keyword
MENU ▼
Read by QxMD icon Read
search

High tolerance

keyword
https://www.readbyqxmd.com/read/28449424/fecal-microbiota-transplantation-for-refractory-and-recurrent-clostridium-difficile-infection-a-case-series-of-nine-patients
#1
Byoung Wook Bang, Jin Seok Park, Hyung Kil Kim, Yong Woon Shin, Kye Sook Kwon, Hea Yoon Kwon, Ji Hyeon Baek, Jin Soo Lee
Background/Aims: Fecal microbiota transplantation (FMT) is a highly effective therapy for refractory and recurrent Clostridium difficile infection (CDI). Despite its excellent efficacy and recent widespread use, FMT has not been widely used in South Korea thus far. We describe our experience with FMT to treat refractory/recurrent CDI. Methods: We conducted a chart review of patients who underwent FMT for refractory/recurrent CDI at Inha University Hospital, between March 2014 and June 2016...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449232/safety-pharmacokinetics-and-pharmacologic-effects-of-the-selective-androgen-receptor-modulator-gsk2881078-in-healthy-men-and-postmenopausal-women
#2
Richard V Clark, Ann C Walker, Susan Andrews, Philip Turnbull, Jeffrey A Wald, Mindy H Magee
AIM: Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of the SARM GSK2881078. METHODS: In Part A, healthy young men (n = 10) received a single dose of study drug (0 mg, 0.05 mg, 0.1 mg, 0.2 mg GSK2881078 or matching-placebo). In Part B, repeat-dose cohorts in men (n = 65) were 0...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28449231/resource-partitioning-in-tolerant-and-intolerant-macaques
#3
Nancy Rebout, Christine Desportes, Bernard Thierry
The clumped distribution of food resources promotes food defensibility and can lead to the monopolizing of resources by high-ranking individuals. However, the balance of power is set at different levels according to societies, meaning that resource partitioning should vary between them. This study investigates whether dominance asymmetry and resource partitioning are related in non-human primates by comparing two species with contrasting social styles, namely rhesus macaques (Macaca mulatta) which display strong social intolerance and a steep gradient of dominance, and Tonkean macaques (Macaca tonkeana), which exhibit higher levels of tolerance and more balanced dominance relationships...
April 27, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28449211/operational-tolerance-in-kidney-transplantation-and-associated-biomarkers
#4
REVIEW
Annick Massart, Lidia Ghisdal, Marc Abramowicz, Daniel Abramowicz
In the 1960s, our predecessors won a historical battle against acute rejection and ensured that transplantation became a common life-saving treatment. In parallel to this success, or perhaps because of it, we lost the battle for long-lived transplants, being overwhelmed with chronic immune insults and the toxicities of immunosuppression. It is likely that current powerful treatments block acute rejection, but at the same time condemn the few circulating donor cells that would have been able to elicit immunoregulatory host responses towards the allograft...
April 27, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28449129/phenotypic-differences-determine-drought-stress-responses-in-ecotypes-of-arundo-donax-adapted-to-different-environments
#5
Mastaneh Ahrar, Dilyana Doneva, Massimiliano Tattini, Cecilia Brunetti, Antonella Gori, Mirco Rodeghiero, Georg Wohlfahrt, Franco Biasioli, Claudio Varotto, Francesco Loreto, Violeta Velikova
Arundo donax has been identified as an important biomass and biofuel crop. Yet, there has been little research on photosynthetic and metabolic traits, which sustain the high productivity of A. donax under drought conditions. This study determined phenotypic differences between two A. donax ecotypes coming from stands with contrasting adaptation to dry climate. We hypothesized that the Bulgarian (BG) ecotype, adapted to drier conditions, exhibits greater drought tolerance than the Italian (IT) ecotype, adapted to a more mesic environment...
April 25, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28448985/total-skin-electron-beam-therapy-as-part-of-multimodal-treatment-strategies-for-primary-cutaneous-t-cell-lymphoma
#6
Khaled Elsayad, Katharina H Susek, Hans T Eich
Total-skin electron beam therapy (TSEBT) is one of most effective treatments that has been used for cutaneous T-cell lymphoma. Low-dose TSEBT regimens (10-12 Gy) appear to be an effective alternative to conventional-dose TSEBT (30-36 Gy), yielding short-term remission of cutaneous manifestations with minimal toxicity. TSEBT can be administered to patients any time after a diagnosis of mycosis fungoides (MF). Patients requiring rapid relief from cutaneous lesions or symptoms may particularly benefit from TSEBT as an initial therapy...
April 25, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448840/a-cocktail-of-volatile-compounds-emitted-from-alcaligenes-faecalis-jbcs1294-induces-salt-tolerance-in-arabidopsis-thaliana-by-modulating-hormonal-pathways-and-ion-transporters
#7
Dipto Bhattacharyya, Yong Hoon Lee
In our previous study we showed that volatile organic compounds (VOCs) from Alcaligenes faecalis JBCS1294 (JBCS1294) induced tolerance to salt stress in Arabidopsis thaliana by influencing the auxin and gibberellin pathways and upregulating the expression of key ion transporters. The aim of this study was to evaluate the contribution of each VOC and blends of the VOCs on the induction of salt tolerance and signaling pathways. The key VOCs emitted from JBCS1294 were dissolved in lanolin and applied to one side of bipartite I-plates that contained Arabidopsis seeds on Murashige and Skoog (MS) media supplemented with NaCl on the other side...
