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https://www.readbyqxmd.com/read/28927022/salt-stress-response-mechanisms-using-de-novo-transcriptome-sequencing-of-salt-tolerant-and-sensitive-corchorus-spp-genotypes
#1
Zemao Yang, Ruike Lu, Zhigang Dai, An Yan, Qing Tang, Chaohua Cheng, Ying Xu, Wenting Yang, Jianguang Su
High salinity is a major environmental stressor for crops. To understand the regulatory mechanisms underlying salt tolerance, we conducted a comparative transcriptome analysis between salt-tolerant and salt-sensitive jute (Corchorus spp.) genotypes in leaf and root tissues under salt stress and control conditions. In total, 68,961 unigenes were identified. Additionally, 11,100 unigenes (including 385 transcription factors (TFs)) exhibited significant differential expression in salt-tolerant or salt-sensitive genotypes...
September 18, 2017: Genes
https://www.readbyqxmd.com/read/28927013/transcription-factors-responding-to-pb-stress-in-maize
#2
Yanling Zhang, Fei Ge, Fengxia Hou, Wenting Sun, Qi Zheng, Xiaoxiang Zhang, Langlang Ma, Jun Fu, Xiujing He, Huanwei Peng, Guangtang Pan, Yaou Shen
Pb can damage the physiological function of human organs by entering the human body via food-chain enrichment. Revealing the mechanisms of maize tolerance to Pb is critical for preventing this. In this study, a Pb-tolerant maize inbred line, 178, was used to analyse transcription factors (TFs) expressed under Pb stress based on RNA sequencing data. A total of 464 genes expressed in control check (CK) or Pb treatment samples were annotated as TFs. Among them, 262 differentially expressed transcription factors (DETs) were identified that responded to Pb treatment...
September 18, 2017: Genes
https://www.readbyqxmd.com/read/28926633/effects-of-salinity-on-the-cellular-physiological-responses-of-natrinema-sp-j7-2
#3
Yunjun Mei, Huan Liu, Shunxi Zhang, Ming Yang, Chun Hu, Jian Zhang, Ping Shen, Xiangdong Chen
The halophilic archaea (haloarchaea) live in hyersaline environments such as salt lakes, salt ponds and marine salterns. To cope with the salt stress conditions, haloarchaea have developed two fundamentally different strategies: the "salt-in" strategy and the "compatible-solute" strategy. Although investigation of the molecular mechanisms underlying the tolerance to high salt concentrations has made outstanding achievements, experimental study from the aspect of transcription is rare. In the present study, we monitored cellular physiology of Natrinema sp...
2017: PloS One
https://www.readbyqxmd.com/read/28926597/altered-embryonic-development-in-northern-bobwhite-quail-colinus-virginianus-induced-by-pre-incubation-oscillatory-thermal-stresses-mimicking-global-warming-predictions
#4
Kelly S Reyna, Warren W Burggren
Global warming is likely to alter reproductive success of ground-nesting birds that lay eggs normally left unattended for days or even weeks before actual parental incubation, especially in already warm climates. The native North American bobwhite quail (Colinus virginianus) is such a species, and pre-incubation quail eggs may experience temperatures ≥45°C. Yet, almost nothing is known about embryonic survival after such high pre-incubation temperatures. Freshly laid bobwhite quail eggs were exposed during a 12 day pre-incubation period to one of five thermal regimes: low oscillating temperatures (25-40°C, mean = 28...
2017: PloS One
https://www.readbyqxmd.com/read/28926559/novelties-in-evaluation-and-monitoring-of-human-immunodeficiency-virus-1-infection-is-standard-virological-suppression-enough-for-measuring-antiretroviral-treatment-success
#5
Valentina Svicher, Giulia Marchetti, Adrianna Ammassari, Francesca Ceccherini-Silberstein, Loredana Sarmati
The high potency and tolerability of the currently available antiretroviral drugs has modified HIV-1 infection from a life-threatening disease to a chronic illness. Nevertheless, some issues still remain open to optimize the management of HIV-1 infected patients in term of maintenance of virological suppression over time, identifying patients that could benefit from simplification therapy, and reducing co-mordibities driven by chronic inflammation. The availability of robust and affordable virological and immunological markers can help in solving these issues by providing information on the burden of HIV-1 reservoir in all the anatomical compartments in which the virus replicates as well as on persistent inflammation, immune activation and senescence despite successful virological suppression...
