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https://www.readbyqxmd.com/read/28107563/are-commercial-sweet-cherry-rootstocks-adapted-to-climate-change-short-term-waterlogging-and-co2-effects-on-sweet-cherry-cv-burlat
#1
Margarita Pérez-Jiménez, María Hernández-Munuera, M Carmen Piñero, Gregorio López-Ortega, Francisco M Del Amor
High CO2 is able to ameliorate some negative effects due to climate change and intensify others. This study involves the sweet cherry (Prunus avium) cultivar 'Burlat' grafted on the 'Mariana 2624', 'Adara' and 'LC 52' rootstocks. In a climate chamber at two CO2 concentrations: ambient (400 µmol mol(-1) ) and elevated (800 µmol mol(-1) ), the plants were submitted to waterlogging for seven days, followed by seven days of recovery after drainage. Waterlogging drastically decreased the rate of photosynthesis, significantly endangering plant survival, particularly for the 'LC 52' and 'Adara' rootstocks...
January 20, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28107473/butimba-intensifying-the-hunt-for-child-tb-in-swaziland-through-household-contact-tracing
#2
Anna Maria Mandalakas, Katherine Ngo, Pilar Alonso Ustero, Rachel Golin, Florence Anabwani, Bulisile Mzileni, Welile Sikhondze, Robert Stevens
BACKGROUND: Limited data exists to inform contact tracing guidelines in children and HIV-affected populations. We evaluated the yield and additionality of household contact and source case investigations in Swaziland, a TB/HIV high-burden setting, while prioritizing identification of childhood TB. METHODS: In partnership with 7 local TB clinics, we implemented standardized contact tracing of index cases (IC) receiving TB treatment. Prioritizing child contacts and HIV-affected households, screening officers screened contacts for TB symptoms and to identify risk factors associated with TB...
2017: PloS One
https://www.readbyqxmd.com/read/28107341/complex-dynamics-of-virus-spread-from-low-infection-multiplicities-implications-for-the-spread-of-oncolytic-viruses
#3
Ignacio A Rodriguez-Brenes, Andrew Hofacre, Hung Fan, Dominik Wodarz
While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported unusual early dynamics in an experimental system using adenovirus infection of human embryonic kidney (293) cells. Under identical experimental conditions, inoculation at low infection multiplicities resulted in either robust spread, or in limited spread that eventually stalled, with both outcomes occurring with approximately equal frequencies...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28107259/paget-s-disease-of-the-vulva-a-review-of-20-years-experience
#4
Raghava Parashurama, Vivek Nama, Richard Hutson
BACKGROUND: Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center. METHODS: We reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016...
January 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28105913/mumal2-improving-sensitivity-in-shotgun-proteomics-using-cost-sensitive-artificial-neural-networks-and-a-threshold-selector-algorithm
#5
Fabio Ribeiro Cerqueira, Adilson Mendes Ricardo, Alcione de Paiva Oliveira, Armin Graber, Christian Baumgartner
BACKGROUND: This work presents a machine learning strategy to increase sensitivity in tandem mass spectrometry (MS/MS) data analysis for peptide/protein identification. MS/MS yields thousands of spectra in a single run which are then interpreted by software. Most of these computer programs use a protein database to match peptide sequences to the observed spectra. The peptide-spectrum matches (PSMs) must also be assessed by computational tools since manual evaluation is not practicable...
December 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28105853/identification-of-potential-molecular-associations-between-chikungunya-virus-non-structural-protein-2-and-human-host-proteins
#6
J Rana, S Gulati, S Rajasekharan, A Gupta, V Chaudhary, S Gupta
Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is considered to be the master regulator of viral RNA replication and host responses generated during viral infection. This protein has two main functional domains: an N-terminal domain which exhibits NTPase, RNA triphosphatase and helicase activities and a C-terminal protease domain. Understanding how CHIKV nsP2 interacts with its host proteins is essential for elucidating all the required processes for viral replication and pathogenesis along with the identification of potential targets for antiviral therapy...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28105791/the-future-of-pleiotropic-therapy-in-heart-failure-lessons-from-the-benefits-of-exercise-training-on-endothelial-function
#7
REVIEW
Gilles W De Keulenaer, Vincent F M Segers, Faiez Zannad, Dirk L Brutsaert
A novel generation of drugs is introduced in the treatment of heart failure (HF). These drugs, including phosphodiesterase-5 inhibitors, guanylate cyclase stimulators and activators, share the feature that their action is either endothelial-mediated or substitutes for endothelial pathways, in particular the nitric oxide-cyclic guanosine monophosphate pathway, thereby influencing homeostatic balances in virtually each organ system in a pleiotropic fashion. Unfortunately, recent clinical trials with some of these drugs have shown disappointing results, at least in the setting of HF with a preserved ejection fraction...
