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https://www.readbyqxmd.com/read/29241207/disease-remission-in-children-and-adolescents-with-intermediate-uveitis-a-survival-analysis
#1
Lara Borrego-Sanz, Lydia Abásolo, Consuelo López-Abad, Benjamín Fernández-Gutiérrez, Julián García-Feijoo, David Diaz-Valle, Esperanza Pato, Luis Rodriguez-Rodriguez
PURPOSE: To report the incidence rate (IR) of remission in pediatric noninfectious intermediate uveitis (IU). METHODS: Longitudinal retrospective cohort study, including 19 patients (32 eyes) between 1985 and 2014, followed-up until loss or January 2016. Remission was defined following the Standardization of Uveitis Nomenclature workshop criteria, prolonged remission as a remission spanning 12 months and until the end of follow-up, and relapse as recurrence of inflammatory activity in an eye in remission...
December 14, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29240599/title-prevalence-and-visual-outcome-of-glaucoma-with-uveitis-in-a-thai-population
#2
Neha Sharma, Amit Kumar Purang, Julie Pegu, Madhu Bhoot, Suneeta Dubey
No abstract text is available yet for this article.
December 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29239680/the-spots-system-an-ocular-scoring-system-optimized-for-use-in-modern-preclinical-drug-development-and-toxicology
#3
Joshua Seth Eaton, Paul E Miller, Ellison Bentley, Sara M Thomasy, Christopher J Murphy
PURPOSE: To present a semiquantitative ocular scoring system comprising elements and criteria that address many of the limitations associated with systems commonly used in preclinical studies, providing enhanced cross-species applicability and predictive value in modern ocular drug and device development. METHODS: Revisions to the ocular scoring systems of McDonald-Shadduck and Hackett-McDonald were conducted by board-certified veterinary ophthalmologists at Ocular Services On Demand (OSOD) over the execution of hundreds of in vivo preclinical ocular drug and device development studies and general toxicological investigations...
December 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29230617/retrospective-review-on-the-outcome-and-safety-of-transscleral-diode-laser-cyclophotocoagulation-in-refractory-glaucoma-in-chinese-patients
#4
Janice J C Cheung, Kenneth K W Li, Samuela W K Tang
PURPOSE: Transscleral cyclodiode laser cyclophotocoagulation (TSCP) is often reserved for treatment of refractory glaucoma. This retrospective study investigates the safety and efficacy of TSCP among the Chinese population. METHODS: A retrospective review was performed on electronic patient records of all patients receiving TSCP between years 2009 to year 2016. Patient demographics, indication for laser, success and response rate, change in intraocular pressure (IOP), number of treatment sessions, laser energy, glaucoma medication, visual acuity, pain symptoms and complication rate were documented...
December 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29229445/optical-coherence-tomography-angiography
#5
REVIEW
Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detailed far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid, and the requirement for understanding the origins of image artifacts...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29226649/comparison-of-the-diagnostic-power-of-serum-il-6-il-8-and-tnf-%C3%AE-for-the-idiopathic-anterior-uveitis-in-children
#6
Beata Zelazowska-Rutkowska, Malgorzata Mrugacz, Bogdan Cylwik
BACKGROUND: Uveitis is the inflammation of the uvea that often occurs in children. There are many causes of disease, but some of them do not have any reasons and are then called idiopathic uveitis. Cytokines play an important role in the regulation of the immune response. Determination of cytokine profiles could contribute to the explanation of the etiology of uveitis and could serve to evaluate the inflammation intensity as well as be helpful in the early diagnosis this disease. The purpose of this study was to determine the serum level of selected inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF-α) and to compare their diagnostic power as a markers of idiopathic anterior uveitis in children...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29219956/surgical-outcomes-of-preoperative-steroid-for-rhegmatogenous-retinal-detachment-with-associated-choroidal-detachment
#7
A Denwattana, S Prakhunhungsit, S Thoongsuwan, N Rodanant, N Phasukkijwatana
PurposeTo investigate the effect of preoperative steroid on anatomical and functional outcomes of vitrectomy in patients with rhegmatogenous retinal detachment with associated choroidal detachment (RRD-CD), a rare but particular type of RRD.Patients and methodsThis retrospective cohort study included RRD-CD patients at Siriraj Hospital during January 2005 to December 2014. Patients with preexisting uveitis or RRD with giant retinal tears were excluded. Preoperative, intraoperative, and postoperative data were reviewed and analyzed...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29215921/authors-reply-to-letter-to-the-editor-in-response-to-smit-d-meyer-d-maritz-j-et-al-polymerase-chain-reaction-and-goldmann-witmer-coefficient-to-examine-the-role-of-epstein-barr-virus-in-uveitis
#8
Derrick P Smit, David Meyer, Jean Maritz, Jolanda D F De Groot-Mijnes
No abstract text is available yet for this article.
