keyword
https://read.qxmd.com/read/38630468/design-synthesis-and-mechanistic-studies-of-r-3-amino-5-5-difluorocyclohex-1-ene-1-carboxylic-acid-as-an-inactivator-of-human-ornithine-aminotransferase
#1
JOURNAL ARTICLE
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio M Ferreira, Graham Moran, Neil L Kelleher, Dali Liu, Richard B Silverman
Human ornithine aminotransferase ( h OAT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, has been shown to play an essential role in the metabolic reprogramming and progression of hepatocellular carcinoma (HCC). HCC accounts for approximately 75% of primary liver cancers and is within the top three causes of cancer death worldwide. As a result of treatment limitations, the overall 5-year survival rate for all patients with HCC is under 20%. The prevalence of HCC necessitates continued development of novel and effective treatment methods...
April 17, 2024: ACS Chemical Biology
https://read.qxmd.com/read/38628205/effects-of-blending-ratio-variation-on-macronutrient-compositions-and-sensory-acceptability-of-dabi-teff-field-pea-based-novel-composite-complementary-flours
#2
JOURNAL ARTICLE
Diriba Chewaka Tura, Tefera Belachew, Dessalegn Tamiru, Kalkidan Hassen Abate
The response of a mixed system is determined by the proportions of the various ingredients that add up to one, not by the combination's total amount. This research aimed at examining the effects of blending ratio variation on the macro-composition and sensory acceptability of dabi teff-field pea-based novel composite complementary flours. Standard methods (AOAC, 2016, Official Methods of Analysis of the Association of Official Analytical Chemists ) were used to determine macronutrients. The sensory attributes were evaluated using a 5-point hedonic scale...
April 2024: Food Science & Nutrition
https://read.qxmd.com/read/38627096/-characterization-of-hoat4-and-moat5-as-functional-orthologs-for-renal-anion-uptake-and-efflux-transport
#3
JOURNAL ARTICLE
Lucy J Martinez-Guerrero, Xiaohong Zhang, Stephen H Wright, Nathan J Cherrington
Organic anions (OA) are compounds including drugs or toxicants that are negatively charged at physiological pH and are typically transported by Organic Anion Transporters (OATs). Human OAT4 (SLC22A11) is expressed in the apical membrane of renal proximal tubules. Although there is no rodent ortholog of hOAT4, rodents express Oat5 (Slc22a19), an anion exchanger that is also localized to the apical membrane of renal proximal tubule cells. The purpose of this study was to determine the functional similarity between mouse Oat5 and human OAT4...
April 16, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38626996/barriers-and-facilitators-for-family-physicians-prescribing-opioid-agonist-therapy-in-saskatchewan
#4
JOURNAL ARTICLE
Teresa Nguyen, Julia Bareham, Katelyn Halpape
OBJECTIVE: To explore barriers and facilitators for family physicians in Saskatchewan prescribing opioid agonist therapy (OAT). DESIGN: Self-administered postal survey. SETTING: Family medicine practices in Saskatchewan. PARTICIPANTS: A total of 218 Saskatchewan family physicians who were not authorized to prescribe OAT as of June 2022. MAIN OUTCOME MEASURES: Descriptive and inferential statistics of physicians' self-reported barriers to and facilitators of prescribing OAT for opioid use disorder (OUD)...
April 2024: Canadian Family Physician Médecin de Famille Canadien
https://read.qxmd.com/read/38616390/first-report-of-anthracnose-leaf-spot-caused-by-colletotrichum-americae-borealis-on-potentilla-anserina-in-china
#5
JOURNAL ARTICLE
Muzhapaer Tuluhong, Yuying Xiao, Meiqi Mu, Wen Xu, Qingwen Zhang, Yuan Wang, GuoWen Cui
Potentilla anserina L. has an abundance of bioactive compounds and is widely recognized for its diverse applications in traditional medicine and as a food. In August 2023, typical symptoms of anthracnose were observed in 80% of P. anserina plants in Harbin, China. Symptoms, characterized by reddish-brown spots, tend to occur more frequently on leaves closer to the ground. They initially appeared as oval or irregular circles, measuring 1 to 3 mm in diameter, and later merged into larger patches surrounded by chlorotic areas on the leaves...
