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https://www.readbyqxmd.com/read/28241397/an-in-vitro-investigation-of-the-marked-impact-of-dendritic-cell-interactions-with-bone-grafts
#1
Lili Zhang, Jin Ke, Yulan Wang, Shuang Yang, Richard J Miron, Yufeng Zhang
The immune response to bone biomaterials plays a critical role during early inflammation and biomaterial-induced osteogenesis. Dendritic cells (DCs) possess a significant impact during immune responses to biomaterials. While conventional strategies to evaluate the osteogenic potential of bone substitute materials focus mainly on osteoblast differentiation. Therefore the present study was to investigate the interactions DCs to porous β-tricalcium phosphate (β-TCP) to investigate whether DCs participate in the material-coordinated osteogenic process...
February 27, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28241127/vitamin-d-promotes-pneumococcal-killing-and-modulates-inflammatory-responses-in-primary-human-neutrophils
#2
Karthik Subramanian, Peter Bergman, Birgitta Henriques-Normark
Streptococcus pneumoniae is a major human pathogen and a leading cause of pneumonia, septicemia, and meningitis worldwide. Despite clinical studies linking vitamin D deficiency and pneumonia, molecular mechanisms behind these observations remain unclear. In particular, the effects of vitamin D on neutrophil responses remain unknown. Using pneumococcal strains, primary neutrophils isolated from human blood, and sera from patients with frequent respiratory tract infections (RTIs), we investigated the effects of vitamin D on neutrophil bactericidal and inflammatory responses, including pattern recognition receptors, antimicrobial peptides, and cytokine regulation...
February 28, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28241093/phase-1-2-study-of-immunotherapy-with-dendritic-cells-pulsed-with-autologous-tumor-lysate-in-patients-with-refractory-bone-and-soft-tissue-sarcoma
#3
Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya
BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28240546/high-purity-mg-staples-suppress-inflammatory-response-in-rectal-anastomoses
#4
Jiazeng Xia, Hui Chen, Jun Yan, Hongliu Wu, Hao Wang, Jian Guo, Xiaonong Zhang, Shaoxiang Zhang, Changli Zhao, Yigang Chen
Magnesium-based materials are promising biodegradable implants, although the impact of magnesium on rectal anastomotic inflammation is poorly understood. Thus, we investigated the inflammatory effects of high-purity Mg staples in rectal anastomoses by in vivo luciferase reporter gene expression in transgenic mice, hematoxylin-eosin staining, immunohistochemistry, and western blotting. As expected, strong IL-1-mediated inflammation and inflammatory cell infiltration were observed 1 day after rectal anastomoses were stapled with high-purity Mg or Ti...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28240190/demonstration-of-biological-and-immunological-equivalence-of-a-generic-glatiramer-acetate
#5
Josephine D D Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor, Tanmoy Ganguly
In April 2015, the US Food and Drug Administration approved the first generic glatiramer acetate, Glatopa® (M356), as fully substitutable for Copaxone® 20 mg/mL for relapsing forms of multiple sclerosis (MS). This approval was accomplished through an Abbreviated New Drug Application that demonstrated equivalence to Copaxone. In vitro and in vivo experiments from multiple redundant orthogonal assays within four biological processes (aggregate biology, antigen-presenting cell biology, T-cell biology, and B-cell biology) modulated by glatiramer acetate in MS established the biological and immunological equivalence of Glatopa and Copaxone and are described...
