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https://www.readbyqxmd.com/read/28918609/associations-among-gastric-juice-ph-atrophic-gastritis-intestinal-metaplasia-and-helicobacter-pylori-infection
#1
Jihee Sung, Nayoung Kim, Jongchan Lee, Young-Jae Hwang, Hyoung Woo Kim, Jung Wha Chung, Jin-Wook Kim, Dong Ho Lee
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio and interleukin (IL)-1β levels were measured...
September 19, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28918107/depression-evening-salivary-cortisol-and-inflammation-in-chronic-fatigue-syndrome-a-psychoneuroendocrinological-structural-regression-model
#2
Sara F Milrad, Daniel L Hall, Devika R Jutagir, Emily G Lattie, Sara J Czaja, Dolores M Perdomo, Mary Ann Fletcher, Nancy Klimas, Michael H Antoni
INTRODUCTION: Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness...
September 13, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28916896/involvement-of-il-17-in-secondary-brain-injury-after-a-traumatic-brain-injury-in-rats
#3
Tan Li, Yong-Mei Zhang, Dong Han, Rong Hua, Bing-Nan Guo, Shu-Qun Hu, Xian-Liang Yan, Tie Xu
The pro-inflammatory activity of interleukin 17, which is produced by the IL-23/IL-17 axis, has been associated with the pathogenesis of traumatic brain injury (TBI). The study investigated the potential role of IL-17 in secondary brain injury of TBI in a rat model. Our data showed that the levels of IL-17 increased from 6 h to 7 days and peaked at 3 days, in both the CNS and serum, which were consistent with the severity of secondary brain injury. The IL-23 inhibitor suberoylanilide hydroxamic acid (SAHA) treatment markedly decreased the expressions of IL-17 and apoptosis-associated proteins cleaved caspase-3 and increased the protein ratio of Bcl-2 (B cell lymphoma/leukemia-2)/Bax (Bcl-2-associated X protein)...
September 15, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28916848/interleukin-17-as-a-predictor-of-sepsis-in-polytrauma-patients-a-prospective-cohort-study
#4
M Ahmed Ali, E S Mikhael, A Abdelkader, L Mansour, R El Essawy, R El Sayed, A Eladawy, A Mukhtar
Sepsis is one of the most serious complications after major trauma, and may be associated with increased mortality. We sought to determine whether there is an association between serum levels of interleukin-17 (IL-17) at the time of admission to the intensive care unit (ICU) and the development of sepsis. We evaluated 100 adult patients with major trauma admitted to the surgical ICU over a 6-month period. Serum levels of IL-17, IL-6, and TNF-α were determined by enzyme-linked immunosorbent assays (ELISA). The IL-17 rs1974226 genotype was determined by real-time PCR...
