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https://www.readbyqxmd.com/read/27859774/a-metabolic-way-to-investigate-related-hurdles-caused-poor-bioavailability-in-oral-delivery-of-isoacteoside-in-rats-employing-uplc-q-tof-ms
#1
Qingling Cui, Yingni Pan, Xiaowei Yan, Bao Qu, Xiaoqiu Liu, Wei Xiao
RATIONALE: Isoacteoside (ISAT), a phenylethanoid glycoside, acting as the principal bioactive component in traditional Chinese medicines, possesses broad pharmacological effects such as neuroprotective, antihypertensive and hepatoprotective activities. However, its pharmaceutical development has been severely limited due to the poor oral bioavailability. It is essential and significant to investigate related hurdles leading to the poor bioavailability of isoacteoside. METHODS: Whole animal metabolism studies were conducted in rats, followed by metabolic mechanism including gastrointestinal stability, intestinal flora metabolism and intestinal enzyme metabolism employing the powerful ultra-high performance liquid chromatography equipped with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS)...
November 17, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27621944/cost-effectiveness-analysis-of-endovascular-coiling-versus-neurosurgical-clipping-for-intracranial-aneurysms-in-republic-of-korea
#2
Hyuk Won Chang, Shang Hun Shin, Sang Hyun Suh, Bum-Soo Kim, Myung Ho Rho
PURPOSE: The International Subarachnoid Aneurysm Trial (ISAT) revealed that in ruptured intracranial aneurysms (RA), endovascular coiling (EC) yields better clinical outcomes than neurosurgical clipping (NC) at 1 year. In unruptured aneurysms (UIA), EC is being increasingly used as an alternative to NC due to patients' preference. There is a lot of difference in treatment cost (EC vs. NC) between countries. There is one recently published study dealing with the comparative cost analysis only in UIAs in South Korea...
September 2016: Neurointervention
https://www.readbyqxmd.com/read/27490560/the-impact-of-low-level-lead-toxicity-on-school-performance-among-hispanic-subgroups-in-the-chicago-public-schools
#3
Michael J Blackowicz, Daniel O Hryhorczuk, Kristin M Rankin, Dan A Lewis, Danish Haider, Bruce P Lanphear, Anne Evens
BACKGROUND: Environmental lead exposure detrimentally affects children's educational performance, even at very low blood lead levels (BLLs). Among children in Chicago Public Schools (CPS), the severity of the effects of BLL on reading and math vary by racial subgroup (White vs. Hispanic vs. non-Hispanic Black). We investigated the impact of BLL on standardized test performance by Hispanic subgroup (Mexican, Puerto Rican, and Other Hispanic). METHODS: We examined 12,319 Hispanic children born in Chicago between 1994 and 1998 who were tested for BLL between birth and 2006 and enrolled in the 3rd grade at a CPS school between 2003 and 2006...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27461035/breast-cancer-isation-explored-social-experiences-of-gynaecological-cancer-in-a-norwegian-context
#4
Kari Nyheim Solbraekke, Geir Lorem
This article's point of departure is recent claims that breast cancer survivorship displaying positivity and self-growth represents the gold standard for all forms of cancer survivorship in English-speaking Western cultures. An interview study of Norwegian women regarding gynaecological cancer followed by hysterectomy is used to explore whether this process is taking place beyond this setting. Results show that the women's experiences of having to display survivorship in this manner are not as notable as found in English-speaking Western countries, neither is their experience of social othering...
July 27, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27410322/nonlinear-optical-properties-of-multilayer-graphene-in-the-infrared
#5
Giorgos Demetriou, Henry T Bookey, Fabio Biancalana, Eitan Abraham, Yu Wang, Wei Ji, Ajoy K Kar
A negative value for the nonlinear refraction in graphene is experimentally observed and unambiguously verified by performing a theoretical analysis arising from the conductivity of the graphene monolayer. The nonlinear optical properties of multi-layer graphene are experimentally studied by employing the Z-scan technique. The measurements are carried out at 1150, 1550, 1900 and 2400 nm with a 100-femtosecond laser source. Under laser illumination the multi-layer graphene exhibits a transmittance increase due to saturable absorption, followed by optical limiting due to two-photon absorption...