April 14, 2024: Plant Disease
https://read.qxmd.com/read/38611952/the-effect-of-essential-oils-from-asteraceae-plants-on-behavior-and-selected-physiological-parameters-of-the-bird-cherry-oat-aphid
#6
JOURNAL ARTICLE
Paweł Czerniewicz, Hubert Sytykiewicz, Grzegorz Chrzanowski
Essential oils (EOs), including those from the Asteraceae plants, have been shown to have promising insecticidal activity against a wide range of insect pests. Understanding the mechanism of action of EOs is one of the studied aspects. The present study aimed to evaluate the effect of essential oils from Achillea millefolium , Santolina chamaecyparissus , Tagetes patula and Tanacetum vulgare on the settling and probing behavior of the bird cherry-oat aphid ( Rhopalosiphum padi L.). In addition, the effect of the oils on the activity of such enzymes as trypsin, pepsin and α - and β -glucosidase involved in the metabolism of proteins and sugars of the insects was examined...
April 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38611566/comparative-analysis-of-vitamin-mineral-content-and-antioxidant-capacity-in-cereals-and-legumes-and-influence-of-thermal-process
#7
JOURNAL ARTICLE
Corina Moisa, Anca Monica Brata, Iulia C Muresan, Felicia Dragan, Ioana Ratiu, Oana Cadar, Anca Becze, Mihai Carbunar, Vlad Dumitru Brata, Alin Cristian Teusdea
Cereals, as the world's most consumed food, face challenges related to nutrient quality due to climate change and increased production impacting soil health. In this study, we investigated the vitamin and mineral content, polyphenols, and antioxidant activity in cereals from Western Romania, analyzing whole and hulled wheat, rye, oat, and soybeans before and after heat treatment. Samples from 2022 crops were processed into dough and subjected to 220 °C for 30 min. The results reveal that, despite efforts to optimize nutrient content, cereals, particularly after heat processing, exhibited lower vitamin and mineral levels than the recommended daily intake...
April 6, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38611549/how-do-mixed-cover-crops-white-mustard-oats-contribute-to-labile-carbon-pools-in-an-organic-cropping-system-in-serbia
#8
JOURNAL ARTICLE
Vladan Ugrenović, Vladimir Filipović, Vladimir Miladinović, Divna Simić, Snežana Janković, Slađan Stanković, Elmira Saljnikov
Sustainable farming is one of the priority goals of the "4 per 1000" concept with regard to the preservation of soil fertility and carbon sequestration. This paper presents a study on the use of a mixture of cover crops of self-grown oats ( Avena sativa L.) and sown white mustard ( Sinapis alba L.) in organic farming under the agroecological conditions of Serbia. The main objective was to identify sensitive carbon pools (microbial carbon and nitrogen, basal respiration and a number of specific groups of soil microorganisms) in organic farming with and without cover crops...
April 3, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38611546/genome-wide-identification-of-nac-family-genes-in-oat-and-functional-characterization-of-asnac109-in-abiotic-stress-tolerance
#9
JOURNAL ARTICLE
Yahui Xu, Jialong Cheng, Haibin Hu, Lin Yan, Juqing Jia, Bin Wu
The plant-specific NAC gene family is one of the largest transcription factor families, participating in plant growth regulation and stress response. Despite extensive characterization in various plants, our knowledge of the NAC family in oat is lacking. Herein, we identified 333 NAC genes from the latest release of the common oat genome. We provide a comprehensive overview of the oat NAC gene family, covering gene structure, chromosomal localization, phylogenetic characteristics, conserved motif compositions, and gene duplications...
April 3, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38611296/nutritional-traits-pasting-properties-and-antioxidant-profile-of-selected-genotypes-of-sorghum-oat-and-maize-eligible-for-gluten-free-products
#10
JOURNAL ARTICLE
Laura Gazza, Valeria Menga, Federica Taddei, Francesca Nocente, Elena Galassi, Chiara Natale, Chiara Lanzanova, Silvana Paone, Clara Fares
The technological and nutritional traits of food-grade sorghum hybrids, hulled/naked oat varieties and maize genotypes of different colors were studied for novel and healthier gluten-free foods. Oat genotypes showed the highest protein content, followed by maize and sorghum. The total starch and the total dietary fiber content were quite similar among the three species. Great variation was found in the amylose content, and the highest was in sorghum (27.12%), followed by oat 16.71% and maize 10.59%. Regarding the pasting profile, the rank of Peak Viscosity was sorghum (742...
