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https://www.readbyqxmd.com/read/29908374/clomiphene-citrate-increases-nitric-oxide-interleukin-10-and-reduces-matrix-metalloproteinase-9-in-women-with-polycystic-ovary-syndrome
#1
Angel Mercy Sylus, Hanumanthappa Nandeesha, Magadi Gopalakrishna Sridhar, Thyagaraju Chitra, Karli Sreenivasulu
OBJECTIVES: Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in PCOS, the effect of clomiphene citrate on them has not been studied till date. The present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9, nitric oxide and interleukin-10 levels in women with PCOS. STUDY DESIGN: 72 women diagnosed with PCOS were enrolled in the study...
June 8, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908372/association-of-fibrotic-remodeling-and-cytokines-chemokines-content-in-epicardial-adipose-tissue-with-atrial-myocardial-fibrosis-in-patients-with-atrial-fibrillation
#2
Ichitaro Abe, Yasushi Teshima, Hidekazu Kondo, Haruka Kaku, Shintaro Kira, Yuki Ikebe, Shotaro Saito, Akira Fukui, Tetsuji Shinohara, Kunio Yufu, Mikiko Nakagawa, Naoki Hijiya, Masatsugu Moriyama, Tatsuo Shimada, Shinji Miyamoto, Naohiko Takahashi
BACKGROUND: Epicardial adipose tissue (EAT) is associated with atrial fibrillation (AF), but the underlying mechanisms remain to be fully elucidated. OBJECTIVE: Using human left atrial appendage (LAA) samples, we examined the interactive relationship between the EAT profile and atrial myocardial fibrosis through histological and biochemical analyses. METHODS: LAA samples were obtained from 59 consecutive AF patients during cardiovascular surgery...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29908317/decreased-interleukin-35-serum-levels-in-patients-with-chronic-spontaneous-urticaria
#3
Tao Chen, Li-Xin Fu, Qiao-Mei Sun, Pei-Mei Zhou, Zai-Pei Guo
No abstract text is available yet for this article.
June 13, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29908291/tumor-necrosis-factor-%C3%AE-interleukin-8-and-eosinophil-cationic-protein-as-serum-markers-of-glucocorticoid-efficacy-in-the-treatment-of-bronchial-asthma
#4
Jing Ren, Yong Sun, Gang Li, Xiao-Jue Zhu, Jin-Guo Cui
BACKGROUND: Bronchial asthma (BA) is a common chronic respiratory disease that has exhibited a rising global incidence in recent years. Glucocorticoids are used for the treatment of BA. Emerging evidence has demonstrated the roles of tumor necrosis factor (TNF-α), interleukin-8 (IL-8) and eosinophil cationic protein (ECP) in BA. The present study investigated whether TNF-α, IL-8 and ECP were associated with the clinical stages and severity of BA and the efficacy of glucocorticoids in the treatment of BA...
June 13, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29908286/il-6-deficiency-alters-spatial-memory-in-4-and-24-month-old-mice
#5
Izabela Bialuk, Andrzej Taranta, Maria Małgorzata Winnicka
Significance of interleukin 6 (IL-6) deficiency in cognitive processes was evaluated in 4- and 24-month-old C57BL/6J IL-6-deficient (IL-6 KO) and control (WT) mice in Morris water maze (MWM), holeboard test (HB) and elevated plus maze (EPM). During 3-day learning escape latency time (ELT) was longer in IL-6 KO than in WT mice, however their swimming was slower, floating longer, and path length did not differ. The comparison of ELT and the distance traveled between the first and the third learning day within each group revealed significant decrease of ELT in all groups with the highest difference in 4-month-old WT mice, and significant decrease of distance travelled only in both groups of WT mice...
June 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29908261/a-proteomic-study-of-the-pulmonary-injury-induced-by-microcystin-lr-in-mice
#6
Sujuan Zhao, Hong Sun, Wei Yan, Dexiang Xu, Tong Shen
MCLR has been shown to act as potent hepatotoxin, and recent studies showed that MCs can accumulate in lung tissue and exert adverse effects. However, the exact mechanism still remain unclear. The present study mainly focuses on the impairments of respiratory system after MCLR exposure in mice. After intratracheal instillation with MCLR (0, 10 and 25 μg/kg bw), histological change was examined in MCLR exposure groups. Results indicated that exposure of MCLR led to serious histopathology alteration and apoptosis in lung of mice...
