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glucose metabolism and fertility

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https://www.readbyqxmd.com/read/29401269/chronic-hyperandrogenemia-and-western-style-diet-beginning-at-puberty-reduces-fertility-and-increases-metabolic-dysfunction-during-pregnancy-in-young-adult-female-macaques
#1
C V Bishop, R L Stouffer, D L Takahashi, E C Mishler, M C Wilcox, O D Slayden, C A True
STUDY QUESTION: What are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates? SUMMARY ANSWER: Testosterone increases the time to achieve pregnancy, while a WSD reduces overall fertility, and the combination of testosterone and WSD additionally impairs glucose tolerance and causes pregnancy loss. WHAT IS KNOWN ALREADY: Both hyperandrogenemia and obesity are hallmarks of polycystic ovary syndrome, which is a leading cause of infertility among women worldwide...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29364913/effect-of-different-levels-of-feed-restriction-and-fish-oil-fatty-acid-supplementation-on-fat-deposition-by-using-different-techniques-plasma-levels-and-mrna-expression-of-several-adipokines-in-broiler-breeder-hens
#2
Namya Mellouk, Christelle Ramé, Maxime Marchand, Christophe Staub, Jean-Luc Touzé, Éric Venturi, Frédéric Mercerand, Angélique Travel, Pascal Chartrin, François Lecompte, Linlin Ma, Pascal Froment, Joëlle Dupont
BACKGROUND: Reproductive hens are subjected to a restricted diet to limit the decline in fertility associated with change in body mass. However, endocrine and tissue responses to diet restriction need to be documented. OBJECTIVE: We evaluated the effect of different levels of feed restriction, with or without fish oil supplementation, on metabolic parameters and adipokine levels in plasma and metabolic tissues of reproductive hens. METHODS: We designed an in vivo protocol involving 4 groups of hens; RNS: restricted (Rt) unsupplemented, ANS: ad libitum (Ad, receiving an amount of feed 1...
2018: PloS One
https://www.readbyqxmd.com/read/29351662/the-versatile-tanycyte-a-hypothalamic-integrator-of-reproduction-and-energy-metabolism
#3
Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
The fertility and survival of an individual rely on the ability of the periphery to promptly, effectively and reproducibly communicate with brain neural networks that control reproduction, food intake and energy homeostasis. Tanycytes, a specialized glial cell type lining the wall of the third ventricle in the median eminence of the hypothalamus, appear to act as the linchpin of these processes by dynamically controlling the secretion of neuropeptides into the portal vasculature by hypothalamic neurons and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on the ability of these cells to adapt their morphology to the physiological state of the individual...
January 17, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29334271/the-safety-of-available-treatments-of-male-hypogonadism-in-organic-and-functional-hypogonadism
#4
G Corona, G Rastrelli, Y Reisman, A Sforza, M Maggi
In the case of primary male hypogonadism (HG), only testosterone (T) replacement therapy (TRT) is possible whereas when the problem is secondary to a pituitary or hypothalamus alteration both T production and fertility can be, theoretically, restored. We here systematically reviewed and discussed the advantages and limits of medications formally approved for the treatment of HG. Areas covered: Data derived from available meta-analyses of placebo controlled randomized trials (RCTs) were considered and analyzed...
January 15, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29307112/the-influences-of-chromium-supplementation-on-glycemic-control-markers-of-cardio-metabolic-risk-and-oxidative-stress-in-infertile-polycystic-ovary-syndrome-women-candidate-for-in-vitro-fertilization-a-randomized-double-blind-placebo-controlled-trial
#5
Mehri Jamilian, Shahrzad Zadeh Modarres, Mehrnush Amiri Siavashani, Maryam Karimi, Alireza Mafi, Vahidreza Ostadmohammadi, Zatollah Asemi
This study was carried out to investigate the effects of chromium intake on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome (PCOS) women candidate for in vitro fertilization (IVF). This randomized double-blind, placebo-controlled trial was done among 40 subjects with infertile PCOS candidate for IVF, aged 18-40 years old. Individuals were randomly allocated into two groups to take either 200 μg/day of chromium (n = 20) or placebo (n = 20) for 8 weeks...
January 6, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29276231/preconception-optimization-of-glucose-and-insulin-metabolism-in-women-wanting-to-conceive-high-rate-of-spontaneous-conception-prior-to-planned-assisted-reproduction
#6
Sara Fill Malfertheiner, Dagmar Gutknecht, Monika Bals-Pratsch
Background: A hyperglycemic metabolic status with insulin resistance can have a negative effect on fertility and pregnancy outcomes. The aim of this retrospective study was to investigate disorders of glucose and insulin metabolism in women wanting to conceive who conceived spontaneously prior to planned assisted reproduction (ART). Associated risk factors of patients in terms of live births and miscarriages were also analyzed. Method: Out of total study population of 589 pregnancies, the pregnancies of 129 women wishing to have children who conceived spontaneously prior to planned ART were analyzed in more detail...
