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https://www.readbyqxmd.com/read/28533034/psychiatric-disorders-and-function-in-adolescents-with-tetralogy-of-fallot
#1
Jennifer E Holland, Adam R Cassidy, Christian Stopp, Matthew T White, David C Bellinger, Michael J Rivkin, Jane W Newburger, David R DeMaso
OBJECTIVES: To assess psychiatric disorders and function in adolescents with repaired tetralogy of Fallot (TOF) without and with a genetic diagnosis and to evaluate associations of functioning with medical factors, IQ, and demographics. STUDY DESIGN: Adolescents with TOF (n = 91) and 87 healthy referents completed a clinician-rated structured psychiatric interview, parent-/self-report measures of psychopathology, and brain magnetic resonance imaging. Twenty-three of the adolescents with TOF had a known genetic diagnosis...
May 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28506353/-effect-of-baicalin-on-atpase-and-ldh-and-its-regulatory-effect-on-the-ac-camp-pka-signaling-pathway-in-rats-with-attention-deficit-hyperactivity-disorder
#2
Rong-Yi Zhou, Jiao-Jiao Wang, Yue You, Ji-Chao Sun, Yu-Chen Song, Hai-Xia Yuan, Xin-Min Han
OBJECTIVE: To study the effect of baicalin on synaptosomal adenosine triphosphatase (ATPase) and lactate dehydrogenase (LDH) and its regulatory effect on the adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway in rats with attention deficit hyperactivity disorder (ADHD). METHODS: A total of 40 SHR rats were randomly divided into five groups: ADHD model, methylphenidate hydrochloride treatment (0.07 mg/mL), and low-dose (3...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28490212/effects-of-adhd-on-writing-composition-product-and-process-in-school-age-students
#3
Celestino Rodríguez, Mark Torrance, Lucy Betts, Rebeca Cerezo, Trinidad García
OBJECTIVE: This study examined the relationship between ADHD and writing performance. METHOD: Students in Grades 3 to 7, 84 with ADHD and 135 age- and gender-matched controls completed a writing task (including process logs), and measures of working memory and attention. RESULTS: Students with ADHD wrote texts of similar length but with poorer structure, coherence, and ideation. In all, 6.7% of the variance in writing quality was explained by whether or not the student had an ADHD diagnosis, after control for IQ and age-within-year, with ADHD students producing text that was less coherent, well structured, and ideationally rich, and spending less time thinking about and reviewing their text...
May 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28486878/sleep-and-quality-of-life-in-children-with-traumatic-brain-injury-and-adhd
#4
Ozalp Ekinci, Çetin Okuyaz, Serkan Günes, Nuran Ekinci, Gülhan Örekeci, Halenur Teke, Meltem Çobanoğulları Direk
Objective Attention problems are common in children who sustain a traumatic brain injury (TBI). The differential features of TBI-related Attention Deficit Hyperactivity Disorder (ADHD) and primary ADHD are largely unknown. This study aimed to compare sleep problems and quality of life between children with TBI and ADHD and children with primary ADHD. Methods Twenty children with TBI (mean age = 12.7 ± 3.1 years) who had clinically significant ADHD symptoms according to the structured diagnostic interview and rating scales and a control group with primary ADHD (n = 20) were included...
January 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28482185/effect-of-exposure-to-polycyclic-aromatic-hydrocarbons-on-basal-ganglia-and-attention-deficit-hyperactivity-disorder-symptoms-in-primary-school-children
#5
Marion Mortamais, Jesus Pujol, Barend L van Drooge, Didac Macià, Gerard Martínez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been proposed as environmental risk factors for attention deficit hyperactivity disorder (ADHD). The effects of these pollutants on brain structures potentially involved in the pathophysiology of ADHD are unknown. OBJECTIVE: The aim of this study was to investigate the effects of PAHs on basal ganglia volumes and ADHD symptoms in school children. METHODS: We conducted an imaging study in 242 children aged 8-12years, recruited through a set of representative schools of the city of Barcelona, Spain...
