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stress induced cardiomyopathy

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https://www.readbyqxmd.com/read/29778534/fibroblast-growth-factor-19-protects-the-heart-from-oxidative-stress-induced-diabetic-cardiomyopathy-via-activation-of-ampk-nrf2-ho-1-pathway
#1
Xin Li, Di Wu, Ye Tian
Diabetes affects cardiac structure and function, where it leads to diabetic cardiomyopathy. Reactive oxygen species (ROS) produced by oxidative stress play an important role in the development of diabetic cardiomyopathy. Fibroblast growth factor (FGF) 19, an enterokine, is synthesized and released into the ileum. In the present study, we revealed that FGF19 induced an antioxidant response through stimulating the expression of nuclear erythroid factor 2 (NE-F2)-related factor 2 (Nrf2) and as well as reducing ROS production through the AMPK signaling pathway...
May 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772531/effects-of-oxidized-lipids-and-lipoproteins-on-cardiac-function
#2
Tahar Hajri
Oxidative modifications of lipids and lipoproteins have long been linked to the pathogenesis of cardiovascular diseases including atherosclerosis and coronary disease. Furthermore, overwhelming evidence indicate that oxidized lipids are also associated with myocardial dysfunction and cardiomyopathy. Oxidized lipid derivatives are generated by enzymatic and non-enzymatic reactions with unsaturated lipids in the cell and foods. In addition, blood LDL particles are prone to oxidation leading to the formation of oxidized LDL (oxLDL), which is often associated with obesity, diabetes and metabolic disease...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29771705/the-causality-nexus-between-the-tako-tsubo-syndrome-and-an-assault-a-forensic-case-report
#3
Malek Zribi, Syrine Azza Manoubi, Narjes Karray, Salma Charfeddine, Wiem Benamar, Zouhir Hammami, Samir Kammoun, Samir Maatoug
"Tako-tsubo" cardiomyopathy, also known as "broken heart syndrome," is one of the rarest types of stress-induced cardiomyopathy. It frequently mimics acute coronary syndrome, characterized by transient left ventricular dysfunction, electrocardiographic changes, and release of myocardial enzymes. After treatment, the patients are cured in most cases without sequelae. Tako-tsubo syndrome is rarely considered as a reason for consultation in the forensic department.Herein, we report a case of a 68-year-old woman who was assaulted by her police officer neighbor...
May 4, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29765130/copy-number-variants-implicate-cardiac-function-and-development-pathways-in-earthquake-induced-stress-cardiomyopathy
#4
Cameron J Lacey, Kit Doudney, Paul G Bridgman, Peter M George, Roger T Mulder, Julie J Zarifeh, Bridget Kimber, Murray J Cadzow, Michael A Black, Tony R Merriman, Klaus Lehnert, Vivienne M Bickley, John F Pearson, Vicky A Cameron, Martin A Kennedy
The pathophysiology of stress cardiomyopathy (SCM), also known as takotsubo syndrome, is poorly understood. SCM usually occurs sporadically, often in association with a stressful event, but clusters of cases are reported after major natural disasters. There is some evidence that this is a familial condition. We have examined three possible models for an underlying genetic predisposition to SCM. Our primary study cohort consists of 28 women who suffered SCM as a result of two devastating earthquakes that struck the city of Christchurch, New Zealand, in 2010 and 2011...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29761889/a-novel-human-s10f-hsp20-mutation-induces-lethal-peripartum-cardiomyopathy
#5
Guan-Sheng Liu, George Gardner, George Adly, Min Jiang, Wen-Feng Cai, Chi Keung Lam, Fawzi Alogaili, Nathan Robbins, Jack Rubinstein, Evangelia G Kranias
Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Previous findings showed that cardiac-specific overexpression of this mutant were associated with reduced autophagy, left ventricular dysfunction and early death in male mice. However, this study indicates that females have normal function with no alterations in autophagy but died within a week after 1-4 pregnancies...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29761372/outcomes-of-takotsubo-cardiomyopathy-in-hospitalized-cancer-patients
