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Interferon gamma

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https://www.readbyqxmd.com/read/29692776/interleukin-15-cultured-dendritic-cells-enhance-anti-tumor-gamma-delta-t-cell-functions-through-il-15-secretion
#1
Heleen H Van Acker, Sébastien Anguille, Hans De Reu, Zwi N Berneman, Evelien L Smits, Viggo F Van Tendeloo
Dendritic cell (DC) vaccination can be an effective post-remission therapy for acute myeloid leukemia (AML). Yet, current DC vaccines do not encompass the ideal stimulatory triggers for innate gamma delta (γδ) T cell anti-tumor activity. Promoting type 1 cytotoxic γδ T cells in patients with AML is, however, most interesting, considering these unconventional T cells are primed for rapid function and exert meaningful control over AML. In this work, we demonstrate that interleukin (IL)-15 DCs have the capacity to enhance the anti-tumoral functions of γδ T cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29692308/functional-studies-of-t-regulatory-lymphocytes-in-human-schistosomiasis-in-western-kenya
#2
Bartholomew N Ondigo, Eric M Ndombi, Sarah C Nicholson, John K Oguso, Jennifer M Carter, Nupur Kittur, William Evan Secor, Diana M S Karanja, Daniel G Colley
Immunoregulation is considered a common feature of Schistosoma mansoni infections, and elevated levels of T regulatory (Treg) lymphocytes have been reported during chronic human schistosomiasis. We now report that the removal of Treg (CD4+/CD25hi /CD127low lymphocytes) from peripheral blood mononuclear cells (PBMCs) of S. mansoni -infected individuals leads to increased levels of phytohemagglutinin (PHA)-stimulated interferon gamma (IFNγ) production and decreased interleukin-10 (IL-10) responses. Exposure to schistosome antigens did not result in measurable IFNγ by either PBMC or Treg-depleted populations...
April 23, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29691471/baricitinib-induced-blockade-of-interferon-gamma-receptor-and-interleukin-6-receptor-for-the-prevention-and-treatment-of-graft-versus-host-disease
#3
Jaebok Choi, Matthew L Cooper, Karl Staser, Kidist Ashami, Kiran R Vij, Bing Wang, Lynne Marsala, Jessica Niswonger, Julie Ritchey, Bader Alahmari, Samuel Achilefu, Ikuo Tsunoda, Mark A Schroeder, John F DiPersio
The therapeutic benefits of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are derived from the graft-versus-leukemia (GvL) effects of the procedure. There is a strong association between the GvL effects and graft-versus-host disease (GvHD), a major life-threatening complication of allo-HSCT. The limiting of GvHD while maintaining the GvL effect remains the goal of allo-HSCT. Therefore, identifying optimal therapeutic targets to selectively suppress GvHD while maintaining the GvL effects represents a significant unmet medical need...
April 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29690614/cytokine-expression-and-macrophage-localization-in-xenograft-and-allograft-tumor-models-stimulated-with-lipopolysaccharide
#4
Junko Masuda, Tsukasa Shigehiro, Takuma Matsumoto, Ayano Satoh, Akifumi Mizutani, Chiho Umemura, Shoki Saito, Mayumi Kijihira, Eiji Takayama, Akimasa Seno, Hiroshi Murakami, Masaharu Seno
T cell-deficient mice such as nude mice are often used to generate tumor xenograft for the development of anticancer agents. However, the functionality of the other immune cells including macrophages, dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs) in the xenograft are largely unknown. Macrophages and dendritic cells (DCs) acquire functionally distinct properties in response to various environmental stimuli; the interaction of these cells with MDSCs in tumor microenvironments regulates cancer progression...