May 5, 2017: Environment International
https://www.readbyqxmd.com/read/28481576/evaluation-of-a-four-item-dsm-5-limited-prosocial-emotions-specifier-scale-within-and-across-settings-with-spanish-children
#6
Raquel Seijas, Mateu Servera, Gloria García-Banda, Christopher T Barry, G Leonard Burns
The objective was to evaluate a 4-item measure of the DSM-5 Limited Prosocial Emotions (LPE) specifier (a 4-item measure of prosocial emotions). Mothers, fathers, primary teachers, and ancillary teachers completed measures of prosocial emotions (PE), oppositional defiant disorder (ODD), attention-deficit/hyperactivity disorder (ADHD)-inattention (IN), ADHD-hyperactivity/impulsivity (HI), academic and social impairment on 811 Spanish first-grade children (46% girls). Confirmatory factor and structural regression analyses showed PE symptom scores to have (a) good reliability for the 4 sources (80% to 89% true score variance), (b) invariance of like-symptom loadings and intercepts across the 4 sources, (c) strong convergent and discriminant validity within home and school settings, (d) no convergent validity across settings, and (e) associations with academic and social impairment independent of the ODD dimension (the unique effects of PE also remained significant after controlling for ODD, ADHD-IN, and ADHD-HI for mothers and ancillary teachers)...
May 8, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28473750/no-association-between-cortical-gyrification-or-intrinsic-curvature-and-attention-deficit-hyperactivity-disorder-in-adolescents-and-young-adults
#7
Natalie J Forde, Lisa Ronan, Marcel P Zwiers, Aaron F Alexander-Bloch, Stephen V Faraone, Jaap Oosterlaan, Dirk J Heslenfeld, Catharina A Hartman, Jan K Buitelaar, Pieter J Hoekstra
Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of the previously used morphological parameters. The innovative approach of applying intrinsic curvature analysis, which is predictive of gyrification pattern, to the cortical surface applied herein allowed us greater sensitivity to determine whether the structural connectivity abnormalities thus far identified at a centimeter scale also occur at a millimeter scale within the cortical surface...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28458999/magnetization-transfer-imaging-identifies-basal-ganglia-abnormalities-in-adult-adhd-that-are-invisible-to-conventional-t1-weighted-voxel-based-morphometry
#8
Arjun Sethi, Edwin Evelyn-Rahr, Nicholas Dowell, Sanjay Jain, Valerie Voon, Hugo D Critchley, Neil A Harrison, Mara Cercignani
In childhood, Attention Deficit Hyperactivity Disorder (ADHD) is reliably associated with reduced volume of the striatum. In contrast, striatal abnormalities are infrequently detected in voxel-based morphometry (VBM) neuroimaging studies of adults with ADHD. This discrepancy has been suggested to reflect normalisation of striatal morphology with age and prolonged treatment of symptoms. If so, this would indicate that while striatal abnormalities are linked to symptom expression in childhood, they cannot explain the persistence of these symptoms in adulthood...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28449235/psychometric-properties-of-the-mental-health-and-social-inadaptation-assessment-for-adolescents-mia-in-a-population-based-sample
#9
Sylvana M Côté, Massimiliano Orri, Mara Brendgen, Frank Vitaro, Michel Boivin, Christa Japel, Jean R Séguin, Marie-Claude Geoffroy, Alexandra Rouquette, Bruno Falissard, Richard E Tremblay
We report on the psychometric properties of the Mental Health and Social Inadaptation Assessment for Adolescents (MIA), a self-report instrument for quantifying the frequency of mental health and psychosocial adaptation problems using a dimensional approach and based on the DSM-5. The instrument includes 113 questions, takes 20-25 minutes to answer, and covers the past 12 months. A population-based cohort of adolescents (n = 1443, age = 15 years; 48% males) rated the frequency at which they experienced symptoms of Attention Deficit Hyperactivity Disorder (ADHD), Conduct Disorder, Oppositional Defiant Disorder, Depression, Generalized Anxiety, Social Phobia, Eating Disorders (i...
