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https://www.readbyqxmd.com/read/28106826/colorectal-carcinoma-a-general-overview-and-future-perspectives-in-colorectal-cancer
#1
REVIEW
Inés Mármol, Cristina Sánchez-de-Diego, Alberto Pradilla Dieste, Elena Cerrada, María Jesús Rodriguez Yoldi
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western countries, with its incidence increasing year by year. The probability of suffering from colorectal cancer is about 4%-5% and the risk for developing CRC is associated with personal features or habits such as age, chronic disease history and lifestyle. In this context, the gut microbiota has a relevant role, and dysbiosis situations can induce colonic carcinogenesis through a chronic inflammation mechanism...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28093322/anti-pathogenic-and-probiotic-attributes-of-lactobacillus-salivarius-and-lactobacillus-plantarum-strains-isolated-from-feces-of-algerian-infants-and-adults
#2
Hamza Ait Seddik, Farida Bendali, Benoit Cudennec, Djamel Drider
Sixty-seven (67) lactic acid bacteria (LAB) isolates belonging to Lactobacillus genus were isolated from human feces and tested for their auto-aggregation and cell surface hydrophobicity in order to establish their adhesion capabilities, a prerequisite for probiotic selection. Strains with the upmost auto-aggregation and cell surface hydrophobicity scores were identified by MALDI-TOF spectrometry and 16S rDNA sequencing as Lactobacillus plantarum (p25lb1 and p98lb1) and Lactobacillus salivarius (p85lb1 and p104lb1)...
January 13, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28081123/yersinia-enterocolitica-a-neglected-cause-of-human-enteric-infections-in-c%C3%A3-te-d-ivoire
#3
Daniel Saraka, Cyril Savin, Stephane Kouassi, Bakary Cissé, Eugène Koffi, Nicolas Cabanel, Sylvie Brémont, Hortense Faye-Kette, Mireille Dosso, Elisabeth Carniel
BACKGROUND: Enteropathogenic Yersinia circulate in the pig reservoir and are the third bacterial cause of human gastrointestinal infections in Europe. In West Africa, reports of human yersiniosis are rare. This study was conducted to determine whether pathogenic Yersinia are circulating in pig farms and are responsible for human infections in the Abidjan District. METHODOLOGY/PRINCIPAL FINDINGS: From June 2012 to December 2013, pig feces were collected monthly in 41 swine farms of the Abidjan district...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28061804/the-extracellular-proteome-of-two-bifidobacterium-species-reveals-different-adaptation-strategies-to-low-iron-conditions
#4
Pamela Vazquez-Gutierrez, Marc J A Stevens, Peter Gehrig, Simon Barkow-Oesterreicher, Christophe Lacroix, Christophe Chassard
BACKGROUND: Bifidobacteria are among the first anaerobic bacteria colonizing the gut. Bifidobacteria require iron for growth and their iron-sequestration mechanisms are important for their fitness and possibly inhibit enteropathogens. Here we used combined genomic and proteomic analyses to characterize adaptations to low iron conditions of B. kashiwanohense PV20-2 and B. pseudolongum PV8-2, 2 strains isolated from the feces of iron-deficient African infants and selected for their high iron-sequestering ability...
January 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28056227/detection-and-dissemination-of-the-colistin-resistance-gene-mcr-1-from-isolates-and-fecal-samples-in-china
#5
Xia Chen, Xiaofei Zhao, Jie Che, Yanwen Xiong, Yanmei Xu, Lifeng Zhang, Ruiting Lan, Lining Xia, Timothy R Walsh, Jianguo Xu, Jinxing Lu, Juan Li
A recently identified colistin resistance gene, mcr-1, has been reported in many countries. In this study, we established a new real-time PCR method to detect the mcr-1 gene in a variety of isolates and fecal samples from 20 provinces and municipal cities in China. Of the 2330 isolates (from 10 species) screened, 54 (2.3%) isolates were positive for mcr-1. All of the mcr-1-positive isolates that were identified belonged to Escherichia coli (E. coli) strains, among which 9, 1, and 44 were identified as enteropathogenic E...
