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https://www.readbyqxmd.com/read/29235191/the-effect-of-cyanidin-3-o-glucoside-on-uva-induced-damage-in-human-dermal-fibroblasts
#1
Shi Wu, Yunfeng Hu, Zhen Li, Weibin Bai, Jiayi Zhao, Cuiqin Huang, Qin Li, Chongzhu Fan, Liehua Deng, Daxiang Lu
BACKGROUND/PURPOSE: Ultraviolet-A (UVA) radiation can induce photoaging and skin cancer, but means to prevent or treat UVA-induced skin damage require further study. We investigated the effects of cyanidin-3-o-glucoside (C3G), a monomer of anthocyanin, on UVA-induced damage in primary human dermal fibroblasts (HDFs), and we identify possible mechanisms underlying the protective effects of this compound. METHODS: Primary HDFs were pretreated with 80 μM C3G for 2 h and UVA irradiated at 12 J/cm2 ...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29234179/vitamin-e-coated-polysulfone-membrane-based-hemodiafiltration-attenuates-inflammation-in-a-rat-model-of-lipopolysaccharide-induced-systemic-inflammation
#2
Yoshihiro Hatanaka, Satoru Inoue, Koji Goto, Norihisa Yasuda, Seigo Hidaka, Takaaki Kitano
Background: Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and vitamin E-coated polysulfone (VEPS) membranes, which are anticipated to exhibit the antioxidant and anti-inflammatory properties of vitamin E...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29225810/achieving-high-convection-volumes-in-postdilution-online-hemodiafiltration-a-prospective-multicenter-study
#3
Camiel L M de Roij van Zuijdewijn, Isabelle Chapdelaine, Menso J Nubé, Peter J Blankestijn, Michiel L Bots, Constantijn J A M Konings, Ton K Kremer Hovinga, Femke M Molenaar, Neelke C van der Weerd, Muriel P C Grooteman
Background. Available evidence suggests a reduced mortality risk for patients treated with high-volume postdilution hemodiafiltration (HDF) when compared with hemodialysis (HD) patients. As the magnitude of the convection volume depends on treatment-related factors rather than patient-related characteristics, we prospectively investigated whether a high convection volume (defined as ≥22 L/session) is feasible in the majority of patients (>75%). Methods. A multicenter study was performed in adult prevalent dialysis patients...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29222454/stromal-versican-regulates-tumor-growth-by-promoting-angiogenesis
#4
Keiichi Asano, Courtney M Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J Lindner, Tyler Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Suneel S Apte, Satoshi Hirohata
The proteoglycan versican is implicated in growth and metastases of several cancers. Here we investigated a potential contribution of stromal versican to tumor growth and angiogenesis. We initially determined versican expression by several cancer cell lines. Among these, MDA-MB231 and B16F10 had none to minimal expression in contrast to Lewis lung carcinoma (LLC). Notably, tumors arising from these cell lines had higher versican levels than the cell lines themselves suggesting a contribution from the host-derived tumor stroma...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221927/st2-as-a-novel-prognostic-marker-in-end-stage-renal-disease-patients-on-hemodiafiltration
#5
Evgenija Homsak, Robert Ekart
BACKGROUND: Patients with end-stage renal disease (ESRD) are prone to severe heart failure (HF) and to several life-threatening events. Therefore, the ability to assess disease prognosis and the risk of short-term events or death is of great importance. The role of soluble ST2 (sST2) as a potential new prognostic marker in ESRD patients is not yet known. The aim of our study was to assess the prognostic value of sST2 in ESRD patients on hemodiafiltration (HDF) and compare it with NT-proBNP, an established prognostic marker for HF and renal disease...
December 5, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29198593/a-new-generation-of-cellulose-triacetate-suitable-for-online-haemodiafiltration
#6
Francisco Maduell, Raquel Ojeda, Marta Arias-Guillén, Néstor Fontseré, Manel Vera, Lida Rodas, Miquel Gómez, Karen P Huablocho, Fanny Esquivel, Paola D Mori, Valentina Hoffmann, Jessica Ugalde, Nayra Rico
BACKGROUND: Online haemodiafiltration (OL-HDF) is currently the most effective dialysis technique that also improves survival. To date, high permeability membranes with low albumin loss, such as polysulfone, polyamide and polyacrylonitrile membranes have been the most widely used. However, the initially restricted use of cellulose triacetate (CTA) membranes in OL-HDF has expanded. The aim of the study was to ascertain whether the latest generation asymmetric CTA membranes are more effective in obtaining high convective transport...
