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https://www.readbyqxmd.com/read/29149346/novel-pathways-of-endocrine-disruption-through-pesticides-interference-with-human-mineralocorticoid-receptors
#1
Jianyun Zhang, Xin Huang, Hongling Liu, Weiping Liu, Jing Liu
Mineralocorticoid receptor (MR) is one member of the steroid receptor family. In addition to its important role in Na+/K+ homeostasis, MR is reported as a tumor-suppressor in carcinogenesis. So far, little was known about the ability of pesticides to interfere with MR. In this study, a total of 43 pesticides and/or metabolites were investigated for their potential effects on human MR. None of the tested pesticides exhibited MR agonistic potency, while 16 compounds showed antagonistic activities. Further investigations indicated that these 16 chemicals individually antagonized aldosterone-induced alkaline phosphatase expression in vascular smooth muscle cells and aldosterone-inhibited hepatocellular carcinoma cell proliferation at higher concentrations, and the mixture of these 16 pesticides at environmentally relevant concentrations significantly disrupted MR activity...
November 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29078749/endocrine-and-exocrine-pancreatic-insufficiency-after-acute-pancreatitis-long-term-follow-up-study
#2
Jianfeng Tu, Jingzhu Zhang, Lu Ke, Yue Yang, Qi Yang, Guotao Lu, Baiqiang Li, Zhihui Tong, Weiqin Li, Jieshou Li
BACKGROUND: Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate the incidence of endocrine and exocrine pancreatic insufficiency after AP and the risk factors of endocrine pancreatic insufficiency through a long-term follow-up investigation. METHODS: Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients with AP episodes...
October 27, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28655321/stratified-analysis-and-clinical-significance-of-elevated-serum-triglyceride-levels-in-early-acute-pancreatitis-a-retrospective-study
#3
Jianhua Wan, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia, Nonghua Lu
BACKGROUND: Hypertriglyceridemia is one of the three most common causes of AP, which is associated with the AP prognosis that has not been clearly defined. METHODS: In this retrospective study, 1539 AP patients, who had serum triglyceride (TG) levels measured within the first 72 h, were assessed. The study groups consisted of patients with normal, mild, moderate, and severe/very severe HTG levels based on the Endocrine Society Clinical Practice Guidelines. We collected baseline demographic information, laboratory values, complications, and clinical outcome data in different HTG severity groups to analyze the clinical significance of elevated TG levels in AP...
June 27, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28384239/induction-of-osteoblastic-differentiation-of-neural-crest-derived-stem-cells-from-hair-follicles
#4
Eri Urano-Morisawa, Masamichi Takami, Tetsuo Suzawa, Akifumi Matsumoto, Noriko Osumi, Kazuyoshi Baba, Ryutaro Kamijo
The neural crest (NC) arises near the neural tube during embryo development. NC cells migrate throughout the embryo and have potential to differentiate into multiple cell types, such as peripheral nerves, glial, cardiac smooth muscle, endocrine, and pigment cells, and craniofacial bone. In the present study, we induced osteoblast-like cells using whisker follicles obtained from the NC of mice. Hair follicle cells derived from the NC labeled with enhanced green fluorescent protein (EGFP) were collected from protein zero-Cre/floxed-EGFP double transgenic mice and cultured, then treated and cultured in stem cell growth medium...
2017: PloS One
https://www.readbyqxmd.com/read/28099885/oestrus-synchronisation-and-superovulation-alter-the-cervicovaginal-mucus-proteome-of-the-ewe
#5
Jessie W Maddison, Jessica P Rickard, Naomi C Bernecic, Guillaume Tsikis, Clement Soleilhavoup, Valerie Labas, Lucie Combes-Soia, Gregoire Harichaux, Xavier Druart, Tamara Leahy, Simon P de Graaf
Although essential for artificial insemination (AI) and MOET (multiple ovulation and embryo transfer), oestrus synchronisation and superovulation are associated with increased female reproductive tract mucus production and altered sperm transport. The effects of such breeding practices on the ovine cervicovaginal (CV) mucus proteome have not been detailed. The aim of this study was to qualitatively and quantitatively investigate the Merino CV mucus proteome in naturally cycling (NAT) ewes at oestrus and mid-luteal phase, and quantitatively compare CV oestrus mucus proteomes of NAT, progesterone synchronised (P4) and superovulated (SOV) ewes...