September 19, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28926513/pharmacokinetics-and-safety-profile-of-single-dose-administration-of-an-estrogen-receptor-%C3%AE-selective-phytoestrogenic-phytoserm-formulation-in-perimenopausal-and-postmenopausal-women
#6
Gerson Hernandez, Liqin Zhao, Adrian A Franke, Yu-Ling Chen, Wendy J Mack, Roberta D Brinton, Lon S Schneider
OBJECTIVE: Selected estrogen receptor β-selective phytoestrogen (phytoSERM), a preparation of genistein, daidzein, and S-equol, has an 83-fold selective affinity for estrogen receptor (ER) β, and may promote neuronal survival and estrogenic mechanisms in the brain without exerting feminizing activity in the periphery. The aim of this study was to assess the safety, tolerability, and single-dose pharmacokinetics of the phytoSERM formulation in perimenopausal and postmenopausal women...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28926264/methylation-of-c-sp-3-h-c-sp-2-h-bonds-with-methanol-catalyzed-by-cobalt-system
#7
Zhenghui Liu, Zhenzhen Yang, Xiaoxiao Yu, Hongye Zhang, Bo Yu, Yanfei Zhao, Zhimin Liu
A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand P(CH2CH2PPh2)3(PP3), and a base (denoted as [Co]/PP3/base), is developed for the methylation of C(sp(3))-H and C(sp(2))-H bonds using methanol as a methylating reagent. The Co(BF4)2·6H2O/PP3/K2CO3 catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance, and methyl-substituted products were obtained in good to excellent yields at 100 °C...
September 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28926233/copper-i-catalyzed-regio-and-stereoselective-intramolecular-alkylboration-of-propargyl-ethers-and-amines
#8
Hiroaki Iwamoto, Yu Ozawa, Koji Kubota, Hajime Ito
The copper(I)-catalyzed regio- and stereoselective intramolecular alkylation of propargyl ethers and amines bearing an alkyl electrophilic moiety has been developed. The reaction showed high functional group tolerance and gave highly functionalized alkenylboronates bearing heterocyclic rings, which are versatile synthetic intermediates in organic chemistry. The borylation products can be transformed into multi-substituted alkenes through stereospecific transformations. Mechanistic studies showed that the chemo- and stereoselectivity of copper(I)-catalyzed borylation depends on the type of leaving group...
September 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28926189/environmental-peer-pressure-cd4-t-cell-help-in-tolerance-and-transplantation
#9
REVIEW
Dana Tedesco, Arash Grakoui
The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic-rich intestinal blood, oxidative stress and metabolic intermediates, there is no appreciable immune response. Interestingly, patients undergoing orthotopic liver transplantation benefit from a high rate of graft acceptance in comparison to other solid organ transplant recipients. In fact, co-transplantation of a donor liver in tandem with a rejection-prone graft increases the likelihood of graft acceptance...
September 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28926120/glecaprevir-pibrentasvir-for-hcv-genotype-3-patients-with-cirrhosis-and-or-prior-treatment-experience-a-partially-randomized-phase-iii-clinical-trial
#10
David Wyles, Fred Poordad, Stanley Wang, Laurent Alric, Franco Felizarta, Paul Y Kwo, Benedict Maliakkal, Kosh Agarwal, Tarek Hassanein, Frank Weilert, Samuel S Lee, Jens Kort, Sandra S Lovell, Ran Liu, Chih-Wei Lin, Tami Pilot-Matias, Preethi Krishnan, Federico J Mensa
BACKGROUND: This study assessed the efficacy and safety of ribavirin (RBV)-free coformulated glecaprevir/pibrentasvir (G/P) in patients with hepatitis C virus (HCV) genotype (GT) 3 infection with either prior treatment experience and/or compensated cirrhosis, a patient population with limited treatment options. METHODS: SURVEYOR-II, Part 3 was a partially-randomized, open-label, multicenter, phase 3 study. Treatment-experienced (prior interferon (IFN) or pegIFN ± ribavirin or SOF plus ribavirin ± pegIFN therapy) patients without cirrhosis were randomized 1:1 to receive 12 or 16 weeks of G/P (300 mg/120 mg) once daily...
