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stress induced cardiomyopathy

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https://www.readbyqxmd.com/read/28920632/acute-cardiotoxicity-induced-by-doxorubicin-in-right-ventricle-is-associated-with-increase-of-oxidative-stress-and-apoptosis-in-rats
#1
N Anghel, H Herman, C Balta, M Rosu, M S Stan, D Nita, A Ivan, Z Galajda, A Ardelean, A Dinischiotu, A Hermenean
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents, but its efficiency is seriously limited by the risk of developing cardiomyopathy. The most recognized cardiotoxic effect is left ventricular (LF) dysfunction, but MRI and echocardiography data demonstrated significant right ventricle (RV) function impairment. In order to clarify this aspect, the present study investigated the potential of DOX to induce acute RV cardiotoxicity at the same time as LV impairment. Rats were intraperitoneally (i...
September 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28914755/thioredoxin-2-offers-protection-against-mitochondrial-oxidative-stress-in-h9c2-cells-and-against-myocardial-hypertrophy-induced-by-hyperglycemia
#2
Hong Li, Changqing Xu, Quanfeng Li, Xiuxiang Gao, Erkio Sugano, Hiroshi Tomita, Liming Yang, Sa Shi
Mitochondrial oxidative stress is thought to be a key contributor towards the development of diabetic cardiomyopathy. Thioredoxin 2 (Trx2) is a mitochondrial antioxidant that, along with Trx reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), scavenges H₂O₂ and offers protection against oxidative stress. Our previous study showed that TrxR inhibitors resulted in Trx2 oxidation and increased ROS emission from mitochondria. In the present study, we observed that TrxR inhibition also impaired the contractile function of isolated heart...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28887671/histamine-2-receptor-antagonism-elicits-protection-against-doxorubicin-induced-cardiotoxicity-in-rodent-model
#3
Sundar Kumar Kondru, Ajay Godwin Potnuri, Lingesh Allakonda, Prasad Konduri
Doxorubicin (DOX), an anthracycline-based antibiotic, is regularly used in the management of carcinomas, and haematological malignancies have been downplayed in chemotherapy because of its ability to induce dilated cardiomyopathy (DCM). Dexrazoxane is approved to combat the cardiotoxicity, but limited by its adverse effects. Redox imbalance and reactive oxygen species generation plays major role in DOX-induced cardiotoxicity. Histamine, known to mediate various cardiovascular effects, but nevertheless the role of histamine or its receptors in DOX-induced DCM is remained obscure...
September 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28887535/metabolic-stress-induced-cardiomyopathy-is-caused-by-mitochondrial-dysfunction-due-to-attenuated-erk5-signaling
#4
Wei Liu, Andrea Ruiz-Velasco, Shoubao Wang, Saba Khan, Min Zi, Andreas Jungmann, Maria Dolores Camacho-Muñoz, Jing Guo, Guanhua Du, Liping Xie, Delvac Oceandy, Anna Nicolaou, Gina Galli, Oliver J Müller, Elizabeth J Cartwright, Yong Ji, Xin Wang
The prevalence of cardiomyopathy from metabolic stress has increased dramatically; however, its molecular mechanisms remain elusive. Here, we show that extracellular signal-regulated protein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific deletion of Erk5 in mice (Erk5-CKO) leads to dampened cardiac contractility and mitochondrial abnormalities with repressed fuel oxidation and oxidative damage upon high fat diet (HFD). Erk5 regulation of peroxisome proliferator-activated receptor γ co-activator-1α (Pgc-1α) is critical for cardiac mitochondrial functions...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28878116/inhibition-of-nadph-oxidase-2-nox2-prevents-sepsis-induced-cardiomyopathy-by-improving-calcium-handling-and-mitochondrial-function
#5
Leroy C Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti, Grace J Kim, Emanuele Barca, Dhanendra Tomar, Nicholas E Hoffman, Prakash Subramanyam, Henry M Colecraft, Michio Hirano, Adam J Ratner, Muniswamy Madesh, Konstantinos Drosatos, John P Morrow
Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have been observed during sepsis, but the mechanisms responsible for these abnormalities have not been determined. We hypothesized that NADPH oxidase 2 (NOX2) activation could be responsible for sepsis-induced oxidative stress and cardiomyopathy. Treatment of isolated adult mouse cardiomyocytes with low concentrations of the endotoxin lipopolysaccharide (LPS) increased total cellular reactive oxygen species (ROS) and mitochondrial superoxide...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28870983/ischaemia-as-a-cause-of-lvot-gradient-reversal-in-hocm
#6
Camelia Demetrescu, Shelley Rahman Haley, Aigul Baltabaeva
We present the case of a sprightly 84 year old female with hypertrophic obstructive cardiomyopathy (HOCM) echo phenotype with asymmetrical septal hypertrophy, significant left ventricular (LV) outflow obstruction (LVOT) and mitral regurgitation (MR) at rest. Valsalva provocation caused an increase in LVOT dynamic gradient and MR severity. The patient presented with progressive decrease in exercise capacity and chest pain relieved by rest or sublingual GTN spray. Exercise stress echo demonstrated a paradoxical response with reduction of both LVOT gradient and severity of MR...
