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Nicholas E Anton, John M Sawyer, James R Korndorffer, Christopher G DuCoin, Graham McRary, Lava R Timsina, Dimitrios Stefanidis
BACKGROUND: Assessment tools specific to intracorporeal suturing are lacking. The purpose of this study was to validate a novel Intracorporeal Suturing Assessment Tool (ISAT) by comparing it with existing measures that have been reported to have validity evidence. METHODS: Videos of laparoscopic suturing were assessed by 3 blinded laparoscopic experts using the validated Global Operative Assessment of Laparoscopic Skills (GOALS) scale and the ISAT. Correlations between these instruments were calculated, and sensitivity analyses compared both tools with objective suturing scores...
December 20, 2017: Surgery
Yoshiki Murase, Hiroki Nakanishi, Gakushi Tsuji, Takeshi Sunami, Norikazu Ichihashi
One of the largest challenges in the synthesis of artificial cell that can reproduce is in vitro assembly of ribosomes from in vitro synthesized rRNAs and proteins. In this study, to circumvent the chemical modification of 16S rRNA for reconstitution of fully active 30S subunit, we performed artificial evolution of 16S rRNA, which forms the functional 30S subunit without chemical modifications. We first established an in vitro selection scheme by combining the integrated synthesis, assembly, and translation (iSAT) system with the liposome sorting technique...
October 20, 2017: ACS Synthetic Biology
Zsolt Zador, Wendy Huang, Matthew Sperrin, Michael T Lawton
BACKGROUND: Following the International Subarachnoid Aneurysm Trial (ISAT), evolving treatment modalities for acute aneurysmal subarachnoid hemorrhage (aSAH) has changed the case mix of patients undergoing urgent surgical clipping. OBJECTIVE: To update our knowledge on outcome predictors by analyzing admission parameters in a pure surgical series using variable importance ranking and machine learning. METHODS: We reviewed a single surgeon's case series of 226 patients suffering from aSAH treated with urgent surgical clipping...
July 31, 2017: Operative Neurosurgery (Hagerstown, Md.)
Jun Zhang, Tian Jiang, Xin Zheng, Chao Shen, Xiang'ai Cheng
Halide perovskite has attracted significant attention because of excellent optical properties. Here, we study the optical properties of CsPbBr3 perovskite nanosheets and observe that the nonlinear optical properties can be tuned by the thickness. The photoluminescence (PL) properties and nonlinear absorption effects induced by saturation absorption (SA) and two-photon absorption (TPA) in CsPbBr3 nanosheets with different thicknesses (from 104.6 to 195.4 nm) have been studied. The PL intensity increases nearly three times with changing from the thinnest one to the thinnest under the same excitation condition...
September 1, 2017: Optics Letters
Mario Teo, Mathew R Guilfoyle, Carole Turner, Peter J Kirkpatrick
BACKGROUND: The management of aneurysmal subarachnoid hemorrhage (aSAH) has changed dramatically in the last few decades with the publication of a few major studies, including ISAT (International Subarachnoid Aneurysm Trial, the International Cooperative Study on the Timing of Aneurysm Surgery Study). The aim of this study is to analyze the outcome of patients with aSAH based on a contemporary series, identify the risk factors for poor outcome, and focus on patients with good-grade aSAH (to match the ISAT cohort)...
September 2017: World Neurosurgery
J A Boedo, D L Rudakov
We present a method to calculate the ion saturation current, Isat, for Langmuir probes at high frequency (>100 kHz) using the harmonics technique and we compare that to a direct measurement of Isat. It is noted that the Isat estimation can be made directly by the ratio of harmonic amplitudes, without explicitly calculating Te. We also demonstrate that since the probe tips using the harmonic method are oscillating near the floating potential, drawing little power, this method reduces tip heating and arcing and allows plasma density measurements at a plasma power flux that would cause continuously biased tips to arc...
March 2017: Review of Scientific Instruments
Junjie Zhao, Hao Lin, Richard Summers, Mingmin Yang, Brian G Cousins, Janice Tsui
Intracranial aneurysm is a leading cause of stroke. Its treatment has evolved over the past 2 decades. This review summarizes the treatment strategies for intracranial aneurysms from 3 different perspectives: open surgery approach, transluminal treatment approach, and new technologies being used or trialed. We introduce most of the available treatment techniques in detail, including contralateral clipping, wrapping and clipping, double catheters assisting coiling and waffle-cone technique, and so on. Data from major trials such as Analysis of Treatment by Endovascular approach of Non-ruptured Aneurysms (ATENA), Internal Subarachnoid Trial (ISAT), Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms (CLARITY), and Barrow Ruptured Aneurysm Trial (BRAT) as well as information from other clinical reports and local experience are reviewed to suggest a clinical pathway for treating different types of intracranial aneurysms...