January 5, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28049143/the-ruler-protein-escp-of-the-enteropathogenic-escherichia-coli-type-iii-secretion-system-is-involved-in-calcium-sensing-and-secretion-hierarchy-regulation-by-interacting-with-the-gatekeeper-protein-sepl
#6
Lihi Shaulov, Jenia Gershberg, Wanyin Deng, B Brett Finlay, Neta Sal-Man
: The type III secretion system (T3SS) is a multiprotein complex that plays a central role in the virulence of many Gram-negative bacterial pathogens. To ensure that effector proteins are efficiently translocated into the host cell, bacteria must be able to sense their contact with the host cell. In this study, we found that EscP, which was previously shown to function as the ruler protein of the enteropathogenic Escherichia coli T3SS, is also involved in the switch from the secretion of translocator proteins to the secretion of effector proteins...
January 3, 2017: MBio
https://www.readbyqxmd.com/read/28043017/evolution-and-structural-dynamics-of-bacterial-glycan-binding-adhesins
#7
REVIEW
Kristof Moonens, Han Remaut
Infectious disease processes like bacterial adherence or the activity of secreted toxins frequently gain host and tissue specificity by glycan binding interactions with the host glycome. Recent functional and structural studies highlight the high niche specialization of bacterial lectins, but also reveal a remarkable plasticity in their glycan binding sites and mechanisms, to adapt to host glycome dynamics or changing environmental conditions at the site of infection. In this review we put emphasis on new structural insights in host adaptation and dynamics of bacterial carbohydrate binding adhesins and toxins in human pathogens like uropathogenic and enteropathogenic Escherichia coli, Helicobacter pylori, Yersinia pestis or Vibrio cholera...
December 30, 2016: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28036049/antimicrobial-resistant-enteropathogenic-escherichia-coli-and-salmonella-spp-in-houseflies-infesting-fish-in-food-markets-in-zambia
#8
Mwansa M Songe, Bernard M Hang'ombe, Theodore J D Knight-Jones, Delia Grace
Diarrhea is one of the most common diseases and is a leading cause of death in developing countries. This is often caused by contaminated food. Poor food hygiene standards are exacerbated by the presence of flies which can transmit a variety of infectious microorganisms, particularly through animal source foods. This fact becomes especially important in developing countries like Zambia, where fish is a highly valued source of protein. Our interest in this study was to identify if the flies that beset food markets in Zambia carry important pathogenic bacteria on their bodies, and subsequently if these bacteria carry resistance genes to commonly used antibiotics, which would indicate problems in eradicating these pathogens...
December 28, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28028851/review-on-the-effects-of-potential-prebiotics-on-controlling-intestinal-enteropathogens-salmonella-and-escherichia%C3%A2-coli-in-pig-production
#9
REVIEW
T H T Tran, N Everaert, J Bindelle
Salmonella enterica serotypes (Salmonella sp.) are the second cause of bacterial foodborne zoonoses in humans after campylobacteriosis. Pork is the third most important cause for outbreak-associated salmonellosis, and colibacillosis is the most important disease in piglets and swine. Attachment to host cells, translocation of effector proteins into host cells, invasion and replication in tissues are the vital virulence steps of these pathogens that help them to thrive in the intestinal environment and invade tissues...
December 27, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28017454/assessment-of-factors-influencing-the-within-batch-seroprevalence-of-human-enteropathogenic-yersinia-spp-of-pigs-at-slaughter-age-and-the-analogy-with-microbiology
#10
G Vanantwerpen, D Berkvens, L De Zutter, K Houf
The microbiologically and serologically-based prevalence of human enteropathogenic Yersinia spp. at moment of slaughter varies between pig farms due to different herd-level factors. A face-to-face questionnaire concerning a broad range of farm aspects (e.g., management and housing system, biosecurity, and hygiene measurements) was performed on one hundred farms. Factors influencing the seropositivity of 7047 pigs against human pathogenic Yersinia spp. were determined and compared to the microbiology. At the slaughterhouse, pieces of diafragm of on average 70 slaughter pigs per batch were sampled to determine the level of antibodies against enteropathogenic Yersinia spp...
December 5, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28013045/the-mechanism-underlying-ler-mediated-alleviation-of-gene-repression-by-h-ns
#11
Minsang Shin
Secretion of effector proteins in Enteropathogeneic Escherichia coli (EPEC) and Enterohemorrhagic Escherichia coli (EHEC) is mediated by a specialized type III secretion system, components of which are encoded in the LEE operons 1 to 5. H-NS, a global repressor in E. coli, silences the expression of LEE operons. Ler, a master regulator in LEE operons, shares 24% amnio acid identity and 44% amino acid similarity to H-NS. Interestingly, rather than a gene silencer, its main role has been characterized as an antagonizing protein that relieves H-NS-mediated transcriptional silencing...