June 13, 2016: Optics Express
https://www.readbyqxmd.com/read/27366977/landmark-papers-in-cerebrovascular-neurosurgery-2015
#6
REVIEW
Justin M Moore, Christoph J Griessenauer, Raghav Gupta, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
The management of cerebrovascular disease has advanced considerably in 2015. Five randomized control trials have firmly established the role of endovascular thrombectomy for ischemic strokes due to large vessel occlusion. The randomized trial of intraarterial treatment for acute ischemic stroke (MR CLEAN) (Berkhemer et al. NEJM 2015;372:11-20) was the first of a series on the topic. There was a total of 5 randomized controlled trials published showing benefit in terms of functional outcomes at 90days for mechanical thrombectomy including the Endovascular Therapy for Ischemic stroke with perfusion-imaging selection (EXTEND IA) (Campbell et al...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27152183/development-and-reliability-of-an-audit-tool-to-assess-the-school-physical-activity-environment-across-12-countries
#7
S T Broyles, K T Drazba, T S Church, J-P Chaput, M Fogelholm, G Hu, R Kuriyan, A Kurpad, E V Lambert, C Maher, J Maia, V Matsudo, T Olds, V Onywera, O L Sarmiento, M Standage, M S Tremblay, C Tudor-Locke, P Zhao, P T Katzmarzyk
OBJECTIVES: Schools are an important setting to enable and promote physical activity. Researchers have created a variety of tools to perform objective environmental assessments (or 'audits') of other settings, such as neighborhoods and parks; yet, methods to assess the school physical activity environment are less common. The purpose of this study is to describe the approach used to objectively measure the school physical activity environment across 12 countries representing all inhabited continents, and to report on the reliability and feasibility of this methodology across these diverse settings...
December 2015: International Journal of Obesity Supplements
https://www.readbyqxmd.com/read/27102908/trials-and-tribulations-an-evidence-based-approach-to-aneurysm-treatment
#8
Thomas Sorenson, Giuseppe Lanzino
Since the introduction of embolic coils in the early 1990s, endovascular treatment has gained much traction for use when treating ruptured and unruptured intracranial aneurysms. Three prospective studies have been conducted comparing endovascular coil embolization versus clipping for ruptured intracranial aneurysms. The first study took place in Finland and was the first head-to-head look at treating ruptured aneurysms by either endovascular coiling or surgical clipping. Results from this study suggested better functional outcome after endovascular treatment than surgery at the expenses of higher rates of incomplete aneurysm occlusion...
March 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/26871113/nature-of-the-collapse-transition-in-interacting-self-avoiding-trails
#9
Tiago J Oliveira, Jürgen F Stilck
We study the interacting self-avoiding trail (ISAT) model on a Bethe lattice of general coordination q and on a Husimi lattice built with squares and coordination q=4. The exact grand-canonical solutions of the model are obtained, considering that up to K monomers can be placed on a site and associating a weight ω_{i} with an i-fold visited site. Very rich phase diagrams are found with nonpolymerized, regular polymerized, and dense polymerized phases separated by lines (or surfaces) of continuous and discontinuous transitions...
January 2016: Physical Review. E
https://www.readbyqxmd.com/read/26733126/-clip-first-policy-in-management-of-intracranial-mca-aneurysms-single-centre-experience-with-a-systematic-review-of-literature
#10
REVIEW
Anna Steklacova, Ondrej Bradac, Frantisek Charvat, Patricia De Lacy, Vladimir Benes
BACKGROUND: The results of microsurgical treatment for middle cerebral artery (MCA) aneurysms (ANs) have been highly satisfying for decades, notoriously posing a challenge for interventional neuroradiologists. Following the International Subarachnoid Aneurysm Trial (ISAT) study results, most centres across Europe and the USA switched to a "coil first" policy. The purpose of this study is to evaluate and critically review the substantiation of this change. METHODS: The authors conducted a single-institution retrospective study of MCA AN treatment between January 2000 and December 2013 maintaining a "clip first" policy...