December 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29240275/metabolic-stress-induces-modifications-in-the-epigenetic-program-of-preimplantation-bovine-embryos
#7
R Tremblay, I Dufort, M A Sirard
The mammalian embryo is sensitive to and adapts to its metabolic environment. The mother's metabolic health and nutrient availability, for example, can modulate the oviductal fluid composition and thus embryo development. In this project, we induced energetic stress in bovine embryos during early culture to observe the epigenetic responses associated with metabolic stress, using a treatment paradigm known to decrease blastocyst rates. Embryos were generated using oocytes from slaughtered cows, and then exposed to an elevated glucose concentration (5 mM versus 0...
December 14, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29230199/resource-legacies-of-organic-and-conventional-management-differentiate-soil-microbial-carbon-use
#8
Melissa M Arcand, David J Levy-Booth, Bobbi L Helgason
Long-term contrasts in agricultural management can shift soil resource availability with potential consequences to microbial carbon (C) use efficiency (CUE) and the fate of C in soils. Isothermal calorimetry was combined with 13C-labeled glucose stable isotope probing (SIP) of 16S rRNA genes to test the hypothesis that organically managed soils would support microbial communities with greater thermodynamic efficiency compared to conventional soils due to a legacy of lower resource availability and a resultant shift toward communities supportive of more oligotrophic taxa...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29207483/biochemical-physiological-and-transcriptomic-comparison-between-burley-and-flue-cured-tobacco-seedlings-in-relation-to-carbohydrates-and-nitrate-content
#9
Yafei Li, Huijuan Yang, Dong Chang, Shuzhen Lin, Yuqing Feng, Jingjing Li, Hongzhi Shi
Burley tobacco is a genotype of chloroplast-deficient mutant with accumulates high levels of tobacco-specific nitrosamines (TSNAs) which would induce malignant tumors in animals. Nitrate is a principle precursor of tobacco-specific nitrosamines. Nitrate content in burley tobacco was significantly higher than that in flue-cured tobacco. The present study investigated differences between the two tobacco types to explore the mechanisms of nitrate accumulation in burley tobacco. transcripts (3079) related to the nitrogen and carbon metabolism were observed...
December 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29178045/considering-choline-as-methionine-precursor-lipoproteins-transporter-hepatic-promoter-and-antioxidant-agent-in-dairy-cows
#10
REVIEW
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Rab N Soomro, Mohamed E Abd El-Hack, Mervat A Abdel-Latif, Wen Li, Ren Hao, Feifei Sun, Bello M Bodinga, Khawar Hayat, Junhu Yao, Yangchun Cao
During the transition period, fatty liver syndrome may be caused in cows undergo negative energy balance, ketosis or hypocalcemia, retained placenta or mastitis problems. During the transition stage, movement of non-esterified fatty acids (NEFA) increases into blood which declines the hepatic metabolism or reproduction and consequently, lactation performance of dairy cows deteriorates. Most of studies documented that, choline is an essential nutrient which plays a key role to decrease fatty liver, NEFA proportion, improve synthesis of phosphatidylcholine, maintain lactation or physiological function and work as anti-oxidant in the transition period of dairy cows...
November 25, 2017: AMB Express
https://www.readbyqxmd.com/read/29136166/diabetes-induced-hyperglycemia-impairs-male-reproductive-function-a-systematic-review
#11
Constanze C Maresch, Dina C Stute, Marco G Alves, Pedro F Oliveira, David M de Kretser, Thomas Linn
BACKGROUND: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing...
November 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29105171/performance-body-fat-reserves-and-plasma-metabolites-in-brown-swiss-dairy-cows-indoor-feeding-versus-pasture-based-feeding
#12
H-J Frey, J J Gross, R Petermann, S Probst, R M Bruckmaier, P Hofstetter
Feeding dairy cows indoors or on pasture affects not only labour, machinery and housing costs, but also animals' performance and metabolism. This study investigates the effects of indoor feeding (IF) with a partial-mixed ration (PMR) versus pasture-based feeding (PF) on milk production, fertility, backfat thickness (BFT), body weight (BW) loss and energy metabolism of Brown Swiss (BS) dairy cows with similar genetic production potential. The IF herd consisted of 13 cows fed a PMR composed of maize and grass silage plus protein concentrate according to each cow's requirements...
November 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29083015/prenatal-and-or-postnatal-high-fat-diet-alters-testicular-parameters-in-adult-wistar-albino-rats
#13
Pamella Campos-Silva, Waldemar S Costa, Francisco J B Sampaio, Bianca M Gregorio
Here, we evaluated the effects of a high-fat diet during the prenatal and/or postnatal period on the metabolic parameters and testes of 4-month-old Wistar rats. The experimental groups, composed of male Wistar rats, were: C/C (n=8), HF/HF (n=8) (pups with the same diet as their dams, after weaning), C/HF (n=8), and HF/C (n=9) (pups with a different diet after weaning, from that of their dams). The biometric parameters, blood glucose levels, serum levels, the gonadosomatic index, sperm parameters, testes, and genital fat deposits were evaluated...
