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https://www.readbyqxmd.com/read/29792968/applicability-of-endochitinase-of-flavobacterium-johnsoniae-with-transglycosylation-activity-in-generating-long-chain-chitooligosaccharides
#1
Papa Rao Vaikuntapu, Mohan Krishna Mallakuntla, Subha Narayan Das, Bhoopal Bhuvanachandra, Bellamkonda Ramakrishna, Sandhya Rani Nadendla, Appa Rao Podile
Chitin and its derivatives are used for a variety of applications. Flavobacterium johnsoniae UW1 is an aerobic Gram-negative bacterium and genome analysis revealed the presence of 10 glycoside hydrolases (GHs) that may degrade or modify chitin. The gene encoding chitinase B (FjchiB), which encodes a single catalytic GH18 domain has been cloned and heterologously expressed in Escherichia coli. FjChiB was optimally active in 50 mM sodium citrate buffer (pH 6.0) at 40 °C. FjChiB was salt-tolerant and catalytically versatile, with substrate specificity towards 75% DDA (degree of de-acetylation) chitosan, followed by colloidal chitin...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792927/bacillus-subtilis-as-probiotic-candidate-for-red-sea-bream-growth-performance-oxidative-status-and-immune-response-traits
#2
Amr I Zaineldin, Sayed Hegazi, Shunsuke Koshio, Manabu Ishikawa, Abdulnasser Bakr, Abeer M S El-Keredy, Mahmoud A O Dawood, Serge Dossou, Weilong Wang, Zhang Yukun
The effects of dietary administration of Bacillus subtilis on the growth, digestive enzyme activity, blood chemistry, oxidative status and immune response of red sea bream (Pagrus major) were evaluated in the current study. Fish fed five different levels of B. subtilis at 0 (BS0), 1 × 104 (BS1), 1 × 106 (BS2), 1 × 108 (BS3) and 1 × 1010 (BS4) CFU kg-1 diet for 60 days. The obtained results showed that B. subtilis supplementation significantly improved growth performance (FBW, WG and SGR), feed utilization (FI, FCE, PER and PG) and whole-body protein content when compared to the control group (P < 0...
May 21, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29792923/high-throughput-sequencing-identifies-chilling-responsive-genes-in-sweetpotato-ipomoea-batatas-lam-during-storage
#3
Zeyi Xie, Zhilin Zhou, Hongmin Li, Jingjing Yu, Jiaojiao Jiang, Zhonghou Tang, Daifu Ma, Baohong Zhang, Yonghua Han, Zongyun Li
Sweetpotato (Ipomoea batatas L.) is a globally important economic food crop. It belongs to Convolvulaceae family and origins in the tropics; however, sweetpotato is sensitive to cold stress during storage. In this study, we performed transcriptome sequencing to investigate the sweetpotato response to chilling stress during storage. A total of 110,110 unigenes were generated via high-throughput sequencing. Differentially expressed genes (DEGs) analysis showed that 18,681 genes were up-regulated and 21,983 genes were down-regulated in low temperature condition...
May 21, 2018: Genomics
https://www.readbyqxmd.com/read/29792594/an-nmdar-positive-and-negative-allosteric-modulator-series-share-a-binding-site-and-are-interconverted-by-methyl-groups
#4
Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin, Yesim A Tahirovic, Rhonda L Moore, David Menaldino, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to improve the therapeutic index. We describe here a series of negative allosteric NMDAR modulators with submaximal inhibition at saturating concentrations. Modest changes to the chemical structure interconvert negative and positive modulation. All modulators share the ability to enhance agonist potency and are use-dependent, requiring the binding of both agonists before modulators act with high potency...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29792559/frozen-white-leg-shrimp-litopenaeus-vannamei-in-korean-markets-as-a-source-of-aeromonas-spp-harboring-antibiotic-and-heavy-metal-resistance-genes
#5
Benthotage C J De Silva, Sabrina Hossain, Pasan S Dahanayake, Gang-Joon Heo
As the most consumed shrimp variety, white-leg shrimp (Litopenaeus vannamei) owns a high market demand in Korea. This study sought to screen the frozen white-leg shrimp for Aeromonas spp. harboring antimicrobial and heavy metal resistance characteristics. A total of 44 Aeromonas spp. strains were isolated and tested for antibiotic susceptibility and heavy metal tolerance followed by PCR-based detection of resistance genes and integrons. It was observed that resistance to ampicillin and oxacillin was 100% among isolates...
