keyword
https://read.qxmd.com/read/38404827/analysis-of-the-role-of-panoptosis-in-seizures-via-integrated-bioinformatics-analysis-and-experimental-validation
#21
JOURNAL ARTICLE
Yueying Liu, Yuanjin Chang, Xiaofan Jiang, Huiya Mei, Yingsi Cao, Dongqin Wu, Ruijin Xie, Wenjun Jiang, Emely Vasquez, Yu Wu, Shunyan Lin, Yachuan Cao
BACKGROUND: Epilepsy is recognized as the most common chronic neurological condition among children, and hippocampal neuronal cell death has been identified as a crucial factor in the pathophysiological processes underlying seizures. In recent studies, PANoptosis, a newly characterized form of cell death, has emerged as a significant contributor to the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. PANoptosis involves the simultaneous activation of pyroptosis, apoptosis, and necroptosis within the same population of cells...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38402163/jianpiyishen-formula-prevents-cisplatin-induced-acute-kidney-injury-in-mice-by-improving-necroptosis-through-mapk-pathway
#22
JOURNAL ARTICLE
Zhongtang Li, Riming He, Jiahui Liu, Xiaoming Jin, Beibei Jiang, Yunlan Lao, Shudong Yang
BACKGROUND: Acute kidney injury (AKI), characterized by necroptosis and activation of MAPK pathway, causes sudden declines in renal function. To date, efficacious treatments are lacking. JianPiYiShen Formula (JPYSF) has a protective effect on the kidneys. The aim of this study is to explore the mechanism of JPYSF in cisplatin-induced AKI. METHODS: Male C57/BL6J mice were divided into control group, cisplatin group and cisplatin + JPYSF group. Before establishing the model, the cisplatin + JPYSF group was administered JPYSF (18...
February 24, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38400065/ie1-of-human-cytomegalovirus-inhibits-necroptotic-cell-death-via-direct-and-indirect-modulation-of-the-necrosome-complex
#23
JOURNAL ARTICLE
Anna Theresa Heusel, Sophie Rapp, Thomas Stamminger, Myriam Scherer
Programmed necrosis is an integral part of intrinsic immunity, serving to combat invading pathogens and restricting viral dissemination. The orchestration of necroptosis relies on a precise interplay within the necrosome complex, which consists of RIPK1, RIPK3 and MLKL. Human cytomegalovirus (HCMV) has been found to counteract the execution of necroptosis during infection. In this study, we identify the immediate-early 1 (IE1) protein as a key antagonist of necroptosis during HCMV infection. Infection data obtained in a necroptosis-sensitive cell culture system revealed a robust regulation of post-translational modifications (PTMs) of the necrosome complex as well as the importance of IE1 expression for an effective counteraction of necroptosis...
February 13, 2024: Viruses
https://read.qxmd.com/read/38377943/guanine-nucleotide-exchange-factor-rabgef1-facilitates-tnf-induced-necroptosis-by-targeting-ciap1
#24
JOURNAL ARTICLE
Danni Chen, Yushi Chen, Jianting Feng, Wenyang Huang, Zeteng Han, Yuanyuan Liu, Qiaofa Lin, Lisheng Li, Yingying Lin
Necroptosis is a form of regulated cell death that depends on the receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL). The molecular mechanisms underlying distinct instances of necroptosis have only recently begun to emerge. In the present study, we characterized RABGEF1 as a positive regulator of RIPK1/RIPK3 activation in vitro. Based on the overexpression and knockdown experiments, we determined that RABGEF1 accelerated the phosphorylation of RIPK1 and promoted necrosome formation in L929 cells...
February 10, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38376358/high-fat-diet-disrupts-the-gut-microbiome-leading-to-inflammation-damage-to-tight-junctions-and-apoptosis-and-necrosis-in-nyctereutes-procyonoides-intestines
#25
JOURNAL ARTICLE
Chengwei Wei, Tianchao Xu, Yuan Geng, Jie Yang, Hongli Lv, Meng-Yao Guo
Given the burgeoning Nyctereutes procyonoides breeding industry and its growing scale, it is imperative to investigate the impact of high-fat diets on the health of these animals. This study involved 30 male Nyctereutes procyonoides of comparable weights (3 kg ±0.5), randomly assigned to either a control group or a high-fat diet group ( n = 15 each). The latter group was fed a mixture of lard and basal diet in a 2:5 ratio, establishing a high-fat diet model in Nyctereutes procyonoides. This diet induced diarrhea and histopathological changes in the Nyctereutes procyonoides...