October 30, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28993852/the-effects-of-the-obesogen-tributyltin-on-the-metabolism-of-sertoli-cells-cultured-ex-vivo
#14
Ana M Cardoso, Marco G Alves, Ana C Sousa, Ivana Jarak, Rui A Carvalho, Pedro F Oliveira, José E Cavaco, Luís Rato
Human exposure to environmental contaminants is widespread. Some of these contaminants have the ability to interfere with adipogenesis, being thus considered as obesogens. Recently, obesogens have been singled out as a cause of male infertility. Sertoli cells (SCs) are essential for male fertility and their metabolic performance, especially glucose metabolism, is under a tight endocrine control, being essential for the success of spermatogenesis. Herein, we studied the impact of the model obesogen tributyltin in the metabolic profile of SCs...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28973717/tissue-distribution-and-early-developmental-expression-patterns-of-aldolase-a-b-and-c-in-grass-carp-ctenopharyngodon-idellus
#15
J J Fan, J J Bai, D M Ma, L Y Yu, P Jiang
Aldolase is a key enzyme involved in glycolysis, gluconeogenesis, and the pentose phosphate pathway. To establish the expression patterns of all three aldolase isozyme genes in different tissues and during early embryogenesis in lower vertebrates, as well as to explore the functional differences between these three isozymes, the grass carp was selected as a model owing to its relatively high glucose-metabolizing capability. Based on the cDNA sequences of the aldolase A, B, and C genes, the expression patterns of these three isozymes were analyzed in different tissues and during early embryogenesis using quantitative real-time polymerase chain reaction (qRT-PCR)...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28911368/systemic-adiponectin-treatment-reverses-polycystic-ovary-syndrome-like-features-in-an-animal-model
#16
Anusha Singh, Puran Bora, Amitabh Krishna
The present study examined the efficacy of adiponectin for regulating the reproductive, metabolic and fertility status of mice with polycystic ovary syndrome (PCOS). PCOS was induced in prepubertal (21- to 22-day-old) mice using dehydroepiandrosterone (6mg 100g-1day-1 for 25days), after which mice were administered either a low or high dose of adiponectin (5 or 15µgmL-1, s.c., respectively). PCOS mice exhibited typical features, including the presence of numerous cystic follicles, increased circulating androgens, increased body mass, altered steroidogenesis, decreased insulin receptor expression and increased serum triglycerides, serum glucose, Toll-like receptor (TLR)-4 (a marker of inflammation) and vascular endothelial growth factor (VEGF; a marker of angiogenesis)...
September 15, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28881243/assessing-biological-effects-of-fluoxetine-in-developing-zebrafish-embryos-using-gas-chromatography-mass-spectrometry-based-metabolomics
#17
Priti Mishra, Zhiyuan Gong, Barry C Kelly
Continuous low-dose exposure of pharmaceutically active compounds (PhACs) in aquatic ecosystems is a concern worldwide. In this study, we utilized a gas chromatography mass spectrometry (GC-MS) based metabolomics approach to assess endogenous metabolite changes in developing zebrafish embryos exposed to different concentrations of the widely used antidepressant, fluoxetine. Embryos were exposed from 2 h post fertilization (hpf) until 96 hpf. Using the Fiehn GC-MS library, a total of 31 metabolites were positively identified in embryos...
August 31, 2017: Chemosphere
https://www.readbyqxmd.com/read/28851737/cholesterol-metabolism-and-cx43-cx46-cx50-gap-junction-protein-expression-and-localisation-in-normal-and-diabetic-and-obese-ob-ob-and-db-db-mouse-testes
#18
R-Marc Pelletier, Casimir D Akpovi, Li Chen, Maria Leiza Vitale
Decreased fertility and birth rates are afflictions arising from metabolic disorders. This study assesses cholesterol metabolism and Cx46, Cx50, Cx43 expression in interstitium- and seminiferous tubule-enriched fractions of leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice, two type 2 diabetes and obesity models associated with infertility. Testosterone decreased, glucose, free and esterified cholesterol increased in serum whereas in interstitium, free and esterified cholesterol decreased in ob/ob and db/db...
August 29, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28834550/osteocalcin-dependent-regulation-of-glucose-metabolism-and-fertility-skeletal-implications-for-the-development-of-insulin-resistance
#19
REVIEW
Pawanrat Tangseefa, Sally K Martin, Stephen Fitter, Paul A Baldock, Christopher G Proud, Andrew C W Zannettino
The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our understanding of these new regulatory axes remains in its infancy, the bone-specific protein, osteocalcin, has been shown to be centrally involved. Undercarboxylated osteocalcin acts as a secretagogue in a feed-forward loop to stimulate pancreatic β-cell proliferation and insulin secretion, improve insulin sensitivity, and promote testosterone production...
August 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28804986/effects-of-hydroxycitric-acid-on-lipid-droplet-accumulation-in-chicken-embryos
#20
Mengling Peng, Longlong Li, Lei Yu, Chongyang Ge, Haitian Ma
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P < 0...
August 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
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