keyword
https://read.qxmd.com/read/38267522/impact-of-cd-28-cd86-ctla-4-and-pd-1-genes-polymorphisms-on-acute-renal-allograft-rejection-and-graft-survival-among-egyptian-recipients
#21
JOURNAL ARTICLE
Moatasem Elsayed Ghoneim, Hussein Sheashaa, Ehab Wafa, Amira Awadalla, Asmaa E Ahmed, Mohamed Sobh, Ahmed Abdulrahman Shokeir
To study the impact of four gene polymorphisms on acute renal allograft rejection (AR) and graft survival among Egyptian population. These 4 gene polymorphisms include: (1) CD 28 (rs3116496), (2) CD86 (rs1129055), (3) CTLA-4 (rs3087243), (4) PD-1 (rs2227982). This is a non-concurrent cohort study including 50 kidney transplant recipients diagnosed histopathologically as (AR) [study group] and another 50 matched allograft recipients without AR [control group]. Blood samples were taken from both groups and subjected to genotyping for the selected four genetic polymorphisms by TaqMan genotyping assay...
January 24, 2024: Scientific Reports
https://read.qxmd.com/read/38266883/exploration-of-the-shared-gene-signatures-and-biological-mechanisms-between-ischemia-reperfusion-injury-and-antibody-mediated-rejection-in-renal-transplantation
#22
JOURNAL ARTICLE
Shan Jiang, Hua Su
BACKGROUND: Antibody-mediated rejection (ABMR) plays a crucial role in graft loss during allogeneic renal transplantation. In renal transplantation, ischemia-reperfusion injury (IRI) is unavoidable, serves as a major contributor to acute rejection, and is linked to graft loss. However, the mechanisms underlying IRI and ABMR are unclear. Therefore, this study aimed to investigate the shared genetic characteristics and biological mechanisms between IRI and ABMR. METHODS: Gene expressions for IRI (GSE43974) and ABMR (GSE129166 and GSE36059) were retrieved from the Gene Expression Omnibus database...
January 22, 2024: Transplant Immunology
https://read.qxmd.com/read/38256619/interpretation-of-ldh-values-after-kidney-transplantation
#23
JOURNAL ARTICLE
Zoltán Sándor, Dorottya Katics, Ádám Varga, Károly Kalmár Nagy, Péter Szakály
Kidney transplantation is the gold-standard therapy for end-stage renal disease. However, in the early postoperative period following allograft kidney transplantation, insufficient graft function presents a diagnostic challenge to clinicians. Ischemic damage to the graft and/or an early autoimmune rejection may cause a decrease in function. Ischemic damage is a benign and transient condition, while acute immune rejection requires immediate therapy. A kidney graft ultrasound may produce a false negative result, and graft biopsy is invasive and slow to return results...
January 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38224843/renal-transplantation-for-infantile-and-juvenile-cystinosis-two-case-report-and-review-of-the-literature
#24
Karen El Ghoul, Dany Akiki, Nagi Nawfal, Maroun Abou Jaoude
Cystinosis is a rare autosomal recessive lysosomal storage disorder characterized by cystine buildup in various tissues, including the kidneys. Renal involvement is the primary manifestation, leading to end-stage renal disease (ESRD) if left untreated. Kidney transplantation (KT) in patients with cystinosis has significantly improved their prognosis for the disease outcome. Detailed reports on preoperative and Long-term postoperative management in these patients remain sparse. This report discusses the outcomes of two young adult patients of Middle Eastern descent with cystinosis who underwent KT...
January 14, 2024: Transplant Immunology
https://read.qxmd.com/read/38222990/herpetic-keratitis-following-treatment-of-acute-antibody-mediated-rejection-in-a-renal-transplantation-recipient
#25
Geeta Behera, Sandip Sarkar, Jagadeeshwari Jayaseelan, Sreejith Parameswaran
We report an incident case of herpetic keratitis in a renal transplant recipient treated for acute renal allograft rejection. A lady in her forties, a renal transplant recipient on treatment for allograft rejection, was referred with mild ocular symptoms in the right eye for two days. On evaluation, she had mild conjunctival hyperemia and extensive herpetic epithelial keratitis involving the limbal and central corneas. The patient healed without sequelae from the antivirals and lubricants. Viral keratitis in immunosuppressed patients should be suspected, even in patients with mild symptoms, as early initiation of treatment can prevent rapid stromal involvement and scarring...
