Dora Koller, Marina Mitjans, Manuela Kouakou, Eleni Friligkou, Brenda Cabrera-Mendoza, Joseph D Deak, Natalia Llonga, Gita A Pathak, Brendan Stiltner, Solveig Løkhammer, Daniel F Levey, Hang Zhou, Alexander S Hatoum, Rachel L Kember, Henry R Kranzler, Murray B Stein, Roser Corominas, Ditte Demontis, María Soler Artigas, Josep Antoni Ramos-Quiroga, Joel Gelernter, Marta Ribasés, Bru Cormand, Renato Polimanti
We characterized the genetic architecture of the attention-deficit hyperactivity disorder-substance use disorder (ADHD-SUD) relationship by investigating genetic correlation, causality, pleiotropy, and common polygenic risk. Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (Neff = 51,568), cannabis use disorder (CanUD, Neff = 161,053), opioid use disorder (OUD, Neff = 57,120), problematic alcohol use (PAU, Neff = 502,272), and problematic tobacco use (PTU, Neff = 97,836)...
March 2024: Psychiatry Research