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https://www.readbyqxmd.com/read/27911918/statin-use-and-self-reported-hindering-muscle-complaints-in-older-persons-a-population-based-study
#1
Milly A van der Ploeg, Rosalinde K E Poortvliet, Sophie C E van Blijswijk, Wendy P J den Elzen, Petra G van Peet, Wouter de Ruijter, Jeanet W Blom, Jacobijn Gussekloo
PURPOSE: Statins are widely used by older persons in primary and secondary prevention of cardiovascular disease. Although serious adverse events are rare, many statin users report mild muscle pain and/or muscle weakness. It's unclear what impact statins exert on a patient's daily life. Research on statin related side effects in older persons is relatively scarce. We therefore investigated the relation between statin use and self-reported hindering muscle complaints in older persons in the general population...
2016: PloS One
https://www.readbyqxmd.com/read/27898476/bilateral-rectus-femoris-muscle-rupture-following-statin-medication
#2
Kamal Mezian, Jan Vacek, Leoš Navrátil, Levent Özçakar
No abstract text is available yet for this article.
November 24, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27897416/curcumin-an-effective-adjunct-in-patients-with-statin-associated-muscle-symptoms
#3
REVIEW
Amirhossein Sahebkar, Nikou Saboni, Matteo Pirro, Maciej Banach
In spite of the unequivocal efficacy of statins in reducing primary and secondary cardiovascular events, the use of these drugs in a considerable number of patients is limited because of statin intolerance, mainly statin-associated muscle symptoms (SAMS). SAMS encompass a broad spectrum of clinical presentations, including mild muscular aching and other types of myalgias, myopathy with the significant elevation of creatine kinase, and the rare but life-threatening rhabdomyolysis. Among several pathophysiologic mechanisms of SAMS, mitochondrial dysfunction is thought to be one of the main one...
September 22, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27892461/liver-specific-atp-citrate-lyase-inhibition-by-bempedoic-acid-decreases-ldl-c-and-attenuates-atherosclerosis
#4
Stephen L Pinkosky, Roger S Newton, Emily A Day, Rebecca J Ford, Sarka Lhotak, Richard C Austin, Carolyn M Birch, Brennan K Smith, Sergey Filippov, Pieter H E Groot, Gregory R Steinberg, Narendra D Lalwani
Despite widespread use of statins to reduce low-density lipoprotein cholesterol (LDL-C) and associated atherosclerotic cardiovascular risk, many patients do not achieve sufficient LDL-C lowering due to muscle-related side effects, indicating novel treatment strategies are required. Bempedoic acid (ETC-1002) is a small molecule intended to lower LDL-C in hypercholesterolemic patients, and has been previously shown to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase (AMPK) activity in rodents...
November 28, 2016: Nature Communications
https://www.readbyqxmd.com/read/27878791/new-concepts-in-the-management-of-dyslipidaemiaa
#5
Baris Gencer, Nicolas Rodondi, Francois Mach
Recently, the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) published a consensus paper giving guidance on the definition and management of statin-associated muscle symptoms (SAMS), as well as the use of proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in very high-risk patients. The occurrence of SAMS can have a major negative impact on treatment adherence and, consequently, on the prognosis of cardiovascular diseases. In addition, both the ESC guidelines on the prevention of cardiovascular disease (CVD) in clinical practice with sections addressing global strategies to minimise the burden of CVD at population and individual levels, and the 2016 ESC/EAS guideline for the management of dyslipidaemias, focus on evaluation and treatment of SAMS...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27876411/disruption-of-mitochondrial-quality-control-in-peripheral-artery-disease-new-therapeutic-opportunities
#6
REVIEW
Cintia B Ueta, Katia S Gomes, Márcio A Ribeiro, Daria Mochly-Rosen, Julio C B Ferreira
Peripheral artery disease (PAD) is a multifactorial disease initially triggered by reduced blood supply to the lower extremities due to atherosclerotic obstructions. It is considered a major public health problem worldwide, affecting over 200 million people. Management of PAD includes smoking cessation, exercise, statin therapy, antiplatelet therapy, antihypertensive therapy and surgical intervention. Although these pharmacological and non-pharmacological interventions usually increases blood flow to the ischemic limb, morbidity and mortality associated with PAD continue to increase...
November 19, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27870723/influence-of-baseline-psychological-health-on-muscle-pain-during-atorvastatin-treatment
#7
Amanda L Zaleski, Beth A Taylor, Linda S Pescatello, Ellen A Dornelas, Charles Michael White, Paul D Thompson
BACKGROUND: 3-hydroxy-3-methylglutaryl coenzyme A reductase reductase inhibitors (statins) are generally well tolerated, with statin-associated muscle symptoms (SAMS) the most common side effect (~10%) seen in statin users. However, studies and clinical observations indicate that many of the self-reported SAMS appear to be nonspecific (ie, potentially not attributable to statins). OBJECTIVE: Mental health and well-being influence self-perception of pain, so we sought to assess the effect of baseline well-being and depression on the development of muscle pain with 6 months of atorvastatin 80 mg/d (ATORVA) or placebo in healthy, statin-naive adults...
