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https://www.readbyqxmd.com/read/29050190/-current-research-of-sympathetic-ophthalmia
#1
Y Di, J J Ye
Sympathetic ophthalmia (SO) is a rare, bilateral, non-necrotizing, granulomatous uveitis that usually occurs after open ocular injury or intraocular surgery. The pathophysiology is not clearly understood, but generally SO is an immediate hypersensitivity mediated by T lymphocytes which are related to ocular tissue antigens. The main histopathological features are granulation tissues composed of lymphocytes, macrophages and multinucleated giant cells. The clinical manifestations are different from person to person, which might be mild or severe...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050189/-clinical-features-and-treatments-of-retrocorneal-fungal-infection
#2
J Cheng, H L Zhai, J Y Wang, L X Xie
Objective: To evaluate the clinical features of retrocorneal fungal infection and the therapeutic effects. Methods: This was a retrospective, noncomparative study of nine patients with retrocorneal fungal infection and an intact corneal epithelium treated at Qingdao Eye Hospital. The history, clinical features, diagnostic methods, pathogens and therapeutic effects were analyzed. Results: Five patients had a history of trauma by plant, two had a non-plant injury, and two had unidentified reasons. The duration between the initial onset and the first visit to our hospital was 7...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050183/-the-diagnostic-investigations-should-be-efficient-for-patients-with-uveitis
#3
M F Zhang
Uveitis is a common and etiologically complex disease. The diagnosis of uveitis is mainly based on clinical findings, and no ancillary test is needed for diagnosis of the most common uveitis entities in China. Ancillary tests, however, are needed to identify the underlying cause when the clinical presentation points to some specific disease entity, and when infectious uveitis or masquerade syndrome is suspected. A variety of ophthalmic imaging techniques and laboratory tests analyzing blood or intraocular fluid are currently available for etiological identification in uveitis as well as for disease follow-up...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049193/efficacy-and-safety-of-immunomodulatory-drugs-in-patients-with-anterior-uveitis-a-systematic-literature-review
#4
Alejandro Gómez-Gómez, Estíbaliz Loza, Maria Piedad Rosario, Gerard Espinosa, José M García Ruiz de Morales, Jose M Herreras, Santiago Muñoz-Fernández, Miguel Cordero-Coma
BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complementary hand search was also performed. The selection criteria were as follows: (population) noninfectious AU patients, adults; (intervention) immunomodulatory drugs (any dose, regimen, route of administration, duration of treatment); (outcome) control of inflammation, steroid-sparing effect, AU flares, adverse events, and so on; (study design) systematic literature reviews, randomized controlled trials, and observational studies...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046981/ophthalmologic-disease-in-hiv-infection-recent-changes-in-pathophysiology-and-treatment
#5
REVIEW
Michael W Stewart
PURPOSE OF REVIEW: Ophthalmologic conditions were among the earliest described findings in patients with the acquired immunodeficiency syndrome (AIDS). The purpose of this review is to highlight recent changes in the pathophysiology and management of ophthalmologic conditions in patients infected with the human immunodeficiency virus (HIV). RECENT FINDINGS: The introduction of highly active antiretroviral therapy (HAART) in 1996 changed ophthalmologic findings from predominantly acute infectious diseases to chronic, slowly progressive, debilitating conditions...