March 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/26474147/trials-and-tribulations-an-evidence-based-approach-to-aneurysm-treatment
#11
T Sorenson, G Lanzino
Since the introduction of embolic coils in the early 1990s, endovascular treatment has gained much traction for use when treating ruptured and unruptured intracranial aneurysms. Three prospective studies have been conducted comparing endovascular coil embolization versus clipping for ruptured intracranial aneurysms. The first study took place in Finland and was the first head-to-head look at treating ruptured aneurysms by either endovascular coiling or surgical clipping. Results from this study suggested better functional outcome after endovascular treatment than surgery at the expenses of higher rates of incomplete aneurysm occlusion...
October 16, 2015: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/26337329/results-of-surgical-clipping-in-a-neurointerventional-dominant-department
#12
Mario Teo, Sean Martin, Arachchige Ponweera, Alistair Macey, Nigel Suttner, Jennifer Brown, Jerome St George
OBJECTIVES: It has been 10 years since the publication of International Subarachnoid Aneurysm Trial (ISAT) (1-3) and the first-line treatment for cerebral aneurysms in many UK neurosurgical centres is endovascular occlusion. Local audit has shown a significant reduction in surgical clipping cases since 2002, with a fall from over 150 cases per year pre ISAT, to approximately 25 cases per year currently. More so the cases referred for surgical occlusion represent more challenging lesions...
2015: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/26256068/management-of-recurrent-aneurysms-following-endovascular-therapy
#13
Kevin S Chen, Thomas J Wilson, William R Stetler, Matthew C Davis, David A Giles, Elyne N Kahn, Neeraj Chaudhary, Joseph J Gemmete, B Gregory Thompson, Aditya S Pandey
The aim of the current study is to describe the complication rates and clinical outcomes in patients who either underwent repeat intervention or conservative management with radiographic surveillance when presenting with aneurysmal recurrence after endovascular treatment. Since publication of the international subarachnoid aneurysm trial (ISAT), an increasing number of patients are treated with endovascular therapy. However, recurrence after endovascular therapy continues to pose a challenge, and there is minimal evidence to guide its management...
December 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26238743/treatment-of-intracranial-aneurysms-clipping-versus-coiling
#14
REVIEW
Ann Liu, Judy Huang
Intracranial aneurysms (IAs) have an estimated incidence of up to 10 % and can lead to serious morbidity and mortality. Because of this, the natural history of IAs has been studied extensively, with rupture rates ranging from 0.5 to 7 %, depending on aneurysm characteristics. The spectrum of presentation of IAs ranges from incidental detection to devastating subarachnoid hemorrhage. Although the gold standard imaging technique is intra-arterial digital subtraction angiography, other modalities such as computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are being increasingly used for screening and treatment planning...
September 2015: Current Cardiology Reports
https://www.readbyqxmd.com/read/26228283/assessment-of-intra-interobserver-reliability-of-the-sonographic-optic-nerve-sheath-diameter-measurement
#15
Tuba Cimilli Ozturk, Hasan Demir, Rasim Yorulmaz, Serdar Ozdemir, Gokhan Isat, Ozge Ecmel Onur
Diagnosis and measuring the level of increase in intracranial pressure (ICP) is critical, especially for the management of trauma patients in the emergency department and intensive care unit. However, measurements are operator-dependent as in all of the sonographic diagnoses. The aim of this study is to assess the operator variations in the measurement of optic nerve sheath diameter (ONSD). There were four emergency medicine specialists involved in the study. Each had at least 1 year of experience of ultrasound scans and performed at least 25 prior ocular scans examining the ONSD...