November 18, 2016: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/27862587/are-non-allergic-drug-reactions-commonly-documented-as-medication-allergies-a-national-cohort-of-veterans-admissions-from-2000-to-2014
#8
Kevin W McConeghy, Aisling R Caffrey, Haley J Morrill, Amal N Trivedi, Kerry L LaPlante
PURPOSE: Adverse drug reactions (ADRs) including medication allergies are not well-described among large national cohorts. This study described the most common documented medication allergies and their reactions among a national cohort of Veterans Affairs (VA) inpatients. METHODS: We evaluated inpatient admissions in any VA Medical Center from 1 January 2000 to 31 December 2014. Each admission was linked with allergy history preceding or upon admission. Individual drugs were aggregated into drug class category including: penicillins, sulfonamides, angiotensin converting enzyme (ACE) inhibitors, opiates, HMG-CoA reductase inhibitors ("statins") and non-steroidal anti-inflammatory inhibitors (NSAID)...
November 13, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27861905/attenuation-of-experimental-autoimmune-neuritis-with-locally-administered-lovastatin-encapsulating-plga-nanoparticles
#9
Kelly A Langert, Bruktawit Goshu, Evan B Stubbs
Acute inflammatory demyelinating polyneuropathy (AIDP) is an aggressive antibody- and T cell-mediated variant of Guillain-Barré Syndrome (GBS), a prominent and debilitating autoimmune disorder of the peripheral nervous system. Despite advancements in clinical management, treatment of patients with AIDP/GBS and its chronic variant CIDP remains palliative and relies on the use of non-specific immune-modulating therapies. Our laboratory has previously reported that therapeutic administration of statins safely attenuates the clinical severity of experimental autoimmune neuritis (EAN), a well-characterized animal model of AIDP/GBS, by restricting the migration of autoreactive leukocytes across peripheral nerve microvascular endoneurial endothelial cells (PNMECs) that form the blood-nerve barrier...
November 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27828790/naoxintong-enhances-atorvastatin-induced-plaque-stability-while-ameliorating-atorvastatin-induced-hepatic-inflammation
#10
Xiaoxiao Yang, Yan Li, Lei Sun, Ying Liu, Chuanrui Ma, Yuanli Chen, Hao Tan, Qi Li, Xiaoju Li, Yong Wang, Yajun Duan, Buchang Zhao, Jihong Han
Buchang NaoXinTong (NXT) is a Chinese medicine which has been used for many years for treatment of patients with coronary heart disease (CHD) in China. Statins substantially reduce hypercholesterolemia and CHD mortality and morbidity. However, there is still a lot of CHD patients do not respond well to statin therapy. Herein, we report the effects of NXT on atorvastatin-inhibited atherosclerosis and atorvastatin-induced hepatic side effects. After 10 weeks high-fat diet (HFD) feeding, apoE deficient mice were randomly divided into 4 groups, and received the following treatment for another 8 weeks: group 1, HFD; group 2, HFD containing NXT; group 3, HFD containing atorvastatin; and group 4, HFD containing both NXT and atorvastatin...
October 26, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27815113/rosuvastatin-safety-an-experimental-study-of-myotoxic-effects-and-mitochondrial-alterations-in-rats
#11
Samar O El-Ganainy, Ahmed El-Mallah, Dina Abdallah, Mahmoud M Khattab, Mahmoud M Mohy El-Din, Aiman S El-Khatib
Myopathy is the most commonly reported adverse effect of statins. All statins are associated with myopathy, though with different rates. Rosuvastatin is a potent statin reported to induce myopathy comparable to earlier statins. However, in clinical practice most patients could tolerate rosuvastatin over other statins. This study aimed to evaluate the myopathic pattern of rosuvastatin in rats using biochemical, functional and histopathological examinations. The possible deleterious effects of rosuvastatin on muscle mitochondria were also examined...
November 1, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27814594/cardiac-allograft-vasculopathy-microvascular-arteriolar-capillaries-capioles-and-survival
#12
Carlos A Labarrere, Beate R Jaeger, Ghassan S Kassab
Cardiac allograft vasculopathy (CAV) is a serious complication of heart transplantation in adults and children. Risk factors include human leukocyte antigen mismatches, number and duration of rejection episodes, type of immunosuppression, antibody-mediated rejection, hypertension, hyperlipidemia, obesity, smoking, diabetes, cytomegalovirus infection, mode of donor brain death, donor age and ischemia/reperfusion injury. Endothelial injury and dysfunction in CAV are characterized by changes in adhesion molecules and up-regulation of major histocompatibility class II antigens followed by endothelial activation of complement C4d...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27805428/statin-myopathy-navigating-the-maze
#13
Christos V Rizos, Moses S Elisaf
Statins hold a central role in cardiovascular disease (CVD) prevention having proved both their efficacy and their safety. However, the development of side effects, most commonly muscle related symptoms, can lead to suboptimal treatment adhesion or even discontinuation. This translates to poor CVD risk management. As a result, it is imperative that physicians differentiate true statin-associated muscle symptoms (SAMS) from other causes as well as assess statin intolerance. Moreover, an alternative treatment strategy should be implemented for the management of these patients...
