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https://www.readbyqxmd.com/read/29677453/l-carnitine-induced-amelioration-of-hdf-induced-hepatic-dysfunction-is-accompanied-by-a-reduction-in-hepatic-tnf-%C3%AE-and-tgf%C3%AE-1
#1
Mabrouk Attia Abd Eldaim, Fatma Mohamed Ibrahim, Sahar H Orabi, Azza Hassan Morsi, Hesham Saad ElSabbagh
In this study the possible mechanisms through which L-carnitine ameliorates the adverse effects of high fat diet (HFD) induced obesity on rats was evaluated. 56 Wister albino rats were randomly assigned into seven groups. Control rats fed basal diet. 2nd group fed basal diet and injected with L-carnitine 200 mg/kg i.p. 3rd group fed HFD. 4th group fed HFD and injected with L-Carnitine 200 mg/kg i.p for 8 weeks. 5th group fed HFD for 10 weeks. 6th group fed HFD for 10 weeks and injected with L-Carnitine 200 mg/kg i...
April 20, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29672974/inhibition-of-uvb-induced-pro-inflammatory-cytokines-and-mmp-expression-by-zanthoxylum-rhetsa-bark-extract-and-its-active-constituent-hesperidin
#2
Ramesh Kumar Santhanam, Sharida Fakurazi, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari
The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions of different polarity obtained from the methanolic extract of the bark material were initially tested for anticollagenase and antielastase activities. The ethyl acetate fraction showed bioactivity against the protease enzymes. Hence, it was subjected to further purification via column chromatography, to yield a major constituent, hesperidin. Subsequently, the ethyl acetate fraction and hesperidin were tested for their effects against UVB-induced cytotoxicity and expressions of inflammatory cytokines (IL-6, IL-1β, and TNF-α), NF-κB, and MMPs (MMP1, 3, and 9) in human dermal fibroblasts (HDF)...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29670967/investigation-of-hsa-as-a-biocompatible-coating-material-for-arsenic-trioxide-nanoparticles
#3
Maneka Hoonjan, Geetanjali Sachdeva, Sudeshna Chandra, Prashant S Kharkar, Niteshkumar Sahu, Purvi Bhatt
The anticancer properties of arsenic trioxide (As2O3) are accompanied by highly cytotoxic effects on normal cells. This necessitates developing modalities towards the targeted delivery of As2O3. Albumins, on account of their large structure and presence of several interacting groups, are ideal for encapsulating or carrying various drugs. In the present study, human serum albumin (HSA) was chosen as a coating agent to increase the biocompatibility of As2O3. An in situ chemical precipitation method was adopted for the synthesis of HSA-coated As2O3 nanoparticles (HSA-As2O3NPs) that were further characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet-visible (UV-vis) spectroscopy, inductively coupled plasma atomic emission spectrometry (ICP-AES), zeta potential and transmission electron microscopy (TEM)...
April 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29670658/in-vitro-wound-healing-potential-of-stem-extract-of-alternanthera-sessilis
#4
Katyakyini Muniandy, Sivapragasam Gothai, Woan Sean Tan, S Suresh Kumar, Norhaizan Mohd Esa, Govindasamy Chandramohan, Khalid S Al-Numair, Palanisamy Arulselvan
Impaired wound healing is one of the serious problems among the diabetic patients. Currently, available treatments are limited due to side effects and cost effectiveness. In line with that, we attempted to use a natural source to study its potential towards the wound healing process. Therefore, Alternanthera sessilis ( A. sessilis ), an edible and medicinal plant, was chosen as the target sample for the study. During this investigation, the wound closure properties using stem extract of A. sessilis were analyzed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29651176/cloning-of-ompa-gene-from-acinetobacter-baumannii-into-the-eukaryotic-expression-vector-pbudce4-1-as-dna-vaccine
#5
Hossein Ansari, Abbas Doosti, Mohammad Kargar, Mahdi Bijanzadeh, Mojtaba Jaafarinia
Antibiotic resistant features of Acinetobacter baumannii is partly due to the decreased outer membrane proteins (OMPs) permeability. The OmpA is one of the most conserved proteins among A. baumannii with a considerable antigenic potential to stimulate the multidimensional immune system responses. The present study was aimed to clone the ompA gene into the eukaryotic expression vector with potential as DNA vaccine. The ompA gene of A. baumannii was amplified using polymerase chain reaction (PCR). The target DNA was cloned and sub-cloned into the pTZ57R/T and pBudCE4...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29649800/is-there-enough-evidence-to-prove-that-hemodiafiltration-is-superior
#6
Hideki Kawanishi
The evidence concerning online hemodiafiltration (HDF) includes the following: (1) the increase of removal of uremic toxin, (2) the prevention of dialysis rerated hypotension, (3) the recovery of survival, and (4) the recovery of dialysis related uncertain symptoms. Although clinical evidence has been noted, the hypothesis of the efficacy of HDF are still indefinite and require further precise research.