#6
Parijat Saurav Joy, Achuta Kumar Guddati, Iuliana Shapira
BACKGROUND: Chemotherapy-induced cardiomyopathy is a critical complication of treatment for cancer. The emotional stress of a cancer diagnosis, ongoing chemotherapy, abnormal cancer-related wasting syndrome may contribute to cardiac morbidity in these patients. The burden of Takotsubo Cardiomyopathy (TCM) in cancer patients is unknown. The incidence of TCM and related outcomes in cancer patients was investigated in this study. METHODS: The 2007-2013 National Inpatient Sample (NIS) was analyzed for patients with a prior and new diagnosis of TCM with and without malignancy...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29761112/takotsubo-cardiomyopathy-mimicking-stent-thrombosis-after-percutaneous-coronary-intervention
#7
Furqan Khattak, Muhammad Khalid, Ghulam Murtaza, Timir K Paul
Takotsubo cardiomyopathy, also known as "broken heart syndrome," is a transient left ventricular dysfunction associated with stress (usually emotional) induced myocardial injury and stunning. It often presents as myocardial infarction on surface electrocardiogram (EKG). Diagnosis is made by coronary angiography, which rules out coronary artery disease and shows pathognomonic apical ballooning. In this article, we present a case of a 72-year-old woman who initially presented with an ST segment elevation myocardial infarction on EKG...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29752433/palmitic-acid-but-not-high-glucose-induced-myocardial-apoptosis-is-alleviated-by-n%C3%A2-acetylcysteine-due-to-attenuated-mitochondrial-derived-ros-accumulation-induced-endoplasmic-reticulum-stress
#8
Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Weijin Fang
Pharmacological inhibition of reactive oxygen species (ROS) is a potential strategy to prevent diabetes-induced cardiac dysfunction. This study was designed to investigate precise effects of antioxidant N‑acetylcysteine (NAC) in alleviating diabetic cardiomyopathy (DCM). Echocardiography and histologic studies were performed 12 weeks after streptozocin injection. Protein levels involved in endoplasmic reticulum stress (ERS) and apoptosis were analyzed by western blotting in diabetic hearts or high-glucose (HG, 30 mM)- and palmitic acid (PA, 300 μM)-cultured neonatal rat cardiomyocytes (NRCMs)...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#9
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29729319/autophagy-and-lysosomal-pathways-in-nervous-system-disorders
#10
REVIEW
Baris Bingol
Autophagy is an evolutionarily conserved pathway for delivering cytoplasmic cargo to lysosomes for degradation. In its classically studied form, autophagy is a stress response induced by starvation to recycle building blocks for essential cellular processes. In addition, autophagy maintains basal cellular homeostasis by degrading endogenous substrates such as cytoplasmic proteins, protein aggregates, damaged organelles, as well as exogenous substrates such as bacteria and viruses. Given their important role in homeostasis, autophagy and lysosomal machinery are genetically linked to multiple human disorders such as chronic inflammatory diseases, cardiomyopathies, cancer, and neurodegenerative diseases...
May 2, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29727174/exposure-to-vinyl-chloride-and-its-influence-on-western-diet-induced-cardiac-remodeling
#11
Yaqin Liang, Anna L Lang, Jian Zhang, Jing Chen, Kai Wang, Liya Chen, Juliane I Beier, Yan Qian, Lu Cai
Obesity, usually caused by high fat diets (HFD), is a major public health issue worldwide, causing obesity associated cardiomyopathy. Moreover, the environmental toxicant vinyl chloride (VC) can exacerbate HFD-induced fatty liver disease. However, whether VC serves to enhance obesity-associated cardiomyopathy remains unclear. This study aims to investigate the interaction of western diet (WD) containing relatively low fat (42%) with VC on cardiac remodeling and its underling mechanisms. Adult male C57BL/6J mice were exposed to WD coinhalation of low-dose VC (<1 ppm/d) for 12 weeks...