February 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28239640/serum-il-8-is-a-marker-of-white-matter-hyperintensities-in-patients-with-alzheimer-s-disease
#6
Yanan Zhu, Yuek Ling Chai, Saima Hilal, M Kamran Ikram, Narayanaswamy Venketasubramanian, Boon-Seng Wong, Christopher P Chen, Mitchell K P Lai
INTRODUCTION: Neuroinflammation and cerebrovascular disease (CeVD) have been implicated in cognitive impairment and Alzheimer's disease (AD). The present study aimed to examine serum inflammatory markers in preclinical stages of dementia and in AD, as well as to investigate their associations with concomitant CeVD. METHODS: We performed a cross-sectional case-control study including 96 AD, 140 cognitively impaired no dementia (CIND), and 79 noncognitively impaired participants...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28239080/the-therapeutic-efficacy-of-tonsil-derived-mesenchymal-stem-cells-in-dextran-sulfate-sodium-induced-acute-murine-colitis-model
#7
Eun Mi Song, Sung Ae Jung, Ko Eun Lee, Ji Young Jang, Kang Hoon Lee, Chung Hyun Tae, Chang Mo Moon, Yang Hee Joo, Seong Eun Kim, Hye Kyung Jung, Ki Nam Shim
Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitor cells currently under investigation for its efficacy as the treatment for inflammatory bowel disease. In this study, we evaluated the efficacy of tonsil-derived mesenchymal stem cells (T-MSCs) as a novel source of mesenchymal stem cells and traced their localization in a murine model of acute colitis induced by dextran sulfate sodium (DSS). Methods: C57BL/6 mice were randomly assigned to the following three groups: the normal control group, DSS colitis group (DSS+phosphate buffered saline), and T-MSC group (DSS+T-MSCs, 1×10(6))...
February 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28238855/mkp-1-negatively-regulates-lps-mediated-il-1%C3%AE-production-through-p38-activation-and-hif-1%C3%AE-expression
#8
Harvinder Talwar, Christian Bauerfeld, Mohamad Bouhamdan, Pershang Farshi, Yusen Liu, Lobelia Samavati
Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that plays a major role in inflammatory diseases as well as cancer. The inflammatory response after Toll-like receptor (TLR) 4 activation is tightly regulated through phosphorylation of MAP kinases, including p38 and JNK pathways. The activation of MAP kinases is negatively regulated by MAPK phosphatases (MKPs). MKP-1 preferentially dephosphorylates p38 and JNK. IL-1β is regulated through the activation of MAPK, including p38 as well as several transcription factors...
February 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28238753/glucocorticoid-induced-leucine-zipper-overexpression-inhibits-lipopolysaccharide-induced-retinal-inflammation-in-rats
#9
Ruiping Gu, Boya Lei, Qinmeng Shu, Gang Li, Gezhi Xu
Glucocorticoid-induced leucine zipper (GILZ) mediates several effects of glucocorticoids and has important anti-inflammatory properties. Here, we explored the role of GILZ in inhibiting retinal inflammation. Endotoxin-induced uveitis (EIU) was established in rats by intravitreal injection of lipopolysaccharide (LPS). GILZ levels decreased in the EIU retina at 4 h after LPS injection and slowly recovered within 24 h. Retinal GILZ was downregulated by recombinant lentivirus-delivered short-hairpin RNA targeting GILZ (shRNA-GILZ-rLV) and upregulated by recombinant lentivirus-mediated GILZ overexpression (Oe-GILZ-rLV)...
February 24, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28238747/role-of-c-ebp-homologous-protein-chop-and-endoplasmic-reticulum-in-asthma-exacerbation-by-regulating-the-il-4-stat6-tfec-il-4r%C3%AE-positive-feedback-loop-in-m2-macrophages
#10
Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong
BACKGROUND: C/EBP homologous protein (CHOP), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during the development of asthma. However, its exact role in asthma pathogenesis is not fully understood. OBJECTIVES: We aimed to determine the function and mechanism of CHOP in the pathogenesis of allergic asthma in patients and animals. METHODS: Studies were conducted in asthmatic patients and CHOP(-/-) mice to dissect the role of CHOP and ER stress in asthma pathogenesis...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238632/the-cationic-liposomal-adjuvants-caf01-and-caf09-formulated-with-the-major-outer-membrane-protein-elicit-robust-protection-in-mice-against-a-chlamydia-muridarum-respiratory-challenge
#11
Sukumar Pal, Delia F Tifrea, Frank Follmann, Peter Andersen, Luis M de la Maza
Two cationic liposomal adjuvants CAF01 and CAF09 were formulated with the native or the recombinant Chlamydia muridarum major outer membrane protein (nMOMP and rMOMP). BALB/c mice were immunized with the four vaccine formulations using the subcutaneous followed by the intranasal (i.n.) routes. As positive controls mice were inoculated i.n. with live C. muridarum and negative controls received i.n. minimal essential medium (MEM). Four weeks after the last immunization mice were challenged i.n. with 10(4) inclusion forming units (IFU) of C...
