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https://www.readbyqxmd.com/read/28421162/r-ideal-a-framework-for-systematic-clinical-evaluation-of-technical-innovations-in-radiation-oncology
#1
Helena M Verkooijen, Linda G W Kerkmeijer, Clifton D Fuller, Robbert Huddart, Corinne Faivre-Finn, Marcel Verheij, Stella Mook, Arjun Sahgal, Emma Hall, Chris Schultz
The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and patients' demand for high-tech treatments have led to widespread implementation of innovations before, or even without, robust evidence of improved outcomes has been generated. The standard phase I-IV framework for drug evaluation is not the most efficient and desirable framework for assessment of technological innovations. In order to provide a standard assessment methodology for clinical evaluation of innovations in radiotherapy, we adapted the surgical IDEAL framework to fit the radiation oncology setting...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28390771/contemporary-outcomes-of-surgical-revascularization-of-the-lower-extremity-in-patients-on-dialysis
#2
Ajit Rao, Melissa Baldwin, James Cornwall, Michael Marin, Peter Faries, Ageliki Vouyouka
OBJECTIVE: Peripheral arterial disease is a common comorbidity found in up to 38% of patients with end-stage renal disease (ESRD). With an increase in the survival rate of patients with ESRD by >25%, there is a lack of contemporary data on the safety of open surgical revascularization of the lower extremity (OSRLE) in this population of patients. We sought to identify the perioperative morbidity and mortality and independent risk factors of mortality in dialysis patients undergoing OSRLE...
April 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28343029/meta-analysis-of-transhiatal-esophagectomy-in-carcinoma-of-esophagogastric-junction-does-it-have-an-advantage
#3
REVIEW
Rong Yan, Chengxue Dang
PURPOSE: Compare the clinical outcome of Transhiatal Esophagectomy (THE) approach and open Thoracic Esophagectomy (TTE) approach in the carcinoma of esophagogastric junction (CEGJ). METHODS: Relevant literature published until 2016 from PubMed, Cochrane Library, Ovid (Medline) and EMBASE were retrieved. Meta-analysis was achieved by using the Stata12 software. RESULTS: A total of 18 studies and 2202 cases of patients were involved in this meta-analysis...
March 22, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28340610/the-importance-of-informational-clinical-and-personal-support-in-patient-experience-with-total-knee-replacement-a-qualitative-investigation
#4
Laurie J Goldsmith, Nitya Suryaprakash, Ellen Randall, Jessica Shum, Valerie MacDonald, Richard Sawatzky, Samar Hejazi, Jennifer C Davis, Patrick McAllister, Stirling Bryan
BACKGROUND: Total knee arthroplasty (TKA) is the most frequently performed joint replacement surgery in North America. Patient perspectives on TKA have been investigated in various ways, including finding as many as 20% of TKA patients are dissatisfied with their surgical outcomes. Understanding the patient experience with TKA broadly and in relation to patient satisfaction is a key gap in existing literature. METHODS: We report on the qualitative component of a mixed methods prospective cohort study examining patient experience and satisfaction post-TKA for adults in British Columbia, Canada...
March 24, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28325197/east-versus-west-differences-in-surgical-management-in-asia-compared-with-europe-and-north-america
#5
REVIEW
Tomio Ueno, Michihisa Iida, Shigefumi Yoshino, Shigeru Takeda, Hisako Kubota, Masaharu Higashida, Yasuo Oka, Atushi Tsuruta, Hideo Matsumoto, Hiroaki Nagano
In recent decades, there has been considerable worldwide progress in the treatment of gastric cancer. Gastrectomy with a modified D2 lymphadenectomy (sparing the distal pancreas and spleen) has increasingly gained acceptance as a preferable standard surgical approach among surgeons in the East and the West. Despite growing consensus significant differences still exist in surgical techniques in clinical trials and clinical practices secondary to variations in epidemiology, clinicopathologic features, and surgical outcomes among geographic regions...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28316305/the-statesmanship-of-william-crawford-gorgas-m-d-surgeon-general-medical-corps-united-states-army
#6
Roy E Gandy, Raven M Christopher, Charles B Rodning
If statesmanship can be characterized as a bed rock of principles, a strong moral compass, a vision, and an ability to articulate and effect that vision, then the fortitude, tenacity, imperturbability, and resilience of William Crawford Gorgas cannot be overestimated. As Chief Sanitary Officer in Cuba and as Chief Medical Officer in Panama, he actualized strategies to eradicate the vectors of yellow fever and malaria. His superiors initially pigeonholed his requisitions, refused to provide him with any authority, and clamored for his dismissal...
