Shaofu Qiu, Kangkang Liu, Chaojie Yang, Ying Xiang, Kaiyuan Min, Kunpeng Zhu, Hongbo Liu, Xinying Du, Mingjuan Yang, Ligui Wang, Yong Sun, Haijian Zhou, Muti Mahe, Jiayong Zhao, Shijun Li, Deshan Yu, Jane Hawkey, Kathryn E Holt, Stephen Baker, Juntao Yang, Xuebin Xu, Hongbin Song
Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefR aziR ), reduced susceptibility to fluoroquinolones, and even colistin resistance (colR ). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020. We collect 155 outbreak isolates and 152 sporadic isolates. The cefR aziR isolates, including outbreak strains, are mainly distributed in a distinct clade located in global Lineage III...
November 30, 2022: Nature Communications