November 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27798246/high-intensity-atorvastatin-induced-rhabdomyolysis-in-an-elderly-patient-with-nstemi-a-case-report-and-review-of-the-literature
#14
Glen A Huynh, Audrey J Lee
A 91-year-old male was admitted to the hospital for worsening muscle weakness, muscle pain, and unexplained soreness for the past 10 days. Four months prior to his admission, the patient had experienced a myocardial infarction and was initiated on atorvastatin 80 mg daily. Although the provider had instructed the patient to decrease the atorvastatin dose to 40 mg daily 3 months prior to admission, the patient did not adhere to the lower dose regimen until 10 days prior to hospitalization. Upon admission, the patient presented with muscle weakness and pain, a serum creatinine phosphokinase of 18 723 U/L, and a serum creatinine of 1...
October 26, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27793139/a-short-term-statin-treatment-changes-the-contractile-properties-of-fast-twitch-skeletal-muscles
#15
Antoine Boulanger Piette, Sébastien S Dufresne, Jérôme Frenette
BACKGROUND: Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper healthcare management. The purpose of the present study was to investigate the early after-effects of lovastatin on the slow-twitch soleus (Sol) and fast-twitch extensor digitorum longus (EDL) muscles. METHODS: Adult C57BL/6 mice were orally administrated with placebo or lovastatin [50 mg/kg/d] for 28 days...
October 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27782356/simvastatin-alleviates-airway-inflammation-and-remodelling-through-up-regulation-of-autophagy-in-mouse-models-of-asthma
#16
Wen Gu, Rong Cui, Tao Ding, Xiaoming Li, Juan Peng, Weiguo Xu, Fengfeng Han, Xuejun Guo
BACKGROUND AND OBJECTIVE: Statins have been widely used in inflammatory diseases including asthma, because of their anti-inflammatory and immunomodulatory properties. It has been shown that simvastatin induces autophagy and cell death in some circumstances. However, the possible cross-talk between simvastatin and autophagic processes in lung disease is largely unknown. Thus, we investigated the impact of simvastatin on airway inflammation and airway remodelling and the possible relationship of these processes to a simvastatin-induced autophagic pathway in mouse models of asthma...
October 26, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27776432/statin-associated-muscle-symptoms-position-paper-from-the-luso-latin-american-consortium
#17
Andrei C Sposito, José Rocha Faria Neto, Luiz Sergio F de Carvalho, Alberto Lorenzatti, Alberto Cafferata, Gerardo Elikir, Eduardo Esteban, Enrique C Morales Villegas, Luiz Carlos Bodanese, Rodrigo Alonso, Alvaro J Ruiz, Viviane Z Rocha, Andre A Faludi, Hermes T Xavier, Ota Vio Rizzi Coelho, Marcelo H V Assad, Maria C Izar, Raul D Santos, Francisco A H Fonseca, Alberto Mello E Silva, Pedro Marques da Silva, Marcelo C Bertolami
In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27764723/efficacy-and-safety-of-long-term-treatment-with-statins-for-coronary-heart-disease-a-bayesian-network-meta-analysis
#18
Yongbin Lu, Zhiyuan Cheng, Yaxue Zhao, Xiaoyu Chang, Cynthia Chan, Yana Bai, Ning Cheng
BACKGROUND AND AIMS: Our study aims to evaluate the efficacy and safety of long-term treatment of statins for coronary heart disease (CHD). METHODS: Efficacy outcomes included changes in blood lipids, risk of CHD mortality and all-cause mortality. Safety outcomes were evaluated by the risk of adverse events (AE). Bayesian network meta-analysis was used to compare the direct and indirect effects between different statins. RESULTS: The systematic review showed that levels of blood lipids decreased during statin treatment...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27759359/statin-induced-rhabdomyolysis
#19
Sachinkumar N Ambapkar, Naresh Shetty, Arpita Dwivedy
Rhabdomyolysis is syndrome characterized by muscle necrosis which causes the release of myoglobin into the bloodstream. The manifestations of this syndrome range from asymptomatic elevation of muscle enzymes to life-threatening cases associated with extremely high enzyme levels, electrolyte imbalance and acute renal failure. Symptoms of rhabdomyolysis include dark urine, muscle weakness and fatigue. Statins are the most commonly used drugs for prevention and management of dyslipidemia. We present an interesting case report on statin induced rhabdomyolysis with renal failure...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27757045/pharmacogenomics-of-statins-understanding-susceptibility-to-adverse-effects
#20
Joseph P Kitzmiller, Eduard B Mikulik, Anees M Dauki, Chandrama Murkherjee, Jasmine A Luzum
Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and morbidity worldwide. Statins are among the most commonly prescribed classes of medications, and their prescribing indications and target patient populations have been significantly expanded in the official guidelines recently published by the American and European expert panels. Adverse effects of statin pharmacotherapy, however, result in significant cost and morbidity and can lead to nonadherence and discontinuation of therapy...
2016: Pharmacogenomics and Personalized Medicine
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