January 1, 2017: Angiology
Lauren B Raine, John R Biggan, Carol L Baym, Brian J Saliba, Neal J Cohen, Charles H Hillman
There is a growing trend of decreasing physical fitness among adolescents, which may result not only in poorer physical health, but also in poorer academic achievement. PURPOSE: The purpose of this study was to investigate the changes in aerobic fitness and academic achievement in reading and mathematics during middle school. METHODS: This study employed a prospective, longitudinal cross-sectional design. Fifty-two adolescents were followed from sixth grade through eighth grade...
October 10, 2017: Pediatric Exercise Science
Juergen Konczalla, Volker Seifert, Juergen Beck, Erdem Güresir, Hartmut Vatter, Andreas Raabe, Gerhard Marquardt
OBJECTIVE Outcome analysis of comatose patients (Hunt and Hess Grade V) after subarachnoid hemorrhage (SAH) is still lacking. The aims of this study were to analyze the outcome of Hunt and Hess Grade V SAH and to compare outcomes in the current period with those of the pre-International Subarachnoid Aneurysm Trial (ISAT) era as well as with published data from trials of decompressive craniectomy (DC) for middle cerebral artery (MCA) infarction. METHODS The authors analyzed cases of Hunt and Hess Grade V SAH from 1980-1995 (referred to in this study as the earlier period) and 2005-2014 (current period) and compared the results for the 2 periods...
January 2018: Journal of Neurosurgery
Davide Brivio, Earl Ada, Erno Sajo, Piotr Zygmanski
We studied the effective contact potential difference (ECPD) of thin film nanostructures and its role in self-powered X-ray sensors, which use the high-energy current detection scheme. We compared the response to kilovoltage X-rays of several nanostructures made of disparate combinations of conductors (Al, Cu, Ta, ITO) and oxides (SiO2, Ta2O5, Al2O3). We measured current-voltage curves in parallel-plate configuration separated by an air gap and determined three characteristic parameters: current at zero voltage bias I0, the voltage offset for zero current ECPD, and saturation current Isat...
March 29, 2017: ACS Applied Materials & Interfaces
Daniel D Cavalcanti, Roberto C de Paula, Paula L Alvarenga, Paulo José da Mata Pereira, Paulo Niemeyer Filho
OBJECTIVE: Many new endovascular devices have been used under the guidance of the International Subarachnoid Aneurysm Trial. Clipping still offers higher occlusion rates, and its technique continues to evolve, resulting in smaller exposures and reduced manipulation to brain tissue. We sought to evaluate the routine use of the minisphenoidal approach to manage intracranial aneurysms in a high-volume institution. METHODS: We retrospectively reviewed our database of patients with aneurysm from October 2013 to May 2016...
June 2017: World Neurosurgery
Qingling Cui, Yingni Pan, Xiaowei Yan, Bao Qu, Xiaoqiu Liu, Wei Xiao
RATIONALE: Isoacteoside (ISAT), a phenylethanoid glycoside, acting as the principal bioactive component in traditional Chinese medicines, possesses broad pharmacological effects such as neuroprotective, antihypertensive and hepatoprotective activities. However, its pharmaceutical development has been severely limited due to the poor oral bioavailability. It is essential and significant to investigate related hurdles leading to the poor bioavailability of isoacteoside. METHODS: Whole animal metabolism studies were conducted in rats, followed by metabolic mechanism including gastrointestinal stability, intestinal flora metabolism and intestinal enzyme metabolism employing the powerful ultra-high performance liquid chromatography equipped with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS)...
November 17, 2016: Rapid Communications in Mass Spectrometry: RCM
Hyuk Won Chang, Shang Hun Shin, Sang Hyun Suh, Bum-Soo Kim, Myung Ho Rho
PURPOSE: The International Subarachnoid Aneurysm Trial (ISAT) revealed that in ruptured intracranial aneurysms (RA), endovascular coiling (EC) yields better clinical outcomes than neurosurgical clipping (NC) at 1 year. In unruptured aneurysms (UIA), EC is being increasingly used as an alternative to NC due to patients' preference. There is a lot of difference in treatment cost (EC vs. NC) between countries. There is one recently published study dealing with the comparative cost analysis only in UIAs in South Korea...