May 10, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29723491/qsox1-a-novel-actor-of-cardiac-protection-upon-acute-stress-in-mice
#12
Anais Caillard, Malha Sadoune, Arthur Cescau, Mehdi Meddour, Marine Gandon, Evelyne Polidano, Claude Delcayre, Kelly Da Silva, Philippe Manivet, Ana-Maria Gomez, Alain Cohen-Solal, Nicolas Vodovar, Zhenlin Li, Alexandre Mebazaa, Jane-Lise Samuel
QSOX1, a sulfhydryl oxidase, was shown to be upregulated in the heart upon acute heart failure (AHF). The aim of the study was to unravel QSOX1 roles during AHF. We generated and characterized mice with QSOX1 gene deletion. The QSOX1-/- mice were viable but adult male exhibited a silent dilated cardiomyopathy. The QSOX1-/- hearts were characterized by low protein SERCA2a levels associated with a calcium homeostasis alteration, high levels of the endoplasmic reticulum (ER) chaperone proteins Grp78/Bip, and of the ER apoptosis sensor CHOP, indicating a chronic unfolded protein response (UPR)...
April 30, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29721501/resveratrol-prevents-diabetic-cardiomyopathy-by-increasing-nrf2-expression-and-transcriptional-activity
#13
Guan Wang, Xianjin Song, Lei Zhao, Zhibo Li, Bing Liu
Objective: This study investigated if resveratrol ameliorates diabetic cardiomyopathy by targeting associated oxidative stress mechanisms. Method: Type 1 diabetes mellitus (DM) in FVB mice was induced by several intraperitoneal injections of a low dose of streptozotocin. Hyperglycemic and age-matched control mice were given resveratrol (10 mg/kg per day) for 1 month and subsequently monitored for an additional 6 months. Mice were assigned to four groups: control, resveratrol, DM, and DM/resveratrol...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29720537/isosteviol-ameliorates-diabetic-cardiomyopathy-in-rats-by-inhibiting-erk-and-nf%C3%AE%C2%BAb-signaling-pathways
#14
Shenggao Tang, Xiaoyu Liu, Ji-Ming Ye, Tingting Hu, Yingying Yang, Ting Han, Wen Tan
Diabetes induced injury of myocardium, defined as diabetic cardiomyopathy (DCM), accounts for significant mortality and morbidity in diabetic population. Alleviation of DCM by a potent drug remains considerable interests in experimental and clinical researches because hypoglycemic drugs cannot effectively control this condition. Here we explored the beneficial effects of isosteviol sodium (STVNa) on type 1 diabetes induced DCM and the potential mechanisms involved. Male Wistar rats were induced to diabetes by injection of streptozotocin (STZ)...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29719380/astragalus-polysaccharides-protect-cardiac-stem-and-progenitor-cells-by-the-inhibition-of-oxidative-stress-mediated-apoptosis-in-diabetic-hearts
#15
Wei Chen, Jing Ju, Yehong Yang, Hao Wang, Wenjie Chen, Xuelan Zhao, Hongying Ye, Yu Zhang
Introduction: Diabetic cardiomyopathy is characterized by an imbalance between myocyte death and regeneration mediated by the progressive loss of cardiac stem and progenitor cells (CSPCs) by apoptosis and necrosis due to the activation of oxidative stress with diabetes. In this study, we evaluated the beneficial effect of astragalus polysaccharides (APS) therapy on the protection of CSPCs through its antioxidative capacity in diabetic hearts. Materials and methods: Streptozotocin (STZ)-induced diabetic mice and heterozygous (SOD2+/-) knockout mice were employed and administered with APS...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29712757/defective-flux-of-thrombospondin-4-through-the-secretory-pathway-impairs-cardiomyocyte-membrane-stability-and-causes-cardiomyopathy
#16
Matthew J Brody, Davy Vanhoutte, Tobias G Schips, Justin G Boyer, Chinmay V Bakshi, Michelle A Sargent, Allen J York, Jeffery D Molkentin
Thrombospondins are stress-inducible secreted glycoproteins with critical functions in tissue injury and healing. Thrombospondin-4 (Thbs4) is protective in cardiac and skeletal muscle where it activates an adaptive endoplasmic reticulum (ER) stress-response, induces expansion of the ER, and enhances sarcolemmal stability. However, it is unclear if Thbs4 has these protective functions from within the cell, from the extracellular matrix, or from the secretion process itself. Here we generated transgenic mice with cardiac-specific overexpression of a secretion-defective mutant of Thbs4 to evaluate its exclusive intracellular and secretion-dependent functions...
