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https://www.readbyqxmd.com/read/29926649/-effects-of-simulated-100-m-trimix-conventional-diving-on-oxidative-stress-and-inflammatory-reaction-in-rabbits
#1
Yang-Yang Li, Lu Shi, Yan-Meng Zhang, Chan-Juan Xiao, Hong-Tao Liu
OBJECTIVE: To investigate the effects of simulated 100 m Trimix conventional diving on tissue inflammatory cytokines in rabbits. METHODS: Eight New Zealand rabbits were performed a simulated 100 m Trimix conventional diving program which was established according to the Haldane theory. The expression levels of interferon-gamma(IFN- γ ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), myeloperoxidase(MPO) and matrix metallo proteinase-9 (MMP-9) in rabbits lung and brain tissues were detected by Elisa after diving decompression...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926339/immunological-role-of-cd4-cd28-null-t-lymphocytes-natural-killer-cells-and-interferon-gamma-in-pediatric-patients-with-sickle-cell-disease-relation-to-disease-severity-and-response-to-therapy
#2
Mohsen Saleh ElAlfy, Amira Abdel Moneam Adly, Fatma Soliman ElSayed Ebeid, Deena Samir Eissa, Eman Abdel Rahman Ismail, Yasser Hassan Mohammed, Manar Elsayed Ahmed, Aya Sayed Saad
Sickle cell disease (SCD) is associated with alterations in immune phenotypes. CD4+ CD28null T lymphocytes have pro-inflammatory functions and are linked to vascular diseases. To assess the percentage of CD4+ CD28null T lymphocytes, natural killer cells (NK), and IFN-gamma levels, we compared 40 children and adolescents with SCD with 40 healthy controls and evaluated their relation to disease severity and response to therapy. Patients with SCD steady state were studied, focusing on history of frequent vaso-occlusive crisis, hydroxyurea therapy, and IFN-gamma levels...
June 20, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29925772/lead-pb-exposure-enhances-expression-of-factors-associated-with-inflammation
#3
REVIEW
Emilia Metryka, Karina Chibowska, Izabela Gutowska, Anna Falkowska, Patrycja Kupnicka, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka
The human immune system is constantly exposed to xenobiotics and pathogens from the environment. Although the mechanisms underlying their influence have already been at least partially recognized, the effects of some factors, such as lead (Pb), still need to be clarified. The results of many studies indicate that Pb has a negative effect on the immune system, and in our review, we summarize the most recent evidence that Pb can promote inflammatory response. We also discuss possible molecular and biochemical mechanisms of its proinflammatory action, including the influence of Pb on cytokine metabolism (interleukins IL-2, IL-4, IL-8, IL-1b, IL-6), interferon gamma (IFNγ), and tumor necrosis factor alpha (TNF-α); the activity and expression of enzymes involved in the inflammatory process (cyclooxygenases); and the effect on selected acute phase proteins: C-reactive protein (CRP), haptoglobin, and ceruloplasmin...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29922267/an-improved-tobacco-mosaic-virus-tmv-conjugated-multiantigen-subunit-vaccine-against-respiratory-tularemia
#4
Ahd A Mansour, Sukalyani Banik, Ragavan V Suresh, Hardeep Kaur, Meenakshi Malik, Alison A McCormick, Chandra S Bakshi
Francisella tularensis , the causative agent of the fatal human disease known as tularemia is classified as a Category A Select Agent by the Centers for Disease Control. No licensed vaccine is currently available for prevention of tularemia in the United States. Previously, we published that a tri-antigen tobacco mosaic virus (TMV) vaccine confers 50% protection in immunized mice against respiratory tularemia caused by F. tularensis . In this study, we refined the TMV-vaccine formulation to improve the level of protection in immunized C57BL/6 mice against respiratory tularemia...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29915722/new-therapies-and-immunological-findings-in-cutaneous-t-cell-lymphoma
#5
REVIEW
Kazuyasu Fujii
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Both diseases are considered T-helper cell type 2 (Th2) diseases. Not only the tumor cells but also the tumor microenvironment can promote Th2 differentiation, which is beneficial for the tumor cells because a Th1 environment enhances antitumor immune responses...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29915022/enhanced-cancer-immunotherapy-with-smad3-slilencing-nk-92-cells
#6
Qing Ming Wang, Patrick Ming-Kuen Tang, Guang-Yu Lian, Chunjie Li, Jinghong Li, Xiao-Ru Huang, Ka-Fai To, Hui-Yao Lan
Natural killer (NK) cells, early effectors in anti-cancer immunity, are paralyzed by TGF-β1, an immunosuppressive cytokine produced by cancer cells. Development and activity of NK cells are largely inhibited in the Smad3-dependent tumor microenvironment. Here, we used genetic engineering to generate a stable SMAD3-silencing human NK cell line NK-92-S3KD, whose cancer-killing activity and cytokine production were significantly enhanced under TGF-β1-rich condition compared to the parental cell line. Interestingly, we identified that IFNG gene is a direct E4BP4 target gene...
