortex-in-motion-perception
#17
Tiago Marques, Mathew T Summers, Gabriela Fioreze, Marina Fridman, Rodrigo F Dias, Marla B Feller, Leopoldo Petreanu
Visual motion is an ethologically important stimulus throughout the animal kingdom. In primates, motion perception relies on specific higher-order cortical regions. Although mouse primary visual cortex (V1) and higher-order visual areas show direction-selective (DS) responses, their role in motion perception remains unknown. Here, we tested whether V1 is involved in motion perception in mice. We developed a head-fixed discrimination task in which mice must report their perceived direction of motion from random dot kinematograms (RDKs)...
May 12, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29779391/-is-preoperative-systemic-chemotherapy-recommended-for-resectable-colorectal-liver-metastases-oncosurgical-aspects
#18
Kristóf Dede, Zsuzsa Póti, Attila Bursics
Surgical resection is still the only curative treatment for colorectal liver metastases, but this is one part of a complex therapy. Nowadays a patient with colorectal liver metastasis is not treated only by a surgeon or by an oncologist or even only by an invasive radiologist. Collective decisions, complement treatments give the only chance to treat these patients for longer time. Patients with colorectal liver metastases could be regarded as patients with chronic disease. Specially interesting are the various treatment options of resectable colorectal liver metastases...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29778918/cognitive-mechanisms-of-sleep-outcomes-in-a-randomized-clinical-trial-of-internet-based-cognitive-behavioral-therapy-for-insomnia
#19
Philip I Chow, Karen S Ingersoll, Frances P Thorndike, Holly R Lord, Linda Gonder-Frederick, Charles M Morin, Lee M Ritterband
OBJECTIVE: The aim of this study was to investigate in a randomized clinical trial the role of sleep-related cognitive variables in the long-term efficacy of an online, fully automated cognitive behavioral therapy intervention for insomnia (CBT-I) (Sleep Healthy Using the Internet [SHUTi]). METHOD: Three hundred and three participants (Mage  = 43.3 years; SD = 11.6) were randomly assigned to SHUTi or an online patient education condition and assessed at baseline, postintervention (nine weeks after baseline), and six and 12 months after the intervention period...
December 20, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29778616/routine-portal-vein-resection-for-pancreatic-adenocarcinoma-shows-no-benefit-in-overall-survival
#20
Fritz Klein, Finja Berresheim, Matthäus Felsenstein, Thomas Malinka, Uwe Pelzer, Timm Denecke, Johann Pratschke, Marcus Bahra
BACKGROUND: Extended pancreatic resections including resections of the portal (PV) may nowadays be performed safely. Limitations in distinguishing tumor involvement from inflammatory adhesions however lead to portal vein resections (PVR) without evidence of tumor infiltration in the final histopathological examination. The aim of this study was to analyze the impact of these "false negative" resections on operative outcome and long-term survival. METHODS: 40 patients who underwent pancreatic resection with PVR for pancreatic adenocarcinoma (PA) without tumor infiltration of the PV (PVR-group) were identified...
May 9, 2018: European Journal of Surgical Oncology
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