March 24, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38611291/comparison-of-physical-and-compositional-attributes-between-commercial-plant-based-and-dairy-yogurts
#11
JOURNAL ARTICLE
Likhitha Marlapati, Rabia F S Basha, Amelia Navarre, Amanda J Kinchla, Alissa A Nolden
A primary strategy led by the food industry to improve the sustainability of the agricultural food supply is the development of modern plant-based alternatives. The information provided via marketing and product packaging provides consumers with the expectation that these products provide a similar product experience to conventional products, yet it is not well understood whether these commercial alternative products are comparable to traditional animal-based products. To aid in developing improved plant-based products, this study aimed to compare the quality and physical attributes of commercially available plant-based and dairy yogurts...
March 23, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38603934/effect-of-different-sous-vide-cooking-temperature-time-combinations-on-the-functional-and-sensory-properties-of-goose-meat
#12
JOURNAL ARTICLE
M Wereńska
The effect of goose meat sous-vide (SV) cooking at 6 combinations of temperature (60°C, 80°C) and time (4, 6, 12h) on selected functional properties was investigated. The study conducted an assessment of cooking loss (CL), moisture content, pH, longitudinal (LS), and transverse (TS) shrinkage, shear force (SF), texture profile analysis (TPA), color parameters (L*, a*, b*, C, h°), ΔE and carried out sensory evaluation. A total of 168 breast muscles (BM with and without skin) from 17-wk-old "Polish oat geese" were utilized...
April 1, 2024: Poultry Science
https://read.qxmd.com/read/38600772/host-range-characterization-of-phytophthora-sansomeana-across-corn-soybean-wheat-winter-cereal-rye-dry-bean-and-oats-and-an-in-vitro-assessment-of-seed-treatment-sensitivity
#13
JOURNAL ARTICLE
Austin Glenn McCoy, Janette L Jacobs, Martin I Chilvers
Formally described in 2009, Phytophthora sansomeana is a pathogen of increasing interest in native, agricultural, and horticulturally important plant species. The objective of this study was to elucidate the symptomatic and asymptomatic host range of P. sansomeana on six agricultural crop species commonly used in field crop rotations in Michigan. In addition, sensitivity to oomicides commonly used in seed treatments including, oxathiapiprolin, mefenoxam, ethaboxam, and pyraclostrobin was performed to aid in disease management recommendations...
April 10, 2024: Plant Disease
https://read.qxmd.com/read/38594065/sars-cov-2-vaccine-uptake-and-risks-of-severe-covid-19-disease-among-people-prescribed-opioid-agonist-therapy-in-scotland
#14
JOURNAL ARTICLE
Alan Yeung, Max Wilkinson, Jen Bishop, Bob Taylor, Norah Palmateer, Lee Barnsdale, Jaroslaw Lang, Claire Cameron, Duncan McCormick, Tracey Clusker, Andrew McAuley, Sharon Hutchinson
BACKGROUND: There is limited evidence quantifying the risk of severe COVID-19 disease among people with opioid dependence. We examined vaccine uptake and severe disease (admission to critical care or death with COVID-19) among individuals prescribed opioid agonist therapy (OAT). METHOD: A case-control design was used to examine vaccine uptake in those prescribed OAT compared with the general population, and the association between severe disease and OAT. In both analyses, 10 controls from the general population were matched (to each OAT recipient and COVID-19 case, respectively) according to socio-demographic factors...
April 9, 2024: Journal of Epidemiology and Community Health
https://read.qxmd.com/read/38593178/photouranium-catalyzed-c-f-activation-hydroxylation-via-water-splitting
#15
JOURNAL ARTICLE
Xiu Zhao, Leiyang Bai, Jiayi Li, Xuefeng Jiang
The C-F bond is the strongest covalent single bond (126 kcal/mol) in carbon-centered bonds, in which the highest electronegativity of fluorine (χ = 4) gives rise to the shortest bond length (1.38 Å) and the smallest van der Waals radius ( r w = 1.47 Å), resulting in enormous challenges for activation and transformation. Herein, C-F conversion was realized via photouranium-catalyzed hydroxylation of unactivated aryl fluorides using water as a hydroxyl source to deliver multifunctional phenols under ambient conditions...