January 2024: Curēus
https://read.qxmd.com/read/38216361/immunoglobulin-a-deposits-in-renal-allografts-a-prospective-longitudinal-single-center-study
#26
JOURNAL ARTICLE
Kartik Ganesh, J K Jayaram, Renu Mariam Thomas, Tena Thomas Abraham, Jithin S Kumar, Sunita S Simon, M Abi Abraham
AIMS AND BACKGROUND: To describe the prevalence of IgA deposits (IgAD) in renal allografts in a cohort of renal transplant recipients and to analyze their management strategies and histopathology. To assess graft function and proteinuria after 1 year of follow-up. MATERIALS AND METHODS: A prospective longitudinal follow-up study was carried out in VPS Lakeshore Hospital and Research Centre, Kochi, Kerala, over a period of 5 years (July 2015 to June 2020). Kidney transplant recipients with allograft biopsies that reported IgAD on immunofluorescence were included in the study...
2024: Transplantation Proceedings
https://read.qxmd.com/read/38215274/screening-of-novel-biomarkers-for-acute-kidney-transplant-rejection-using-dia-ms-based-proteomics
#27
JOURNAL ARTICLE
Ce Wang, Gang Feng, Jie Zhao, Yang Xu, Yang Li, Lin Wang, Meng Wang, Miao Liu, Yilin Wang, Hong Mu, Chunlei Zhou
BACKGROUND: Kidney transplantation is the preferred treatment for patients with end-stage renal disease. However, acute rejection poses a threat to the graft long-term survival. The aim of this study was to identify novel biomarkers to detect acute kidney transplant rejection. METHODS: The serum proteomic profiling of kidney transplant patients with T cell-mediated acute rejection (TCMR) and stable allograft function (STA) was analyzed using data-independent acquisition mass spectrometry (DIA-MS)...
January 12, 2024: Proteomics. Clinical Applications
https://read.qxmd.com/read/38199857/diuretic-use-in-post-kidney-transplant-patients-a-retrospective-chart-review
#28
JOURNAL ARTICLE
Zohreh Gholizadeh Ghozloujeh, Soo Min Jang, Amir Abdipour
BACKGROUND: The occurrence of delayed graft function (DGF) significantly enhances the possibility of both acute and chronic rejection of the transplanted organ, thereby reducing patient quality of life and survival rates. To prevent and manage oliguria in renal transplant patients, loop diuretics are presently commonly used. In our study, we assessed the possible impact of furosemide on the incidence of DGF among kidney transplant recipients. METHODS: A review of medical records was conducted to examine demographic characteristics and kidney transplant outcomes in an adult (older than 18 years old) population...
2024: Transplantation Proceedings
https://read.qxmd.com/read/38193573/the-medical-cost-and-outcome-of-desensitization-protocol-in-kidney-transplantation-recipients-with-high-immunological-risks
#29
JOURNAL ARTICLE
Ryoichi Maenosono, Kohei Unagami, Rikako Oki, Yuya Fujiwara, Taro Banno, Daigo Okada, Takafumi Yagisawa, Taichi Kanzawa, Toshihito Hirai, Kazuya Omoto, Norio Hanafusa, Haruhito Azuma, Toshio Takagi, Hideki Ishida
BACKGROUND: Kidney transplantation is a well-established alternative in renal replacement therapy. Compared with hemodialysis, low-immunological-risk kidney transplantation can reduce the medical treatment costs associated with end-stage renal disease. However, there are few reports on whether high-immunological-risk kidney transplantation reduces the financial burden on governments. We investigated the medical costs of high-immunological-risk kidney transplantation in comparison with the cost of hemodialysis in Japan...
January 9, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
https://read.qxmd.com/read/38174152/predictors-of-graft-function-and-survival-in-second-kidney-transplantation-a-single-center-experience
#30
JOURNAL ARTICLE
Mahmoud Khalil, Rabea Ahmed Gadelkareem, Medhat Ahmed Abdallah, Mohamed Abdel-Basir Sayed, Fathy Gaber Elanany, Paolo Fornara, Nasreldin Mohammed
BACKGROUND: The increasing kidney retransplantation rate has created a parallel field of research, including the risk factors and outcomes of this advanced form of renal replacement therapy. The presentation of experiences from different kidney transplantation centers may help enrich the literature on kidney retransplantation, as a specific topic in the field of kidney transplantation. AIM: To identify the risk factors affecting primary graft function and graft survival rates after second kidney transplantation (SKT)...