January 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28008293/hormonal-and-echocardiographic-abnormalities-in-adult-patients-with-sickle-cell-anemia-in-bahrain
#6
Taysir S Garadah, Ahmed A Jaradat, Mohammed E Alalawi, Adla B Hassan
BACKGROUND: Adrenal, thyroid, and parathyroid gland hormonal changes are recognized in children with homozygous (HbSS) sickle-cell anemia (SCA), but are not clear in adult patients with SCA. AIM: To assess the metabolic and endocrine abnormalities in adult patients with SCA and evaluate left ventricular (LV) systolic and diastolic functions compared with patients with no SCA and further study the relationship between serum levels of cortisol, free thyroxine (T4), and testosterone with serum ferritin...
2016: Journal of Blood Medicine
https://www.readbyqxmd.com/read/27422605/mir-132-regulates-osteogenic-differentiation-via-downregulating-sirtuin1-in-a-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-dependent-manner
#7
Kai Gong, Bo Qu, Dongfa Liao, Da Liu, Cairu Wang, Jingsong Zhou, Xianming Pan
MicroRNAs (miRNAs) play significant roles in multiple diseases by regulating the expression of their target genes. Type 2 diabetes mellitus (T2DM) is a chronic endocrine and metabolic disease with complex mechanisms. T2DM can result in diabetic osteoporosis (DO), which is characterized by bone loss, decreased bone mineral density and increased bone fractures. The promotion of osteogenic differentiation of osteoblasts is an effective way to treat osteoporosis. In the present study, high glucose (HG) and free fatty acids (FFA) were employed to mimic T2DM in MC3T3-E1 cells...
September 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27401186/synergistic-estrogenic-effects-of-fusarium-and-alternaria-mycotoxins-in-vitro
#8
Katharina Vejdovszky, Kathrin Hahn, Dominik Braun, Benedikt Warth, Doris Marko
Mycotoxins are toxic secondary metabolites formed by various fungal species that are found as natural contaminants in food. This very heterogeneous group of compounds triggers multiple toxic mechanisms, including endocrine disruptive potential. Current risk assessment of mycotoxins, as for most chemical substances, is based on the effects of single compounds. However, concern on a potential enhancement of risks by interactions of single substances in naturally occurring mixtures has greatly increased recently...
March 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/26918604/high-throughput-microscopy-identifies-bisphenol-ap-a-bisphenol-a-analog-as-a-novel-ar-down-regulator
#9
Fabio Stossi, Radhika D Dandekar, Michael J Bolt, Justin Y Newberg, Maureen G Mancini, Akash K Kaushik, Vasanta Putluri, Arun Sreekumar, Michael A Mancini
Prostate cancer remains a deadly disease especially when patients become resistant to drugs that target the Androgen Receptor (AR) ligand binding domain. At this stage, patients develop recurring castrate-resistant prostate cancers (CRPCs). Interestingly, CRPC tumors maintain dependency on AR for growth; moreover, in CRPCs, constitutively active AR splice variants (e.g., AR-V7) begin to be expressed at higher levels. These splice variants lack the ligand binding domain and are rendered insensitive to current endocrine therapies...
March 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/25777084/structurally-diverse-ppar%C3%AE-activating-environmental-toxicants-induce-adipogenesis-and-suppress-osteogenesis-in-bone-marrow-mesenchymal-stromal-cells
#10
James Watt, Jennifer J Schlezinger
Environmental obesogens are a newly recognized category of endocrine disrupting chemicals that have been implicated in contributing to the rising rates of obesity in the United States. While obesity is typically regarded as an increase in visceral fat, adipocyte accumulation in the bone has been linked to increased fracture risk, lower bone density, and osteoporosis. Exposure to environmental toxicants that activate peroxisome proliferator activated receptor γ (PPARγ), a critical regulator of the balance of differentiation between adipogenesis and osteogenesis, may contribute to the increasing prevalence of osteoporosis...