May 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29792175/pulse-actinomycin-d-as-first-line-treatment-of-low-risk-post-molar-non-choriocarcinoma-gestational-trophoblastic-neoplasia
#6
Lei Li, Xirun Wan, Fengzhi Feng, Tong Ren, Junjun Yang, Jun Zhao, Fang Jiang, Yang Xiang
BACKGROUND: Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN. METHODS: From January 2013 to October 2016, according to the FIGO criteria for the diagnosis of post-molar disease and the FIGO risk-factor scoring system for GTN, a total of 135 patients with post-molar non-choriocarcinoma GTN who were chemotherapy-naive with a FIGO score < 7 were treated with single-agent pulse Act-D as a first-line regimen, in Peking Union Medical College Hospital...
May 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29792020/daclatasvir-and-asunaprevir-combination-therapy-for-patients-with-chronic-hepatitis-c-virus-genotype-1b-infection-in-real-world
#7
Jae Young Oh, Byung Seok Kim, Chang Hyeong Lee, Jeong Eun Song, Heon Ju Lee, Jung Gil Park, Jae Seok Hwang, Woo Jin Chung, Byoung Kuk Jang, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Sang Gyu Kwak
Background/Aims: Previous studies have reported a high rate of sustained virologic response (SVR) and a low rate of serious adverse events with the use of daclatasvir (DCV) and asunaprevir (ASV) combination therapy. We evaluated the efficacy and safety of DCV and ASV combination therapy for patients with chronic hepatitis C virus (HCV) genotype 1b infection in real world. Methods: We enrolled 278 patients (184 treatment-naïve patients) from five hospitals in Daegu and Gyeongsangbuk-do...
May 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29791880/dietary-cadmium-intake-from-rice-and-vegetables-and-potential-health-risk-a-case-study-in-xiangtan-southern-china
#8
Hongping Chen, Xinping Yang, Peng Wang, Zixuan Wang, Ming Li, Fang-Jie Zhao
Soil contamination in some areas of southern China has resulted in elevated dietary intake of cadmium (Cd), posing a potential risk to human health. A survey of paired soil-rice (n = 200) and soil-vegetable (n = 142) samples was conducted in Xiangtan county of Hunan province, southern China. The concentrations of Cd in all the samples were determined by inductively coupled plasma mass spectrometry. Dietary intakes of Cd from the consumption of locally produced rice and vegetables were estimated for different age groups...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791811/the-putative-transient-receptor-potential-trp-channel-protein-encoded-by-the-orf19-4805-is-involved-in-cation-sensitivity-antifungal-tolerance-and-filamentation-in-candida-albicans
#9
Linghuo Jiang, Yi Yang
The ancient family of cation channels, transient receptor potential (TRP) channels, is highly conserved in eukaryotes and plays various physiological functions from sensation of ion homeostasis to reception of pain and vision. Calcium-permeable TRP channels have been identified from the plant Arabidopsis thaliana (AtCsc1) and the budding yeast Saccharomyces cerevisiae (ScCsc1), respectively. In this study, we have characterized the functions of the Csc1 homolog, the orf19.4805, in Candida albicans. The orf19...
May 23, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29791723/functional-and-morphological-recovery-is-incomplete-after-acute-and-acute-recurrent-pancreatitis-in-children
#10
Srikanth Puttaiah Kadyada, Babu Ram Thapa, Karanvir Kaushal, Rama Walia, S V Rana, Narendra Dhaka, Sadhna B Lal, Rajendra Prasad, Subhamoy Das, Rajini Thakur, Kishore Kamal
OBJECTIVE: There is lack of data on functional and morphological recovery after an attack of acute pancreatitis (AP) or acute recurrent pancreatitis (ARP) in children. This study aims to evaluate the functional impairment and morphological changes in the pancreas after recovery. METHODS: All consecutive patients presenting with AP (n=61) or ARP (n=35), as per standard diagnostic criteria were enrolled. After 2 months of pancreatitis, fecal elastase-1(μg/g) and 2-hour oral glucose tolerance test to calculate oral disposition index (DIo )mmol/L-1 (beta cell function) were done...