December 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28007052/rotavirus-is-frequent-among-adults-hospitalised-for-acute-gastroenteritis
#12
Karen Rokkedal Lausch, Lena Westh, Lena Hagelskjær Kristensen, Jens Lindberg, Britta Tarp, Carsten Schade Larsen
INTRODUCTION: Rotavirus infection is the most common aetiology of acute gastroenteritis (AGE) among young children. In adults, diagnostics focus mainly on bacterial causes, though recent studies suggest that rotavirus is a frequent agent. The aim of this study was to examine the proportion of rotavirus in adults hospitalised with AGE and to identify possible predictors. METHODS: During a 24-month period from 1 May 2010 adults (> 15 years) with AGE admitted to one of four hospitals in the Central Denmark Region were examined for rotavirus with VIKIA Rota-Adeno rapid test in addition to routine culture for bacterial pathogens...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28003592/antibiotic-susceptibilities-and-genetic-characterization-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-isolated-from-stools-of-pediatric-diarrhea-patients-in-surabaya-indonesia
#13
Eddy Bagus Wasito, Katsumi Shigemura, Kayo Osawa, Alpha Fardah, Akiho Kanaida, Dadik Raharjo, K Kuntaman, Usman Hadi, Sugeng Harijono, Subijanto Marto Sudarmo, Tatsuya Nakamura, Keigo Shibayama, Masato Fujisawa, Toshiro Shirakawa
The purpose of this study was to investigate extended-spectrum beta-lactamase (ESBL)-producing E. coli isolated from pediatric (0-3 year old) diarrhea patients, as well as bacterial antibiotic susceptibilities, ESBL typing, multilocus sequence typing (MLST) typing and diarrheagenic E. coli (DEC)-typing in Surabaya, Indonesia, where this kind of survey is rarely done. ESBL-producing E. coli were detected in 18.8 % of strains. Many ESBL-producing E. coli had significantly less susceptibility to gentamicin (p<0...
December 22, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28003473/primase-is-required-for-helicase-activity-and-helicase-alters-the-specificity-of-primase-in-the-enteropathogen-clostridium-difficile
#14
Erika van Eijk, Vasileios Paschalis, Matthew Green, Annemieke H Friggen, Marilynn A Larson, Keith Spriggs, Geoffrey S Briggs, Panos Soultanas, Wiep Klaas Smits
DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clostridium difficile is the main cause of healthcare-associated diarrhoea and its DNA replication machinery is virtually uncharacterized. We identify and characterize the mechanistic details of the putative replicative helicase (CD3657), helicase-loader ATPase (CD3654) and primase (CD1454) of C...
December 2016: Open Biology
https://www.readbyqxmd.com/read/27994110/dynamics-and-trends-in-fecal-biomarkers-of-gut-function-in-children-from-1-24-months-in-the-mal-ed-study
#15
Benjamin J J McCormick, Gwenyth O Lee, Jessica C Seidman, Rashidul Haque, Dinesh Mondal, Josiane Quetz, Aldo A M Lima, Sudhir Babji, Gagandeep Kang, Sanjaya K Shrestha, Carl J Mason, Shahida Qureshi, Zulfiqar A Bhutta, Maribel Paredes Olortegui, Pablo Peñataro Yori, Amidou Samie, Pascal Bessong, Caroline Amour, Estomih Mduma, Crystal L Patil, Richard L Guerrantl, Dennis R Lang, Michael Gottlieb, Laura E Caulfield, Margaret N Kosek
Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from an unparalleled number of fecal samples collected during the first 2 years of each child's life...