April 12, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28448785/a-class-ii-myosin-is-required-for-growth-conidiation-cell-wall-integrity-and-pathogenicity-of-magnaporthe-oryzae
#8
Min Guo, Leyong Tan, Xiang Nie, Zhengguang Zhang
In eukaryotic organisms, myosin proteins are the major ring components that are involved in cytokinesis. To date, little is known about the biological functions of myosin proteins in Magnaporthe oryzae. In this study, insertional mutagenesis conducted in M. oryzae led to identification of Momyo2, a pathogenicity gene predicted to encode a class-II myosin protein homologous to Saccharomyces cerevisiae Myo1. According to qRT-PCR, Momyo2 is highly expressed during early infectious stage. When this gene was disrupted, the resultant mutant isolates were attenuated in virulence on rice and barley...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28448624/overexpression-of-the-protein-phosphatase-2a-regulatory-subunit-a-gene-zmpp2aa1-improves-low-phosphate-tolerance-by-remodeling-the-root-system-architecture-of-maize
#9
Jiemin Wang, Laming Pei, Zhe Jin, Kewei Zhang, Juren Zhang
Phosphate (Pi) limitation is a constraint for plant growth and development in many natural and agricultural ecosystems. In this study, a gene encoding Zea mays L. protein phosphatase 2A regulatory subunit A, designated ZmPP2AA1, was induced in roots by low Pi availability. The function of the ZmPP2AA1 gene in maize was analyzed using overexpression and RNA interference. ZmPP2AA1 modulated root gravitropism, negatively regulated primary root (PR) growth, and stimulated the development of lateral roots (LRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28448598/a-low-volume-polyethylene-glycol-solution-was-associated-with-an-increased-suboptimal-bowel-preparation-rate-but-had-similar-recommendations-for-an-early-repeat-colonoscopy-procedure-times-and-adenoma-detection-rates
#10
Sam C Hankins, Bryan B Brimhall, Vineel Kankanala, Gregory L Austin
BACKGROUND/AIMS: Low-volume polyethylene glycol (PEG) bowel preparations are better tolerated by patients than high-volume preparations and may achieve similar preparation quality. However, there is little data comparing their effects on a recommendation for an early repeat colonoscopy (because of a suboptimal preparation), procedure times, adenoma detection rate (ADR), and advanced adenoma detection rate (AADR). METHODS: This is a retrospective cohort study of outpatient colonoscopies performed during a one-year period at a single academic medical center in which low-volume MoviPrep® (n = 1841) or high-volume Colyte® (n = 1337) was used...
2017: PloS One
https://www.readbyqxmd.com/read/28448540/bruchid-egg-induced-transcript-dynamics-in-developing-seeds-of-black-gram-vigna-mungo
#11
Indrani K Baruah, Debashis Panda, Jagadale M V, Deba Jit Das, Sumita Acharjee, Priyabrata Sen, Bidyut Kumar Sarmah
Black gram (Vigna mungo) seeds are a rich source of digestible proteins, however, during storage these seeds are severely damaged by bruchids (Callosobruchus spp.), reducing seed quality and yield losses. Most of the cultivated genotypes of black gram are susceptible to bruchids, however, few tolerant genotypes have also been identified but the mechanism of tolerance is poorly understood. We employed Suppression Subtractive Hybridization (SSH) to identify specifically, but rarely expressed bruchid egg induced genes in black gram...
2017: PloS One
https://www.readbyqxmd.com/read/28448319/tranexamic-acid-reduces-blood-loss-and-transfusion-requirements-in-primary-simultaneous-bilateral-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#12
Yuangang Wu, Timin Yang, Yi Zeng, Haibo Si, Canfeng Li, Bin Shen
: The aim of this meta-analysis is to assess the effectiveness and safety of intravenous application tranexamic acid (TXA) in primary simultaneous bilateral total knee arthroplasty (TKA). We searched electronic databases including PubMed, Embase, the Web of Science, the Cochrane Library and the Google Scholar, for published studies involving the intravenous application TXA in primary simultaneous bilateral TKA. All randomized controlled trials were included. The focus of the meta-analysis was on the outcomes of total blood loss, drainage volume, transfusion requirements and deep venous thrombosis (DVT) and/or pulmonary embolism...
April 26, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28448075/visible-light-induced-and-iron-catalyzed-methylation-of-n-arylacrylamides-with-dimethyl-sulphoxide-a-convenient-access-to-3-ethyl-3-methyl-oxindoles
#13
Zuguang Xie, Pinhua Li, Yu Hu, Ning Xu, Lei Wang
A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulphoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.