April 27, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#10
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28439100/ventral-striatal-regulation-of-crem-mediates-impulsive-action-and-drug-addiction-vulnerability
#11
M L Miller, Y Ren, H Szutorisz, N A Warren, C Tessereau, G Egervari, A Mlodnicka, M Kapoor, B Chaarani, C V Morris, G Schumann, H Garavan, A M Goate, M J Bannon, J M Halperin, Y L Hurd
Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood. Here we report the critical role of ventral striatal cAMP-response element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability. Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28433949/the-dimensional-structure-of-psychopathology-in-22q11-2-deletion-syndrome
#12
Maria Niarchou, Tyler M Moore, Sunny X Tang, Monica E Calkins, Donna M McDonald-McGuinn, Elaine H Zackai, Beverly S Emanuel, Ruben C Gur, Raquel E Gur
BACKGROUND: 22q11.2 Deletion Syndrome (22q11.2DS) is one of the strongest known genetic risk factors for developing schizophrenia. Individuals with 22q11.2DS have high rates of neurodevelopmental disorders in childhood, while in adulthood ∼25% develop schizophrenia. Similar to the general population, high rates of comorbidity are common in 22q11.2DS. Employing a dimensional approach where psychopathology is examined at the symptom-level as complementary to diagnostic categories in a population at such high genetic risk for schizophrenia can help gain a better understanding of how psychopathology is structured as well as its genetic underpinnings...
April 15, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28420972/multi-modal-multi-measure-and-multi-class-discrimination-of-adhd-with-hierarchical-feature-extraction-and-extreme-learning-machine-using-structural-and-functional-brain-mri
#13
Muhammad Naveed Iqbal Qureshi, Jooyoung Oh, Beomjun Min, Hang Joon Jo, Boreom Lee
Structural and functional MRI unveil many hidden properties of the human brain. We performed this multi-class classification study on selected subjects from the publically available attention deficit hyperactivity disorder ADHD-200 dataset of patients and healthy children. The dataset has three groups, namely, ADHD inattentive, ADHD combined, and typically developing. We calculated the global averaged functional connectivity maps across the whole cortex to extract anatomical atlas parcellation based features from the resting-state fMRI (rs-fMRI) data and cortical parcellation based features from the structural MRI (sMRI) data...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28418789/transitions-and-motivations-for-substance-misuse-in-prison-inmates-with-adhd-and-conduct-disorder-validation-of-a-new-instrument
#14
Susan Young, Rafael A González, Kim Wolff, Laura Mutch, Isabella Malet-Lambert, Gisli H Gudjonsson
OBJECTIVE: There is a reasonable theoretical base for understanding the possible causes and motivations behind substance misuse and its dependency. There is a need for a reliable and valid measure that delineates the markers of substance use from its initiation and identifies different motivations for drug use transitioning, maintenance, and dependency. We addressed this gap in the United Kingdom by examining and validating the Substance Transitions in Addiction Rating Scale (STARS). METHODS: For this review, 390 male prisoners were screened for conduct disorder and assessed with a clinical diagnostic interview for attention deficit/hyperactivity disorder (ADHD)...
April 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28406942/the-brain-anatomy-of-attention-deficit-hyperactivity-disorder-in-young-adults-a-magnetic-resonance-imaging-study
#15
Jean-G Gehricke, Frithjof Kruggel, Tanyaporn Thampipop, Sharina Dyan Alejo, Erik Tatos, James Fallon, L Tugan Muftuler
BACKGROUND: This is one of the first studies to examine the structural brain anatomy and connectivity associated with an ADHD diagnosis and child as well as adult ADHD symptoms in young adults. It was hypothesized that an adult ADHD diagnosis and in particular childhood symptoms, are associated with widespread changes in the brain macro- and microstructure, which can be used to develop a morphometric biomarker for ADHD. METHODS: Voxel-wise linear regression models were used to examine structural and diffusion-weighted MRI data in 72 participants (31 young adults with ADHD and 41 controls without ADHD) in relation to diagnosis and the number of self-reported child and adult symptoms...