April 9, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38593116/comparative-characteristics-of-oat-doubled-haploids-and-oat-%C3%A3-maize-addition-lines-anatomical-features-of-the-leaves-chlorophyll-a-fluorescence-and-yield-parameters
#16
JOURNAL ARTICLE
Marzena Warchoł, Katarzyna Juzoń-Sikora, Dragana Rančić, Ilinka Pećinar, Tomasz Warzecha, Dominika Idziak-Helmcke, Kamila Laskoś, Ilona Czyczyło-Mysza, Kinga Dziurka, Edyta Skrzypek
As a result of oat (Avena sativa L.) × maize (Zea mays L.) crossing, maize chromosomes may not be completely eliminated at the early stages of embryogenesis, leading to the oat × maize addition (OMA) lines development. Introgression of maize chromosomes into oat genome can cause morphological and physiological modifications. The aim of the research was to evaluate the leaves' anatomy, chlorophyll a fluorescence, and yield parameter of oat doubled haploid (DH) and OMA lines obtained by oat × maize crossing...
2024: PloS One
https://read.qxmd.com/read/38592877/physiological-regulation-of-photosynthetic-related-indices-antioxidant-defense-and-proline-anabolism-on-drought-tolerance-of-wild-soybean-glycine-soja-l
#17
JOURNAL ARTICLE
Song Lin, Weimei Zhang, Guifeng Wang, Yunxiang Hu, Xuanbo Zhong, Guixiang Tang
Wild soybean ( Glycine soja L.), drought-tolerant cultivar Tiefeng 31 ( Glycine max L.), and drought-sensitive cultivar Fendou 93 ( Glycine max L.) were used as materials to investigate the drought tolerance mechanism after 72 h 2.5 M PEG 8000 (osmotic potential -0.54 MPa)-simulated drought stress at the seedling stage. The results indicated that the leaves of the G. soja did not wilt under drought stress. However, both the drought-tolerant and drought-sensitive cultivated soybean cultivars experienced varying degrees of leaf wilt...
March 19, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38592875/thiamethoxam-induced-intergenerational-sublethal-effects-on-the-life-history-and-feeding-behavior-of-rhopalosiphum-padi
#18
JOURNAL ARTICLE
Hina Gul, Ihsan Ul Haq, Ali Güncan, Arzlan Abbas, Shanza Khan, Aqsa Yaseen, Farman Ullah, Nicolas Desneux, Xiaoxia Liu
Thiamethoxam, a second-generation neonicotinoid insecticide is widely used for controlling sap-sucking insect pests including Rhopalosiphum padi . The current study aimed to investigate the life-history parameters and feeding behavior of R. padi following treatments with sublethal concentrations of thiamethoxam. The lethal concentration 50 (LC50 ) value of thiamethoxam against adult R. padi was 11.458 mg L-1 after 48 h exposure. The sublethal concentrations of thiamethoxam (LC5 and LC10 ) significantly decreased the adult longevity, fecundity, and reproductive days in the directly exposed aphids (F0 generation)...
March 17, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38592829/the-impact-of-peach-rootstocks-and-winter-cover-crops-on-reproduction-of-ring-nematode
#19
JOURNAL ARTICLE
Sagar Gc, Ivan Alarcon-Mendoza, David Harshman, Churamani Khanal
Two peach rootstocks ('Guardian' and 'MP-29') and ten winter cover crops (rye, wheat, barley, triticale, oat, Austrian winter pea, crimson clover, balansa clover, hairy vetch, and daikon radish) were evaluated in a greenhouse environment to determine their suitability to host ring nematode, Mesocriconema xenoplax . Each crop was inoculated with 500 ring nematodes, and the experiments were terminated 60 days after inoculation. The reproduction factor (ratio of final and initial nematode population) ranged from 0 to 13...
March 12, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38589687/indoxyl-sulphate-tnf%C3%AE-axis-mediates-uremic-encephalopathy-in-rodent-acute-kidney-injury
#20
JOURNAL ARTICLE
Ling Jiang, Xue-Ying Sun, Si-Qian Wang, Yan-Lin Liu, Ling-Jue Lu, Wen-Han Wu, Hao Zhi, Zhong-Yan Wang, Xiao-Dong Liu, Li Liu
Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier (BBB) function. Anionic uremic toxins are substrates or inhibitors of organic anionic transporters (OATs). In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice...
April 8, 2024: Acta Pharmacologica Sinica
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