September 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28926107/fenofibrate-reverses-changes-induced-by-high-fat-diet-on-metabolism-in-mice-muscle-and-visceral-adipocytes
#11
Flávia de Toledo Frias, Karina Cunha E Rocha, Mariana de Mendonça, Gilson Massahiro Murata, Hygor Nunes Araujo, Luís Gustavo Oliveira de Sousa, Érica de Souza, Sandro Massao Hirabara, Nayara de Carvalho Leite, Everardo Magalhães Carneiro, Rui Curi, Leonardo Reis Silveira, Alice Cristina Rodrigues
The effect of fenofibrate on the metabolism of skeletal muscle and visceral white adipose tissue of diet-induced obese (DIO) mice was investigated. C57BL/6J male mice were fed either a control or high-fat diet for eight weeks. Fenofibrate (50 mg/Kg b.w., daily) was administered by oral gavage during the last two weeks of the experimental period. Insulin-stimulated glucose metabolism in soleus muscles, glucose tolerance test, insulin tolerance test, indirect calorimetry, lipolysis of visceral white adipose tissue, expression of miR-103-3p in adipose tissue and miR-1a, miR-133a/b, miR-206, let7b-5p, miR-23b-3p, miR-29-3p, miR-143-3p in soleus muscle, genes related to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were investigated...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925801/mf59-adjuvanted-influenza-vaccine-fluad%C3%A2-elicits-higher-immune-responses-than-a-non-adjuvanted-influenza-vaccine-fluzone%C3%A2-a-randomized-multicenter-phase-iii-pediatric-trial-in-mexico
#12
Aurelio Cruz-Valdez, Gabriel Valdez-Zapata, Sanjay S Patel, Flavia V Castelli, Marcia G Garcia, Wim T Jansen, Ashwani Kumar Arora, Esther Heijnen
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent influenza vaccine FLUAD® (aTIV) and a non-adjuvanted TIV, in healthy children (aged 6 to <72 months) from 3 centers in Mexico, during the 2014-2015 season. The primary objectives were to assess the non-inferiority of aTIV to TIV, measured by geometric mean titers (GMTs), and the safety of aTIV and TIV...
September 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28924578/effects-of-subthalamic-nucleus-deep-brain-stimulation-on-objective-sleep-outcomes-in-parkinson-s-disease
#13
Amy W Amara, Harrison C Walker, Allen Joop, Gary Cutter, Jennifer L DeWolfe, Susan M Harding, David G Standaert
BACKGROUND: Sleep dysfunction is a common and disabling non-motor symptom in Parkinson's disease. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms and subjective sleep in PD, but alternative stimulation parameters to optimize sleep have not been explored. We hypothesized that low frequency STN DBS would improve objective sleep more than conventional settings. METHODS: Twenty PD subjects with STN DBS (18 unilateral, 2 bilateral) underwent 3 non-consecutive nights of polysomnography: DBS off; DBS high frequency (≥130 Hz); and DBS low frequency (60 Hz)...
March 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28924451/phenotypic-landscape-of-non-conventional-yeast-species-for-different-stress-tolerance-traits-desirable-in-bioethanol-fermentation
#14
Vaskar Mukherjee, Dorota Radecka, Guido Aerts, Kevin J Verstrepen, Bart Lievens, Johan M Thevelein
BACKGROUND: Non-conventional yeasts present a huge, yet barely exploited, resource of yeast biodiversity for industrial applications. This presents a great opportunity to explore alternative ethanol-fermenting yeasts that are more adapted to some of the stress factors present in the harsh environmental conditions in second-generation (2G) bioethanol fermentation. Extremely tolerant yeast species are interesting candidates to investigate the underlying tolerance mechanisms and to identify genes that when transferred to existing industrial strains could help to design more stress-tolerant cell factories...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28924449/outcomes-after-sofosbuvir-containing-regimens-for-hepatitis-c-virus-in-patients-with-decompensated-cirrhosis-a-real-world-study
#15
Fanpu Ji, Wenjun Wang, Shuangsuo Dang, Shengbang Wang, Burong Li, Dan Bai, Wenxue Zhao, Hong Deng, Changyin Tian, Zongfang Li
BACKGROUND: Direct-acting antivirals have been used for decompensated cirrhotic patients with hepatitis C virus (HCV) infection. However, the benefits in Chinese patients with decompensated cirrhosis are unclear. METHODS: Thirty patients with HCV infection and decompensated cirrhosis were administered sofosbuvir-containing regimens at our hospital between April and December 2015. The efficacy and safety of the treatments was determined by sustained virological response at week 12 (SVR 12), change of liver function and adverse events...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28924448/comparison-of-visible-imaging-thermography-and-spectrometry-methods-to-evaluate-the-effect-of-heterodera-schachtii-inoculation-on-sugar-beets
#16
Samuel Joalland, Claudio Screpanti, Frank Liebisch, Hubert Vincent Varella, Alain Gaume, Achim Walter
BACKGROUND: Phenotyping technologies are expected to provide predictive power for a range of applications in plant and crop sciences. Here, we use the disease pressure of Beet Cyst Nematodes (BCN) on sugar beet as an illustrative example to test the specific capabilities of different methods. Strong links between the above and belowground parts of sugar beet plants have made BCN suitable targets for use of non-destructive phenotyping methods. We compared the ability of visible light imaging, thermography and spectrometry to evaluate the effect of BCN on the growth of sugar beet plants...