April 30, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29706494/is-there-a-role-for-genes-in-exercise-induced-atrial-cardiomyopathy
#17
REVIEW
Diane Fatkin, Charles D Cox, Inken G Huttner, Boris Martinac
In endurance athletes, prolonged high intensity exercise participation can have deleterious effects on the myocardium with subsequent structural and electrical remodelling. In a subset of athletes, there is a predilection for atrial involvement and the risk of atrial fibrillation (AF) is increased. The mechanisms underpinning exercise-induced atrial cardiomyopathy have yet to be fully elucidated and the contribution of an individual's genetic makeup is unknown. Some athletes may have rare genetic variants that are sufficient to cause AF irrespective of exercise exposure...
April 9, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29696485/relationship-between-microvascular-changes-autonomic-denervation-and-myocardial-fibrosis-in-chagas-cardiomyopathy-evaluation-by-mri-and-spect-imaging
#18
Gustavo Canavaci Barizon, Marcus Vinicius Simões, André Schmidt, Leonardo Pippa Gadioli, Luiz Otávio Murta Junior
BACKGROUND: The relationship between microvasculopathy, autonomic denervation, and myocardial fibrosis, in Chagas cardiomyopathy is incompletely understood. The aim of this study was to explore the relative extent and anatomic distribution of myocardial hypoperfusion, autonomic denervation, and myocardial scarring using Single-Photon Emission Computerized Tomography (SPECT) imaging and Magnetic Resonance Imaging (MRI). METHODS: Thirteen patients with Chagas disease all had Iodine-123-metaiodobenzylguanidine (MIBG) SPECT, 99m Tc-Sestamibi (MIBI) rest-stress SPECT, and gadolinium late enhancement MRI imaging within a 2-month interval...
April 25, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29685075/synergistic-effect-of-cranberry-extract-and-losartan-against-aluminium-chloride-induced-hepatorenal-damage-associated-cardiomyopathy-in-rats
#19
Shereen Mohamed Galal, Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed El Kiki
The present study was designed to evaluate the effect of cranberry extract (CRAN) and/or losartan (LOS) against aluminium chloride (AlCl3 ) induced hepatorenal damage associated cardiomyopathy in rats. To induce hepatorenal and cardiotoxicity, animals were received (AlCl3 ; 70 mg/kg i.p.) for 8 weeks day after day and treated with CRAN (100 mg/kg b.wt.) orally daily for 4 weeks started after 4 weeks from AlCl3 injection accompanied with an administration of LOS (5 mg/kg i.p.) three times weekly for 4 weeks...
April 23, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29679641/ethanol-induced-cardiomyocyte-toxicity-involves-autophagy-nfkb-transcription-factor
#20
Jessica Maiuolo, Alessia Maretta, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Francesca Bosco, Rocco Mollace, Federica Scarano, Ernesto Palma, Miriam Scicchitano, Saverio Nucera, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Carolina Muscoli, Vincenzo Mollace
Chronic ethanol (EtOH) consumption causes early detrimental consequences in many tissues including the myocardium, though the molecular mechanisms leading to the alcoholic cardiomyopathy (ACM) still remain to be elucidated. Here, we studied several biomolecular changes occurring in cardiomyoblasts after their exposure to sublethal concentrations of EtOH and the potential synergistic effect with methylmercury (MM) or doxorubicin (DOXO), which are known to produce direct myocardial dysfunction. In addition, the possible role of autophagic responses and Nuclear Factor kappa-B (NFkB) modulation in early post-alcoholic myocardial damage has been investigated...
April 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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