June 18, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29914793/stimulated-peripheral-blood-mononuclear-cells-from-chlamydia-infected-women-release-predominantly-th1-polarizing-cytokines
#7
Stephen J Jordan, Rakesh K Bakshi, LaDraka' T Brown, Xiaofei Chi, William M Geisler
Chlamydia trachomatis infection (chlamydia) is the most prevalent sexually transmitted bacterial infection and causes significant reproductive morbidity in women. Little is known about how immunity to chlamydia develops in women, though animal models of chlamydia indicate that T-helper type 1 (Th1) responses are important for chlamydia clearance and protective immunity, whereas T-helper type 2 (Th2) responses are associated with persisting infection. In chlamydia-infected women, whether the predominant immune response is Th1- or Th2-polarizing remains controversial...
June 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29914681/ip-10-a-potential-biomarker-for-detection-of-mycobacterium-bovis-infection-in-warthogs-phacochoerus-africanus
#8
Eduard O Roos, Francisco Olea-Popelka, Peter Buss, Lin-Mari de Klerk-Lorist, David Cooper, Robin M Warren, Paul D van Helden, Sven D C Parsons, Michele A Miller
Bovine tuberculosis (bTB) is endemic in several areas of South Africa and has been reported in multiple species, including common warthogs (Phacochoerus africanus). Limited diagnostic tests and disease control programs exist for African wildlife. Thus, there is a need to develop techniques for bTB detection in species such as warthogs to assess their role in disease maintenance and spread in multi-host ecosystems. In this study, we obtained blood samples from warthogs in bTB endemic areas to investigate biomarkers for detection of Mycobacterium bovis infection...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29914675/antigen-specific-interferon-gamma-release-is-decreased-following-the-single-intradermal-comparative-cervical-skin-test-in-african-buffaloes-syncerus-caffer
#9
C Clarke, D Cooper, W J Goosen, R McFadyen, R M Warren, P D van Helden, S D C Parsons, M A Miller
Effective disease management of wildlife relies on the strategic application of ante-mortem diagnostic tests for early identification and removal of M. bovis-infected animals. To improve diagnostic performance, interferon-gamma release assays (IGRAs) are often used in conjunction with the tuberculin skin test (TST). Since buffaloes are major maintenance hosts of M. bovis, optimal application of bovine TB diagnostic tests are especially important. We aimed to determine whether the timing of blood collection relative to the TST has an influence on IFN-γ production and diagnostic outcome in African buffaloes...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29914604/diagnostic-imaging-of-hepatic-tuberculosis-case-series
#10
V Schininà, F Albarello, M Cristofaro, F Di Stefano, N Fusco, G Cuzzi, S M Arend, D Goletti, E Busi Rizzi
BACKGROUND: Hepatic tuberculosis (TB) shows non-specific symptoms, and liver imaging may provide diagnostic clues. Here we describe a series of patients with hepatic TB showing characteristic radiological findings. METHODS: Single-centre retrospective evaluation of patients with hepatic TB diagnosed over a period of 16 years who underwent ultrasound, computed tomography (CT) and/or magnetic resonance imaging (MRI). Hepatic lesions were classified as miliary, nodular, serohepatic or cholangitis...