2017: PloS One
https://www.readbyqxmd.com/read/28405786/maternal-responsiveness-as-a-predictor-of-self-regulation-development-and-attention-deficit-hyperactivity-symptoms-across-preschool-ages
#16
Ursula Pauli-Pott, Susan Schloß, Katja Becker
Preschool-age "hot" executive function capacity (i.e. reward-related effortful control) represents an early kind of self-regulation that is involved in social adjustment development as well as the development of subtypes of attention-deficit/hyperactivity disorder (ADHD). Early self-regulation development might be malleable by responsive parenting. We analyzed whether maternal responsiveness/sensitivity predicts reward-related control (RRC) development within the preschool period, and whether RRC mediates a negative link between maternal responsiveness and ADHD symptoms...
April 12, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28398986/living-with-symptoms-of-attention-deficit-hyperactivity-disorder-in-adulthood-a-systematic-review-of-qualitative-evidence
#17
Merete B Bjerrum, Preben U Pedersen, Palle Larsen
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) relates to four dimensions of behavior: inattentiveness, restlessness, impulsiveness and hyperactivity. Symptoms affect multiple areas of daily life such as academic performance and social functioning. Despite the negative effects of ADHD, people diagnosed with ADHD do not necessarily regard themselves as being impaired. However, it is unclear how adults with ADHD experience and manage their symptoms. OBJECTIVES: To identify and synthesize the best available evidence on how adults experience living with ADHD...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28390269/validity-and-reliability-of-the-attention-deficit-hyperactivity-disorder-self-report-scale-asrs-v1-1-in-a-clinical-sample-with-eating-disorders
#18
Samantha Carlucci, Iryna Ivanova, Hany Bissada, Giorgio A Tasca
Individuals with eating disorders (EDs) commonly experience comorbid attention deficit hyperactivity disorder (ADHD). The shared features of EDs and ADHD, such as inattention, impulsivity and hyperactivity, may exacerbate ED symptomatology and pose challenges to treatment. It is important to screen patients with EDs for symptoms of ADHD to optimize their treatment outcomes. However, the psychometrics of common measures of ADHD have not yet been examined within an ED population. An example of such a measure is the ADHD self-report scale (ASRS-v1...
March 30, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28387843/child-executive-control-as-a-moderator-of-the-longitudinal-association-between-sleep-problems-and-subsequent-attention-deficit-hyperactivity-disorder-symptoms
#19
Katherine M Kidwell, Maren Hankey, Jennifer Mize Nelson, Kimberly Andrews Espy, Timothy D Nelson
To examine the longitudinal associations among sleep, executive control (EC), and attention-deficit/hyperactivity disorder (ADHD) symptoms in childhood.  In this longitudinal study ( N  = 271), parents answered questions about sleep problems when children were 3 years old, children completed a comprehensive EC task battery at 4.5 years, and teachers completed standardized measures of child ADHD symptoms in 4th grade.  Latent moderated structural equation models demonstrated that sleep problems at 3 years and EC deficits at 4...
April 6, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28383930/sluggish-cognitive-tempo-in-adults-psychometric-validation-of-the-adult-concentration-inventory
#20
Stephen P Becker, G Leonard Burns, Annie A Garner, Matthew A Jarrett, Aaron M Luebbe, Jeffery N Epstein, Erik G Willcutt
As interest in sluggish cognitive tempo (SCT) increases, a primary limitation for the field is the lack of a unified set of symptoms for assessing SCT. No existing SCT measure includes all items identified in a recent meta-analysis as optimal for distinguishing between SCT and attention-deficit/hyperactivity disorder (ADHD) inattention. This study evaluates a new self-report measure for assessing SCT in adulthood, the Adult Concentration Inventory (ACI), which was developed in response to the meta-analytic findings for assessing SCT...
April 6, 2017: Psychological Assessment
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