September 15, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28916742/haplotype-of-the-interleukin-17a-gene-is-associated-with-osteitis-after-bacillus-calmette-guerin-vaccination
#5
Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Eero Lauhkonen, Juho Vuononvirta, Kirsi Nuolivirta, Liisa Kröger, Laura Pöyhönen, Minna K Karjalainen, Qiushui He
Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis after newborn vaccination. IL17A rs4711998, rs8193036 and rs2275913 SNPs were determined in 131 adults had presented with BCG osteitis after newborn BCG vaccination...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916002/characterization-of-immune-response-in-staphylococcus-aureus-chronically-infected-bovine-mammary-glands-during-active-involution
#6
Carolina S Andreotti, Celina Baravalle, Sofía C Sacco, Melisa Lovato, Elizabet A L Pereyra, María S Renna, Hugo H Ortega, Luis F Calvinho, Bibiana E Dallard
The aim of this study was to characterize the immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic naturally acquired S. aureus intramammary infections (IMI) were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking and samples for immunohistochemical analysis were taken. Protein expression of toll-like receptor 2 (TLR2) and TLR4 was significantly higher in S...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28914844/-molecular-genetic-predictors-of-resistance-to-anti-helicobacter-pylori-therapy
#7
I V Maev, D N Andreev
In current clinical practice, there is no optimal empirical therapy for Helicobacter pylori (H. pylori) infection and there is a progressive decrease in the efficiency of classical eradication therapy (ET) regimens. The variability in the efficiency of ET in a specific patient is largely due to the heterogeneous molecular genetic mechanisms underlying the resistance of the microorganism to the components of the treatment regimens. The basis of the mechanisms for antibiotic resistance in H. pylori is mainly the point mutations in some genes, which determine alterations in the mechanisms of action of drugs, such as clarithromycin (domain V of 23S rRNA), metronidazole (rdxA, frxA), amoxicillin (pbp1A), tetracycline (16S rRNA), and levofloxacin (gyrA)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914804/the-role-of-erk-signaling-in-experimental-autoimmune-encephalomyelitis
#8
Katharina Birkner, Beatrice Wasser, Julia Loos, Alexander Plotnikov, Rony Seger, Frauke Zipp, Esther Witsch, Stefan Bittner
Extracellular signal-regulated kinase (ERK) signaling plays a crucial role in regulating immune cell function and has been implicated in autoimmune disorders. To date, all commercially available inhibitors of ERK target upstream components, such as mitogen-activated protein (MAP) kinase/ERK kinase (MEKs), but not ERK itself. Here, we directly inhibit nuclear ERK translocation by a novel pharmacological approach (Glu-Pro-Glu (EPE) peptide), leading to an increase in cytosolic ERK phosphorylation during T helper (Th)17 cell differentiation...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28913994/mouse-model-of-il-17-dominant-rhinitis-using-polyinosinic-polycytidylic-acid
#9
Jun Sang Bae, Eun Hee Kim, Ji Hye Kim, Ji Hun Mo
Interleukin (IL)-17 plays an important role in rhinitis and the level thereof correlates with the severity of disease. However, no mouse model for IL-17-dominant rhinitis has yet been developed. Our objective was to establish a mouse model of IL-17-dominant rhinitis via intranasal application of polyinosinic-polycytidylic acid (abbreviated as Poly(I:C)). Mice were divided into 6 groups (n=8 for each group); 1) 1 negative control group, 2) 1 positive control group (OVA/alum model), 3) 2 Poly(I:C) groups (10 or 100 μg), and 4) 2 OVA/Poly(I:C) groups (10 or 100 μg)...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913840/loss-of-regulatory-characteristics-in-cd4-cd25-hi-t-cells-induced-by-impaired-transforming-growth-factor-beta-secretion-in-pneumoconiosis
#10
Lu-Qin Bian, Ling Mao, Ying Bi, Shao-Wei Zhou, Zi-Dan Chen, Jun Wen, Jin Shi, Ling Wang
Pneumoconiosis is caused by the accumulation of airborne dust in the lung, which stimulates a progressive inflammatory response that ultimately results in lung fibrosis and respiratory failure. It is possible that regulatory cells in the immune system could function to suppress inflammation and possibly slow or reverse disease progression. However, results in this study suggest that in pneumoconiosis patients, the regulatory T cells (Tregs) and B cells are functionally impaired. First, we found that pneumoconiosis patients presented an upregulation of CD4(+) CD25(+) T cells compared to controls, whereas the CD4(+) CD25(+) and CD4(+) CD25(hi) T cells were enriched with Th1- and Th17-like cells but not Foxp3-expressing Treg cells and evidenced by significantly higher T-bet, interferon (IFN)-γ, and interleukin (IL)-17 expression but lower Foxp3 and transforming growth factor (TGF)-β expression...
