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Sudarshan Singh Rathore, Muthukrishnan Isravel, Sridharan Vellaisamy, David Raj Chellappan, Lalitha Cheepurupalli, Thiagarajan Raman, Jayapradha Ramakrishnan
Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory potential. The efficacy of compound-6 in pulmonary cryptococosis model using H99 strain was investigated. The effective dose was found to provide 100% survival, with a significant reduction of yeast burden in lungs and brain...
November 13, 2017: Scientific Reports
Mahmoud Shorman, Derek Evans, Christy Gibson, John Perfect
Cryptococcosis is a fungal disease which has been characterized by its identified risk groups. There are many risk factors identified. We present a surprising four cases of disseminated cryptococcosis in intravenous drug abuse (IVDA) patients in a short period of time and in one geographical area, this observation suggest that there may be a new association with IVDA and cryptococosis.
December 2016: Medical Mycology Case Reports
Dayany da Silva A Maciel, Viviane P Freitas, Geanne A Alves Conserva, Tatiana R Alexandre, Sonia U Purisco, Andre G Tempone, Márcia Souza C Melhem, Massuo J Kato, Elsie F Guimarães, João Henrique G Lago
Crude CH2Cl2 extract from leaves of Piper laevicarpu (Piperaceae) displayed antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi (Y strain) and antimicrobial potential against Cryptococcus gattii (strain-type WM 178). Bioactivity-guided fractionation of crude extract afforded one new natural bioactive lactam derivative, named laevicarpin. The structure of isolated compound, which displayed a very rare ring system, was elucidated based on NMR, IR and MS spectral analysis. Using MTT assay, the trypomastigotes of T...
June 2016: Fitoterapia
Rodrigo Ferreyra Dillon, Cruz D Lascano, Fernando Riera, Eduardo Albiero
No abstract text is available yet for this article.
March 2011: Reumatología Clinica
Juliana Grechi, Monica Marinho-Carvalho, Patricia Zancan, Leonardo Paes Cinelli, Andre M O Gomes, Marcio L Rodrigues, Leonardo Nimrichter, Mauro Sola-Penna
The encapsulated yeast Cryptococcus neoformans is the causative agent of cryptococosis, an opportunistic life-threatening infection. C. neoformans is coated by a polysaccharide capsule mainly composed of glucuronoxylomannan (GXM). GXM is considered a key virulence factor of this pathogen. The present work aimed at evaluating the effects of GXM on the key glycolytic enzyme, 6-phosphofructo-1-kinase (PFK). GXM inhibited PFK activity in cultured murine macrophages in both dose- and time-dependent manners, which occurred in parallel to cell viability decrease...
April 29, 2011: Journal of Biological Chemistry
P C Oliveira, C S Q Medeiros, D P C Macêdo, S L Andrade, M T A L Correia, S D Mesquita, R G Lima-Neto, R P Neves
AIMS: The in vitro activity of ciclopirox olamine was evaluated against Cryptococcus spp. obtained from the cerebrospinal fluid (CSF) of immunocompromised patients. METHODS AND RESULTS: The antifungal activity of ciclopirox olamine was tested against Cryptococcus spp. obtained from the CSF of immunocompromised patients, using amphotericin B and fluconazole as controls. The minimal inhibitory concentration was determined following the microdilution method indicated by the Clinical and Laboratory Standards Institute...
November 2010: Letters in Applied Microbiology
Paul Persad, Rajendrakumar Patel, Jeffery Stephens, Sandy Francis-Rogers, Praveen Talat
Cryptococcal skin infection in persons with AIDS has been demonstrated. We describe a patient with nasal and facial infection with cryptococci after traumatic injury with battery acid.
2010: Dermatology Online Journal
Lázaro Vélez, Luz Teresita Correa, Maria Angélica Maya, Patricia Mejía, Jorge Ortega, Victoria Bedoya, Héctor Ortega
BACKGROUND: Fast and accurate etiologic diagnosis of pneumonia in immunocompromised patients is essential for a good outcome. Utility of bronchoalveolar lavage (BAL) samples has already been established, but studies about them are scarce and limited to few countries. We aimed to evaluate the accuracy of a diagnostic protocol, emphasizing on local epidemiology, rapidity, and yield of different techniques. METHODS: One year prospective study of 101 consecutive immunosuppressed patients admitted with suspected pneumonia to a university hospital...
October 2007: Respiratory Medicine
Tomaz de Aquino Moreira, Marcelo Simão Ferreira, Rosineide Marques Ribas, Aércio Sebastião Borges
Ninety-six patients with cryptococcosis confirmed by clinical and laboratorial diagnosis were assessed in a prospective study in a University Hospital from March 1998 to November 2003; of these, 81.3% were HIV seropositive patients. Cryptococcus neoformans was isolated from different samples, of which the cerebrospinal fluid 74 (77%) was the most frequent. C. neoformans var neoformans was isolated in 89 cases, where as C. neoformans var gattii was isolated in 7. Cryptococcal meningoencephalitis was detected in 56...
May 2006: Revista da Sociedade Brasileira de Medicina Tropical
Weerawat Manosuthi, Somnuek Sungkanuparph, Supeda Thongyen, Nopphanath Chumpathat, Boonchuay Eampokalap, Unchana Thawornwan, Suporn Foongladda
OBJECTIVES: To compare the MICs of FLUconazole (FLU) and amphotericin B against isolates of Cryptococcus neoformans (C. neoformans) obtained from the CerebroSpinal Fluid (CSF); and clinical outcomes of HIV-infected patients diagnosed with cryptococcal meningitis. MATERIAL AND METHOD: There were two groups including those who did not receive FLU (group A) and those who did receive either FLU 400 mg/week for primary prophylaxis cryptococosis or 200 mg/day for secondary prophylaxis cryptococosis (group B)...