July 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29914252/saliva-levels-of-caspase-1-tnf-%C3%AE-and-ifn-%C3%AE-in-primary-sj%C3%A3-gren-s-syndrome-oral-mucosal-abnormalities-revisited
#11
Gonca Karabulut, Gül Kitapçıoğlu, Özgün Özçaka, Esin Alpöz, Ayşe Nalbantsoy, Hayriye Koçanaoğulları, Sercan Gücenmez, Gökhan Keser, Yasemin Kabasakal
Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjögren's syndrome (pSjS). We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) in patients with pSjS. Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as well as 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS, indicating low disease activity...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29914089/nobiletin-inhibits-cd36-dependent-tumor-angiogenesis-migration-invasion-and-sphere-formation-through-the-cd36-stat3-nf-%C3%AE-b-signaling-axis
#12
Nipin Sp, Dong Young Kang, Doh Hoon Kim, Jong Hwan Park, Hyo Gun Lee, Hye Jee Kim, Pramod Darvin, Yeong-Min Park, Young Mok Yang
Targeted cancer therapy with natural compounds is more effective than nontargeted therapy. Nobiletin is a flavonoid derived from citrus peel that has anticancer activity. Cluster of differentiation 36 (CD36) is a member of the class B scavenger receptor family that is involved in importing fatty acids into cells. CD36 plays a role in tumor angiogenesis by binding to its ligand, thrombospondin-1 (TSP-1), and then interacting with transforming growth factor beta 1 (TGFβ1). CD36 is implicated in tumor metastasis through its roles in fatty acid metabolism...
June 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29910738/immunomodulatory-effects-of-dietary-seaweeds-in-lps-challenged-atlantic-salmon-salmo-salar-as-determined-by-deep-rna-sequencing-of-the-head-kidney-transcriptome
#13
Arjan P Palstra, Jeroen Kals, Ainhoa Blanco Garcia, Ron P Dirks, Marnix Poelman
Seaweeds may represent immuno-stimulants that could be used as health-promoting fish feed components. This study was performed to gain insights into the immunomodulatory effects of dietary seaweeds in Atlantic salmon. Specifically tested were 10% inclusion levels of Laminaria digitata (SW1) and a commercial blend of seaweeds (Oceanfeed® ) (SW2) against a fishmeal based control diet (FMC). Differences between groups were assessed in growth, feed conversion ratio and blood parameters hematocrit and hemoglobin...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29906789/new-and-noteworthy-in-tuberculosis-diagnostics-and-treatment
#14
Susan Swindells
People with HIV infection with latent tuberculosis (TB) infection (LTBI) are at a 10-fold greater risk of developing active disease. Interferon gamma release assays and tuberculin skin testing have approximately 65% to 70% specificity for diagnosing LTBI in HIV-infected patients. LTBI can be successfully treated with isoniazid preventive therapy and early antiretroviral therapy (ART). Rapid molecular diagnostics have approximately 88% sensitivity and 98% specificity for identifying active TB. ART should be started early in patients with TB...
June 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29904578/early-clearance-versus-control-what-is-the-meaning-of-a-negative-tuberculin-skin-test-or-interferon-gamma-release-assay-following-exposure-to-mycobacterium-tuberculosis
#15
REVIEW
Erin W Meermeier, David M Lewinsohn
The elimination of tuberculosis (TB) cannot reasonably be achieved by treatment of individual cases and will require an improved vaccine or immunotherapy. A challenge in developing an improved TB vaccine has been the lack of understanding what is needed to generate sterilizing immunity against Mycobacterium tuberculosis (Mtb) infection. Several epidemiological observations support the hypothesis that humans can eradicate Mtb following exposure. This has been termed early clearance and is defined as elimination of Mtb infection prior to the development of an adaptive immune response, as measured by a tuberculin skin test or interferon-gamma release assay...