May 4, 2015: Toxicology
https://www.readbyqxmd.com/read/25538250/osteoblast-menin-regulates-bone-mass-in-vivo
#11
Ippei Kanazawa, Lucie Canaff, Jad Abi Rafeh, Aarti Angrula, Jingjing Li, Ryan C Riddle, Iris Boraschi-Diaz, Svetlana V Komarova, Thomas L Clemens, Monzur Murshed, Geoffrey N Hendy
Menin, the product of the multiple endocrine neoplasia type 1 (Men1) tumor suppressor gene, mediates the cell proliferation and differentiation actions of transforming growth factor-β (TGF-β) ligand family members. In vitro, menin modulates osteoblastogenesis and osteoblast differentiation promoted and sustained by bone morphogenetic protein-2 (BMP-2) and TGF-β, respectively. To examine the in vivo function of menin in bone, we conditionally inactivated Men1 in mature osteoblasts by crossing osteocalcin (OC)-Cre mice with floxed Men1 (Men1(f/f)) mice to generate mice lacking menin in differentiating osteoblasts (OC-Cre;Men1(f/f) mice)...
February 13, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25510822/clinical-associations-of-incidentally-detected-parotid-gland-calcification-on-ct
#12
Karen Buch, Rohini N Nadgir, Akifumi Fujita, Andrew D Tannenbaum, Al Ozonoff, Osamu Sakai
OBJECTIVES/HYPOTHESIS: Parotid gland calcifications can be incidental findings on computed tomography (CT) and have been reported to be associated with chronic inflammatory conditions. Associations between parotid gland calcification and other common medical conditions have not been reported. METHODS: Following institutional review board approval, 1,571 patients who underwent noncontrast head CT with 1.25-mm slice thickness on a 64-detector row CT between January 2011 and July 2011 were retrospectively reviewed for parotid gland calcifications...
June 2015: Laryngoscope
https://www.readbyqxmd.com/read/25326128/regulatory-polymorphisms-in-human-dbh-affect-peripheral-gene-expression-and-sympathetic-activity
#13
Elizabeth S Barrie, David Weinshenker, Anurag Verma, Sarah A Pendergrass, Leslie A Lange, Marylyn D Ritchie, James G Wilson, Helena Kuivaniemi, Gerard Tromp, David J Carey, Glenn S Gerhard, Murray H Brilliant, Scott J Hebbring, Joseph F Cubells, Julia K Pinsonneault, Greg J Norman, Wolfgang Sadee
RATIONALE: Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally. DBH variants are associated with large changes in circulating DBH and implicated in multiple disorders; yet causal relationships and tissue-specific effects remain unresolved. OBJECTIVE: To characterize regulatory variants in DBH, effect on mRNA expression, and role in modulating sympathetic tone and disease risk. METHODS AND RESULTS: Analysis of DBH mRNA in human tissues confirmed high expression in the locus coeruleus and adrenal gland, but also in sympathetically innervated organs (liver>lung>heart)...
December 5, 2014: Circulation Research
https://www.readbyqxmd.com/read/24217090/pscs-and-glp-1r-occurrence-in-normal-pancreas-acute-chronic-pancreatitis-and-effect-of-their-activation-by-a-glp-1r-agonist
#14
Taichi Nakamura, Tetsuhide Ito, Masahiko Uchida, Masayuki Hijioka, Hisato Igarashi, Takamasa Oono, Masaki Kato, Kazuhiko Nakamura, Koichi Suzuki, Robert T Jensen, Ryoichi Takayanagi
There is increasing concern about the development of pancreatitis in patients with diabetes mellitus who received long-term glucagon-like peptide-1 (GLP-1) analog treatment. Its pathogenesis is unknown. The effects of GLP-1 agonists on pancreatic endocrine cells are well studied; however, there is little information on effects on other pancreatic tissues that might be involved in inflammatory processes. Pancreatic stellate cells (PSCs) can have an important role in pancreatitis, secreting various inflammatory cytokines/chemokines, as well as collagen...
January 2014: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/23935926/effects-of-thyroxine-exposure-on-osteogenesis-in-mouse-calvarial-pre-osteoblasts
#15
James J Cray, Kameron Khaksarfard, Seth M Weinberg, Mohammed Elsalanty, Jack C Yu
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes. At present, very little is known about the role of gene-environment interactions in modulating craniosynostosis phenotypes, but prior evidence suggests a role for endocrine factors. Here we provide a report of the effects of thyroid hormone exposure on murine calvaria cells...