May 23, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29791512/cpr-ir-is-an-insulin-resistance-index-that-is-minimally-affected-by-hepatic-insulin-clearance-a-preliminary-research
#11
Tsuyoshi Okura, Risa Nakamura, Yohei Fujioka, Sonoko Kawamoto-Kitao, Yuichi Ito, Kazuhisa Matsumoto, Kyoko Shoji, Keisuke Sumi, Kazuhiko Matsuzawa, Shoichiro Izawa, Etsuko Ueta, Masahiko Kato, Takeshi Imamura, Shin-Ichi Taniguchi, Kazuhiro Yamamoto
BACKGROUND: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. METHODS: Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, insulin and serum C-peptide immunoreactivity (CPR) were measured, and HOMA-IR and HIC were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/29791398/ultralow-chirp-photonic-crystal-fiber-mach-zehnder-interferometer
#12
William O F Carvalho, Danilo H Spadoti, Enrique Silvestre, Felipe Beltran-Mejia
A photonic crystal fiber Mach-Zehnder interferometer design was optimized to obtain high performance and ultralow chirp. Two long-period gratings were used to excite the cladding modes, and the rich structure of the cladding was tailored to obtain a slightly chirped free spectral range, as required by the Telecommunication Standardization Sector of the International Telecommunication Union (ITU-T) Norm G.694.1. Finally, a fabrication tolerance analysis was performed. The advantages of the proposed device are an ultralow chirp, high bandwidth, and fabrication robustness tolerance...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791332/polarization-dependent-wide-angle-color-filter-incorporating-meta-dielectric-nanostructures
#13
Shangliang Wu, Yan Ye, Minghui Luo, Linsen Chen
A metadielectric nanostructure with narrow cavities is proposed, behaving as a reflective color filter for TM-polarized light while as a broadband reflector for TE-polarized light. By varying the cavity depth or changing the incident light polarization, reflective colors of the proposed structure cover the entire visible spectrum conveniently. In particular, the reflections of this proposed structure show good angular tolerance up to 50° for both polarizations. Furthermore, it can display colors even with two grating slits, which shows high printing resolution up to 70555 dpi, having great potential for applications of a large area color imaging and anticounterfeiting devices...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791237/the-future-of-chronic-lymphocytic-leukemia-potential-directions-from-ash-2017
#14
Stefano Molica
Novel targeted therapies - including ibrutinib, venetoclax and idelalisib - have revolutionized the treatment landscape of chronic lymphocytic leukemia (CLL). Therefore, studying combinations of novel agents (NAs) with distinct mechanism of action and non-overlapping toxicities is challenging. Area covered: The 2017 American Society Hematology (ASH) Annual Meeting, has represented a showcase for several trials combining NAs. These studies are currently evaluating the efficacy NA plus anti-CD20 monoclonal antibody, NA plus NA (with or without anti-CD20 monoclonal antibody) and NA plus chemo-immunotherapy...
May 23, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29791203/short-term-thermoneutral-housing-alters-glucose-metabolism-and-markers-of-adipose-tissue-browning-in-response-to-a-high-fat-diet-in-lean-mice
#15
Zachary Stephen Clayton, Carrie E McCurdy
Systemic insulin resistance and glucose intolerance occur with as little as 3 days of a high-fat diet (HFD) in mice and humans; the mechanisms that initiate acute insulin resistance are unknown. Most laboratories house mice at 22{degree sign}C, which is below their thermoneutral temperature (~30{degree sign}C). Cold stress has been shown to increase white adipose tissue (WAT) browning, alter lipid trafficking and impair immune function, while energy intake and expenditure decrease with increasing ambient temperature; importantly, dysregulation of these parameters have been strongly linked to obesity-induced insulin resistance...