February 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28238064/hepatic-inflammation-fibrosis-cancer-axis-in-the-rat-hepatocellular-carcinoma-induced-by-diethylnitrosamine
#12
Yong-Fang Ding, Zhen-Hui Wu, Ying-Jie Wei, Luan Shu, Yun-Ru Peng
PURPOSE: Hepatocellular carcinoma (HCC) cases are closely associated with chronic inflammation and fibrosis which is known as hepatic inflammation-fibrosis-cancer (IFC) axis. The aim of this study is to elucidate the development characteristics of the rat HCC model based on IFC axis. METHODS: The diethylnitrosamine (DEN)-induced rat HCC, which presents a stepwise histopathological progression that is similar to human HCC, was used to analyze the features of the different stages (inflammation, fibrosis, cancer)...
February 25, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28237998/optimization-of-herbicidin-a-production-in-submerged-culture-of-streptomyces-scopuliridis-m40
#13
Sanghyun Ha, Keon Jin Lee, Sang Il Lee, Hyun Jung Gwak, Jong-Hee Lee, Tae-Woon Kim, Hak-Jong Choi, Ja-Young Jang, Jung-Sub Choi, Chang-Jin Kim, Jin-Cheol Kim, Hyeong Hwan Kim, Hae Woong Park
Herbicidin A is a potent herbicide against dicotyledonous plants as well as an antibiotic against phytopathogens. In this study, fermentation parameters for herbicidin A production in submerged culture of Streptomyces scopuliridis M40 were investigated. The herbicidin A concentration varied with the C/N ratio. High C/N ratios (>4) resulted in a herbicidin A production of more than 900 mg/L, whereas maximally 600 mg/L was obtained at ratios between 1-3.5. In 5-L batch fermentation, there was a positive correlation between the oxygen uptake rate (OUR) and herbicidin A production...
February 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28237889/giardia-duodenalis-induces-dysbiosis-of-human-intestinal-microbiota-biofilms
#14
Jennifer K Beatty, Sarah V Akierman, Jean-Paul Motta, Stacy Muise, Matthew L Workentine, Joe J Harrison, Amol Bhargava, Paul L Beck, Kevin P Rioux, Gordon Webb McKnight, John L Wallace, Andre G Buret
Giardia duodenalis is a prevalent cause of acute diarrheal disease worldwide. However, recent outbreaks in Italy and Norway have revealed a link between giardiasis and the subsequent development of chronic post-infectious irritable bowel syndrome (PI-IBS). While the mechanisms underlying the causation of PI-IBS remain obscure, recent findings suggest that alterations in gut microbiota communities are linked to the pathophysiology of IBS. In the present study, we use a laboratory biofilm system to culture and enrich mucosal microbiota from human intestinal biopsies...
February 22, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28237856/wogonin-a-plant-derived-small-molecule-exerts-potent-anti-inflammatory-and-chondroprotective-effects-through-the-activation-of-ros-erk-nrf2-signaling-pathways-in-human-osteoarthritis-chondrocytes
#15
Nazir M Khan, Abdul Haseeb, Mohammad Y Ansari, Pratap Devarapalli, Sara Haynie, Tariq M Haqqi
Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis. Here, we evaluated the potential chondroprotective and anti-inflammatory effects of Wogonin, a naturally occurring flavonoid, in IL-1β-stimulated human OA chondrocytes and cartilage explants. Wogonin completely suppressed the expression and production of inflammatory mediators including IL-6, COX-2, PGE2, iNOS and NO in IL-1β-stimulated OA chondrocytes. Further, Wogonin exhibits potent chondroprotective potential by switching the signaling axis of matrix degradation from catabolic towards anabolic ends and inhibited the expression, production and activities of matrix degrading proteases including MMP-13, MMP-3, MMP-9, and ADAMTS-4 in OA chondrocytes, and blocked the release of s-GAG and COL2A1 in IL-1β-stimulated OA cartilage explants...