2013: PloS One
https://www.readbyqxmd.com/read/23924189/body-mass-index-affects-proliferation-and-osteogenic-differentiation-of-human-subcutaneous-adipose-tissue-derived-stem-cells
#16
COMPARATIVE STUDY
Trivia P Frazier, Jeffrey M Gimble, Jessica W Devay, Hugh A Tucker, Ernest S Chiu, Brian G Rowan
BACKGROUND: Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiological functions, and contains adipose tissue-derived stem cells (ASCs). ASCs can differentiate into cells of multiple lineages, and as such are applicable to tissue engineering and regenerative medicine. Yet the question of whether ASC functionality is affected by the donor's body mass index (BMI) still exists...
August 7, 2013: BMC Cell Biology
https://www.readbyqxmd.com/read/23917222/crosstalk-between-pkc%C3%AE-and-notch-4-in-endocrine-resistant-breast-cancer-cells
#17
J Yun, A Pannuti, I Espinoza, H Zhu, C Hicks, X Zhu, M Caskey, P Rizzo, G D'Souza, K Backus, M F Denning, J Coon, M Sun, E H Bresnick, C Osipo, J Wu, P R Strack, D A Tonetti, L Miele
The Notch pathway is functionally important in breast cancer. Notch-1 has been reported to maintain an estrogen-independent phenotype in estrogen receptor α (ERα)+ breast cancer cells. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells. Estrogen-independent breast cancer cell lines have higher Notch activity than estrogen-dependent lines. Protein kinase Cα (PKCα) overexpression is common in endocrine-resistant breast cancers and promotes tamoxifen (TAM)-resistant growth in breast cancer cell lines...
2013: Oncogenesis
https://www.readbyqxmd.com/read/23824345/characteristics-management-and-outcome-of-primary-hyperparathyroidism-in-south-africa-a-single-centre-experience
#18
Imran M Paruk, Tonya M Esterhuizen, Sureka Maharaj, Fraser J Pirie, Ayesha A Motala
INTRODUCTION: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcaemia and elevated parathyroid hormone (PTH) levels. However, it remains a relatively underdiagnosed disease in the developing world primarily due to a lack of routine blood chemistry screening. The aim of this analysis was to evaluate the characteristics, management and outcome of patients with PHPT at a tertiary referral clinic in South Africa. METHODS: A retrospective analysis was undertaken on all patients with a diagnosis of PHPT attending the endocrinology clinic at a tertiary referral hospital in Durban, South Africa, between January 2003 and June 2009...
November 2013: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/23782148/the-crosstalk-between-gut-inflammation-and-gastrointestinal-disorders-during-acute-pancreatitis
#19
REVIEW
Zhen-Zhen Guo, Pu Wang, Zhi-Hui Yi, Zhi-Yin Huang, Cheng-Wei Tang
The intestinal inflammation caused by intestinal ischemia reperfusion during acute pancreatitis (AP) often leads to multiple organ dysfunction and aggravation of acute pancreatitis. This review concerns up-date progress of the pathophysiology and molecular mechanism of the excessive production of gut-derived cytokines. The regulation effects of immuno-neuro-endocrine network for pancreatic necrosis are the basis for pharmacological therapeutic in AP. The translation from basic research to clinical trials for the prevention or treatment of severe acute pancreatitis (SAP) is of great value...
2014: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/22669468/undercarboxylated-osteocalcin-is-positively-associated-with-free-testosterone-in-male-patients-with-type-2-diabetes-mellitus
#20
I Kanazawa, K Tanaka, N Ogawa, M Yamauchi, T Yamaguchi, T Sugimoto
UNLABELLED: Although a recent study showed that undercarboxylated osteocalcin (ucOC) is important for male fertility and testosterone production by testes, little is known about the relationship between ucOC and testosterone in humans. We found for the first time that ucOC is positively associated with free testosterone in men with type 2 diabetes. INTRODUCTION: The ucOC has been shown to play a key role in energy metabolism as an endocrine hormone. Although a recent animal study demonstrated that ucOC is also important for male fertility and testosterone production by the testes, association between serum osteocalcin and testosterone levels has not been understood in humans...
March 2013: Osteoporosis International
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