December 7, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29214394/serious-adverse-events-associated-with-anti-tumor-necrosis-factor-alpha-agents-in-pediatric-onset-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis-in-a-real-life-setting
#9
Serena Pastore, Samuele Naviglio, Arianna Canuto, Loredana Lepore, Stefano Martelossi, Alessandro Ventura, Andrea Taddio
OBJECTIVES: Anti-tumor necrosis factor alpha (anti-TNF-α) agents are generally well tolerated, yet they can be associated with serious adverse events (SAEs) in a minority of patients. We examined the incidence of SAEs in a pediatric referral center for chronic rheumatologic and gastroenterological inflammatory disorders. METHODS: Retrospective analysis of SAEs occurring during treatment with anti-TNF-α agents in patients with juvenile idiopathic arthritis (JIA) (n = 78)  or pediatric-onset inflammatory bowel disease (IBD) (n = 105) seen at the Institute for Maternal and Child Health IRCCS "Burlo Garofolo" in Trieste, Italy, between June 2001 and February 2016...
December 6, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29210959/acute-frosted-retinal-periphlebitis-in-a-patient-with-mediterranean-fever
#10
Köse Özlem, Willermain François, Caspers Laure, Postelmans Laurence, El Ouardighi Hind, Guillaume Marie-Paule, Makhoul Dorine
PURPOSE: To present a case of frosted branch periphlebitis in a young Armenian patient with familial Mediterranean fever. METHODS: Case report. RESULTS: A 37-year-old man presented with a unilateral decreased visual acuity and floaters for 4 days on the left eye (LE). Visual acuity was 20/20 in the right eye (RE) and 20/28 in the LE. Anterior segment and fundus examinations of the RE were normal. Slit-lamp examination of LE revealed a mild nongranulomatous anterior uveitis and vitritis...
November 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29208835/effects-of-fuchs-uveitis-syndrome-on-the-ultrastructure-of-the-anterior-lens-epithelium-a-transmission-electron-microscopic-study
#11
Kemal Tekin, Yasemin Ozdamar Erol, Mustafa Fevzi Sargon, Merve Inanc, Pinar Cakar Ozdal, Nilufer Berker
PURPOSE: The purpose of the study was to investigate the electron microscopic findings of the lens epithelial cells (LECs) in patients with Fuchs uveitis syndrome (FUS) who suffered from cataracts and to compare those with age-matched controls. METHODS: This study was a prospective, comparative case series. The anterior lens capsules (ALC: basement membrane and associated LECs) were taken from 12 eyes of 12 cases of FUS and ten eyes of ten control patients. The ALCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM)...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208813/decision-making-and-management-of-uveitic-cataract
#12
REVIEW
Nicole Shu-Wen Chan, Seng-Ei Ti, Soon-Phaik Chee
The visual outcome of uveitic cataract surgery depends on the underlying uveitic diagnosis, the presence of vision-limiting pathology and perioperative optimization of disease control. A comprehensive preoperative ophthalmic assessment for the presence of concomitant ocular pathology, with particular emphasis on macula and optic nerve involvement, is essential to determine which patients will benefit from improved vision after cataract surgery. Meticulous examination in conjunction with adjunct investigations can help in preoperative surgical planning and in determining the need for combined or staged procedures...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29204932/a-retrospective-cohort-study-of-patients-treated-with-anti-tuberculous-therapy-for-presumed-ocular-tuberculosis
#13
Erika Marie Damato, Sarah Dawson, Xiaoxuan Liu, Chandoshi Mukherjee, John Horsburgh, Alastair K Denniston, Edward Moran, Martin Dedicoat, Philip Ian Murray
BACKGROUND: Uveitis involving the posterior segment is a significant and potentially blinding condition. The diagnosis and treatment of patients with uveitis associated with tuberculosis remains controversial, and commonly, patients are systemically well. Use of the interferon-gamma release assays has added to the controversy, as the significance of a positive test may be uncertain. We aim to report the outcomes of anti-tuberculous treatment in a cohort of patients treated in Birmingham, for presumed "ocular tuberculosis", based on clinical findings, systemic assessment and specific testing for tuberculosis...