November 29, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29197506/cadmium-exposure-exacerbates-severe-hyperlipidemia-and-fatty-liver-changes-in-zebrafish-via-impairment-of-high-density-lipoproteins-functionality
#7
Jae-Yong Kim, Suk-Jeong Kim, Myung Ae Bae, Jae-Ryong Kim, Kyung-Hyun Cho
Cadmium (Cd) is a heavy metal with several toxicities that have destructive effect on most organ systems. However, its toxic effects on human lipoproteins are largely remained unknown especially in hyperlipidemic zebrafish model. Treatment of human high-density lipoprotein (HDL) with cadmium chloride (CdCl2, final 12 and 24μM) caused spontaneous formation of multimeric apoA-I as well as increased production of glycated extent products. Cd-HDL3 accelerated uptake of oxidized LDL (oxLDL) into macrophages and induced severe senescence in human dermal fibroblast (HDF) cells...
November 29, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29186592/beta-2-microglobulin-clearance-in-high-flux-dialysis-and-convective-dialysis-modalities-a-meta-analysis-of-published-studies
#8
Maria-Eleni Roumelioti, Gregory Trietley, Thomas D Nolin, Yue-Harn Ng, Zhi Xu, Ahmed Alaini, Rocio Figueroa, Mark L Unruh, Christos P Argyropoulos
Background: Recent meta-analyses suggest that higher removal of beta-2 microglobulin (β2M) with either high-flux (HFD) dialysis or hemodiafiltration (HDF) may be associated with decreased total and cardiovascular mortality in dialysis patients. However, there are limited data about the performance of high flux dialyzers and/or convective therapies in removing β2M. Methods: This is a random effects meta-analysis and meta-regression of data extracted from randomized controlled trials and observational studies in hemodialysis, hemofiltration and HDF regarding the efficiency of high flux dialyzers to remove β2M...
November 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29161688/plasma-beta-trace-protein-as-a-marker-of-residual-renal-function-the-effect-of-different-hemodialysis-modalities-and-intra-individual-variability-over-time
#9
Amaryllis H van Craenenbroeck, Ann-Christin Bragfors-Helin, Abdul Rashid Qureshi, Bengt Lindholm, Bodil Sjöberg, Björn Anderstam, Olof Heimburger, Peter Stenvinkel, Peter Bárány
BACKGROUND/AIMS: Beta-trace protein (BTP) is a low-molecular-weight molecule, which may be used to assess residual renal function (RRF) in dialysis patients. Here we evaluated the influence of hemodialysis (HD) and hemodiafiltration (HDF) on plasma BTP, and analyzed the inter- and intra-individual variability of plasma BTP over time in HD and peritoneal dialysis (PD) patients. METHODS: In 12 prevalent HD patients, the effect of a single session of low-flux HD, high-flux HD and HDF on plasma BTP was studied...