January 19, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28105725/antifungal-peptides-a-potential-new-class-of-antifungals-for-treating-vulvovaginal-candidiasis-caused-by-fluconazole-resistant-candida-albicans
#8
Siew Mei Samantha Ng, Yi Yong Alvin Yap, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Timothy Barkham, Jeanette Woon Pei Teo, Jeffrey Hill, Cheng San Brian Chia
Vulvovaginal candidiasis/candidosis is a common fungal infection afflicting approximately 75% of women globally caused primarily by the yeast Candida albicans. Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile. However, its widespread use has led to the emergence of fluconazole-resistant C. albicans, posing a universal clinical concern. Coupled to the dearth of new antifungal drugs entering the market, it is imperative to introduce new drug classes to counter this threat...
January 19, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28105541/spatial-distribution-of-mast-cells-around-vessels-and-glands-in-human-gastric-carcinoma
#9
Diego Guidolin, Simona Ruggieri, Tiziana Annese, Cinzia Tortorella, Andrea Marzullo, Domenico Ribatti
The spatial distribution of mast cells inside the tumor stroma has been little investigated. In this study, we have evaluated tumor mast cells (MCs) distribution in gastric cancer through the analysis of the morphological features of the spatial patterns generated by these cells, including size, shape, and architecture of the cell pattern. The pattern of distribution of tryptase- and chymase-positive MCs around the blood vessels and gastric glands in human gastric adenocarcinoma samples was investigated by immunohistochemical techniques and by introducing a quantitative approach to characterize the spatial distribution of MCs...
January 19, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28104679/genome-sequencing-of-the-behaviour-manipulating-virus-lbfv-reveals-a-possible-new-virus-family
#10
D Lepetit, B Gillet, S Hughes, K Kraaijeveld, J Varaldi
Parasites are sometimes able to manipulate the behaviour of their hosts. However, the molecular cues underlying this phenomenon are poorly documented. We previously reported that the parasitoid wasp Leptopilina boulardi which develops from Drosophila larvae is often infected by an inherited DNA virus. In addition to being maternally transmitted, the virus benefits from horizontal transmission in superparasitized larvae (Drosophila that have been parasitized several times). Interestingly, the virus forces infected females to lay eggs in already parasitized larvae, thus increasing the chance of being horizontally transmitted...
January 19, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28104498/laparoscopic-myomectomy-a-single-centre-retrospective-review-of-514-patients
#11
Elisabeth Mary Ruth Bean, Alfred Cutner, Tom Holland, Arvind Vashisht, Davor Jurkovic, Ertan Saridogan
STUDY OBJECTIVE: To review surgical outcomes and histopathological findings following laparoscopic myomectomy by a team at a university teaching hospital. DESIGN: This was a retrospective review of consecutive cases of laparoscopic myomectomy carried out by members of our minimal access surgery team between January 2004 and December 2015. DESIGN CLASSIFICATION: Canadian Task Force Classification II-3 SETTING: University Teaching Hospital PATIENTS: Women undergoing laparoscopic myomectomy INTERVENTIONS: Laparoscopic myomectomy MEASUREMENTS AND MAIN RESULTS: We collected women's demographic data, clinical histories and surgical outcomes, including complication rates and the incidence of undiagnosed uterine malignancy...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28103927/influence-of-age-and-sex-on-hospitalization-of-nursing-home-residents-a-cross-sectional-study-from-germany
#12
Falk Hoffmann, Guido Schmiemann
BACKGROUND: Nursing homes residents (NHR) are frequently transferred to hospitals. There is some evidence that male NHR are more often hospitalized than females, but the influence of age is less clear and predictors might differ between sexes. Analyses according to age groups between males and females have only been investigated once and none of the existing studies have conducted multivariate analyses stratified by sex. Aim of this study was to fill this gap. METHODS: We used data of the "Inappropriate Medication in patients with REnal insufficiency in Nursing homes" (IMREN) study, which was conducted between October 2014 and April 2015 in nursing homes in northwestern Germany (Bremen and Lower Saxony)...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28103820/the-relationship-between-midwife-led-group-based-versus-conventional-antenatal-care-and-mode-of-birth-a-matched-cohort-study
#13
Lauren Kearney, Mary Kynn, Alison Craswell, Rachel Reed
BACKGROUND: Midwife facilitated, group models of antenatal care have emerged as an alternative to conventional care both within Australia and internationally. Group antenatal care can be offered in a number of different ways, however usually constitutes a series of sessions co-ordinated by a midwife combining physical assessment, antenatal education and peer support in a group setting. Midwife-led group antenatal care is viewed positively by expectant mothers, with no associated adverse outcomes identified in the published literature for women or their babies when compared with conventional care...