December 18, 2023: World Journal of Transplantation
https://read.qxmd.com/read/38174145/anti-thymocyte-globulin-for-treatment-of-t-cell-mediated-allograft-rejection
#31
REVIEW
Sumit Acharya, Suraj Lama, Durga Anil Kanigicherla
Anti-thymocyte globulin (ATG) is a pivotal immunosuppressive therapy utilized in the management of T-cell-mediated rejection and steroid-resistant rejection among renal transplant recipients. Commercially available as Thymoglobulin (rabbit-derived, Sanofi, United States), ATG-Fresenius S (rabbit-derived), and ATGAM (equine-derived, Pfizer, United States), these formulations share a common mechanism of action centered on their interaction with cell surface markers of immune cells, imparting immunosuppressive effects...
December 18, 2023: World Journal of Transplantation
https://read.qxmd.com/read/38172705/acute-renal-failure-after-kidney-transplantation-due-to-mizoribine-induced-ureteral-stones
#32
JOURNAL ARTICLE
Mao Ding, Hongchao Zhao, Hengcheng Zhu
INTRODUCTION: Mizoribine (MZR) is used to prevent rejection reactions after kidney transplantation and increase the risk of hyperuricemia. There is a lack of reports of MZR-induced ureteral stones after kidney transplantation. The surgery treatment of ureteral stones in transplanted kidney is a challenging clinical issue that should only be performed by experienced urologists at professional centers. It is very important to have a thorough understanding of the patient's medical history, analyze the causes of stone formation, and choose a reasonable treatment plan based on the characteristics of the stones...
January 3, 2024: BMC Nephrology
https://read.qxmd.com/read/38152417/fixed-low-dose-versus-concentration-controlled-initial-tacrolimus-dosing-with-reduced-target-levels-in-the-course-after-kidney-transplantation-results-from-a-prospective-randomized-controlled-non-inferiority-trial-slow-low-study
#33
JOURNAL ARTICLE
Julian Stumpf, Klemens Budde, Oliver Witzke, Claudia Sommerer, Thomas Vogel, Peter Schenker, Rainer Peter Woitas, Mirian Opgenoorth, Evelyn Trips, Eva Schrezenmeier, Christian Hugo
BACKGROUND: Optimal initial tacrolimus dosing and early exposure of tacrolimus after renal transplantation is not well studied. METHODS: In this open-label, 6 months, multicenter, randomized controlled, non-inferiority study, we randomly assigned 432 renal allograft recipients to receive basiliximab induction, mycophenolate and steroids and either standard prolonged-release tacrolimus (trough levels: 7-9 ng/ml; Standard Care arm), or an initial 7-day fixed 5 mg/day dose of prolonged-release tacrolimus followed by lower tacrolimus predose levels (trough levels: 5-7 ng/ml; Slow & Low arm)...
January 2024: EClinicalMedicine
https://read.qxmd.com/read/38146570/beyond-immunosuppression-the-intricate-relationship-between-tacrolimus-and-microangiopathy
#34
REVIEW
Ripudaman S Munjal, Jagdish Sharma, Srinija Polishetti, Pushkar Sai Valleru, Himanshi Banker, Ramansh Bandhu Gupta, Fnu Anamika, Rohit Jain
Tacrolimus, widely known as Prograf, has become the preferred immunosuppressant for preventing graft rejection in solid organ transplant recipients, particularly in steroid-sparing regimens. Its efficacy and reduced risk of acute and chronic rejection compared to cyclosporine have made it the preferred treatment option for transplant patients. However, tacrolimus has drawbacks as it is associated with adverse effects, such as renal tubular necrosis, kidney failure, hypertension, metabolic acidosis, and new-onset diabetes mellitus...
November 2023: Curēus
https://read.qxmd.com/read/38146146/functional-mri-evaluation-of-blood-oxygen-dependent-bold-in-renal-allograft-dysfunction-a-prospective-study
#35
JOURNAL ARTICLE
Hashim Mohamed Farg, Tarek El-Diasty, Bedeir Ali-El-Dein, Ayman Refaie, Mohamed Abou El-Ghar
BACKGROUND: Blood oxygen level dependent-magnetic resonance imaging (BOLD-MRI) is a non-invasive functional imaging technique that can be used to assess renal allograft dysfunction. PURPOSE: To evaluate the diagnostic performance of BOLD-MRI using a 3-T scanner in discriminating causes of renal allograft dysfunction in the post-transplant period. MATERIAL AND METHODS: This prospective study was conducted on 112 live donor-renal allograft recipients: 53 with normal graft function, as controls; 18 with biopsy-proven acute rejection (AR); and 41 with biopsy-proven acute tubular necrosis (ATN)...