December 19, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27981539/growth-and-adhesion-to-ht-29-cells-inhibition-of-gram-negatives-by-bifidobacterium-longum-bb536-e-lactobacillus-rhamnosus-hn001-alone-and-in-combination
#16
R Inturri, A Stivala, P M Furneri, G Blandino
OBJECTIVE: The aim of this study was to test the inhibitory effect of supernatants of broth cultures of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001, both individually and in combination, against Gram-negative strains (uropathogens, enteropathogens and a reference strain). Moreover, in vitro protection of B. longum BB536 and L. rhamnosus HN001, both individually and in combination, against pathogen adhesion to HT-29 cell line, was investigated. MATERIALS AND METHODS: The inhibitory activity was performed by the agar diffusion test and in vitro antagonistic activity against pathogen adhesion to human epithelial intestinal HT-29 cells was performed using standardized culture techniques...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27965649/the-12-gastrointestinal-pathogens-spectrum-of-acute-infectious-diarrhea-in-a-sentinel-hospital-shenzhen-china
#17
Hongwei Shen, Jinjin Zhang, Yinghui Li, Sirou Xie, Yixiang Jiang, Yanjie Wu, Yuhui Ye, Hong Yang, Haolian Mo, Chaoman Situ, Qinghua Hu
Acute infectious gastroenteritis is one of the most common diseases among all ages, particularly in developing countries. The pathogen spectrum may differ among different regions and seasons. To investigate the etiology of acute diarrhea in Shenzhen, a prospective study was conducted from August 2014 to September 2015. Stools from 412 patients with diarrhea (286 of whom were adults) including the general epidemiological information of the patients were collected. The 19 pathogens were detected by conventional culture method or multiplex PCR assay, which included five viruses (rotavirus, adenovirus, sapovirus, norovirus, and astrovirus), 11 bacterial pathogens (Salmonella, Campylobacter jejuni, Shigella, Listeria monocytogenes, Vibrio parahaemolyticus, Vibrio cholera, Enterohemorrhagic (EHEC), enteropathogenic (EPEC), enteroinvasive (EIEC), enterotoxigenic (ETEC); and enteroaggregative Escherichia coli (EAEC)) and three parasites (Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27957599/evaluation-of-the-biofire-filmarray%C3%A2-gastrointestinalpanel-in-a-midwestern-academic-hospital
#18
C N Murphy, R C Fowler, P C Iwen, P D Fey
The BioFire FilmArray® Gastrointestinal Panel (GIP) was implemented to replace traditional stool culture and enzyme immunoassay (EIA) testing for stool pathogens. The purpose of this study was to evaluate the detection rate, incidence of coinfection, and culture recovery rate of gastrointestinal (GI) pathogens detected by the GIP over a 1-year period. A total of 2257 stools collected from January to December 2015 were tested using the GIP. Clostridium difficile colonization was also evaluated by an antigen/toxin EIA and confirmatory polymerase chain reaction (PCR)...
December 12, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27956522/genetic-characterization-of-the-galactitol-utilization-pathway-of-salmonella-enterica-serovar-typhimurium
#19
Nicoletta Nolle, Angela Felsl, Ralf Heermann, Thilo M Fuchs
: Galactitol degradation by salmonellae remains underinvestigated, although this metabolic capability contributes to growth in animals (1). The genes responsible for this metabolic capability are part of a 9.6-kb gene cluster that spans from gatY to gatR (STM3253 to STM3262) and encodes a phosphotransferase system, four enzymes, and a transporter of the major facilitator superfamily. Genome comparison revealed the presence of this genetic determinant in nearly all Salmonella strains. The generation time of Salmonella enterica serovar Typhimurium (S Typhimurium) strain ST4/74 was higher in minimal medium with galactitol than with glucose...
December 12, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27956465/hfq-and-three-hfq-dependent-small-regulatory-rnas-mgrr-ryhb-and-mcas-coregulate-the-locus-of-enterocyte-effacement-in-enteropathogenic-escherichia-coli
#20
Shantanu Bhatt, Marisa Egan, Jasmine Ramirez, Christian Xander, Valerie Jenkins, Sarah Muche, Jihad El-Fenej, Jamie Palmer, Elisabeth Mason, Elizabeth Storm, Thomas Buerkert
Enteropathogenic Escherichia coli (EPEC) is a significant cause of infantile diarrhea and death in developing countries. The pathogenicity island locus of enterocyte effacement (LEE) is essential for EPEC to cause diarrhea. Besides EPEC, the LEE is also present in other gastrointestinal pathogens, most notably enterohemorrhagic E. coli (EHEC). Whereas transcriptional control of the LEE has been meticulously examined, posttranscriptional regulation, including the role of Hfq-dependent small RNAs, remains undercharacterized...
February 2017: Pathogens and Disease
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