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28158933/interventions-for-treating-simple-bone-cysts-in-the-long-bones-of-children
#7
REVIEW
Jia-Guo Zhao, Jia Wang, Wan-Jie Huang, Peng Zhang, Ning Ding, Jian Shang
BACKGROUND: Simple bone cysts, also known as a unicameral bone cysts or solitary bone cysts, are the most common type of benign bone lesion in growing children. Cysts may lead to repeated pathological fracture (fracture that occurs in an area of bone weakened by a disease process). Occasionally, these fractures may result in symptomatic malunion. The main goals of treatment are to decrease the risk of pathological fracture, enhance cyst healing and resolve pain. Despite the numerous treatment methods that have been used for simple bone cysts in long bones of children, there is no consensus on the best procedure...
February 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28134049/outcomes-after-orthopedic-trauma
#8
Michael Suk, Monica Daigl, Richard E Buckley, Dean G Lorich, David L Helfet, Beate Hanson
BACKGROUND: Clinical orthopedic research needs better ability to assess patient expectations with regard to orthopedic trauma surgery outcomes. The aim of this study was to investigate to which extent patient expectations prior to surgery could be met after surgery. METHODS: Patients (≥18 years) with surgical ankle fractures were prospectively recruited at 5 orthopedic trauma clinics in the United States (USA), Canada, and Brazil and followed up for 12 months...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27901415/burden-of-surgical-site-infections-associated-with-select-spine-operations-and-involvement-of-staphylococcus-aureus
#9
Harshila Patel, Hanane Khoury, Douglas Girgenti, Sharon Welner, Holly Yu
BACKGROUND: Spine operations may be indicated for treatment of diseases including vertebral injuries, degenerative spinal conditions, disk disease, spinal misalignments, or malformations. Surgical site infection (SSI) is a clinically important complication of spine surgery. Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), is a leading cause of post-spinal SSIs. METHODS: PubMed and applicable infectious disease conference proceedings were searched to identify relevant published studies...
November 30, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27697192/the-arthroscopy-association-of-north-america-advanced-arthroscopy-traveling-fellowship-a%C3%A2-10-year-history
#10
Mary K Mulcahey, Brian R Waterman
In its brief 10-year existence, the Arthroscopy Association of North America Advanced Arthroscopy Traveling Fellowship has quickly established itself as the paramount educational experience for aspiring young surgeons in sports medicine and arthroscopy. The Traveling Fellowship is structured as a 10-day experience with visits to 3 host sites and culminates at the AANA Annual Meeting. With 4 selected fellows and an honorary "Godfather," the Traveling Fellowship affords a unique and invaluable opportunity to forge enduring friendships and rare mentorships with established leaders in the field of Arthroscopy...
October 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27597512/laminectomy-and-fusion-versus-laminoplasty-for-the-treatment-of-degenerative-cervical-myelopathy-results-from-the-aospine-north-america-and-international-prospective-multicenter-studies
#11
Michael G Fehlings, Carlo Santaguida, Lindsay Tetreault, Paul Arnold, Giuseppe Barbagallo, Helton Defino, Shashank Kale, Qiang Zhou, Tim S Yoon, Branko Kopjar
BACKGROUND CONTEXT: It remains unclear whether cervical laminoplasty (LP) offers advantages over cervical laminectomy and fusion (LF) in patients undergoing posterior decompression for degenerative cervical myelopathy (DCM). PURPOSE: The objective of this study is to compare outcomes of LP and LF. STUDY DESIGN/SETTING: This is a multicenter international prospective cohort study. PATIENT SAMPLE: A total of 266 surgically treated symptomatic DCM patients undergoing cervical decompression using LP (N=100) or LF (N=166) were included...
