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Michael P Whyte, Emilina Lim, William H McAlister, Gary S Gottesman, Lien Trinh, Deborah J Veis, Vinieth N Bijanki, Matthew G Boden, Angela Nenninger, Steven Mumm, David Buchbinder
Pediatric granulomatous arthritis (PGA) refers to two formerly separate entities; autosomal dominant Blau syndrome (BS) and its sporadic phenocopy early-onset sarcoidosis (EOS). In 2001 BS and in 2005 EOS became explained by heterozygous mutations within the gene that encodes nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also called caspase recruitment domain-containing protein 15 (CARD15). NOD2 is a microbe sensor in leukocyte cytosol that activates and regulates inflammation. PGA is characterized by a triad of auto-inflammatory problems (dermatitis, uveitis, and arthritis) in early childhood, which suggests the causal NOD2/CARD15 mutations are activating defects...
June 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Violeta Claudia Bojinca, Mihai Bojinca, Madalina Gheorghe, Adelina Birceanu, Cristina Ileana Iosif, Serban Mihai Balanescu, Andra Rodica Balanescu
Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]...
July 2018: Biomedical Reports
Maria Osminina, Nathalia Geppe, Elena Afonina
Case history of a small girl outlet with epilepsy, followed by scleroderma skin damage and uveitis, neurovasculitis with white matter foci in brain on the side of skin lesion in two months, immunologic disease activity. Resistance to conventional immunosuppressive therapy forced us to initiate the treatment with tocilizumab. It was well tolerated and led to significant improvement of brain, ocular and skin manifestations.
June 18, 2018: Reumatología Clinica
T A Gheita, E M Abd El Latif
OBJECTIVE: The aim of this study was to assess disease characteristics, autoantibodies, and disease activity in granulomatosis with polyangiitis (GPA) patients with ocular manifestations. METHODS: The cohort included 46 GPA patients visiting the ophthalmology clinic. Ocular manifestations were recorded, clinical and slit lamp examinations were performed. The Birmingham Vasculitis Activity Score (BVAS) was recorded. Laboratory investigations and the antineutrophil cytoplasmic antibody (ANCA) assay were performed...
June 20, 2018: Zeitschrift Für Rheumatologie
Annika Reinhardt, Immo Prinz
γδ T cells, αβ T cells, and innate lymphoid cells (ILCs) are capable of producing interleukin (IL)-17A, IL-17F, and IL-22. Among these three families of lymphocytes, it is emerging that γδ T cells are, at least in rodents, the main source of these key pro-inflammatory cytokines. γδ T cells were implicated in multiple inflammatory and autoimmune diseases, including psoriasis, experimental autoimmune encephalomyelitis and uveitis, colitis, and rheumatoid arthritis. Recent findings pointed toward a central role of γδ T cells in the pathogenesis of spondyloarthritis (SpA), a group of inflammatory rheumatic diseases affecting the axial skeleton...
2018: Frontiers in Immunology
Inês Leal, David Cordeiro Sousa, João Costa, António Vaz-Carneiro
Non-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration...
May 30, 2018: Acta Médica Portuguesa
Audrey Chow, Bruce Burkemper, Rohit Varma, Damien C Rodger, Narsing Rao, Grace M Richter
BACKGROUND: Uveitis is defined as a collection of syndromes involving intraocular inflammation which can lead to pain, tissue damage, and vision loss. Ophthalmic surgery in uveitis patients can be challenging due to inflammation-induced fibrosis and scarring. Trabeculectomy and implantation of glaucoma drainage devices (aqueous shunts) have been used in surgical management of uveitic glaucoma, however there is a paucity of literature examining the comparative results of these entities in this unique setting...