September 2016: Neurointervention
Michael J Blackowicz, Daniel O Hryhorczuk, Kristin M Rankin, Dan A Lewis, Danish Haider, Bruce P Lanphear, Anne Evens
BACKGROUND: Environmental lead exposure detrimentally affects children's educational performance, even at very low blood lead levels (BLLs). Among children in Chicago Public Schools (CPS), the severity of the effects of BLL on reading and math vary by racial subgroup (White vs. Hispanic vs. non-Hispanic Black). We investigated the impact of BLL on standardized test performance by Hispanic subgroup (Mexican, Puerto Rican, and Other Hispanic). METHODS: We examined 12,319 Hispanic children born in Chicago between 1994 and 1998 who were tested for BLL between birth and 2006 and enrolled in the 3rd grade at a CPS school between 2003 and 2006...
August 1, 2016: International Journal of Environmental Research and Public Health
Kari Nyheim Solbraekke, Geir Lorem
This article's point of departure is recent claims that breast cancer survivorship displaying positivity and self-growth represents the gold standard for all forms of cancer survivorship in English-speaking Western cultures. An interview study of Norwegian women regarding gynaecological cancer followed by hysterectomy is used to explore whether this process is taking place beyond this setting. Results show that the women's experiences of having to display survivorship in this manner are not as notable as found in English-speaking Western countries, neither is their experience of social othering...
July 27, 2016: Sociology of Health & Illness
Giorgos Demetriou, Henry T Bookey, Fabio Biancalana, Eitan Abraham, Yu Wang, Wei Ji, Ajoy K Kar
A negative value for the nonlinear refraction in graphene is experimentally observed and unambiguously verified by performing a theoretical analysis arising from the conductivity of the graphene monolayer. The nonlinear optical properties of multi-layer graphene are experimentally studied by employing the Z-scan technique. The measurements are carried out at 1150, 1550, 1900 and 2400 nm with a 100-femtosecond laser source. Under laser illumination the multi-layer graphene exhibits a transmittance increase due to saturable absorption, followed by optical limiting due to two-photon absorption...
June 13, 2016: Optics Express
Justin M Moore, Christoph J Griessenauer, Raghav Gupta, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
The management of cerebrovascular disease has advanced considerably in 2015. Five randomized control trials have firmly established the role of endovascular thrombectomy for ischemic strokes due to large vessel occlusion. The randomized trial of intraarterial treatment for acute ischemic stroke (MR CLEAN) (Berkhemer et al. NEJM 2015;372:11-20) was the first of a series on the topic. There was a total of 5 randomized controlled trials published showing benefit in terms of functional outcomes at 90days for mechanical thrombectomy including the Endovascular Therapy for Ischemic stroke with perfusion-imaging selection (EXTEND IA) (Campbell et al...
September 2016: Clinical Neurology and Neurosurgery
S T Broyles, K T Drazba, T S Church, J-P Chaput, M Fogelholm, G Hu, R Kuriyan, A Kurpad, E V Lambert, C Maher, J Maia, V Matsudo, T Olds, V Onywera, O L Sarmiento, M Standage, M S Tremblay, C Tudor-Locke, P Zhao, P T Katzmarzyk
OBJECTIVES: Schools are an important setting to enable and promote physical activity. Researchers have created a variety of tools to perform objective environmental assessments (or 'audits') of other settings, such as neighborhoods and parks; yet, methods to assess the school physical activity environment are less common. The purpose of this study is to describe the approach used to objectively measure the school physical activity environment across 12 countries representing all inhabited continents, and to report on the reliability and feasibility of this methodology across these diverse settings...
December 2015: International Journal of Obesity Supplements
Thomas Sorenson, Giuseppe Lanzino
Since the introduction of embolic coils in the early 1990s, endovascular treatment has gained much traction for use when treating ruptured and unruptured intracranial aneurysms. Three prospective studies have been conducted comparing endovascular coil embolization versus clipping for ruptured intracranial aneurysms. The first study took place in Finland and was the first head-to-head look at treating ruptured aneurysms by either endovascular coiling or surgical clipping. Results from this study suggested better functional outcome after endovascular treatment than surgery at the expenses of higher rates of incomplete aneurysm occlusion...
March 2016: Journal of Neurosurgical Sciences
Tiago J Oliveira, Jürgen F Stilck
We study the interacting self-avoiding trail (ISAT) model on a Bethe lattice of general coordination q and on a Husimi lattice built with squares and coordination q=4. The exact grand-canonical solutions of the model are obtained, considering that up to K monomers can be placed on a site and associating a weight ω_{i} with an i-fold visited site. Very rich phase diagrams are found with nonpolymerized, regular polymerized, and dense polymerized phases separated by lines (or surfaces) of continuous and discontinuous transitions...
January 2016: Physical Review. E
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