2018: F1000Research
https://www.readbyqxmd.com/read/29904012/tuberculosis-specific-interferon-gamma-production-in-a-current-refugee-cohort-in-western-europe
#16
Alexandra Jablonka, Christian Dopfer, Christine Happle, Georgios Sogkas, Diana Ernst, Faranaz Atschekzei, Stefanie Hirsch, Annabelle Schäll, Adan Jirmo, Philipp Solbach, Reinhold Ernst Schmidt, Georg M N Behrens, Martin Wetzke
BACKGROUND: In 2015, a high number of refugees with largely unknown health statuses immigrated to Western Europe. To improve caretaking strategies, we assessed the prevalence of latent tuberculosis infection (LTBI) in a refugee cohort. METHODS: Interferon-Gamma release assays (IGRA, Quantiferon) were performed in n = 232 inhabitants of four German refugee centers in the summer of 2015. RESULTS: Most refugees were young, male adults. Overall, IGRA testing was positive in 17...
June 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29902634/interferon-gamma-transcript-detection-on-t-cells-based-on-magnetic-actuation-and-multiplex-double-tagging-electrochemical-genosensing
#17
Soledad Carinelli, Cristina Xufré, Mercè Martí, María Isabel Pividori
Interferon-γ is a proinflammatory cytokine, and its production is related with effective host defense against intracellular pathogens. Therefore, the level of interferon-γ is considered a good biomarker for intracellular infections. It is also useful for the assessment, treatment progression and follow-up of non-communicable diseases, including cancer and autoimmune disorders, among others. This work addresses the development of a novel interferon-γ release assay (IGRA) to evaluate the expression of interferon-γ transcripts as biomarker produced by isolated T cells, as a main advantage...
May 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29901251/latent-tuberculosis-infection-opportunities-and-challenges
#18
REVIEW
Cynthia B E Chee, Randall Reves, Ying Zhang, Robert Belknap
Diagnosing and treating latent tuberculosis (TB) infection (LTBI) is recognized by the World Health Organization as an important strategy to accelerate the decline in global TB and achieve TB elimination. Even among low-TB burden countries that have achieved high rates of detection and successful treatment for active TB, a number of barriers have prevented implementing or expanding LTBI treatment programmes. Of those infected with TB, relatively few will develop active disease and the current diagnostic tests have a low predictive value...
June 14, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29899087/human-asymptomatic-epitope-peptide-cxcl10-based-prime-pull-vaccine-induces-herpes-simplex-virus-specific-gamma-interferon-positive-cd107-cd8-t-cells-that-infiltrate-the-cornea-and-trigeminal-ganglia-of-humanized-hla-transgenic-rabbits-and-protect-against-ocular
#19
Arif A Khan, Ruchi Srivastava, Hawa Vahed, Soumyabrata Roy, Sager S Walia, Grace J Kim, Mona A Fouladi, Taikun Yamada, Vincent T Ly, Cynthia Lam, Anthony Lou, Vivianna Nguyen, Undariya Boldbaatar, Roger Geertsema, Nigel W Fraser, Lbachir BenMohamed
Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea causing potentially blinding herpetic disease. A clinical herpes vaccine is still lacking. In the present study, a novel prime/pull vaccine was tested in Human Leukocyte Antigen- (HLA-) transgenic rabbit model of ocular herpes (HLA Tg rabbit). Three asymptomatic (ASYMP) peptide epitopes were selected from the HSV-1 membrane glycoprotein C (UL44400-408 ), the DNA replication binding helicase (UL9196-204 ), and the tegument protein (UL25572-580 ), all preferentially recognized by CD8+ T cells from "naturally protected" HSV-1-seropositive healthy ASYMP individuals (who never had recurrent corneal herpetic disease)...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29898582/decreased-il-1ra-and-ncam-1-cd56-serum-levels-in-unmedicated-patients-with-schizophrenia-before-and-after-antipsychotic-treatment
#20
Che-Sheng Chu, Dian-Jeng Li, Chin-Liang Chu, Chih-Ching Wu, Ti Lu
Objective: Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ. Methods: Thirty patients with SZ without antipsychotic treatment for at least two weeks participated. We measured the serum levels of fourteen cytokines at hospital admission and after 8-week antipsychotic treatment. Severity was measured by expanded version of 24-items brief psychiatric rating scale (BPRS-E)...
June 15, 2018: Psychiatry Investigation
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