April 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29688129/genetic-and-substrate-level-modulation-of-bacillus-subtilis-physiology-for-enhanced-extracellular-human-interferon-gamma-production
#5
Nitin Kumar, Rajat Pandey, Ashish Anand Prabhu, Veeranki Venkata Dasu
Human interferon-gamma (hIFNG) production is limited by various gene level bottle-necks including translation, protein folding and secretion which depends upon the physiological state of the organism. In this study gene-level and substrate-level modulations have been used to control Bacillus subtilis physiology for >10.39 fold extracellular soluble hIFNG production. Two variants of the native human interferon-gamma gene (hifng) were designed and synthesized namely BScoIFNGhis and BScoIFNG having codon adaptation index 25...
April 24, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29687464/protective-effects-of-sea-cucumber-holothuria-atra-extract-on-testicular-dysfunction-induced-by-immune-suppressant-drugs-in-wistar-rats
#6
D Y Saad, M M Soliman, A A Mohamed, G B Youssef
The current study was aimed to evaluate the protective effect of Holothurian atra (HA) extract; naturally occurring marine resource, against methotrexate (MTX) induced testicular dysfunction. Mature rats received either MTX (20 mg/kg, intraperitoneally) or saline on the 7th day of experiment al design. Seven days prior and after MTX-injection, rats received HA at dose of 300 mg/kg intragastrically (HA + MTX group; HA group alone). Serum was extracted and testicular tissues were examined for the changes in serum biochemistry (liver & kidney biomarkers, testicular hormones and antioxidants), molecular and histopthological alterations using RT-PCR and immunohistochemistry...
April 23, 2018: Andrologia
https://www.readbyqxmd.com/read/29684601/the-effect-of-intermittent-hypoxia-under-different-temperature-on-the-immunomodulation-in-streptococcus-agalactiae-vaccinated-nile-tilapia-oreochromis-niloticus
#7
Jing Wang, Dan-Qi Lu, Biao Jiang, Heng-Li Luo, Ge-Ling Lu, An-Xing Li
Dissolved oxygen (DO) and temperature are the potential immunomodulators in fish and play the important roles in regulating immunity. We studied the effect of intermittent hypoxia under different temperature on the immunomodulation in vaccinated Nile tilapia (Oreochromis niloticus). The expression of immune-related genes, enzymatic activities, histology, cumulative mortality, and S. agalactiae clearance were assessed. Study conditions were intermittently hypoxic (4.0 ± 1.0 mg/L DO) at 30 ± 0.5 °C or 35 ± 0...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29682788/dot-enzyme-linked-immunosorbent-assay-strip-as-a-screening-tool-for-detection-of-autoantibody-to-interferon-gamma-in-sera-of-suspected-cases-of-adult-onset-immunodeficiency
#8
Kritsadee Rattanathammethee, Kriangkrai Chawansuntati, Romanee Chaiwarith, Jutarat Praparattanapan, Khuanchai Supparatpinyo, Jiraprapa Wipasa
BACKGROUND: Being able to detect the presence of autoantibodies to interferon (IFN)-γ in serum is essential for evaluating patients with suspected adult-onset immunodeficiency (AOID) with unusual intracellular infections. Most reported patients with AOID have been Asian, although the exact prevalence of this illness is unknown. To date, no standard assay exists to detect autoantibodies to IFN-γ. An easy-to-use, low-cost assay that can be performed in any laboratory would be a valuable tool for clinical management of AOID, as well as better reveal its prevalence...
April 22, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29680371/the-immunomodulatory-role-of-zinc-in-asthmatic-patients
#9
Nesrine A Mohamed, Marwa Rushdy, Asmaa S M Abdel-Rehim
BACKGROUND: Zinc deficiency may play an important role in the development of atopic asthma. THE AIM OF THE WORK: To assess serum zinc levels in adult atopic, non-atopic asthmatic patients, and in healthy controls and to investigate its modulatory effect on production of interferon gamma (IFN-γ) and interleukin-10 (IL-10) by peripheral blood mononuclear cells (PBMCs) in vitro. METHODS: Sixty asthmatics and 30 apparently healthy volunteers were included in this study...