January 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28103063/delivering-on-the-promise-of-smoke-free-public-housing
#14
Douglas E Levy, Inez F Adams, Gary Adamkiewicz
On November 30, 2016, the US Department of Housing and Urban Development (HUD) published a final rule mandating that public housing authorities it supports prohibit all smoking on their residential premises, including within residents' apartments. The primary rationale for this action was to protect nonsmoking residents from the harms of tobacco smoke exposure. Although the harms of secondhand smoke are clear and the potential for reducing nonsmoking residents' exposure is real, it will be no simple matter to successfully implement the policy requirements set down by HUD...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28102926/sodiation-based-in-source-collision-for-profiling-of-pyranocoumarins-in-radix-peucedani-qianhu-utility-of-sodium-adducts-stability-with-in-source-collision
#15
Wei Yang, Yingfei Li, Chen Kang, Haiyu Zhao, Li Xiang, Chuan Li, Qiao Wang
Full scan mode of liquid chromatography-mass spectrometry equipped with an electrospray ionization source offers a chance on global detection of complicated components; however, the scan mode carries significant challenges in rapidly capturing information of analysts. Sodiation-based in-source collision was proposed here, as a technique for rapid detecting untargeted analytes in full scan analysis, which was based on the stability of sodium adducts and the nonselectivity of in-source collision. Then the technique was applied to profile of angular-type pyranocoumarins (APs) in Radix Peucedani, with full scan analysis performed at two specific in-source collision energy: a high energy 50 V that is tolerated by the sodium adducts of APs, and a low energy 10 V, at which abundant adducts were offered...
January 19, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28102699/tracheostomy-weaning-outcomes-in-relation-to-the-site-of-acquired-brain-injury-a-retrospective-case-series
#16
Kay Mitton, Krystyna Walton, Manoj Sivan
OBJECTIVE: To analyse whether the outcome of tracheostomy weaning is influenced by the site of injury in acquired brain injury. METHODS: A retrospective case review of all the consecutive admissions to an acute neurorehabilitation unit in a 2-year period was performed. Patients with a diagnosis of acquired brain injury and tracheostomy in situ were included in this study. RESULTS: One hundred and six patients were included in the analysis...
January 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28102174/modeling-dynamics-of-mutants-in-heterogeneous-stem-cell-niche
#17
Leili Shahriyari, Ali Mahdipour Shirayeh
Studying the stem cell (SC) niche architecture is a crucial step for investigating the process of oncogenesis and obtaining an effective stem cell therapy for various cancers. Recently, it has been observed that there are two groups of SCs in the SC niche collaborating with each other to maintain tissue homeostasis: border stem cells (BSCs), which are responsible in controlling the number of non-stem cells as well as stem cells, and central stem cells (CeSCs), which regulate the SC niche. Here, we develop a bi-compartmental stochastic model for the SC niche to study the spread of mutants within the niche...
January 19, 2017: Physical Biology
https://www.readbyqxmd.com/read/28102154/effectiveness-of-treatment-of-idiopathic-scoliosis-by-spinecor-dynamic-bracing-with-special-physiotherapy-programme-in-spinecor-system
#18
Karina Rożek, Tomasz Potaczek, Maja Zarzycka, Ewa Lipik, Barbara Jasiewicz
BACKGROUND: The SpineCor dynamic brace for the treatment of idiopathic scoliosis is designed to maintain the correct position of the spine and a new movement strategy for 20 hours per day. The SpineCor exercise system intensifies and complements the brace treatment. This study evaluated the effectiveness of a comprehensive treatment of idiopathic scoliosis involving the SpineCor system. MATERIAL AND METHODS: The study assessed a group of 40 patients (38 girls and 2 boys) with idiopathic scoliosis treated with the SpineCor brace...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102108/readiness-to-change-as-a-moderator-of-therapy-outcome-in-patients-with-somatoform-disorders
#19
Jens Heider, Katharina Köck, Matthias Sehlbrede, Annette Schröder
OBJECTIVE: A considerable amount of patients with somatoform disorders do not benefit from psychotherapy as much as expected. Our aim was to explore whether readiness to change moderates the relationship between the intensity of symptoms and therapy outcome in the early stages of psychotherapy. METHOD: 144 patients with somatoform disorders received an outpatient cognitive-behavioural intervention. Symptom intensity was measured with the Screening for Somatoform Disorders (SOMS-7)...
January 19, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28101946/repeat-hepatectomy-is-independently-associated-with-favorable-long-term-outcome-in-patients-with-colorectal-liver-metastases
#20
Christopher P Neal, Gael R Nana, Michael Jones, Vaux Cairns, Wee Ngu, John Isherwood, Ashley R Dennison, Giuseppe Garcea
Up to three-quarters of patients undergoing liver resection for colorectal liver metastases (CRLM) develop intrahepatic recurrence. Repeat hepatic resection appears to provide the optimal chance of cure for these patients. The aim of this study was to analyze short- and long-term outcomes following index and repeat hepatectomy for CRLM. Clinicopathological data were obtained from a prospectively maintained database. Perioperative variables and outcomes were compared using the Chi-squared test. Variables associated with long-term survival following index and second hepatectomy were identified by Cox regression analyses...
January 19, 2017: Cancer Medicine
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