2017: Plant Methods
https://www.readbyqxmd.com/read/28924143/fructooligosaccharide-fos-and-galactooligosaccharide-gos-increase-bifidobacterium-but-reduce-butyrate-producing-bacteria-with-adverse-glycemic-metabolism-in-healthy-young-population
#17
Feitong Liu, Pan Li, Muxuan Chen, Yuemei Luo, M Prabhakar, Huimin Zheng, Yan He, Qi Qi, Haoyu Long, Yi Zhang, Huafang Sheng, Hongwei Zhou
The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) and galactooligosaccharides (GOS) on glycemia during oral glucose tolerance test (OGTT) and intestinal microbiota. A randomized double-blind cross-over study was performed with 35 adults treated with FOS and GOS for 14 days (16 g/day). Faeces sampling, OGTT and anthropometric parameters were performed...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923931/endothelial-insulin-receptors-differentially-control-insulin-signaling-kinetics-in-peripheral-tissues-and-brain-of-mice
#18
Masahiro Konishi, Masaji Sakaguchi, Samuel M Lockhart, Weikang Cai, Mengyao Ella Li, Erica P Homan, Christian Rask-Madsen, C Ronald Kahn
Insulin receptors (IRs) on endothelial cells may have a role in the regulation of transport of circulating insulin to its target tissues; however, how this impacts on insulin action in vivo is unclear. Using mice with endothelial-specific inactivation of the IR gene (EndoIRKO), we find that in response to systemic insulin stimulation, loss of endothelial IRs caused delayed onset of insulin signaling in skeletal muscle, brown fat, hypothalamus, hippocampus, and prefrontal cortex but not in liver or olfactory bulb...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923875/pharmacological-inhibition-of-the-pseudomonas-aeruginosa-mvfr-quorum-sensing-system-interferes-with-biofilm-formation-and-potentiates-antibiotic-mediated-biofilm-disruption
#19
Damien Maura, Laurence G Rahme
Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of anti-biofilm agents may hold great promise. We show that pharmacological inhibition of the P. aeruginosa quorum sensing regulator MvfR (PqsR) using a benzamide-benzimidazole compound interferes with biofilm formation and potentiates biofilm sensitivity to antibiotics. Such a strategy could have a great potential against P...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28923865/an-in-vitro-comparison-of-ceftolozane-tazobactam-compared-to-traditional-beta-lactams-as-an-alternative-to-combination-antimicrobial-therapy-for-pseudomonas-aeruginosa
#20
Kellie J Goodlet, David P Nicolau, Michael D Nailor
Background: Guidelines for sepsis, febrile neutropenia, and hospital-acquired pneumonia include empiric regimens incorporating two antibiotics from different classes with activity against Pseudomonas aeruginosa for select at-risk patients to increase the likelihood of susceptibility to at least one agent.Objectives: The activity and cross-resistance rates of ceftolozane/tazobactam were compared to β-lactam comparators cefepime, ceftazidime, piperacillin/tazobactam, and meropenem alone and cumulatively with ciprofloxacin or tobramycin against P...
September 18, 2017: Antimicrobial Agents and Chemotherapy
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