September 4, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28862927/inhibition-of-mutant-%C3%AE-b-crystallin-induced-protein-aggregation-by-a-molecular-tweezer
#7
Na Xu, Gal Bitan, Thomas Schrader, Frank-Gerrit Klärner, Hanna Osinska, Jeffrey Robbins
BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity-based pathology in heart disease is just beginning. The molecular tweezer CLR01 is a broad-spectrum inhibitor of abnormal self-assembly of amyloidogenic proteins, including amyloid β-protein, tau, and α-synuclein. This small molecule interferes with aggregation by binding selectively to lysine side chains, changing the charge distribution of aggregation-prone proteins and thereby disrupting aggregate formation...
August 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28854816/carvedilol-inhibits-matrix-metalloproteinase-2-activation-in-experimental-autoimmune-myocarditis-possibilities-of-cardioprotective-application
#8
Monika Skrzypiec-Spring, Katarzyna Haczkiewicz, Agnieszka Sapa, Tomasz Piasecki, Joanna Kwiatkowska, Ireneusz Ceremuga, Mieczyslaw Wozniak, Wieslawa Biczysko, Christopher Kobierzycki, Piotr Dziegiel, Marzenna Podhorska-Okolow, Adam Szelag
AIMS: Acute myocarditis is a potentially lethal inflammatory heart disease that frequently precedes the development of dilated cardiomyopathy and subsequent heart failure. At present, there is no effective standardized therapy for acute myocarditis, besides the optimal care of heart failure and arrhythmias in accordance with evidence-based guidelines and specific etiology-driven therapy for infectious myocarditis. Carvedilol has been shown to be cardioprotective by reducing cardiac pro-inflammatory cytokines present in oxidative stress in certain heart diseases...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28845041/stress-induced-cardiomyopathy-triggered-by-acute-myocardial-infarction-a-case-series-challenging-the-mayo-clinic-definition
#9
Georgios Christodoulidis, Vishwa Kundoor, Edo Kaluski
BACKGROUND Various physical and emotional factors have been previously described as triggers for stress induced cardiomyopathy. However, acute myocardial infarction as a trigger has never been reported. CASE REPORT We describe four patients who presented with an acute myocardial infarction, in whom the initial echocardiography revealed wall motion abnormalities extending beyond the coronary distribution of the infarct artery. Of the four patients identified, the mean age was 59 years; three patients were women and two patients had underlying psychiatric history...