June 13, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29908151/vaccination-with-a-cd4-and-cd8-t-cell-epitopes-based-recombinant-chimeric-protein-derived-from-leishmania-infantum-proteins-confers-protective-immunity-against-visceral-leishmaniasis
#7
Daniel S Dias, Patrícia A F Ribeiro, Vívian T Martins, Daniela P Lage, Lourena E Costa, Miguel A Chávez-Fumagalli, Fernanda F Ramos, Thaís T O Santos, Fernanda Ludolf, Jamil S Oliveira, Tiago A O Mendes, Eduardo S Silva, Alexsandro S Galdino, Mariana C Duarte, Bruno M Roatt, Daniel Menezes-Souza, Antonio L Teixeira, Eduardo A F Coelho
Vaccination seems to be the best approach to control visceral leishmaniasis (VL). Resistance against infection is based on the development of a Th1 immune response characterized by the production of interferons-γ (IFN-γ), interleukin-12 (IL-12), granulocyte-macrophage-colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α), among others. A number of antigens have been tested as potential targets against the disease; few of them are able to stimulate human immune cells. In the present study, 1 prediction of MHC class I and II molecules-specific epitopes in the amino acid sequences of 3 Leishmania proteins: 1 hypothetical, prohibitin, and small glutamine-rich tetratricopeptide repeat-containing proteins, was performed using bioinformatics tools, and a T-cell epitopes-based recombinant chimeric protein was constructed, synthetized and purified to be evaluated in invitro and in vivo experiments...
May 22, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29908096/il-6-tnf-%C3%AE-levels-and-periodontal-status-changes-during-the-menstrual-cycle
#8
Hacer Sahin Aydınyurt, Yusuf Ziya Yuncu, Yasin Tekin, Abdullah Seckin Ertugrul
OBJECTIVES: Sex steroid hormones are thought to affect periodontal tissues. A clear understanding of the effect of the menstrual cycle on oral tissues would be an important milestone in the timing of dental interventions in the future. The aim of this longitudinal, prospective study was to evaluate clinical periodontal parameters and levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) during the menstrual cycle. METHODS: Forty-five patients were included in this study...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29908086/innate-immune-response-reflects-disease-activity-in-eosinophilic-granulomatosis-with-polyangiitis
#9
Naomi Tsurikisawa, Chiyako Oshikata, Maiko Watanabe, Takahiro Tsuburai, Takeshi Kaneko, Hiroshi Saito
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and type-2 innate lymphoid cells (ILC2) are involved in the innate and type-2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown. OBJECTIVE: We investigated the relationships among peripheral blood eosinophil count, serum IL-33 and TSLP concentration, and peripheral blood ILC2 count in patients with EGPA, chronic eosinophilic pneumonia (CEP), or bronchial asthma (BA)...
June 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29908068/macrophages-in-patients-with-recurrent-endometrial-polyps-could-exacerbate-th17-responses
#10
Yali Zhu, Zhihong Liu, Miaomiao Du, Lisha Yi, Guifang Gong, Xiang Tang
Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. However, the requirements of Th17 upregulation are yet unclear. Here, we recruited twenty-six females with symptomatic EP and twenty-four females without EP, and peripheral mononuclear cells were harvested for the examination of circulating immunity...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29907916/the-effects-of-melatonin-supplementation-on-inflammatory-markers-among-patients-with-metabolic-syndrome-or-related-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Maryam Akbari, Vahidreza Ostadmohammadi, Reza Tabrizi, Kamran B Lankarani, Seyed Taghi Heydari, Elaheh Amirani, Russel J Reiter, Zatollah Asemi
OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to determine the effect of melatonin supplementation on the inflammatory markers among individuals with metabolic syndrome (MetS) and related disorders. METHODS: We searched the following databases up to March 2018: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies...
June 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29907915/preventive-effects-of-guanosine-on-intestinal-inflammation-in-2-4-dinitrobenzene-sulfonic-acid-dnbs-induced-colitis-in-rats
#12
Maria Grazia Zizzo, Gaetano Caldara, Annalisa Bellanca, Domenico Nuzzo, Marta Di Carlo, Rosa Serio
BACKGROUND: Guanosine, a guanine-based purine, is an extracellular signaling molecule exerting anti-inflammatory and antioxidative effects in several in vivo and in vitro injury models. We aimed to investigate its protective effects on 2, 4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rat. METHODS: Rats were divided into five groups and colitis was induced by intracolonic instillation of DNBS (15 mg/rat). Guanosine (4 or 8 mg/kg) was administered for 6 days i...