January 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27575626/the-use-of-optimal-cytoreduction-nomenclature-in-ovarian-cancer-literature-can-we-move-toward-a-more-optimal-classification-system
#12
Ana Milena Angarita, Rebecca Stone, Sarah M Temkin, Kimberly Levinson, Amanda N Fader, Edward J Tanner
OBJECTIVES: The objective of this study is to explore how cytoreductive surgical outcomes such as residual disease (RD) and use of the term "optimal cytoreduction" (OCR) have changed over time in the ovarian cancer literature. METHODS: We identified all English-language publications referring to ovarian cancer cytoreduction for a 12-year period. Publications were evaluated for how the diameter of RD was categorized and whether OCR was defined. In addition, the use of RD and OCR terminology trends over time and associations between terminology and the region of corresponding author, study type, and journal impact factor were explored...
October 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27547464/implications-of-different-nephrolithometry-scoring-systems-on-clinical-practice-of-endourologists-an-international-web-based-survey
#13
Mohamed A Elkoushy, Adel H Metwally, Yasser A Noureldin
OBJECTIVES: To assess the implications of different nephrolithometry scoring systems (NLSS) on clinical practice of endourologists to predict stone-free status (SFS) after percutaneous nephrolithotomy (PCNL). METHODS: A web-based survey was sent to members of the Endourological Society. Demographic and practice pattern data were collected. Multiple-choice and open-ended questions were used to assess awareness about the NLSS and their authentic use in clinical practice...
September 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27540038/percutaneous-left-atrial-appendage-occlusion-the-munich-consensus-document-on-definitions-endpoints-and-data-collection-requirements-for-clinical-studies
#14
Apostolos Tzikas, David R Holmes, Sameer Gafoor, Carlos E Ruiz, Carina Blomström-Lundqvist, Hans-Christoph Diener, Riccardo Cappato, Saibal Kar, Randal J Lee, Robert A Byrne, Reda Ibrahim, Dhanunjaya Lakkireddy, Osama I Soliman, Michael Nabauer, Steffen Schneider, Johannes Brachmann, Jeffrey L Saver, Klaus Tiemann, Horst Sievert, A John Camm, Thorsten Lewalter
The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patients groups, comparisons with pharmacological stroke prophylaxis, surgical approaches, and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies, and representatives from the medical device industry regarding definitions for parameters and endpoints to be assessed in clinical studies...
January 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27506995/patterns-of-hepatic-resections-in-north-america-use-of-concurrent-partial-resections-and-ablations
#15
Faiz Gani, Vanessa M Thompson, David J Bentrem, Bruce L Hall, Henry A Pitt, Timothy M Pawlik
BACKGROUND: National registries have not adequately captured concurrent partial hepatic resections or ablations. Therefore, the aim of this analysis was to describe the patterns of concurrent partial resections and ablations in North America. METHODS: Patients undergoing a hepatic resection were identified using the American College of Surgeons-National Surgical Quality Improvement Program Targeted Hepatectomy database. Perioperative outcomes were compared for patients undergoing concurrent "wedge" resections and/or ablations and other subsets...