June 18, 2018: Journal of Ophthalmic Inflammation and Infection
Maren Kasper, Doris Gabriel, Michael Möller, Dirk Bauer, Lena Wildschütz, Herve Courthion, Marta Rodriguez-Aller, Martin Busch, Michael R R Böhm, Karin Loser, Solon Thanos, Robert Gurny, Arnd Heiligenhaus
In the present study, tissue distribution and the therapeutic effect of topically applied cyclosporine A (CsA)-loaded methoxy-poly(ethylene-glycol)-hexyl substituted poly(lactic acid) (mPEGhexPLA) nanocarriers (ApidSOL) on experimental autoimmune uveitis (EAU) were investigated. The CsA-loaded mPEGhexPLA nanocarrier was tolerated well locally and showed no signs of immediate toxicity after repeated topical application in mice with EAU. Upon unilateral CsA treatment, CsA accumulated predominantly in the corneal and sclera-choroidal tissue of the treated eye and in lymph nodes (LN)...
June 18, 2018: Molecular Pharmaceutics
Sarah Elhamiani Khatat, Deborah Culang, Carolyn Gara-Boivin
Two dogs from Quebec were diagnosed with granulocytic anaplasmosis. They both displayed fever, lethargy, and anorexia. Other clinical signs included vomiting, uveitis, polyarthritis, hepatomegaly, and splenomegaly. Thrombocytopenia, anemia, and lymphopenia were identified in both cases. Cytoplasmic inclusions were observed within neutrophils, and Anaplasma phagocytophilum infection was confirmed by polymerase chain reaction in both dogs.
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
R Clemente-Tomás, C A Arciniegas-Perasso, J M Hervás-Hernandis, F García-Ibor, N Ruiz-Del Río, A M Duch-Samper
CLINICAL CASE: The case concerns an 81-year-old woman on treatment with a topical fixed combination of timolol and brimonidine who was diagnosed in the Emergency Department with acute anterior granulomatous hypertensive uveitis. The patient responded favourably to the withdrawal of the eye drops without showing any subsequent relapse. DISCUSSION: Uveitis due to brimonidine is a rare adverse effect, but it must be known. Once the diagnosis is suspected, the effective treatment is the withdrawal of brimonidine, with or without the addition of topical corticosteroids to control inflammation depending on the severity of the condition...
June 14, 2018: Archivos de la Sociedad Española de Oftalmología
Fernanda Maria Silveira Souto, Bárbara Vilela Giampietro, Julia Thiemi Takiuti, Lucia Maria Arruda Campos, Carlos Eduardo Hirata, Joyce Hisae Yamamoto
AIMS: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil. METHODS: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded...
June 15, 2018: British Journal of Ophthalmology
Jan P Ulloa-Padilla, Pedro J Dávila, Natalio J Izquierdo, Omar García-Rodríguez, Ivonne Z Jiménez
OBJECTIVE: To determine what ocular symptoms and signs are most common and if there are any associations with comorbid conditions in patients with Chikungunya fever. METHODS: A retrospective data review and analysis of the ocular symptomatology of 139 patients with Chikungunya fever who visited a local emergency room from August through September 2014. Frequencies were calculated, and Pearson's chisquare test employed. All the patients were confirmed as having Chikungunya with IgM (ELISA) before admittance into the study...
June 2018: Puerto Rico Health Sciences Journal
C Gustavo De Moraes, Michele Pettito, Juan B Yepez, Anavaj Sakuntabhai, Etienne Simon-Loriere, Mussaret B Zaidi, Matthieu Prot, Claude Ruffie, Susan S Kim, Rando Allikmets, Joseph D Terwilliger, Joseph H Lee, Gladys E Maestre
Introduction: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV)...
May 2018: JMM Case Reports
Hande Taylan Sekeroglu, Mehmet Ali Sekeroglu
Major depression is one of the most common psychiatric disorders in the developed countries, and it is well known that depressive symptoms are more frequently encountered in patients with physical disorders, especially those who have chronic diseases. Although there are numerous study concerning the relationship between ocular inflammatory diseases and depression, the majority of them mainly focus on two diseases: uveitis and dry eye disease (DED). With this review, we aimed to analyze the relation between depression and ocular inflammation, specifically DED and uveitis, in the light of the current literature and to summarize the potential mechanisms regarding this interrelation...