September 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28913301/concordant-surgical-treatment-non-melanocytic-skin-cancer-of-the-head-and-neck
#11
Wan Cheol Ryu, In Chang Koh, Yong Hae Lee, Jong Hyun Cha, Sang Il Kim, Chang Gyun Kim
BACKGROUND: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. METHODS: The medical records of 176 patients with head and neck non-melanocytic skin cancer (NMSC) who were treated by a single surgeon at our institution between January 2010 and May 2016 were retrospectively reviewed, and their data (age, sex, pathological type, tumor location/size, treatment modality) were analyzed...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912844/triptolide-inhibits-cd4-memory-t-cell-mediated-acute-rejection-and-prolongs-cardiac-allograft-survival-in-mice
#12
Shuiwei Qiu, Dingliang Lv
There have been numerous investigations into the immunosuppressive effects of triptolide; however, its inhibitory effects on memory T cells remain to be elucidated. Using a cluster of differentiation (CD)4(+) memory T-cell transfer model, the aim of the present study was to determine the inhibitory effects of triptolide on CD4(+) memory T cell-mediated acute rejection and to determine the potential underlying mechanisms. At 4 weeks after skin transplantation, mouse cervical heart transplantation was performed following the transfer of CD4(+) memory T cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912678/il-17a-enhances-microglial-response-to-ogd-by-regulating-p53-and-pi3k-akt-pathways-with-involvement-of-ros-hmgb1
#13
Bin Zhang, Ning Yang, Zhi-Ming Mo, Shao-Peng Lin, Feng Zhang
Cerebral ischemia-reperfusion injury (IRI) has a complex pathogenesis, and interleukin-17 (IL-17) is a newly identified class of the cytokine family that plays an important role in ischemic inflammation. An oxygen-glucose deprivation (OGD) model showed that IL-17A expression was significantly up-regulated in microglial cells. After IL-17A siRNA transfection, the inhibition of proliferation, and the increased apoptosis in microglial cells, induced by OGD/reperfusion, was improved, and the elevation of Caspase-3, Caspase-8, Caspase-9, and poly ADP ribose polymerase (PARP) activities was inhibited...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28912336/elevated-semaphorin-5a-in-patients-with-hashimoto-s-thyroiditis-a-case-control-study
#14
Yongping Liu, Shuo Wang, Qingling Guo, Yongze Li, Jing Qin, Na Zhao, Yushu Li, Zhongyan Shan, Weiping Teng
OBJECTIVE: Hashimoto's thyroiditis (HT) is characterised by elevated specific auto-antibodies, including TgAb and TPOAb. Increasing evidence has demonstrated the essential role of Th17 cells in HT. However, the underlying mechanism is still unclear. Semaphorin 5A (Sema5A) is involved in several autoimmune diseases through regulation of immune cells. The aim of this study was to explore the role of Sema5A in HT. METHODS: We measured serum Sema5A levels in HT (n = 92) and healthy controls (n = 111) by ELISA...