April 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28447887/cyclopiazonic-acid-is-a-pathogenicity-factor-for-aspergillus-flavus-and-a-promising-target-for-screening-germplasm-for-ear-rot-resistance
#14
Subbaiah C Chalivendra, Catherine DeRobertis, Perng-Kuang Chang, Kenneth E Damann
Aspergillus flavus, an opportunistic pathogen, contaminates maize and other key crops with carcinogenic aflatoxins (AFs). Besides AFs, A. flavus makes many more secondary metabolites (SMs) whose toxicity in insects or vertebrates has been studied. However, the role of SMs in the invasion of plant hosts by A. flavus remains to be investigated. Cyclopiazonic acid (CPA), a neurotoxic SM made by A. flavus, is a nanomolar inhibitor of endoplasmic reticulum calcium ATPases (ECAs) and a potent inducer of cell death in plants...
April 24, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28447864/the-use-of-cyproterone-acetate-ethinyl-estradiol-in-hyperandrogenic-skin-symptoms-a-review
#15
J Bitzer, T Römer, A Lopes da Silva Filho
INTRODUCTION: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28447774/nitrogen-and-phosphorus-codoped-mesoporous-carbon-derived-from-polypyrrole-as-superior-metal-free-electrocatalyst-towards-the-oxygen-reduction-reaction
#16
Zhengping Zhang, Junting Sun, Meiling Dou, Jing Ji, Feng Wang
To replace high-cost platinum group metal (PGM) electrocatalysts for oxygen reduction reaction (ORR) that is the crucial cathode reaction in fuel cell technology and metal-air battery, the development of low-cost and high-efficiency non-PGM catalysts for ORR has attracted much attention during the past decades. As one of the promising candidates, the N-doped carbon is highly desirable for its strong designability and outstanding catalytic activity and stability. In this work, a facile and rational strategy is demonstrated for preparation of N, P-codoped mesoporous carbon (N,P-MC) for ORR by the direct pyrolysis treatment of polypyrrole with phytic acid as P-dopant and polystyrene sphere as template...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447736/investigation-of-hypoglycemic-hypolipidemic-and-anti%C3%A2-nephritic-activities-of-paecilomyces-tenuipesn45-in-diet-streptozotocin%C3%A2-induced-diabetic-rats
#17
Chungang Liu, Xuerui Zeng, Yi Li, Hongli Ma, Jingjing Song, Yuhuan Li, Yulin Zhou, Robert J Lee, Di Wang
Due to its pharmacological activities, Paecilomyces tenuipes has previously been used as a folk medicine in Asia. The primary aim of the present study was to investigate the hypoglycemic, hypolipidemic and anti‑nephritic effects of P. tenuipes N45 aqueous extracts (PTNE) in a high fat diet/streptozotocin‑induced diabetic rat model. The rats were treated with 120 mg/kg of metformin or 0.04, 0.2 or 1.0 g/kg PTNE for 4 weeks. The hypoglycemic activity of PTNE was confirmed by the observation of reduced fasting blood glucose level and by partially normalized oral glucose tolerance...
March 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447343/impact-of-perinatal-exposure-to-sucrose-or-high-fructose-corn-syrup-hfcs-55-on-adiposity-and-hepatic-lipid-composition-in-rat-offspring
#18
Carla R Toop, Beverly S Muhlhausler, Kerin O'Dea, Sheridan Gentili
Perinatal exposure to excess maternal intake of added sugars, including fructose and sucrose, is associated with an increased risk of obesity and type 2 diabetes in adult life. However, it is unknown to what extent the type of sugar and the timing of exposure affect these outcomes. The aim of this study was to determine the impact of exposure to maternal consumption of a 10% w/v beverage containing sucrose or high fructose corn syrup-55 (HFCS-55) during the prenatal and/or suckling periods on offspring at 3 and 12 weeks, utilising a cross-fostering approach in a rodent model...
April 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28447333/efficacy-and-tolerability-of-lithium-in-treating-acute-mania-in-youth-with-bipolar-disorder-protocol-for-a-systematic-review
#19
A Duffy, S Patten, S Goodday, A Weir, N Heffer, A Cipriani
BACKGROUND: Epidemiological, clinical, and high-risk studies have provided evidence that the peak period for onset of diagnosable episodes of mania and hypomania starts in mid-to-late adolescence. Moreover, clinically significant manic symptoms may occur even earlier, especially in children at familial risk. Lithium is the gold standard treatment for acute mania in adults, yet to our knowledge, there is no published systematic review assessing lithium treatment of mania in children or adolescents...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28447075/sofosbuvir-velpatasvir-fixed-dose-combination-for-the-treatment-of-chronic-hepatitis-c-virus-infection
#20
V Nehra, S A Rizza, Z Temesgen
The fixed-dose combination of sofosbuvir, a nucleotide analogue NS5B polymerase inhibitor, and velpatasvir, a second-generation NS5A inhibitor, has been approved by the United States Food and Drug Administration and the European Medicines Agency for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection. This combination, administered over 12 weeks as a single-tablet regimen, has resulted in high cure rates in all 6 HCV genotypes and in a variety of patient populations, including patients without cirrhosis, patients with compensated cirrhosis and patients with HIV coinfection...
March 2017: Drugs of Today
keyword
keyword
49965
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"