November 22, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29153030/cytotoxicity-study-of-textile-fabrics-impregnated-with-cuo-nanoparticles-in-mammalian-cells
#10
Gagandeep Singh, James Beddow, Christopher Mee, Lidia Maryniak, Eadaoin M Joyce, Timothy J Mason
Copper and copper compounds have multifunctional properties (antibacterial, antiviral, and antifungal) with promising applications. Copper in its nanoparticle (Cu NPs) forms has been widely used in various industrial and commercial applications. In the current research, the cytotoxic effects of textile fabrics impregnated with copper oxide nanoparticles (CuO NPs) were studied in mammalian cell lines. CuO NPs were impregnated onto textile substrates using 2 different techniques: the sonochemical generation and impregnation of NPs from metal complexes ( insitu) and a "throwing the stones" technology using commercially prepared CuO NPs...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29142400/chemical-composition-of-moringa-oleifera-ethyl-acetate-fraction-and-its-biological-activity-in-diabetic-human-dermal-fibroblasts
#11
Sivapragasam Gothai, Katyakyini Muniandy, Mazni Abu Zarin, Tan Woan Sean, S Suresh Kumar, Murugan A Munusamy, Sharida Fakurazi, Palanisamy Arulselvan
Background: Moringa oleifera (MO), commonly known as the drumstick tree, is used in folklore medicine for the treatment of skin disease. Objective: The objective of this study is to evaluate the ethyl acetate (EtOAc) fraction of MO leaves for in vitro antibacterial, antioxidant, and wound healing activities and conduct gas chromatography-mass spectrometry (GC-MS) analysis. Materials and Methods: Antibacterial activity was evaluated against six Gram-positive bacteria and 10 Gram-negative bacteria by disc diffusion method...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140158/endosomal-trafficking-regulates-receptor-mediated-transcytosis-of-antibodies-across-the-blood-brain-barrier
#12
Arsalan S Haqqani, Christie E Delaney, Eric Brunette, Ewa Baumann, Graham K Farrington, William Sisk, John Eldredge, Wen Ding, Tammy-Lynn Tremblay, Danica B Stanimirovic
Current methods for examining antibody trafficking are either non-quantitative such as immunocytochemistry or require antibody labeling with tracers. We have developed a multiplexed quantitative method for antibody 'tracking' in endosomal compartments of brain endothelial cells. Rat brain endothelial cells were co-incubated with blood-brain barrier (BBB)-crossing FC5, monovalent FC5Fc or bivalent FC5Fc fusion antibodies and control antibodies. Endosomes were separated using sucrose-density gradient ultracentrifugation and analyzed using multiplexed mass spectrometry to simultaneously quantify endosomal markers, receptor-mediated transcytosis (RMT) receptors and the co-incubated antibodies in each fraction...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29133076/comparison-of-the-hemodynamic-tolerance-and-the-biological-parameters-of-four-acetate-free-hemodialysis-methods
#13
George Kosmadakis, Enrique Da Costa Correia, Julie Albaret, Frédéric Somda, Didier Aguilera
PURPOSE: Acetate in hemodialysis solutions exerts inflammatory, vasodilatatory and cardio-depressive effects. Citrate has been proposed as an optimal substitute. The aim of the present trial was the comparison of the hemodynamic and biological parameters on a group of patients dialysed consecutively with 4 acetate-free haemodialysis techniques. METHODS: In a prospective crossover manner, we measured the hemodynamic and biological effects of four acetate-free hemodialysis methods: he acetate-free biofiltration with variable potassium (AFBK) and three methods with a citrate buffer: onventional hemodialysis (HD), on-line hemodiafiltration (HDF) and on-line hemofiltration (HF)...
November 10, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29129045/development-of-s-methylmethionine-sulfonium-derivatives-and-their-skin-protective-effect-against-ultraviolet-exposure
#14
Won-Serk Kim, Wang-Kyun Kim, Nahyun Choi, Wonhee Suh, Jinu Lee, Dae-Duk Kim, Ikyon Kim, Jong-Hyuk Sung
In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material. However, it has an unpleasant odor. Therefore, in the present study, we synthesized odor-free SMMS derivatives by eliminating dimethyl sulfide, which is the cause of the unpleasant odor and identified two derivatives that exhibited skin-protective effects: one derivative comprised (2S,4S)- and (2R,4S)-2-phenylthiazolidine-4-carboxylic acid and the other comprised (2S,4R)-, (2S,4S)-, (2R,4R)-, and (2R,4S)-2-phenyl-1,3-thiazinane-4-carboxylic acid...
November 13, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29120391/cytotoxicity-of-labruscol-a-new-resveratrol-dimer-produced-by-grapevine-cell-suspensions-on-human-skin-melanoma-cancer-cell-line-ht-144
#15
Laetitia Nivelle, Jane Hubert, Eric Courot, Nicolas Borie, Jean-Hugues Renault, Jean-Marc Nuzillard, Dominique Harakat, Christophe Clément, Laurent Martiny, Dominique Delmas, Philippe Jeandet, Michel Tarpin
A new resveratrol dimer (1) called labruscol, has been purified by centrifugal partition chromatography of a crude ethyl acetate stilbene extract obtained from elicited grapevine cell suspensions of Vitis labrusca L. cultured in a 14-liter stirred bioreactor. One dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) analyses including ¹H, (13)C, heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and correlation spectroscopy (COSY) as well as high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) were used to characterize this compound and to unambiguously identify it as a new stilbene dimer, though its relative stereochemistry remained unsolved...