August 28, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28839382/sugemule-3-protects-against-isoprenaline-induced-cardiotoxicity-in-vitro
#10
Yu Wang, Guo-Hua Gong, Ya-Nan Xu, Li-Jun Yu, Cheng-Xi Wei
BACKGROUND: Sugemule-3 (SD) is a traditional Chinese medicine with protective effect of myocardium. However, the underlying mechanisms of the effect had not been elucidated. MATERIALS AND METHODS: In the present study, the serum of SD was prepared. A model of β-adrenergic agonist isoprenaline (ISO)-induced H9c2 cardiomyocytes injury was established in vitro. The changes in cell viability were examined to determine the available concentration of ISO and serum of SD...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28837153/cardioprotective-effects-of-fibroblast-growth-factor-21-against-doxorubicin-induced-toxicity-via-the-sirt1-lkb1-ampk-pathway
#11
Shudong Wang, Yonggang Wang, Zhiguo Zhang, Quan Liu, Junlian Gu
Doxorubicin (DOX) is a highly effective antineoplastic anthracycline drug; however, the adverse effect of the cardiotoxicity has limited its widespread application. Fibroblast growth factor 21 (FGF21), as a well-known regulator of glucose and lipid metabolism, was recently shown to exert cardioprotective effects. The aim of this study was to investigate the possible protective effects of FGF21 against DOX-induced cardiomyopathy. We preliminarily established DOX-induced cardiotoxicity models in H9c2 cells, adult mouse cardiomyocytes, and 129S1/SyImJ mice, which clearly showed cardiac dysfunction and myocardial collagen accumulation accompanying by inflammatory, oxidative stress, and apoptotic damage...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28836409/cardio-protective-role-of-gingerol-along-with-prominent-anti-diabetic-cardiomyopathy-action-in-a-streptozotocin-induced-diabetes-mellitus-rat-model
#12
Li-Ya Yu, Wen-Lei Shi, Xin-GuiGuo Guo
OBJECTIVES: Diabetic cardiomyopathy (DCM) is characterized as a coronary heart disease which expands during diabetes due to alterations in the myocardial function and structure. The currentstudy intends to elucidate the protective effect of gingerol on DCM in a streptozotocin (STZ)-induced diabetes mellitus (DM) rat model. MATERIALS AND METHODS: In this experimental study, the animals were divided into three groups: normal control, DM control, and DM+gingerol (10 mg/kg)...
October 2017: Cell Journal
https://www.readbyqxmd.com/read/28833618/intraoperative-predictors-of-postoperative-takotsubo-syndrome-in-liver-transplant-recipients-an-exploratory-case-control-study
#13
Stephen Aniskevich, Ryan M Chadha, Prith Peiris, C Burcin Taner, Klaus L Torp, Colleen S Thomas, Maria L Yataco, Sher-Lu Pai
INTRODUCTION: Takotsubo syndrome (TTS), also known as Takotsubo's cardiomyopathy or stress induced cardiomyopathy, has been described following a variety of surgeries and disease states. The relationship between intraoperative anesthesia management and the development of this syndrome has never been fully elucidated. OBJECTIVES: The primary objective of this study was to determine the relationship of multiple intraoperative factors on the pathogenesis of TTS. METHODS: A single center retrospective review of all liver transplants performed at Mayo Clinic Florida from January 2005- December 2014...
August 22, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28830979/alterations-in-fatty-acid-metabolism-and-sirtuin-signaling-characterize-early-type-2-diabetic-hearts-of-fructose-fed-rats
#14
Phing-How Lou, Eliana Lucchinetti, Katrina Y Scott, Yiming Huang, Manoj Gandhi, Martin Hersberger, Alexander S Clanachan, Hélène Lemieux, Michael Zaugg
Despite the fact that skeletal muscle insulin resistance is the hallmark of type-2 diabetes mellitus (T2DM), inflexibility in substrate energy metabolism has been observed in other tissues such as liver, adipose tissue, and heart. In the heart, structural and functional changes ultimately lead to diabetic cardiomyopathy. However, little is known about the early biochemical changes that cause cardiac metabolic dysregulation and dysfunction. We used a dietary model of fructose-induced T2DM (10% fructose in drinking water for 6 weeks) to study cardiac fatty acid metabolism in early T2DM and related signaling events in order to better understand mechanisms of disease...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28828027/psychological-features-of-takotsubo-cardiomyopathy-report-of-four-cases
#15
Yaser Jenab, Seyedeh Roghaieh Hashemi, Neda Ghaffari-Marandi, Hoda Zafarghandi, Nazila Shahmansouri
Takotsubo or stress-induced cardiomyopathy is a cardiomyopathy in which the patient has a sudden onset, reversible left ventricular systolic dysfunction without any significant coronary artery disease. Four women, who were at a mean age of 64 years and suffered from chest pain exacerbated by emotional stress, were admitted as cases of acute coronary syndrome and were completely evaluated through precise history taking, physical examination, and ECG. Coronary angiography or coronary multidetector computed tomography was used to exclude significant coronary artery disease...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28827473/restoration-of-circulating-mfge8-milk-fat-globule-egf-factor-8-attenuates-cardiac-hypertrophy-through-inhibition-of-akt-pathway
#16
Ke-Qiong Deng, Jing Li, Zhi-Gang She, Jun Gong, Wen-Lin Cheng, Fu-Han Gong, Xue-Yong Zhu, Yan Zhang, Zhihua Wang, Hongliang Li
Cardiac hypertrophy occurs in response to numerous stimuli like neurohumoral stress, pressure overload, infection, and injury, and leads to heart failure. Mfge8 (milk fat globule-EGF factor 8) is a secreted protein involved in various human diseases, but its regulation and function during cardiac hypertrophy remain unexplored. Here, we found that circulating MFGE8 levels declined significantly in failing hearts from patients with dilated cardiomyopathy. Correlation analyses revealed that circulating MFGE8 levels were negatively correlated with the severity of cardiac dysfunction and remodeling in affected patients...