April 12, 2018: Blood Purification
https://www.readbyqxmd.com/read/29623473/copper-complex-derived-from-s-benzyldithiocarbazate-and-3-acetylcoumarin-induced-apoptosis-in-breast-cancer-cell
#7
Jhi Biau Foo, May Lee Low, Ji Hui Lim, Yan Zhi Lor, Rusyidah Zainol Abidin, Vilasini Eh Dam, Napsiah Abdul Rahman, Chaw Yee Beh, Lee Chin Chan, Chee Wun How, Yin Sim Tor, Latifah Saiful Yazan
Copper complexes have been widely studied for the anti-tumour application as cancer cells are reported to take up greater amounts of copper than normal cells. Preliminary study revealed that the newly synthesised copper complex [Cu(SBCM)2 ] displayed marked anti-proliferative towards triple-negative MDA-MB-231 breast cancer cells. Therefore, Cu(SBCM)2 has great potential to be developed as an agent for the management of breast cancer. The present study was carried out to investigate the mode of cell death induced by Cu(SBCM)2 towards MDA-MB-231 breast cancer cells...
April 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29616618/the-antiwrinkle-and-antimelanogenic-effects-of-the-nonedible-part-of-sorghum-bicolor-l-moench-and-their-augmentation-by-fermentation
#8
Da Eun Lee, Jeong Eun Kwon, Eui Su Choung, Sung Ryul Lee, Se Chan Kang
Sorghum [ Sorghum bicolor (L.) Moench] is a major cereal crop. Despite the wide cultivation of sorghum, its stalks are used as hay and silage. The plant has numerous bioactive compounds including cosmeceutical ingredients. Thus, we investigated the antimelanogenic and SSE that is prepared from the stalk of Sorghum bicolor L. (SSE) after ethanol (EtOH) extraction. Based on the antioxidant capacity, antityrosinase activity, and suppression of the protein expression levels of matrix metalloproteinase (MMP)-1, -2, and -3 in human neonatal foreskin HDF-N cells, a 50% EtOH extraction of SSEs showed antimelanogenic and antiwrinkle potential...
July 2017: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29611208/the-effect-of-on-line-hemodiafiltration-vegetarian-diet-and-urine-volume-on-advanced-glycosylation-end-products-measured-by-changes-in-skin-auto-fluorescence
#9
Arkom Nongnuch, Andrew Davenport
Increasing urea clearance by hemodialysis (HD) has not improved patient survival. Hemodiafiltration (HDF) has been reported to reduce cardiovascular mortality. HDF increases middle sized solute clearances. Advanced glycosylation end products (AGEs) are associated with increased cardiovascular mortality. We wished to determine whether HDF reduces AGEs. Skin auto-fluorescence (SAF) measures circulating AGEs deposited in the skin. We compared SAF measurements 12 months apart in high flux HD and HDF patients. At enrollment SAF was not different (HD 3...
April 2, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29605276/3-dimensional-printing-guide-template-assisted-percutaneous-vertebroplasty-technical-note
#10
Jian Li, JiSheng Lin, Yong Yang, JunChuan Xu, Qi Fei
Percutaneous vertebroplasty (PVP) is currently considered as an effective treatment for pain caused by acute osteoporotic vertebral compression fracture. Recently, puncture-related complications are increasingly reported. It's important to find a precise technique to reduce the puncture-related complications. We report a case and discussed the novel surgical technique with step-by-step operating procedures, to introduce the precise PVP assisted by a 3-dimensional printing guide template. Based on the preoperative CT scan and infrared scan data, a well-designed individual guide template could be established in a 3-dimensional reconstruction software and printed out by a 3-dimensional printer...
