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https://www.readbyqxmd.com/read/29689030/checkpoint-inhibitor-immune-therapy-systemic-indications-and-ophthalmic-side-effects
#1
Lauren A Dalvin, Carol L Shields, Marlana Orloff, Takami Sato, Jerry A Shields
PURPOSE: To review immune checkpoint inhibitor indications and ophthalmic side effects. METHODS: A literature review was performed using a PubMed search for publications between 1990 and 2017. RESULTS: Immune checkpoint inhibitors are designed to treat system malignancies by targeting one of three ligands, leading to T-cell activation for attack against malignant cells. These ligands (and targeted drug) include cytotoxic T-lymphocyte antigen-4 (CTLA-4, ipilimumab), programmed death protein 1 (PD-1, pembrolizumab, nivolumab), and programmed death ligand-1 (PD-L1, atezolizumab, avelumab, durvalumab)...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29689028/detection-of-type-1-choroidal-neovascular-membranes-using-optical-coherence-tomography-angiography-in-tubercular-posterior-uveitis
#2
Kanika Aggarwal, Aniruddha Agarwal, Aman Sharma, Kusum Sharma, Vishali Gupta
PURPOSE: To study optical coherence tomography angiography (OCTA) and multimodal imaging features of Type 1 inflammatory choroidal neovascularization (CNV) in tubercular serpiginous-like choroiditis and response to anti-vascular endothelial growth factor therapy. METHODS: In this study, multimodal imaging was performed using OCTA, enhanced-depth imaging optical coherence tomography, fluorescein angiography, and indocyanine green angiography. Correlation of OCTA with other imaging modalities in the detection of CNV was performed...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29688642/-the-approach-to-infectious-uveitis-in-children
#3
REVIEW
Halima Dabaja-Younis, Yael Ben-Arie-Weintrob, Eytan Z Blumenthal, Imad Kassis
Uveitis is an inflammatory disease of the intraocular structures involving various parts of the eye. Delays in diagnosis or treatment can lead to severe and irreversible vision loss. There are many causes leading to the development of uveitis, including: infectious, inflammatory, autoimmune and idiopathic sources. Uveitis is rarer in children than in other age groups and its diagnosis is challenging and treatment is complex. This disease might present at later stages after vision damage is already present. Uveitis and decreased vision may be the presenting symptom and/or sign of various inflammatory diseases, which would become fully expressed many years later...
April 2018: Harefuah
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#4
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29686678/immunoglobulin-e-mediated-autoimmunity
#5
REVIEW
Marcus Maurer, Sabine Altrichter, Oliver Schmetzer, Jörg Scheffel, Martin K Church, Martin Metz
The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves' disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29686615/theissenolactone-c-exhibited-ocular-protection-of-endotoxin-induced-uveitis-by-attenuating-ocular-inflammatory-responses-and-glial-activation
#6
Fan-Li Lin, Jau-Der Ho, Yu-Wen Cheng, George C Y Chiou, Jing-Lun Yen, Hung-Ming Chang, Tzong-Huei Lee, George Hsiao
The aim of this study was to investigate the effects of a natural component, theissenolactone C (LC53), on the ocular inflammation of experimental endotoxin-induced uveitis (EIU) and its related mechanisms in microglia. Evaluation of the severity of anterior uveitis indicated that LC53 treatment significantly decreased iridal hyperemia and restored the clinical scores. Additionally, the deficient retina functions of electroretinography were improved by LC53. LC53 significantly reduced levels of tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1, protein leakage and activation of matrix metalloproteinases in the anterior section during EIU...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#7
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29681844/topical-corticosteroid-resolved-rubeosis-iridis-with-neovascular-glaucoma-caused-by-noninfectious-granulomatous-uveitis
#8
Daisuke Sora, Kei Takayama, Manzo Taguchi, Tomohito Sato, Yutaka Sakurai, Takayuki Kanda, Masaru Takeuchi
Purpose: We report a case of topical corticosteroid treatment-resolved rubeosis iridis with neovascular glaucoma (NVG) caused by noninfectious granulomatous uveitis. Case Report: A 61-year-old woman with left ocular pain and blurred vision was referred to our department. Visual acuity and intraocular pressure (IOP) were 20/60 and 37 mm Hg in the left eye, respectively. Inflammatory cells, hyphema, and rubeosis iridis were observed. All laboratory tests, including multiplex polymerase chain reaction for infection using aqueous humor, were negative, and there was neither retinal occlusive vasculitis nor retinal ischemia in the fundus...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29678656/complement-mediated-activation-of-the-nlrp3-inflammasome-and-its-inhibition-by-aav-mediated-delivery-of-cd59-in-a-model-of-uveitis
#9
Binit Kumar, Siobhan M Cashman, Rajendra Kumar-Singh
Uveitis is an inflammatory disorder of the eye responsible for approximately 10%-15% of blindness in the US. In this study, we examined the role of the complement membrane attack complex (MAC) and the NLRP3 inflammasome in the pathogenesis of experimental autoimmune uveitis (EAU) in normal and C9-/- mice that are incapable of assembling the MAC. We discovered that the MAC and the NLRP3 inflammasome and associated production of IL-1β are elevated in EAU mice and that MAC may be involved in regulation of Th1 and Th17 cell differentiation...