February 20, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38374093/dopamine-enhances-recovery-after-traumatic-brain-injury-through-ubiquitylation-and-autophagic-degradation-of-ripk1
#26
JOURNAL ARTICLE
Hui Luo, Ning Liu, Chao Lin
BACKGROUND: Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. METHODS: Adult male mice underwent controlled cortical impact (CCI). We administered DA intraperitoneally to mice for 14 consecutive days, starting 8 h before CCI. On day 3 after brain injury, cortical lesion volume and brain water content were measured. On days 7-13, behavioral tests were performed...
February 19, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38372938/inhibition-of-receptor-interacting-protein-kinase%C3%A2-1-in-chronic-plaque-psoriasis-a-multicenter-randomized-double-blind-placebo-controlled-study
#27
JOURNAL ARTICLE
Valerie J Ludbrook, David C Budd, Katie Thorn, Debra Tompson, Bartholomew J Votta, Lucy Walker, Amy Lee, Xin Chen, Amanda Peppercorn, Wei Jing Loo
INTRODUCTION: Receptor-interacting protein kinase 1 (RIPK1), a key mediator of inflammation through necroptosis and proinflammatory cytokine production, may play a role in the pathogenesis of immune-mediated inflammatory diseases such as chronic plaque psoriasis. An experimental medicine study of RIPK1 inhibition with GSK2982772 immediate-release formulation at doses up to 60 mg three times daily in mild to moderate plaque psoriasis indicated that efficacy may be improved with higher trough concentrations of GSK2982772...
February 19, 2024: Dermatology and Therapy
https://read.qxmd.com/read/38372637/role-for-caspase-8-in-the-release-of-il-1%C3%AE-and-active-caspase-1-from-viable-human-monocytes-during-toxoplasma-gondii-infection
#28
JOURNAL ARTICLE
William J Pandori, Stephanie Y Matsuno, Ji-Hun Shin, Samuel C Kim, Tiffany H Kao, Sharmila Mallya, Sarah N Batarseh, Melissa B Lodoen
Monocytes are actively recruited to sites of infection and produce the potent proinflammatory cytokine IL-1β. We previously showed that IL-1β release during Toxoplasma gondii infection of primary human monocytes requires the NLRP3 inflammasome and caspase-1 but is independent of gasdermin D and pyroptosis. To investigate mechanisms of IL-1β release, we generated caspase-1, -4, -5, or -8 knockout (KO) THP-1 monocytic cells. Genetic ablation of caspase-1 or -8, but not caspase-4 or -5, decreased IL-1β release during T...
February 19, 2024: Journal of Immunology
https://read.qxmd.com/read/38367692/the-necroptosis-mediated-imbalance-of-mitochondrial-dynamics-is-involved-in-dehp-induced-toxicity-to-immature-testes-via-the-pgam5-drp1-interaction
#29
JOURNAL ARTICLE
Xiazhu Zhou, Yifan Hong, Jing Chen, Yihang Yu, Siyuan Wang, Yuexin Wei, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui Wei
Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that has been shown to impair male reproduction, but the potential mechanism underlying testicular injury caused by DEHP remains unclear. In vivo, rats were gavaged consecutively from postnatal day (PND) 21 to PND 31 with 0, 250, or 500 mg/kg DEHP for 10 days, and impaired mitochondria and increased necroptosis were observed in immature testes. In vitro, the GC-1 and GC-2 cell lines were exposed to monoethylhexyl phthalate (MEHP) at 100, 200 and 400 μM for 24 h, and this exposure induced oxidative stress damage, necroptosis and mitochondrial injury...
February 15, 2024: Environmental Pollution
https://read.qxmd.com/read/38352847/novel-fused-triazole-compounds-as-ripk1-inhibitors-for-treating-neurodegenerative-autoimmune-and-inflammatory-diseases
#30
EDITORIAL
Ram W Sabnis
Provided herein are novel fused triazole compounds as RIPK1 inhibitors, pharmaceutical compositions, use of such compounds in treating neurodegenerative, autoimmune, and inflammatory diseases, and processes for preparing such compounds.