September 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28911642/lactobacillus-pentosus-gmnl-77-inhibits-skin-lesions-in%C3%A2-imiquimod-induced-psoriasis-like-mice
#15
Yi-Hsing Chen, Chieh-Shan Wu, Ya-Husan Chao, Chi-Chen Lin, Hui-Yun Tsai, Yi-Rong Li, Yi-Zhen Chen, Wan-Hua Tsai, Yu-Kuo Chen
Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910960/-effects-of-human-mesenchymal-stem-cells-on-airway-inflammation-in-allergic-asthma-mice-and-the-underlying-mechanism
#16
N N Ren, H J Chen, Q L Chen, J Eileen, Y G An, Yiguang Lin
Objectives: To investigate the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on airway inflammation in an ovalbumin (OVA) induced asthma mouse model and the underlying mechanism. Methods: Twenty-four BALB/c mice were randomly divided into four equal groups: normal control group, OVA-induced asthmatic model group, hUC-MSCs treated group (50 μl of hUC-MSCs was transplanted into the trachea of asthmatic mice ) and hUC-MSCs control group (50 μl of hUC-MSCs was transplanted into the trachea of control mice)...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28910953/-the-expression-and-association-of-cd14-hla-dr-low-myeloid-derived-suppressor-cell-like-cells-and-interleukin-1%C3%AE-in-ovarian-cancer
#17
H Y Wang, R Zhao, H Ren, M J Zou, J Zhang, Y Zhang
Objective: To analyze the percentage of CD14(+) HLA-DR(Low/-) myeloid-derived suppressor cell-like cell subtypes(MDSCs) and interleukin-1β(IL-1β) concentration in peripheral blood and ascites of ovarian cancer patients, and to explore their association with clinicopathological characteristics. Methods: Blood samples of 31 patients and ascites of 5 patients in Qilu Hospital of Shandong University from January 2016 to December 2016 were collected. Blood samples of 20 healthy volunteers with matched age were collected as control...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28910312/i%C3%AE%C2%BAk-16-decreases-mirna-155-expression-and-attenuates-the-human-monocyte-inflammatory-response
#18
Norman James Galbraith, James Burton, Mathew Brady Ekman, Joseph Kenney, Samuel Patterson Walker, Stephen Manek, Campbell Bishop, Jane Victoria Carter, Sarah Appel Gardner, Hiram C Polk
Excessive inflammatory responses in the surgical patient may result in cellular hypo-responsiveness, which is associated with an increased risk of secondary infection and death. microRNAs (miRNAs), such as miR-155, are powerful regulators of inflammatory signalling pathways including nuclear factor κB (NFκB). Our objective was to determine the effect of IκK-16, a selective blocker of inhibitor of kappa-B kinase (IκK), on miRNA expression and the monocyte inflammatory response. In a model of endotoxin tolerance using primary human monocytes, impaired monocytes had decreased p65 expression with suppressed TNF-α and IL-10 production (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28906255/echinococcus-multilocularis-vesicular-fluid-inhibits-activation-and-proliferation-of-natural-killer-cells
#19
Anne-Pauline Bellanger, Valentine Mougey, Jean-Rene Pallandre, Houssein Gbaguidi-Haore, Yann Godet, Laurence Millon
Alveolar echinococcosis is a severe chronic helminthic disease that mimics slow-growing liver cancer. The immune evasion strategy of Echinococcus multilocularis Leuckart, 1863 remains poorly understood. The aim of this study was to investigate in vitro the impact of E. multilocularis vesicular fluid (Em-VF) on peripheral blood mononuclear cells (PBMC) and on natural killer (NK) cells. PBMC and NK cells were exposed to Em-VF (1 µg/ml) during six days. The effect of Em-VF was assessed on CD69, viability and proliferation, and on and transforming growth factor β (TGF-β), interferon γ (IFN-γ), interleukin 17 (IL-17) and interleukin 10, using flow cytometry and ELISA, respectively...
August 25, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28906040/a-blinded-randomized-clinical-trial-evaluating-the-efficacy-and-safety-of-lokivetmab-compared-to-ciclosporin-in-client-owned-dogs-with-atopic-dermatitis
#20
Hilde Moyaert, Leen Van Brussel, Stasia Borowski, Monica Escalada, Sean P Mahabir, Rodney R Walters, Michael R Stegemann
BACKGROUND: Lokivetmab is an injectable anti-canine-IL-31 monoclonal antibody to treat clinical manifestations of atopic dermatitis (AD) in dogs. HYPOTHESIS/OBJECTIVES: To characterize the efficacy and safety of lokivetmab, and to demonstrate its noninferiority to ciclosporin under field conditions. ANIMALS: Dogs with chronic AD (n = 274) were enrolled from 40 practices in Belgium, The Netherlands, France and Germany. METHODS: Animals were randomized (1:1) to oral ciclosporin (5 mg/kg/once daily) or monthly injectable lokivetmab (1-3...
September 14, 2017: Veterinary Dermatology
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