October 19, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#6
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040047/ultra-widefield-fluorescein-angiography-in-intermediate-uveitis
#7
Wipada Laovirojjanakul, Nisha Acharya, John A Gonzales
PURPOSE: To examine associations between pattern of vascular leakage on ultrawide-field fluorescein angiography (UWFFA) and visual acuity, cystoid macular edema (CME), and inflammatory activity in intermediate uveitis. METHODS: Single center cross-sectional, retrospective review of medical records, spectral domain optical coherence tomography (SD-OCT) and angiographic images of intermediate uveitis patients who underwent UWFFA over a 12-month period. RESULTS: Forty-one eyes from 24 patients were included...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040035/long-term-efficacy-and-safety-of-interferon-alpha-2a-in-the-treatment-of-chinese-patients-with-beh%C3%A3-et-s-uveitis-not-responding-to-conventional-therapy
#8
Peizeng Yang, Guo Huang, Liping Du, Zi Ye, Ke Hu, Chaokui Wang, Jian Qi, Liang Liang, Lili Wu, Qingfeng Cao, Aize Kijlstra
PURPOSE: To investigate the long-term efficacy and safety of interferon alpha-2a (IFNα-2a) in Chinese patients with Behçet's uveitis (BU) refractory to conventional therapy. METHODS: In a prospective observational cohort study, 127 patients were treated with an initial dosage of 3 million units per day in the first three months, followed by gradual tapering of the dose. RESULTS: After 3 months of treatment, IFNα-2a was shown to be effective in 115 cases (91%)...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29040008/analysis-of-the-clinical-profile-and-management-of-inflammatory-choriodal-neovascular-membranes-in-uveitic-eyes-a-study-from-a-tertiary-referral-center
#9
Sudha Ganesh, Arshee Ahmed, Jyotirmay Biswas
PURPOSE: To analyze clinical profile and management of inflammatory choroidal neovascularization (CNV) seen at a referral uveitis clinic. METHODS: Records of patients with uveitis and inflammatory CNV from January 1989 to April 2012 were retrieved and the data was analyzed. RESULTS: Forty-nine eyes of 43 patients were included. Mean age at presentation was 35.81 years. Eighteen eyes (36.7%) had infective etiology and 31 eyes (63.2%) had non-infective etiology...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29039992/polymerase-chain-reaction-and-goldmann-witmer-coefficient-to-examine-the-role-of-epstein-barr-virus-in-uveitis
#10
Derrick Smit, David Meyer, Jean Maritz, Jolanda D F de Groot-Mijnes
PURPOSE: To use polymerase chain reaction (PCR) and Goldmann-Witmer Coefficient (GWC) calculation to search for evidence that Epstein-Barr virus (EBV) causes uveitis. METHODS: A prospective cross-sectional study where participants with positive multiplex EBV PCR results were further investigated by: 1) real-time PCR for EBV viral loads (VL) and 2) EBV GWC. RESULTS: Eleven of 106 consecutive uveitis patients (10.4%) had positive multiplex PCR for EBV on aqueous humor sampling and 7/11 (63...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29038778/ophthalmological-abnormalities-in-wild-european-hedgehogs-erinaceus-europaeus-a-survey-of-300-animals
#11
David Williams, Nina Adeyeye, Erni Visser
In this study we aimed to examine wild European hedgehogs (Erinaceus europaeus) in rescue centres and to determine ocular abnormalities in this animal population. Three hundred animals varying in age from 2 months to 5 years were examined, 147 being male and 153 female. All animals were evaluated with direct and indirect ophthalmoscopy and slit lamp biomicroscopy in animals where lesions were detected. Tonometry using the Tonovet rebound tonometer was undertaken in selected animals as was assessment of tear production using the Schirmer I tear test...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29038541/nk-cells-are-negatively-regulated-by-scd83-in-experimental-autoimmune-uveitis
#12
Wei Lin, Xuejing Man, Peng Li, Nannan Song, Yingying Yue, Bingqing Li, Yuanbin Li, Yufei Sun, Qiang Fu
Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear. Herein, we investigated the status of NK cells in experimental autoimmune uveitis (EAU). We found that the number of CD83(+)CD3(-)NK1.1(+) cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83 (sCD83) were increased...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037906/uveitis-diagnostic-work-up-a-literature-review-and-recommendations-from-an-expert-committee
#13
REVIEW
Pascal Sève, Patrice Cacoub, Bahram Bodaghi, Salim Trad, Jérémie Sellam, David Bellocq, Philip Bielefeld, Damien Sène, Gilles Kaplanski, Dominique Monnet, Antoine Brézin, Michel Weber, David Saadoun, Christophe Chiquet, Laurent Kodjikian
PURPOSE: Diagnosis of uveitis is difficult. Etiologic investigations should take into account the epidemiology of uveitis and should focus on the most severe forms of the disease and those which can be treated. This study was undertaken to establish recommendations for the diagnosis of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 14 experts, including internists, ophthalmologists, and rheumatologists, and are based on a review of the literature and the results of the ULISSE study, which was the first prospective study to assess the efficacy of a standardized strategy for the etiologic diagnosis of uveitis...