August 2015: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/26170846/aneurismal-subarachnoid-hemorrhage-who-remains-for-surgical-treatment-in-the-post-isat-era
#16
Marta Koźba-Gosztyła, Bogdan Czapiga, Włodzimierz Jarmundowicz
INTRODUCTION: Although there have been a number of studies on changes and trends in the management of aneurismal subarachnoid hemorrhage (aSAH) since publication of the International Subarachnoid Aneurysm Trial (ISAT), no data exist on what category of patients still remains for surgical treatment. Our goal was to investigate the changes that occurred in the characteristics of a population of aSAH patients treated surgically in the post-ISAT period in a single neurosurgical center, with limited availability of endovascular service...
June 19, 2015: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/26005741/pre-protection-re-haemorrhage-following-aneurysmal-subarachnoid-haemorrhage-where-are-we-now
#17
Benjamin M Davies, K H Carlos Chung, Louise Dulhanty, James Galea, Hiren C Patel
BACKGROUND: Re-haemorrhage is a negative, prognostic predictor of outcome in aneurysmal subarachnoid haemorrhage (aSAH). The process of aSAH care has changed however, and most reports on re-haemorrhage are from a time when aneurysms were treated predominantly by open microneurosurgery. The current frequency and impact of re-haemorrhage on outcome in the 'post-ISAT' era is therefore unknown. The aim of this study was to review current outcome, risk factors and causes for inpatient re-haemorrhage in aSAH patients...
August 2015: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/25889033/the-impact-of-low-level-lead-toxicity-on-school-performance-among-children-in-the-chicago-public-schools-a-population-based-retrospective-cohort-study
#18
Anne Evens, Daniel Hryhorczuk, Bruce P Lanphear, Kristin M Rankin, Dan A Lewis, Linda Forst, Deborah Rosenberg
BACKGROUND: Environmental lead exposure poses a risk to educational performance, especially among poor, urban children. Previous studies found low-level lead exposure was a risk factor for diminished academic abilities, however, this study is distinct because of the very large sample size and because it controlled for very low birth weight and early preterm birth-two factors closely associated with lower academic performance. In this study we examined the association between lead concentration in whole blood (B-Pb) of Chicago Public School (CPS) children and their performance on the 3(rd) grade Illinois Standard Achievement Tests (ISAT) reading and math scores...
2015: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/25699657/mass-spectrometric-sampling-of-a-liquid-surface-by-nanoliter-droplet-generation-from-bursting-bubbles-and-focused-acoustic-pulses-application-to-studies-of-interfacial-chemistry
#19
Daniel A Thomas, Lingtao Wang, Byoungsook Goh, Eun Sok Kim, J L Beauchamp
The complex chemistry occurring at the interface between liquid and vapor phases contributes significantly to the dynamics and evolution of numerous chemical systems of interest, ranging from damage to the human lung surfactant layer to the aging of atmospheric aerosols. This work presents two methodologies to eject droplets from a liquid water surface and analyze them via mass spectrometry. In bursting bubble ionization (BBI), droplet ejection is achieved via the formation of a jet following bubble rupture at the surface of a liquid to yield 250 μm diameter droplets (10 nL volume)...
March 17, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/25691077/cerebrovascular-neurosurgery-2014
#20
REVIEW
Mohamed Salem, Bradley A Gross, Rose Du, Ajith J Thomas
Continued advances in our understanding of the management of cerebrovascular disease were made in 2014. A randomized trial for management of unruptured brain arteriovenous malformation (ARUBA) (Mohr et al. Lancet 2014;383:614-21.) and the Scottish intracranial vascular malformation study (Al-Shahi Salman et al. JAMA 2014;311:1661-9) were published and contrasted with reports based on extensive surgical experience. We highlight the results from the simvastatin in aneurysmal subarachnoid hemorrhage study (STASH) (Kirkpatrick et al...
May 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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