February 8, 2024: ACS Medicinal Chemistry Letters
https://read.qxmd.com/read/38352389/caspase-8-activity-mediates-tnf%C3%AE-production-and-restricts-coxiella-burnetii-replication-during-murine-macrophage-infection
#31
Chelsea A Osbron, Crystal Lawson, Nolan Hanna, Heather S Koehler, Alan G Goodman
Coxiella burnetii is an obligate intracellular bacteria which causes the global zoonotic disease Q Fever. Treatment options for infection are limited, and development of novel therapeutic strategies requires a greater understanding of how C. burnetii interacts with immune signaling. Cell death responses are known to be manipulated by C. burnetii , but the role of caspase-8, a central regulator of multiple cell death pathways, has not been investigated. In this research, we studied bacterial manipulation of caspase-8 signaling and the significance of caspase-8 to C...
February 3, 2024: bioRxiv
https://read.qxmd.com/read/38351315/author-correction-inhibition-of-ripk1-dependent-regulated-acinar-cell-necrosis-provides-protection-against-acute-pancreatitis-via-the-ripk1-nf-%C3%AE%C2%BAb-aqp8-pathway
#32
Peng-Yu Duan, Yuan Ma, Xi-Na Li, Feng-Zhi Qu, Liang Ji, Xiao-Yu Guo, Wang-Jun Zhang, Fan Xiao, Le Li, Ji-Sheng Hu, Bei Sun, Gang Wang
No abstract text is available yet for this article.
February 13, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38350503/gancao-decoction-attenuates-hepatic-necroptosis-via-activating-caspase-8-in-cholestatic-liver-injury
#33
JOURNAL ARTICLE
Bin Zou, Shuang Zhang, Fengling Li, Fengyi Weng, Jing Zhao, Jingyi Jin, Dongming Yan, Xiaoqing Xu, Gaofeng Chen, Chenghai Liu, Chengzeng Yao, Yue Li, Furong Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Gancao Decoction (GCD) is widely used to treat cholestatic liver injury. However, it is unclear whether is related to prevent hepatocellular necroptosis. AIM OF THE STUDY: The purpose of this study is to clarify the therapeutic effects of GCD against hepatocellular necroptosis induced by cholestasis and its active components. MATERIALS AND METHODS: We induced cholestasis model in wild type mice by ligating the bile ducts or in Nlrp3-/- mice by intragastrical administering Alpha-naphthylisothiocyanate (ANIT)...
February 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38349514/ripks-and-neuroinflammation
#34
REVIEW
Yue Xu, Feng Lin, Guolei Liao, Jiaxing Sun, Wenli Chen, Lei Zhang
Neuroinflammation is an immune response in the central nervous system and poses a significant threat to human health. Studies have shown that the receptor serine/threonine protein kinase family (RIPK) family, a popular research target in inflammation, has been shown to play an essential role in neuroinflammation. It is significant to note that the previous reviews have only examined the link between RIPK1 and neuroinflammation. However, it has yet to systematically analyze the relationship between the RIPK family and neuroinflammation...
February 13, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38335757/anti-necroptosis-and-anti-ferroptosis-compounds-from-the-deep-sea-derived-fungus-aspergillus-sp-mccc-3a00392
#35
JOURNAL ARTICLE
Hao-Yu Yu, Yu-Shi Chen, Yuan Wang, Zheng-Biao Zou, Ming-Min Xie, You Li, Li-Sheng Li, Da-Li Meng, Lan-Qin Wu, Xian-Wen Yang
Eight undescribed (1-8) and 46 known compounds (9-54) were isolated from the deep-sea-derived Aspergillus sp. MCCC 3A00392. Compounds 1-3 were three novel oxoindolo diterpenoids, 4-6 were three bisabolane sesquiterpenoids, while 7 and 8 were two monocyclic cyclopropanes. Their structures were established by exhaustive analyses of the HRESIMS, NMR, and theoretical calculations of the NMR data and ECD spectra. Compounds 10, 33, 38, and 39 were able to inhibit tumor necrosis factor (TNF)-induced necroptosis in murine L929 cell lines...