March 19, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#10
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675382/long-term-outcomes-of-uveitic-glaucoma-treated-with-ahmed-valve-implant-in-a-series-of-chinese-patients
#11
Ning Bao, Zheng-Xuan Jiang, Paul Coh, Li-Ming Tao
AIM: To report long-term outcomes of secondary glaucoma due to uveitis treated with Ahmed glaucoma valve (AGV) implantation in a series of Chinese patients. METHODS: The retrospective study included 67 eyes from 56 patients with uveitic glaucoma who underwent AGV implantation. Success of the treatment was defined as patients achieving intraocular pressure (IOP) levels between 6 and 21 mm Hg with or without additional anti-glaucoma medications and/or a minimum of 20% reduction from baseline IOP...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675026/multiplex-cytokine-analysis-of-aqueous-humor-in-juvenile-idiopathic-arthritis-associated-anterior-uveitis-with-or-without-secondary-glaucoma
#12
Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M Koch, Philipp S Müther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten Heinz
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29672807/imaging-to-differentiate-the-various-forms-of-seronegative-arthritis
#13
Iris Eshed, Kay-Geert A Hermann, Anna Zejden, Iwona Sudoł-Szopińska
Spondyloarthritis (SpA) is a group of diseases characterized by back pain, spinal inflammation, human leukocyte antigen-B27 positivity, and peripheral findings such as dactylitis, enthesitis, and uveitis. It includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated SpA. The role of imaging in the diagnosis, management, and follow-up of patients with SpA has become dramatically more important with the introduction of new therapies such as tumor necrosis factor-α inhibitors...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29672247/management-of-chronic-hypotony-following-bilateral-uveitis-in-a-patient-treated-with-pembrolizumab-for-cutaneous-metastatic-melanoma
#14
Gerard Reid, Paul Lorigan, Heinrich Heimann, Marta Hovan
PURPOSE: To describe the presentation and management of severe ocular adverse events following treatment with pembrolizumab for cutaneous metastatic melanoma. METHODS: Interventional case report. RESULTS: A 73-year-old Caucasian man receiving pembrolizumab treatment for metastatic melanoma presented with panuveitis and subsequent profound hypotony, choroidal effusions, and optic disk swelling bilaterally. Oral prednisolone controlled intraocular inflammation...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29671190/predictors-of-sustained-clinical-response-in-patients-with-beh%C3%A3-et-s-disease-related-uveitis-treated-with-infliximab-and-adalimumab
#15
Claudia Fabiani, Antonio Vitale, Donato Rigante, Giacomo Emmi, Giuseppe Lopalco, Jurgen Sota, Lorenzo Vannozzi, Gerardo di Scala, Silvana Guerriero, Ida Orlando, Rossella Franceschini, Marco Capozzoli, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
To identify clinical variables capable of predicting long-term treatment duration of TNF-α inhibition in patients with Behçet's disease (BD)-related uveitis. Demographic, clinical, and therapeutic data were retrospectively collected from BD patients treated with the tumor necrosis factor (TNF)-α blockers infliximab and adalimumab. Patients still continuing TNF-α inhibitors at 48-month follow-up visits were classified as long-term responders and were statistically compared to patients discontinuing treatment before the 48-month visit...
April 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29670789/repeat-intravitreal-dexamethasone-implant-for-refractory-cystoid-macular-edema-in-syphilitic-uveitis
#16
Cassandra C Lautredou, Joshua S Hardin, John R Chancellor, Sami H Uwaydat, Abdallah A Ellabban, Ahmed B Sallam
Purpose: To report the successful utilization of adjunctive repeat intravitreal corticosteroid therapy for the treatment of cystoid macular edema in syphilis-related uveitis. Methods/Patients: An HIV-positive patient with treated ocular syphilis who developed refractory cystoid macular edema (CME) was treated with repeat intravitreal corticosteroid therapy including dexamethasone intravitreal implants. Results: Treatment led to the resolution of CME and improvement in visual acuity...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29670780/syphilis-related-eye-disease-presenting-as-bilateral-papilledema-retinal-nerve-fiber-layer-hemorrhage-and-anterior-uveitis-in-a-penicillin-allergic-patient
#17
Jamie Dietze, Shane Havens
Purpose . Treponema pallidum is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Human immunodeficiency virus (HIV) is known to expedite the progression of syphilis when patients are coinfected, thus compounding the potential ophthalmic presentations...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29669371/need-for-quantitative-measurement-methods-for-posterior-uveitis-comparison-of-dual-fa-icga-angiography-edi-oct-choroidal-thickness-and-sun-vitreous-haze-evaluation-in-stromal-choroiditis
#18
Filippo Fabro, Carl P Herbort
BACKGROUND/PURPOSE: Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinical trials in comparison to vitreous haze, the present standard outcome used in clinical trials...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#19
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668637/successful-mesenchymal-stem-cell-treatment-of-leg-ulcers-complicated-by-behcet-disease-a-case-report-and-literature-review
#20
Yanhong Li, Zhongming Wang, Yi Zhao, Yubin Luo, Wangdong Xu, Tony N Marion, Yi Liu
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking...
April 2018: Medicine (Baltimore)
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