November 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29104050/approaching-a-new-generation-of-fiberboards-taking-advantage-of-self-lignin-as-green-adhesive
#16
Juan Domínguez-Robles, Quim Tarrés, Marc Delgado-Aguilar, Alejandro Rodríguez, Xavier Espinach, Pere Mutjé
This study describes the use of lignin as natural adhesive for the production high density fiberboards (HDF) made from wheat straw. In the present work, this agricultural residue was used to produce thermomechanical pulp and the used lignin was obtained from the spent liquors generated in the same process. A hot pressing process was conducted to manufacture these fiberboards and different percentages of this green adhesive were targeted. The wheat straw raw material and its pulp were characterized. Apart from that, the chemical composition and the thermal properties of the lignin sample were evaluated...
November 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29080829/development-and-formulation-of-moringa-oleifera-standardised-leaf-extract-film-dressing-for-wound-healing-application
#17
Chai-Yee Chin, Juriyati Jalil, Pei Yuen Ng, Shiow-Fern Ng
ETHNOPHARMACOLOGICAL RELEVANCE: M.oleifera is a medicinal plant traditionally used for skin sores, sore throat and eye infections. Recently, the wound healing property of the leaves of M. oleifera was has been well demonstrated experimentally in both in vivo and in vitro models. However, there is a lack of research which focuses on formulating M.oleifera into a functional wound dressing. In this study, the M.oleifera leaf standardized aqueous extract with highest potency in vitro migration was formulated into a film for wound healing application...
November 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29072350/transition-metal-free-catalytic-hydrodefluorination-of-polyfluoroarenes-via-a-concerted-nucleophilic-aromatic-substitution-with-a-hydrosilicate
#18
Kotaro Kikushima, Mary Grellier, Masato Ohashi, Sensuke Ogoshi
The transition-metal-free catalytic hydrodefluorination (HDF) reaction of polyfluoroarenes is described, which involves a direct hydride transfer from a hydrosilicate as the key intermediate, generated from a hydrosilane and a fluoride salt. The eliminated fluoride regenerates the hydrosilicate to complete the catalytic cycle. Dispersion-corrected density functional theory (DFT) calculations indicated that the HDF reaction proceeds via a concerted nucleophilic aromatic substitution (CSNAr) reaction, whereby a Meisenheimer-type intermediate is not generated...
October 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29069654/expression-profiles-of-long-noncoding-rna-in-uva-induced-human-skin-fibroblasts
#19
Yue Zheng, Qingfang Xu, Yating Peng, Zijian Gong, Haiyan Chen, Wei Lai, Howard I Maibach
BACKGROUND: Long noncoding RNA (lncRNA) are differentially expressed across stages of differentiation and development, but the role of lncRNA in human skin photoaging mechanisms remains poorly understood. OBJECTIVE: This study aimed to determine lncRNA expression changes in human dermal fibroblasts (HDF) induced by repeated UVA irradiation and to explore correlations between lncRNA and skin photoaging prognosis. METHODS: In the UVA-HDF group, HDF were subjected to repeated UVA irradiation (10 J/cm2 UVA twice daily for 7 days); in the control group, HDF received no irradiation...
October 26, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29069222/effect-of-a-rosmarinic-acid-supplemented-hemodialysis-fluid-on-inflammation-of-human-vascular-endothelial-cells
#20
W-J Wang, M-H Cheng, J-H Lin, C-S Weng
Chronic systemic inflammation and repetitive damage of vascular endothelia by incompatible dialysis system are probable causes of cardiovascular disease in patients on dialysis. The present study aimed to assess in vitro biocompatibility and anti-inflammatory effect of hemodialysis fluid supplemented with rosmarinic acid (RA) using human umbilical vein endothelial cells (HUVEC). HUVECs (5×106 cells/mL) were pre-exposed to 1 μg/mL of lipopolysaccharides (LPS) and incubated with RA-supplemented hemodialysis fluid (HDF)...
October 19, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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