August 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28826911/rutin-alleviates-diabetic-cardiomyopathyand-improves-cardiac-function-in-diabetic-apoeknock-outmice
#17
Ruo Huang, Zhendong Shi, Li Chen, Yanqun Zhang, Jing Li, Yi An
Rutin, a natural bioflavonoid, hasdemonstrated anti-diabetic and anti-oxidative bioactivity.Oxidative stressis a potential therapeutic target for diabetic cardiomyopathy.We investigated whether rutinadministration (60mg/kg body weight)reducesdiabetic cardiomyopathy in a diabetic ApoE knock out mouse model.Diabetes was induced in ApoEknockout mice (male, C57BL/6 background) with a high fat diet combined with injection of streptozotocin.Cardiac function was evaluated by echocardiography and cardiac catheter hemodynamic analysis...
August 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28822689/cholesterol-lowering-gene-therapy-counteracts-the-development-of-non-ischemic-cardiomyopathy-in-mice
#18
Ilayaraja Muthuramu, Ruhul Amin, Andrey Postnov, Mudit Mishra, Joseph Pierre Aboumsallem, Tom Dresselaers, Uwe Himmelreich, Paul P Van Veldhoven, Olivier Gheysens, Frank Jacobs, Bart De Geest
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density lipoprotein receptor (AAV8-LDLr) gene transfer was performed in LDLr-deficient mice without and with pressure overload induced by transverse aortic constriction (TAC). AAV8-LDLr gene therapy resulted in an 82.8% (p < 0.0001) reduction of plasma cholesterol compared with controls. Mortality rate was lower (p < 0.05) in AAV8-LDLr TAC mice compared with control TAC mice (hazard ratio for mortality 0...
August 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28818336/association-between-premature-ventricular-complexes-during-exercise-long-term-occurrence-of-life-threatening-arrhythmia-and-mortality
#19
Jorge Aviles-Rosales, Hermes Ilarraza-Lomeli, Marianna Garcia-Saldivia, Jessica Rojano-Castillo, Maria-Dolores Rius-Suarez, Juan-Pablo Nunez-Urquiza, Pedro Iturralde
OBJECTIVE: Exercise-induced premature ventricular complexes (EiPVCs) are often considered as benign arrhythmias, nevertheless they are associated with a high risk of all-cause death in general healthy population. However, an intermediate pathophysiological process remains unclear, particularly in patients with known cardiovascular disease. The aim of this study was to find an association between EiPVCs, the occurrence of life-threatening ventricular arrhythmias (LACO) and all-cause mortality in patients with cardiovascular disease...
August 14, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28818208/catecholamine-dependent-%C3%AE-adrenergic-signaling-in-a-pluripotent-stem-cell-model%C3%A2-of-takotsubo-cardiomyopathy
#20
Thomas Borchert, Daniela Hübscher, Celina I Guessoum, Tuan-Dinh D Lam, Jelena R Ghadri, Isabel N Schellinger, Malte Tiburcy, Norman Y Liaw, Yun Li, Jan Haas, Samuel Sossalla, Mia A Huber, Lukas Cyganek, Claudius Jacobshagen, Ralf Dressel, Uwe Raaz, Viacheslav O Nikolaev, Kaomei Guan, Holger Thiele, Benjamin Meder, Bernd Wollnik, Wolfram-Hubertus Zimmermann, Thomas F Lüscher, Gerd Hasenfuss, Christian Templin, Katrin Streckfuss-Bömeke
BACKGROUND: Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis. OBJECTIVES: The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) model of TTS, to test the hypothesis of altered β-adrenergic signaling in TTS iPSC-cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of TTS...
August 22, 2017: Journal of the American College of Cardiology
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