June 12, 2018: Current Topics in Medicinal Chemistry
Douglas J Veale, Ursula Fearon
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovascular disease. Diagnosis is primarily based on clinical phenotype because of the diversity of the associated features, which can include skin and nail disease, dactylitis, uveitis, and osteitis. Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life...
June 2, 2018: Lancet
Ivan Yeu Ming Yip, Stephen Scotcher
We report the rare case of a 5-year-old boy with an infective cause of papilloedema and bilateral uveitis secondary to Mycoplasma pneumoniae The patient presented with generalised headache and malaise. MRI showed signs of raised intracranial pressure and lumbar puncture opening pressure was 43 cmH2 O.Lumbar puncture did not reveal any infective organisms. Blood tests showed raised inflammatory markers. The patient was started on prednisolone, acetazolamide and intravenous cefotaxime. Following an improvement, the patient was discharged...
June 10, 2018: BMJ Case Reports
Joshua Blair, Robert Barry, Philip I Murray, David J Moore, Alastair K Denniston
BACKGROUND: Non-infectious uveitis represents a sub-type of intraocular inflammation often associated with disorders of immune dysregulation. If untreated, the intraocular inflammation may progress to severe visual impairment and blindness. Current treatment is heavily reliant on systemic corticosteroid, often at doses associated with severe side effects. There is a need for efficacious corticosteroid-sparing immunomodulatory therapy for these patients. Current immunomodulators include various immunosuppressants and biologics but mammalian target of rapamycin (mTOR) inhibitors (such as sirolimus and everolimus) may also be contenders for this role...
June 9, 2018: Systematic Reviews
M D Becker, R Max, A Dimitriou, T Saurenmann, H-M Lorenz, A Jansen, S Lortz, J Grulich-Henn, M Weber
Intraocular inflammation with the imprecise and broad umbrella term "uveitis" is a diagnostic and therapeutic challenge in ophthalmology. Uveitis is one of the most common causes of blindness worldwide and due to the associated costs is comparable to diabetic retinopathy. Patients can be affected by uveitis at any age. Any part of the eye may be affected. The symptoms range from complete absence of symptoms, through all types of vision deterioration up to a red and even very painful eye. Uveitis can be strictly unilateral (also alternating from the left to the right eye) or bilateral with a relapsing or chronic course...
June 7, 2018: Zeitschrift Für Rheumatologie
Weiming Yan, Tao Chen, Pan Long, Zhe Zhang, Qian Liu, Xiaocheng Wang, Jing An, Zuoming Zhang
BACKGROUND Molecular hydrogen (H2) has been widely reported to have benefiicial effects in diverse animal models and human disease through reduction of oxidative stress and inflammation. The aim of this study was to investigate whether hydrogen gas could ameliorate endotoxin-induced uveitis (EIU) in rats. MATERIAL AND METHODS Male Sprague-Dawley rats were divided into a normal group, a model group, a nitrogen-oxygen (N-O) group, and a hydrogen-oxygen (H-O) group. EIU was induced in rats of the latter 3 groups by injection of lipopolysaccharide (LPS)...
June 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Amanda Rey, Ignasi Jürgens, Xavier Maseras, Agnieszka Dyrda, Patricia Pera, Antonio Morilla
Purpose: To evaluate the visual outcomes and complications of phacoemulsification in previously vitrectomized eyes. Patients and methods: A retrospective analysis of 87 consecutive vitrectomized eyes (87 patients) which had undergone phacoemulsification with intraocular lens implantation between 2013 and 2016. Results: The mean interval from pars plana vitrectomy (PPV) to cataract surgery (CS) was 18.8 months. Mean age at CS was 61.5 years...
2018: Clinical Ophthalmology
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