April 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29678297/corrigendum-to-differentiation-dependent-expression-of-interferon-gamma-and-toll-like-receptor-9-in-3t3-f442a-adipocytes-biochimie-89-5-2007-669-675
#10
Wael Khazen, Jean-Pierre M'Bika, Martine Collinet, Mathieu Tramoni, Charles Chany, Ammar Achour, Claude Forest
No abstract text is available yet for this article.
April 17, 2018: Biochimie
https://www.readbyqxmd.com/read/29678232/type-i-and-type-ii-cytokine-production-of-cd4-t-cells-in-immune-response-biased-dairy-cattle-around-calving
#11
M A Paibomesai, S Sharif, N Karrow, B A Mallard
The peripartum period is a period of high stress, transition and management changes for dairy cows. It is associated with higher incidence of both metabolic and pathogenic disease. Both antibody-(AMIR) and cell-(CMIR) mediated immune responses play a key role in the maintenance of health in mammals protecting against extracellular and intracellular pathogens, respectively. Generally, interferon gamma (IFN-γ) has been associated with CMIR, whereas interleukin 4 (IL-4) has been associated with AMIR bias, and interleukin 17 (IL-17A) is associated with pro-inflammatory...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678229/the-use-of-serological-tests-in-combination-with-the-intradermal-tuberculin-test-maximizes-the-detection-of-tuberculosis-infected-goats
#12
Javier Bezos, Álvaro Roy, José Antonio Infantes-Lorenzo, Isabel González, Ángel Venteo, Beatriz Romero, Anna Grau, Olga Mínguez, Lucas Domínguez, Lucía de Juan
The diagnosis of tuberculosis (TB) in goats is based mainly on the single and comparative intradermal tuberculin (SIT and CIT) tests and, exceptionally, on the interferon-gamma (IFN-γ) assay, however they are not perfect in terms of sensitivity and specificity. Nevertheless, various serological assays that provide a potential cost-effective approach for the control of TB are also available or under development, and a variety of results have been reported regarding the ability of these tests to detect infected animals, particularly in the early stages of infection...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29677149/prior-puma-lentivirus-infection-modifies-early-immune-responses-and-attenuates-feline-immunodeficiency-virus-infection-in-cats
#13
Wendy S Sprague, Ryan M Troyer, Xin Zheng, Britta A Wood, Martha Macmillian, Scott Carver, Susan VandeWoude
We previously showed that cats that were infected with non-pathogenic Puma lentivirus (PLV) and then infected with pathogenic feline immunodeficiency virus (FIV) (co-infection with the host adapted/pathogenic virus) had delayed FIV proviral and RNA viral loads in blood, with viral set-points that were lower than cats infected solely with FIV. This difference was associated with global CD4⁺ T cell preservation, greater interferon gamma (IFN-γ) mRNA expression, and no cytotoxic T lymphocyte responses in co-infected cats relative to cats with a single FIV infection...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29674694/the-molecular-basis-of-jak-stat-inhibition-by-socs1
#14
Nicholas P D Liau, Artem Laktyushin, Isabelle S Lucet, James M Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of the family, can also inhibit JAK directly. Here we determine the structural basis of both these modes of inhibition. Due to alterations within the SOCS box domain, SOCS1 has a compromised ability to recruit Cullin5; however, it is a direct, potent and selective inhibitor of JAK catalytic activity...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674199/the-impact-of-female-fetal-sex-on-preeclampsia-and-the-maternal-immune-milieu
#15
Brandie D Taylor, Roberta B Ness, Mark A Klebanoff, Gong Tang, James M Roberts, David M Hougaard, Kristin Skogstrand, Catherine L Haggerty
OBJECTIVE: Small studies suggest that fetal sex alters maternal inflammation. We examined the association between fetal sex, preeclampsia and circulating maternal immune markers. METHODS: This was a secondary data analysis within a nested case-control study of 216 preeclamptic women and 432 randomly selected normotensive controls from the Collaborative Perinatal Project. All women had singleton, primiparous pregnancies without chronic health conditions. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between female fetal sex and preeclampsia...