December 4, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29200130/diffuse-retinal-vascular-leakage-and-cone-rod-dystrophy-in-a-family-with-the-homozygous-missense-c-1429g-a-p-gly477arg-mutation-in-crb1
#14
Hamed Al Sulaiman, Patrik Schatz, Sawsan R Nowilaty, Ehab Abdelkader, Leen Abu Safieh
PURPOSE: To describe a specific cone-rod dystrophy phenotype in a family with the homozygous c.1429G>A; p.Gly477Arg mutation in CRB1. The detailed phenotype of subjects with this specific mutation has not been described previously. METHODS: Clinical examination included full-field electroretinography and high-resolution and widefield retinal imaging and uveitis workup. Molecular genetic analysis included next-generation sequencing of known retinal dystrophy genes and Sanger sequencing for segregation analysis...
December 1, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29195497/bilateral-uveitis-and-macular-edema-induced-by-nivolumab-a-case-report
#15
Claire Theillac, Morgane Straub, Anne-Laure Breton, Luc Thomas, Stéphane Dalle
BACKGROUND: Nivolumab is a fully human antibody which is routinely used at first therapy for metastatic melanoma. Usually, side effects are immune-related adverse events. We report a case of a man who developed bilateral anterior uveitis and macular serous retinal detachment during nivolumab treatment for metastatic melanoma. CASE PRESENTATION: A man on nivolumab treatment for a leg melanoma with duodenal and lymph nodes metastases developed a sudden bilateral visual acuity impairment and bilateral non-painfull redness eyes several days after the third infusion...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29191218/analysis-of-choroidal-and-central-foveal-thicknesses-in-acute-anterior-uveitis-by-enhanced-depth-imaging-optical-coherence-tomography
#16
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
BACKGROUND: Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses during episodes of AAU. METHODS: The medical records of 120 patients with AAU and 120 healthy subjects matched for age, sex, and spherical equivalent of refractive error were reviewed. Subjects were divided into group 1 (AAU-affected eyes), 2 (unaffected fellow eyes), and 3 (healthy control eyes)...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29191216/cosumo-study-protocol-for-the-development-of-a-core-outcome-set-for-efficacy-and-effectiveness-trials-in-posterior-segment-involving-uveitis
#17
Mohammad O Tallouzi, Jonathan M Mathers, David J Moore, Philip I Murray, Nicholas Bucknall, Jane M Blazeby, Melanie Calvert, Alastair K Denniston
BACKGROUND: Uveitis, a group of disorders characterised by intraocular inflammation, causes 10-15% of total blindness in the developed world. The most sight-threatening uveitis affects the posterior segment of the eye (posterior-segment involving uveitis (PSIU)). Numerous different outcomes have been used in clinical trials evaluating alternative treatments for uveitis, limiting inter-trial comparison and aggregation of data. We aim to develop a core outcome set (COS) that would provide a standardised set of outcomes to be measured and reported in all effectiveness trials for PSIU...
December 1, 2017: Trials
https://www.readbyqxmd.com/read/29190170/the-role-of-dexamethasone-implant-in-the-management-of-tubercular-uveitis
#18
Aniruddha Agarwal, Sabia Handa, Kanika Aggarwal, Mansi Sharma, Ramandeep Singh, Aman Sharma, Rupesh Agrawal, Kusum Sharma, Vishali Gupta
PURPOSE: To study the safety and efficacy of intravitreal injection of dexamethasone implant in the management of posterior segment involvement in tubercular uveitis (TBU). METHODS: In this study, retrospective analysis of safety and efficacy of intravitreal injection of dexamethasone implant for various indications such as cystoid macular edema (CME), vitritis, or paradoxical worsening in TB-related intermediate uveitis, retinal vasculitis, and multifocal serpiginoid choroiditis (MSC) was performed...
November 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29190161/in-response-to-smit-d-meyer-d-maritz-j-et-al-polymerase-chain-reaction-and-goldmann-witmer-coefficient-to-examine-the-role-of-epstein-barr-virus-in-uveitis
#19
Philip I Murray, Colin Fink, Deepali Trivedi
No abstract text is available yet for this article.
November 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29190160/clinical-profile-ultra-wide-field-fluorescence-angiography-findings-and-long-term-prognosis-of-uveitis-in-tubulointerstitial-nephritis-and-uveitis-syndrome-at-one-tertiary-medical-institute-in-china
#20
Menglu Yang, Ying Chi, Chunying Guo, Junwen Huang, Li Yang, Liu Yang
PURPOSE: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients. METHODS: A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively. RESULTS: Mild anterior inflammation was observed in all cases. Ultra-wide-field fluorescence angiography (UWFA) was conducted on 13 patients, and peripheral vascular leakage was observed in 22/26 eyes (84...
November 30, 2017: Ocular Immunology and Inflammation
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