February 3, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38335615/sodium-sulfite-triggered-hepatic-apoptosis-necroptosis-and-pyroptosis-by-inducing-mitochondrial-damage-in-mice-and-aml-12-cells
#36
JOURNAL ARTICLE
Meitong Liu, Jing Lu, Jinpin Hu, Yuelin Chen, Xuming Deng, Jianfeng Wang, Shengzhuo Zhang, Jiakang Guo, Weiru Li, Shuang Guan
Sodium sulfite (SS) is a biological derivative of the air pollutant sulfur dioxide, and is often used as a food and pharmaceutical additive. Improper or excessive SS exposure in liver cell death. The phenomenon of simultaneous regulation of apoptosis, necroptosis, and pyroptosis is defined as PANoptosis. However, the specific types of programmed cell death (PCD) caused by SS and their interconnections remain unclear. In the present study, C57BL/6 mice were orally administered SS for 30 d, consecutively, to establish an in vivo mouse exposure model...
February 6, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38331847/saracatinib-inhibits-necroptosis-and-ameliorates-psoriatic-inflammation-by-targeting-mlkl
#37
JOURNAL ARTICLE
Jingyi Li, Xingfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang, Yingying Lin, Fen Hu, Jianting Feng, Zeteng Han, Yushi Chen, Xuan Chen, Qiaofa Lin, Lanqin Wu, Lisheng Li
Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) is the hallmark of tumour necrosis factor α (TNF)-induced necroptosis. Here, we screened a small-molecule compound library and found that saracatinib inhibited TNF-induced necroptosis. By targeting MLKL, Saracatinib interfered with the phosphorylation, translocation, and oligomerization of MLKL induced by TNF...
February 8, 2024: Cell Death & Disease
https://read.qxmd.com/read/38326721/quercetin-alleviates-lipopolysaccharide-induced-cardiac-inflammation-via-inhibiting-autophagy-and-programmed-cell-death
#38
JOURNAL ARTICLE
Jin Hai Yu, Guo Liang Hu, Xiao Quan Guo, Hua Bin Cao, Zhao Fei Xia, Buhe Amin
OBJECTIVE: The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide (LPS) induced septic cardiac dysfunction. METHODS: Specific pathogen-free chicken embryos ( n = 120) were allocated untreated control, phosphate buffer solution (PBS) vehicle, PBS with ethanol vehicle, LPS (500 ng/egg), LPS with quercetin treatment (10, 20, or 40 nmol/egg, respectively), Quercetin groups (10, 20, or 40 nmol/egg). Fifteen-day-old embryonated eggs were inoculated with abovementioned solutions via the allantoic cavity...
January 20, 2024: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/38318355/inhibition-of-ripk1-alleviating-vascular-smooth-muscle-cells-osteogenic-transdifferentiation-via-runx2
#39
JOURNAL ARTICLE
Yue Li, Wei Jie, Yanli Qi, Mingxing Mo, Yaxin Lian, Li Yin, Hui Huang
Vascular calcification (VC) is recognized as a crucial risk factor for cardiovascular diseases. Our previous report revealed that the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) plays a role in this process. However, the underlying molecular mechanisms remain elusive. Notably, receptor-interacting protein kinase 1 (RIPK1) has been implicated in the development of cardiovascular diseases, yet its role and mechanisms in VC remain unexplored. To address this gap, we established models using chronic kidney disease mice and calcifying VSMCs to investigate the impact of RIPK1 on VC...
February 16, 2024: IScience
https://read.qxmd.com/read/38317313/simvastatin-loaded-nanoniosome-protects-h9c2-cells-from-oxygen-glucose-deprivation-reperfusion-injury-by-downregulating-inflammation
#40
JOURNAL ARTICLE
Maryam Naseroleslami, Mahdieh Mehrab Mohseni
BACKGROUND: Simvastatin has anti-inflammatory and antioxidant properties against cardiac I/RI. However, it suffers from low bioavailability and a short half-life. Nanoniosomes are novel drug delivery systems that may increase SIM effectiveness. The present research evaluates the impact of SIM-loaded nanoniosomes on the OGD/R injury model of H9c2 cells. METHODS: Cells were seeded based on five groups: (1) control; (2) OGD/R; (3) OGD/R receiving SIM; (4) OGD/R receiving nanoniosomes; and (5) OGD/R receiving SIM loaded nanoniosomes...
September 30, 2023: Iranian Biomedical Journal
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