March 28, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29602275/study-of-the-effects-of-0-15-terahertz-radiation-on-genome-integrity-of-adult-fibroblasts
#11
Valeria Franchini, Stefania De Sanctis, Jessica Marinaccio, Andrea De Amicis, Elisa Coluzzi, Sara Di Cristofaro, Florigio Lista, Elisa Regalbuto, Andrea Doria, Emilio Giovenale, Gian Piero Gallerano, Roberto Bei, Monica Benvenuto, Laura Masuelli, Ion Udroiu, Antonella Sgura
The applications of Terahertz (THz) technologies have significantly developed in recent years, and the complete understanding of the biological effects of exposure to THz radiation is becoming increasingly important. In a previous study, we found that THz radiation induced genomic damage in fetal fibroblasts. Although these cells demonstrated to be a useful model, exposure of human foetuses to THz radiation is highly improbable. Conversely, THz irradiation of adult dermal tissues is cause of possible concern for some professional and nonprofessional categories...
March 30, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29594139/the-relationship-of-residual-renal-function-with-cardiovascular-morbidity-in-hemodialysis-patients-and-the-potential-role-of-monocyte-chemoattractant-protein-1
#12
Vaia D Raikou, Vasilios Kardalinos, Despina Kyriaki
Background: Residual renal function (RRF) provides several benefits to patients on dialysis. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in atherosclerotic lesions. We considered the relationship between RRF and cardiovascular morbidity and the significant role of MCP-1 serum concentrations in hemodiafiltration (HDF) patients. Methods: We enrolled 76 patients on on-line HDF. RRF was defined by interdialytic urine output, and we studied the patients in two groups according to the preservation or not of urine output...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29593557/3-5-diiodo-l-thyronine-affects-structural-and-metabolic-features-of-skeletal-muscle-mitochondria-in-high-fat-diet-fed-rats-producing-a-co-adaptation-to-the-glycolytic-fiber-phenotype
#13
Elena Silvestri, Federica Cioffi, Rita De Matteis, Rosalba Senese, Pieter de Lange, Maria Coppola, Anna M Salzano, Andrea Scaloni, Michele Ceccarelli, Fernando Goglia, Antonia Lanni, Maria Moreno, Assunta Lombardi
Hyperlipidemic state-associated perturbations in the network of factors controlling mitochondrial functions, i. e., morphogenesis machinery and metabolic sensor proteins, produce metabolic inflexibility, insulin resistance and reduced oxidative capacity in skeletal muscle. Moreover, intramyocellular lipid (IMCL) accumulation leads to tissue damage and inflammation. The administration of the naturally occurring metabolite 3,5-diiodo-L-thyronine (T2) with thyromimetic actions to high fat diet (HFD)-fed rats exerts a systemic hypolipidemic effect, which produces a lack of IMCL accumulation, a shift toward glycolytic fibers and amelioration of insulin sensitivity in gastrocnemius muscle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29575313/catalytic-hydrodefluorination-of-c-f-bonds-by-an-air-stable-p-iii-lewis-acid
#14
Saurabh Chitnis, Felix Krischer, Douglas Wade Stephan
Catalytic hydrodefluorination (HDF) of unactivated fluoroalkanes or CF3-substituted aryl species is performed using the P(III) Lewis acids, [(bipy)PPh]2+ (12+)and [(terpy)PPh]2+ (22+) under mild conditions (25 oC or 50 oC). Mechanistic studies indicate that activation of C-F bond by the P(III) center is key. Particularly noteworthy is that the catalyst 2[B(C6F5)4]2 is air-stable and readily accessible from bench-stable, commercially available reagents in one-step and can be used without isolation.