October 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27492669/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2016-update-on-research
#16
Marshall L Jacobs, Jeffrey P Jacobs, Sara K Pasquali, Kevin D Hill, Christoph Hornik, Sean M O'Brien, David M Shahian, Robert H Habib, Fred H Edwards
The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) is the largest congenital and pediatric cardiac surgical clinical data registry in the world. With more than 400,000 total operations from nearly all centers performing pediatric and congenital heart operations in North America, the STS CHSD is an unparalleled platform for clinical investigation, outcomes research, and quality improvement activities in this subspecialty. In 2015, several major original publications reported analyses of data in the CHSD pertaining to specific diagnostic and procedural groups, age-defined cohorts, or the entire population of patients in the database...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27456474/subcutaneous-phaeohyphomycosis-caused-by-exophiala-spinifera-in-a-european-patient-with-lymphoma-a-rare-occurrence-case-report-and-literature-review
#17
REVIEW
G Bohelay, S Robert, C Bouges-Michel, M Gerin, A Levy, O Fain, F Caux
Exophiala spinifera is a dematiaceous fungus responsible for rare skin infections presenting as phaeohyphomycosis or chromoblastomycosis which has been primarily reported in tropical and subtropical areas (Asia, South and North America). We report the first case of E. spinifera phaeohyphomycosis in a European patient. The phaeohyphomycosis was limited to the skin, involving the finger of an immunocompromised patient presenting with a large B-cell lymphoma treated by R-mini-CHOP regimen. Remission was initially achieved by surgical excision; however, a local subcutaneous relapse required treatment with itraconazole...
November 2016: Mycoses
https://www.readbyqxmd.com/read/27402237/design-and-rationale-of-the-best-endovascular-versus-best-surgical-therapy-for-patients-with-critical-limb-ischemia-best-cli-trial
#18
Matthew T Menard, Alik Farber, Susan F Assmann, Niteesh K Choudhry, Michael S Conte, Mark A Creager, Michael D Dake, Michael R Jaff, John A Kaufman, Richard J Powell, Diane M Reid, Flora Sandra Siami, George Sopko, Christopher J White, Kenneth Rosenfield
BACKGROUND: Critical limb ischemia (CLI) is increasing in prevalence, and remains a significant source of mortality and limb loss. The decision to recommend surgical or endovascular revascularization for patients who are candidates for both varies significantly among providers and is driven more by individual preference than scientific evidence. METHODS AND RESULTS: The Best Endovascular Versus Best Surgical Therapy for Patients With Critical Limb Ischemia (BEST-CLI) Trial is a prospective, randomized, multidisciplinary, controlled, superiority trial designed to compare treatment efficacy, functional outcomes, quality of life, and cost in patients undergoing best endovascular or best open surgical revascularization...
July 8, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27399510/312%C3%A2-risk-factors-and-clinical-outcomes-of-dysphagia-after-anterior-cervical-surgery-in-patients-with-degenerative-cervical-myelopathy-results-from-the-aospine-international-and-north-america-studies
#19
Lindsay Tetreault, Narihito Nagoshi, Hiroaki Nakashima, Paul M Arnold, Giuseppe Barbagallo, Branko Kopjar, Michael G Fehlings
INTRODUCTION: The objective of this study is to determine the incidence and risk factors of postoperative dysphagia and to evaluate short- and long-term clinical outcomes in patients with this complication. METHODS: Four hundred seventy patients undergoing an anterior or a 2-stage surgery were enrolled in the prospective AOSpine CSM-North America or International study at 26 global sites. Logistic regression analyses were conducted to determine important clinical and surgical predictors of dysphagia...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27398891/impact-of-depression-and-bipolar-disorders-on-functional-and-quality-of-life-outcomes-in-patients-undergoing-surgery-for-degenerative-cervical-myelopathy-analysis-of-a-combined-prospective-dataset
#20
Lindsay Tetreault, Narihito Nagoshi, Hiroaki Nakashima, Anoushka Singh, Branko Kopjar, Paul Arnold, Michael G Fehlings
STUDY DESIGN: Analysis of a combined prospective dataset. OBJECTIVE: To compare clinical outcomes in patients with and without preexisting depression or bipolar disorder undergoing surgery for degenerative cervical myelopathy (DCM). SUMMARY OF BACKGROUND DATA: Psychiatric comorbidities, including depression, have been associated with worse clinical outcomes after lumbar spine surgery; however, it is unclear whether these psychiatric disorders are also predictive of outcomes in patients undergoing surgery for the treatment of DCM...
March 15, 2017: Spine
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