May 23, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29791180/-heart-transplantation-and-follow-up-treatment-with-al-amyloidosis-in-5-patients
#16
Zdeněk Adam, Eva Ozábalová, Petr Němec, Helena Bedáňová, Milan Kuman, Jan Krejčí, Lenka Špinarová, Víta Žampachová, Zdeňka Čermáková, Luděk Pour, Marta Krejčí, Viera Sanecká, Martin Štork, Tomáš Pika, Jan Straub, Dagmar Adamová, Yvetta Stavařová, Zdeněk Král, Jiří Mayer
The prognosis for patients with cardiac impairment due to AL-amyloid deposition and severe cardiac insufficiency is poor, with a survival median in the order of months. The classical treatment of AL-amyloidosis in combination with cardiac insufficiency is very poorly tolerated and the treatment of such patients is associated with considerably higher mortality than among other patients with AL-amyloidosis. If, however, patients with an isolated or another dominating cardiac impairment, without severe damage to other organs and tissues, have a heart transplant performed, their cardiovascular condition will significantly improve as a result, along with their ability to tolerate any kind of treatment for AL-amyloidosis including that using high-dose chemotherapy with a transplant of autologous hematopoietic stem cells...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790906/bcseq-an-r-package-for-fast-sequence-mapping-in-high-throughput-shrna-and-crispr-screens
#17
Jiaxing Lin, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S Damrauer, Scott Floyd, Joshua Granek, Andrew Allen, Cliburn Chan, Jichun Xie, Kouros Owzar
Summary: CRISPR-Cas9 and shRNA high-throughput sequencing screens have abundant applications for basic and translational research. Methods and tools for the analysis of these screens must properly account for sequencing error, resolve ambiguous mappings among similar sequences in the barcode library in a statistically principled manner, and be computationally efficient. Herein we present bcSeq, an open source R package that implements a fast and parallelized algorithm for mapping high-throughput sequencing reads to a barcode library while tolerating sequencing error...
May 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29790767/copper-promoted-6-endo-trig-cyclization-of-%C3%AE-%C3%AE-unsaturated-hydrazones-for-the-synthesis-of-1-6-dihydropyridazines
#18
Yong-Qiang Guo, Mi-Na Zhao, Zhi-Hui Ren, Zheng-Hui Guan
A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6- endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good yields, high functional group tolerance, and remarkable regioselectivity under mild conditions. Importantly, the 1,6-dihydropyridazines can be efficiently converted to biologically important pyridazines in the presence of NaOH.
May 23, 2018: Organic Letters
https://www.readbyqxmd.com/read/29790618/intratendinous-injection-of-autologous-adipose-tissue-derived-mesenchymal-stem-cells-for-the-treatment-of-rotator-cuff-disease-a-first-in-human-trial
#19
Chris H Jo, Jee Won Chai, Eui Cheol Jeong, Sohee Oh, Paul S Kim, Jeong Yong Yoon, Kang Sup Yoon
Despite relatively good results of current symptomatic treatments for rotator cuff disease, there has been an unmet need for fundamental treatments to halt or reverse the progress of disease. The purpose of this study was to assess the safety and efficacy of intratendinous injection of autologous adipose-tissue derived MSCs (AD MSCs) in patients with rotator cuff disease. The first part of the study consists of 3 dose-escalation cohorts; the low- (1.0x107 cells), mid- (5.0x107 ), and high-dose (1.0x108 ) groups with 3 patients each for the evaluation of the safety and tolerability...
May 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/29790457/comparison-of-different-conditioning-regimens-of-haploidentical-hematopoietic-stem-cell-transplant-in-patients-with-acute-myeloid-leukemia
#20
Yujie Jiang, Xiaosheng Fang, Xiaohui Sui, Xin Liu, Ying Li, Xianghua Wang, Hongzhi Xu, Lingyan Zhang, Xin Wang
OBJECTIVES: We evaluated the safety and efficacy of 2 conditioning regimens (busulfan/fludarabine vs modified busulfan/cyclophosphamide) in patients with acute myeloid leukemia undergoing haploidentical hematopoietic stem cell transplant. MATERAILS AND METHODS: Twenty patients with primary acute myeloid leukemia had been randomized into busulfan/fludarabine and modified busulfan/cyclophosphamide groups. We retrospectively compared hematopoietic engraftment, regimen-related toxicity, graft-versus-host disease, transplant-related mortality, leukemia-free survival, and overall survival between the groups...
May 23, 2018: Experimental and Clinical Transplantation
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