March 25, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29560129/-hsa-mir-155-5p-drives-aneuploidy-at-early-stages-of-cellular-transformation
#15
Sara Pagotto, Angelo Veronese, Alessandra Soranno, Paola Lanuti, Mirco Di Marco, Marco Vincenzo Russo, Alice Ramassone, Marco Marchisio, Pasquale Simeone, Paolo E Guanciali Franchi, Giandomenico Palka, Renato Mariani Costantini, Carlo M Croce, Rosa Visone
Hsa-miR-155-5p (miR-155) is overexpressed in most solid and hematological malignancies. It promotes loss of genomic integrity in cancer cells by targeting genes involved in microsatellite instability and DNA repair; however, the link between miR-155 and aneuploidy has been scarcely investigated. Here we describe a novel mechanism by which miR-155 causes chromosomal instability. Using osteosarcoma cells (U2OS) and normal human dermal fibroblast (HDF), two well-established models for the study of chromosome congression, we demonstrate that miR-155 targets the spindle checkpoint proteins BUB1, CENP-F, and ZW10, thus compromising chromosome alignment at the metaphase plate...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29549765/one-pot-environmental-friendly-synthesis-of-gold-nanoparticles-using-punica-granatum-juice-a-novel-antioxidant-agent-for-future-dermatological-and-cosmetic-applications
#16
Jennifer Gubitosa, Vito Rizzi, Angela Lopedota, Paola Fini, Anna Laurenzana, Gabriella Fibbi, Fiorenza Fanelli, Andrea Petrella, Valentino Laquintana, Nunzio Denora, Roberto Comparelli, Pinalysa Cosma
HYPOTHESIS: The interesting properties of Gold Nanoparticles (AuNPs) make them attractive for different application fields such as cosmetology, medicine and clinical nanotechnologies. In this work a fast, easy and eco-friendly method for the AuNPs synthesis is proposed by using the Punica Granatum Juice (PGJ) with potential dermatological and cosmetic applications. The AuNPs antioxidant activity, due to the presence of phenols from the juice, and their use as booster for improving the Sun Protection Factor (SPF) in commercial sunscreen formulations, are thus expounded...
March 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29529055/influence-of-dialysis-membrane-composition-on-plasma-bisphenol-a-levels-during-online-hemodiafiltration
#17
Sebastian Mas, Enrique Bosch-Panadero, Pedro Abaigar, Vanesa Camarero, Ignacio Mahillo, Esther Civantos, Didier Sanchez-Ospina, Alberto Ruiz-Priego, Jesus Egido, Alberto Ortiz, Emilio González-Parra
INTRODUCTION: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. METHODS: A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron)...
2018: PloS One
https://www.readbyqxmd.com/read/29524488/regulated-basal-and-bolus-insulin-release-from-glucose-responsive-core-shell-microspheres-based-on-concanavalin-a-sugar-affinity
#18
Meirong Bai, Jing He, Liangfa Kang, Jun Nie, Ruixue Yin
Individual insulin therapy considering the heterogeneity of insulin resistance between patients may bring more benefits than conventional therapy. Therefore, in glucose-responsive insulin delivery systems, more attention should be paid on further regulation of insulin release to meet individual requirements. Our study shows the feasibility of using a photo-crosslinkable shell layer to regulate basal and bolus insulin release from glucose-responsive Con A-polysaccharides network. Core-shell microspheres were fabricated through a two-step high-speed shear-emulsification method...
March 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29523566/long-term-clinical-parameters-after-switching-to-nocturnal-haemodialysis-a-dutch-propensity-score-matched-cohort-study-comparing-patients-on-nocturnal-haemodialysis-with-patients-on-three-times-a-week-haemodialysis-haemodiafiltration
#19
Thijs Thomas Jansz, Akin Özyilmaz, Muriel P C Grooteman, Tiny Hoekstra, Marieke Romijn, Peter J Blankestijn, Michael L Bots, Brigit C van Jaarsveld
OBJECTIVES: Nocturnal haemodialysis (NHD), characterised by 8-hour sessions ≥3 times a week, is known to improve clinical parameters in the short term compared with conventional-schedule haemodialysis (HD), generally 3×3.5-4 hours a week. We studied long-term effects of NHD and used patients on conventional HD/haemodiafiltration (HDF) as controls. DESIGN: Four-year prospective follow-up of patients who switched to NHD; we compared patients with patients on HD/HDF using propensity score matching...
March 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29514159/ten-year-survival-of-end-stage-renal-disease-patients-treated-with-high-efficiency-online-hemodiafiltration-a-cohort-study-of-a-center-in-south-east-asia
#20
Khajohn Tiranathanagul, Paweena Susantitaphong, Nattachai Srisawat, Nanta Mahatanan, Kriang Tungsanga, Kearkiat Praditpornsilpa, Somchai Eiam-Ong
BACKGROUND: Recently, in the first hemodiafiltration (HDF) experience report from South East Asia (SEA), we reported a 3-year prospective study demonstrating the various short-term benefits of high-efficiency online HDF (OL-HDF) over high-flux hemodialysis (HD). Very few long-term survival reports of high-efficiency OL-HDF are available and the data are heterogeneous and incomplete. OBJECTIVES: The present historical cohort study was conducted to determine the long-term survival and outcome of high-efficiency OL-HDF-treated patients...
March 7, 2018: Nephron
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