February 24, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673733/effects-of-dietary-sodium-selenite-and-organic-selenium-sources-on-immune-and-inflammatory-responses-and-selenium-deposition-in-growing-pigs
#16
Michaela Falk, Aksel Bernhoft, Tore Framstad, Brit Salbu, Helene Wisløff, Trond M Kortner, Anja B Kristoffersen, Marianne Oropeza-Moe
The study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29669131/effect-of-dietary-fructooligosaccharide-supplementation-on-internal-organs-salmonella-colonization-immune-response-ileal-morphology-and-ileal-immunohistochemistry-in-laying-hens-challenged-with-salmonella-enteritidis
#17
Pratima Adhikari, Douglas E Cosby, Nelson A Cox, Monique S Franca, Susan M Williams, Robert M Gogal, Casey W Ritz, Woo K Kim
A study was conducted to evaluate the efficacy of fructooligosaccharides (FOS) in controlling the infection of Salmonella Enteritidis (SE) in White Leghorns. A total of 30 laying hens (white leghorns W-36) were challenged both orally and cloacally with approximately 108 colony-forming units of nalidxic acid resistant SE (SENAR) and divided into 3 treatments: 1) SENAR challenged + 0.0% FOS, 2) SENAR challenged + 0.5% FOS (Nutraflora), and 3) SENAR challenged + 1.0% FOS. SENAR recovery via fecal shedding was measured at 3- and 6-d post-infection (dpi), whereas in the ceca and internal organs, SENAR recovery was measured at 7-d post-infection...
April 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/29663956/paradox-of-serial-interferon-gamma-release-assays-variability-width-more-important-than-specificity-size
#18
J E Stout, R Belknap, Y-J Wu, C S Ho
SETTING: Serial screening for latent tuberculous infection (LTBI) is commonly performed in certain populations, such as health care workers. The high apparent conversion rate in some studies of interferon-gamma release assays is puzzling given the claimed high specificity of these tests. OBJECTIVE: To understand how test-retest variability, specificity, and underlying LTBI prevalence affect observed outcomes of repeated testing for LTBI. DESIGN: Mathematical model assuming constant test sensitivity and specificity over time and no new infections...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663954/characteristics-of-a-large-latent-tuberculous-infection-screening-programme-using-quantiferon-%C3%A2-tb-gold-in-korea
#19
H-J Hwang, J-H Park, S Nam, H-J Lee, H-J Kim, S Yu, S-Y Shin
BACKGROUND: As mentioned in the 'Action Strategy for TB Safe Korea' in March 2017, almost 2 million Koreans were screened for latent tuberculous infection (LTBI) in 2017. As a preliminary step, the Korean Institute of Tuberculosis (KIT) screened 23 824 individuals from various population groups. The present study aimed to characterise the data collected from the screening programme using the QuantiFERON®-TB Gold In-Tube (QFT) assay. METHODS: Interferon-gamma release assays were performed using the manual QFT or automated DS2 instruments...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663695/a-magnetically-responsive-biomaterial-system-for-flexibly-regulating-the-duration-between-pro-and-anti-inflammatory-cytokine-deliveries
#20
Anita E Tolouei, Nihan Dülger, Rosa Ghatee, Stephen Kennedy
While inflammation can be problematic, it is nonetheless necessary for proper tissue regeneration. However, it remains unclear how the magnitude and duration of the inflammatory response impacts regenerative outcome. This is partially due to the difficulty in temporally regulating macrophage phenotype at wound sites. Here, a magnetically responsive biomaterial system potentially capable of temporally regulating macrophage phenotypes through sequential, on-demand cytokine deliveries is presented. This material system is designed to (i) rapidly recruit proinflammatory macrophages (M1) through initial cytokine deliveries and (ii) subsequently transition macrophages toward anti-inflammatory phenotypes (M2s) through delayed, magnetically triggered cytokine release...
April 16, 2018: Advanced Healthcare Materials
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