June 2006: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
A Guerrero, N Jain, D L Goldman, B C Fries
Phenotypic switching has been described in serotype A and D strains of Cryptococcus neoformans. It occurs in vivo during chronic infection and is associated with differential gene expression and changes in virulence. The switch involves changes in the polysaccharide capsule and cell wall that affect the yeast's ability to resist phagocytosis. In addition, the phenotypic switch variants elicit qualitatively different inflammatory responses in the host. In animal models of chronic cryptococosis, the immune response of the host ultimately determines which of the switch variants are selected and maintained...
January 2006: Microbiology
L Fernández Rodriguez, R Amann, E Verde, M Ortega, F Anaya
The incidence of cryptococosis ranges from 0.4-5.8% in renal transplant. Meningitis is the principal clinical manifestation, frequently with a subacute curse. In renal transplantation recipients, disseminated cryptococcosis appears as the more frequent presentation. We report a case of a 32 years old woman renal transplant recipient who presents altered mental status, headache and tremor during the month before her assessment to our hospital. Microbiological study was performed in cerebrospinal fluid and cryptococcus was isolated...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
M F Colom, S Frasés, C Ferrer, E Martín-Mazuelos, M Hermoso-de-Mendoza, J M Torres-Rodríguez, G Quindós
The study constitutes an approach to the knowledge of the epidemiology of cryptococosis in Spain. For detection of cases 167 Spanish hospitals were contacted. All cases included were accompanied by the correspondent isolate of Cryptococcus neoformans, together with clinical, demographic and mycological data. Results obtained from January 1998 to end of December 1999 are analysed and presented here. Fifty-six Spanish hospitals reported 58 cases of cryptococcosis; only 43 of them were adequately documented and accompanied by the clinical isolate...
September 2001: Revista Iberoamericana de Micología
Thi Xuan Tuyet Huynh, Huu Chi Nguyen, Minh Quang Vo, Sophie Odermatt-Biays, Antoine Degrémont, Denis Malvy
Cryptococcus neoformans affections during HIV-infection are frequent and serious. The aim of this study was to analyse the epidemiological, clinical, biological and therapeutic characteristics of cryptococcal meningitis in HIV-positive patients, admitted into the Center for Tropical Diseases Ho Chi Minh City (Vietnam), during a 5-month period (May-September 2001). Twenty-one patients (20 men and one woman) were included (identification of C. neoformans from the cerebrospinal fluid). The mean age was 28 years...
October 2003: Santé: Cahiers D'étude et de Recherches Francophones
Carlos José Castro-Sansores, Renán A Góngora-Biachi, Pedro González-Martínez
BACKGROUND: The frequency of neurologic manifestations of the central nervous system (CNS) as a defining disease of acquired immunodeficiency syndrome (AIDS) (neurologic manifestation defining disease [NMDD-AIDS]) varies according to geographic region. The aim of this study was to determine its prevalence among patients with AIDS diagnosed in the state of Yucatán, Mexico. METHODS: We carried out a retrospective study in which AIDS cases reported at the Health Department in the state of Yucatán, Mexico from January 1983 to July 2001 were analyzed...
January 2004: Archives of Medical Research
No abstract text is available yet for this article.
April 10, 1962: Japanese Journal of Medical Science & Biology
M J Vaca, C González, V Vega, M Martínez, M Paradelo
We present a casuistic revision of adrenal pathology, which was studied in our service during the period January 1977-July 2000. We reviewed 59.069 biopsies and 2.674 autopsies and we 84 cases. founded with the following findings: Primary tumors 25% Secundary tumors 51% Infectious diseases 11% Miscellaneous 12% Unsuitable for diagnosis 1% Hyperplasias, adenomas, pheochromocy-tomas, neuroblastoma, adenocarcinoma are included within primary tumors. The metastasic tumors corresponded to: lung, pancreas, mammary gland, kidney and carcinomas; endometrial adenocarcinoma, lymphoma, melanoma, hepatocarcinoma, gastric carcinoma, testicular teratocarcinoma, skin epidermoid carcinoma, uterus choriocarcinoma and a primary germinal tumor of the thymus...
2001: Revista de la Facultad de Ciencias Médicas
D Garza-Garza, J L Buendía-Uribe, E Martínez-Cruz, B Argüero-Licea
In Mexico cryptococosis ranks third in frequency among the mycoses ocurring as complications in AIDS patients. Neither the prevalence of the two varieties of C. neoformans in these patients nor the morphological and physiological changes suffered by these strains in AIDS patients are known. A total of 60 isolates were obtained from patients with AIDS from the Hospital de Infectología, Centro Médico "La Raza" IMSS. The identity of each isolate was established by: growth at 37 degrees C, colony and microscopic characteristics, urease and phenoloxidase activity, carbon sources assimilation...
July 1995: Revista Latinoamericana de Microbiología
F Kuze, T Kurasawa, N Maekawa, Y Suzuki
No abstract text is available yet for this article.
1977: Nihon Rinsho. Japanese Journal of Clinical Medicine
R Duperval, P E Hermans, N S Brewer, G D Roberts
Cryptococcus neoformans was isolated from 65 patients: 11 had meningitis, 11 had disseminated cryptococcosis without meningitis, and 43 had C neoformans isolated from the respiratory tract. Predisposing conditions and the diagnostic value of cultures from various sites and of the latex agglutination test on cerebrospinal fluid and serum are analyzed for patients with extrapulmonary disease. Nine patients had pleural effusions; the effusion was cultured in six and yielded C neoformans in four. None of 11 deaths among 43 patients with respiratory tract isolates could be attributed to cryptococosis...
July 1977: Chest
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