December 25, 2023: Acta Radiologica
https://read.qxmd.com/read/38137602/indoleamine-2-3-dioxygenase-1-ido1-in-kidney-transplantation-a-guardian-against-rejection
#36
JOURNAL ARTICLE
Krzysztof Wiśnicki, Piotr Donizy, Agnieszka Hałoń, Patryk Wawrzonkowski, Dariusz Janczak, Magdalena Krajewska, Mirosław Banasik
Kidney transplantation is a crucial treatment for end-stage kidney disease, with immunosuppressive drugs helping to reduce acute rejection rates. However, kidney graft longevity remains a concern. This study explores the role of indoleamine 2,3-dioxygenase 1 (IDO1) in kidney transplant immunology. IDO1 breaks down tryptophan, affecting immune cell behavior, primarily T-cells. The research focuses on both cellular and antibody-mediated immune responses, often causing graft damage. The study assessed IDO1 expression in renal transplant biopsies from patients with graft function decline, examining its connection to clinical parameters...
December 6, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38133339/concomitant-polyoma-bk-virus-and-west-nile-virus-in-renal-allografts
#37
Riddhish T Sheth, Dalia Y Ibrahim, Amira F Gohara, Obi Ekwenna, Michael A Rees, Deepak Malhotra, William T Gunning
Surveillance of the renal allograft recipient is essential when monitoring renal function to detect the early onset of rejection and alter therapeutic treatments to treat acute rejection or other causes and improve long-term graft function. If renal function begins to deteriorate, a renal biopsy is often indicated to assess the Banff grade of potential rejection or other causes, especially in the setting of polyoma BK viral load elevation. Although BK infection in the allograft is asymptomatic, reactivation of the virus is known to be associated with the acceleration of pathologic change and a poor outcome in the allograft...
December 15, 2023: Pathogens
https://read.qxmd.com/read/38105889/sirolimus-in-combination-with-low-dose-extended-release-tacrolimus-in-kidney-transplant-recipients
#38
JOURNAL ARTICLE
Zhi-Yu Zou, Lin-Rui Dai, Yi-Bo Hou, Chen-Zhen Yu, Ren-Jie Chen, Yan-Yan Chen, Bin Liu, Hui-Bo Shi, Nian-Qiao Gong, Zhi-Shui Chen, Song Chen, Sheng Chang, Wei-Jie Zhang
INTRODUCTION: Many challenges remain for long-term survival of renal allografts. Once-daily sirolimus (SRL) combined with low-dose extended-release tacrolimus (LER-TAC) may improve medication adherence and reduce the potential nephrotoxicity of calcineurin inhibitors (CNI) compared with standard immunosuppression regimens, thus potentially improving long-term graft survival. METHODS: This retrospective, observational, single-center, propensity score matching (PSM) study compared conversion to SRL combined with low-dose ER-TAC and mycophenolic acid (MPA) combined with standard-dose TAC in kidney transplant recipients...
2023: Frontiers in Medicine
https://read.qxmd.com/read/38092720/de-novo-donor-specific-anti-human-leukocyte-antigen-antibody-and-its-outcome-in-pediatric-renal-transplant-recipients-a-single-center-experience-in-india
#39
JOURNAL ARTICLE
Anshuman Saha, Shahenaz F Kapadia, Kinnari B Vala, Varsha B Trivedi, Himanshu V Patel, Pankaj R Shah, Vivek B Kute
Development of de novo donor-specific anti-HLA antibody (dnDSA) is associated with poor graft survival in adults. However, there is a paucity of data about its prevalence and outcome in Indian children. We retrospectively assessed the proportion and spectrum of dnDSA and its outcome on antibody-mediated rejection (ABMR) and graft function. Children ≤18 years who were transplanted between November 2016 and October 2019 were included in this study. Pretransplant donor-specific antibody (DSA) was screened by complement-dependent cytotoxicity, flow cytometry crossmatch, and single antigen bead (SAB) class I and II by Luminex platform...
January 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38091056/prediction-of-acute-rejection-in-renal-allografts-using-shear-wave-dispersion-slope
#40
JOURNAL ARTICLE
Taek Min Kim, Hyungwoo Ahn, Jeong Yeon Cho, Ahram Han, Sang-Il Min, Jongwon Ha, Sang Youn Kim
OBJECTIVES: To evaluate the role of shear-wave dispersion slope for predicting renal allograft dysfunction. METHODS: We retrospectively reviewed 128 kidney transplant recipients (median age, 55 years [interquartile range, 43-62 years]; male, 68) who underwent biopsy for allograft evaluation from November 2022 to February 2023. Cortex and renal sinus fat stiffness and shear-wave dispersion slope were obtained at shear-wave elastography (SWE). Cortex-to-sinus stiffness ratio (SR) and dispersion slope ratio (DSR)-related clinical and pathologic factors were evaluated using multivariable linear regression analysis...
December 13, 2023: European Radiology
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