October 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037464/-ocular-sarcoidosis-what-the-internist-should-know
#14
P Sève, L Kodjikian, Y Jamilloux
Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. This review reports the state of knowledge for these two ocular involvements and proposes an assessment-algorithm for sarcoidosis in patients with suspected sarcoid uveitis. Two groups of patients with sarcoid uveitis can be distinguished: one young and multiethnic group in which ophthalmological findings are various and another group of elderly Caucasian women with mostly chronic posterior uveitis...
October 13, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29035614/the-impact-and-implication-of-peripheral-vascular-leakage-on-ultra-widefield-fluorescein-angiography-in-uveitis
#15
Akshay S Thomas, Travis Redd, John P Campbell, Neal V Palejwala, Justin T Baynham, Eric B Suhler, James T Rosenbaum, Phoebe Lin
PURPOSE: To study if peripheral vascular leakage (PVL) on ultra-widefield fluorescein angiography (UWFFA) prognosticates complications of uveitis or necessitates treatment augmentation. METHODS: Retrospective cohort study of uveitis patients imaged with UWFFA and ≥1 yr of follow-up. RESULTS: We included 73 eyes of 42 patients with uveitis. There was no difference in baseline, intermediate, final visual acuity (p = 0.47-0.95) or rates of cystoid macular edema (CME) (p = 0...
October 16, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29035612/enhanced-vitreous-imaging-in-uveitis
#16
Padmamalini Mahendradas, Sumukh Madhu, Ankush Kawali, Abhijit Sinha Roy, Ruchi Vala, Anand Vinekar, Rohit Shetty
PURPOSE: To study the structural visibility of the posterior vitreous cavity and vitreoretinal interface using Spectral Domain-Optical Coherence Tomography in patients with uveitis using conventional, Enhanced Depth Imaging (EDI), Combined Depth Imaging (CDI), and Enhanced Vitreous Imaging (EVI) techniques. METHODS: It was an observational cross-sectional study of 59 eyes of 33 patients between age group 12-72 years (Median 43) diagnosed as uveitis with posterior segment manifestations underwent OCT using conventional, EDI, CDI, and EVI techniques...
October 16, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29034584/modern-therapeutic-approaches-for-noninfectious-ocular-diseases-involving-inflammation
#17
REVIEW
Michelle L Ratay, Elena Bellotti, Riccardo Gottardi, Steven R Little
Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29028408/tonic-pupil-in-cytomegalovirus-anterior-uveitis-in-an-immunocompetent-adult-male-a-case-report
#18
Kalpana Babu, Deepika C Parameswarappa, Bhagya Sudheer
PURPOSE: To report an interesting case of development of tonic pupil in an immunocompetent male with cytomegalovirus (CMV) anterior uveitis. METHODS: Retrospective case report Results: A 30-year-old Iranian healthy male was diagnosed to have Posner-Schlossman syndrome (OS). Aqueous tap was positive for CMV by multiplex Polymerase chain reaction (PCR). Adequate control of inflammation and Intraocular pressures (IOP) were achieved with topical steroids, ganciclovir gel, and antiglaucoma medications...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29028372/the-effect-of-latanaprost-on-intraocular-inflammation-and-macular-edema
#19
M Reza Razeghinejad
There is debate concerning whether the use of Latanoprost in early postoperative period of cataract surgery and in glaucoma patients with uveitis as it may aggravate the inflammation and results in macular edema (ME), because of blood-ocular barrier disruption. However, there is no solid evidence for disruption of blood-ocular barrier with Latanoprost and aggravation of uveitis or ME formation. Similar to pseudophakic ME, the imaging ME in cases claimed to be secondary to Latanoprost is greater than clinical ME, happens mostly in complicated surgeries, and the vast majority resolve within weeks to months with using a non-steroidal anti-inflammatory drug...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29023181/review-for-disease-of-the-year-varicella-zoster-virus-induced-anterior-uveitis
#20
Ilknur Tugal-Tutkun, Luca Cimino, Yonca Aydin Akova
Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension...
October 12, 2017: Ocular Immunology and Inflammation
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