February 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28237642/oncologic-relevance-of-magnetic-resonance-imaging-detected-threatened-mesorectal-fascia-for-patients-with-mid-or-low-rectal-cancer-a-longitudinal-analysis-before-and-after-long-course-concurrent-chemoradiotherapy
#16
Il Tae Son, Young Hoon Kim, Kyoung Ho Lee, Sung Il Kang, Duck-Woo Kim, Eun Shin, Keun-Wook Lee, Soyeon Ahn, Jae-Sung Kim, Sung-Bum Kang
BACKGROUND: The oncologic importance of threatened mesorectal fascia detected with magnetic resonance imaging is obscured by the heterogeneity of preoperative treatments. We evaluated the oncologic relevance of threatened mesorectal fascia detected with consecutive magnetic resonance imaging performed before and after long-course, concurrent chemoradiotherapy (LCRT) for mid or low rectal cancer. METHODS: We evaluated 196 patients who underwent total mesorectal excision with LCRT...
February 22, 2017: Surgery
https://www.readbyqxmd.com/read/28236763/palmatine-inhibits-trif-dependent-nf-%C3%AE%C2%BAb-pathway-against-inflammation-induced-by-lps-in-goat-endometrial-epithelial-cells
#17
Baoqi Yan, Dongsheng Wang, Shuwei Dong, Zhangrui Cheng, Lidong Na, Mengqi Sang, Hongzao Yang, Zhiqiang Yang, Shidong Zhang, Zuoting Yan
Palmatine, a natural pharmaceutical drug, possesses many biological activities. But its clinical application is rarely reported in the veterinary medicine. The aim of this study was to investigate the anti-inflammatory effects of palmatine on lipopolysaccharide (LPS)-induced inflammation in goat endometrial epithelial cells (gEECs), and the possible molecular mechanisms. Palmatine cell toxicity was determined by MTT assay, and the production of inflammatory cytokine in the cultured medium was measured with ELISA, qRT-PCR and Western blotting...
February 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28236632/accuracy-of-a-combined-insulin-like-growth-factor-binding-protein-1-interleukin-6-test-premaquick-in-predicting-delivery-in-women-with-threatened-preterm-labor
#18
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Lydia Ijeoma Eleje, Joseph Ifeanyichukwu Ikechebelu, Ifeanyichukwu Uzoma Ezebialu, Chukwudi Celestine Obiora, Betrand Obi Nwosu, Chukwuemeka Okwudili Ezeama, Gerald Okanandu Udigwe, Charles Ikechukwu Okafor, Frank Okechukwu Ezugwu
PURPOSE: To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor. METHODS: Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28236037/ppar%C3%AE-%C3%AE-antagonists-reverse-the-ameliorative-effects-of-osthole-on-hepatic-lipid-metabolism-and-inflammatory-response-in-steatohepatitic-rats
#19
Xi Zhao, Feng Wang, Ruijun Zhou, Zengyan Zhu, Meilin Xie
Our previous studies have indicated that osthole may ameliorate the hepatic lipid metabolism and inflammatory response in nonalcoholic steatohepatitic rats, but the underlying mechanisms remain unclear. This study aimed to determine whether the effects of osthole were mediated by the activation of hepatic peroxisome proliferator-activated receptor α/γ (PPARα/γ). A rat model with steatohepatitis was induced by orally feeding high-fat and high-sucrose emulsion for 6 weeks. These experimental rats were then treated with osthole (20 mg/kg), PPARα antagonist MK886 (1 mg/kg) plus osthole (20 mg/kg), PPARγ antagonist GW9662 (1 mg/kg) plus osthole (20 mg/kg) and MK886 (1 mg/kg) plus GW9662 (1 mg/kg) plus osthole (20 mg/kg) for 4 weeks...
February 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28235772/frontline-science-shh-production-and-gli-signaling-is-activated-in-vivo-in-lung-enhancing-the-th2-response-during-a-murine-model-of-allergic-asthma
#20
Ariane S I Standing, Diana C Yánez, Rosie Ross, Tessa Crompton, Anna L Furmanski
The pathophysiology of allergic asthma is driven by Th2 immune responses after aeroallergen inhalation. The mechanisms that initiate, potentiate, and regulate airway allergy are incompletely characterized. We have shown that Hh signaling to T cells, via downstream Gli transcription factors, enhances T cell conversion to a Th2 phenotype. In this study, we showed for the first time, to our knowledge, that Gli-dependent transcription is activated in T cells in vivo during murine AAD, a model for the immunopathology of asthma, and that genetic repression of Gli signaling in T cells decreases the differentiation and recruitment of Th2 cells to the lung...
February 24, 2017: Journal of Leukocyte Biology
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