June 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#13
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907781/attenuation-of-inflammatory-responses-by-syringaresinol-via-map-kinase-mediated-suppression-of-nf-%C3%AE%C2%BAb-signaling-in-vitro-and-in-vivo
#14
Vivek K Bajpai, Md Badrul Alam, Khong Trong Quan, Mi-Kyoung Ju, Rajib Majumder, Shruti Shukla, Yun Suk Huh, MinKyun Na, Sang Han Lee, Young-Kyu Han
We examined the anti-inflammatory effects of (+)-syringaresinol (SGRS), a lignan isolated from Rubia philippinensis, in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells using enzyme-based immuno assay, Western blotting, and RT-PCR analyses. Additionally, in vivo effects of SGRS in the acute inflammatory state were examined by using the carrageenan-induced hind paw edema assay in experimental mice. As a result, treatment with SGRS (25, 50, and 100 μM) inhibited protein expression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) as well as production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin-6 (IL-6) induced by LPS...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907525/tissue-restricted-adaptive-type-2-immunity-is-orchestrated-by-expression-of-the-costimulatory-molecule-ox40l-on-group-2-innate-lymphoid-cells
#15
Timotheus Y F Halim, Batika M J Rana, Jennifer A Walker, Bernhard Kerscher, Martin D Knolle, Helen E Jolin, Eva M Serrao, Liora Haim-Vilmovsky, Sarah A Teichmann, Hans-Reimer Rodewald, Marina Botto, Timothy J Vyse, Padraic G Fallon, Zhi Li, David R Withers, Andrew N J McKenzie
The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) provided tissue-restricted T cell co-stimulation that was indispensable for Th2 and regulatory T (Treg) cell responses in the lung and adipose tissue. Interleukin (IL)-33 administration resulted in organ-specific surface expression of OX40L on ILC2s and the concomitant expansion of Th2 and Treg cells, which was abolished upon deletion of OX40L on ILC2s (Il7raCre/+ Tnfsf4fl/fl mice)...
May 31, 2018: Immunity
https://www.readbyqxmd.com/read/29907500/inhibition-of-regulated-necrosis-attenuates-receptor-interacting-protein-kinase-1-mediated-ischemia-reperfusion-injury-after-lung-transplantation
#16
Takashi Kanou, Akihiro Ohsumi, Hyunhee Kim, Manyin Chen, Xiaohui Bai, Zehong Guan, David Hwang, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
BACKGROUND: Increasing evidence indicates that regulated necrosis plays a critical role during cell death caused by ischemia-reperfusion (IR) injury. Necroptosis is one form of regulated necrosis. Necrostatin-1 (Nec-1), an inhibitor of receptor-interacting protein kinase 1 (RIPK1), is known to reduce necroptosis. We investigated the effect of Nec-1 treatment on IR-induced lung injury in a rat lung transplant model. METHODS: Lewis rats were divided into 4 groups (n = 6 each): (1) Control (no treatment), (2) Donor treatment (D), (3) Recipient treatment (R), and (4) Donor plus Recipient treatment (D+R) groups...
April 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29907363/critical-roles-of-inflammation-in-atherosclerosis
#17
REVIEW
Junji Moriya
There is accumulating evidence that vascular inflammation plays critical roles in pathophysiology of atherosclerosis. It is widely accepted that both innate and adaptive immune responses are important for initiation and progression of atherosclerosis, which mainly consist of monocytes, macrophages, neutrophils, T lymphocytes, and B lymphocytes. Moreover, inflammatory biomarkers such as high-sensitivity C-reactive protein and interleukin-6 are known to predict future cardiovascular events, as well as conventional low-density or high-density lipoprotein cholesterol...
June 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29907361/mesenchymal-stem-cell-expression-of-interleukin-35-protects-against-ulcerative-colitis-by-suppressing-mucosal-immune-responses
#18
Yongjia Yan, Na Zhao, Xianghui He, Hao Guo, Zhixiang Zhang, Tong Liu
BACKGROUND: Interleukin-35 (IL-35) has recently been identified as an immunosuppressive cytokine that has been used as a potential therapy for chronic inflammatory and autoimmune diseases. However, there remains a paucity of data regarding its potential benefits after integration into mesenchymal stem cells (MSCs). METHODS: We used a dextran sulfate sodium (DSS)-induced colitis mice model and treated them with IL-35-MSCs, MSCs or saline. The body weight was recorded daily and inflammatory processes were determined...
June 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29907355/effect-of-changing-the-lipid-component-of-home-parenteral-nutrition-in-adults
#19
Sylwia Osowska, Marek Kunecki, Jacek Sobocki, Joanna Tokarczyk, Krystyna Majewska, Mohamed Omidi, Marek Radkowski, Helena L Fisk, Philip C Calder
BACKGROUND: The effect of different lipid emulsions (LEs) within the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. This study investigated the effect of changing adult HPN patients from a soybean oil based LE (Intralipid) to either a fish oil containing LE (providing n-3 fatty acids) (SMOFLipid) or an olive oil based LE (ClinOleic). METHODS: Thirty two adults receiving long-term HPN with Intralipid as the LE were transferred to receive either SMOFLipid (n = 13) or ClinOleic (n = 19) for 60 days...
June 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29907227/lactate-dehydrogenase-is-associated-with-28-day-mortality-in-patients-with-sepsis-a-retrospective-observational-study
#20
Jun Lu, Zhonghong Wei, Hua Jiang, Lu Cheng, Qiuhua Chen, Mingqi Chen, Jing Yan, Zhiguang Sun
BACKGROUND: Sepsis is a major health care problem, which affects millions of people around the world. Glucose metabolic reprogramming of immune cells plays a crucial role during advancement of sepsis. However, the association between glucose metabolic reprogramming and mortality in patients with sepsis is unclear. Lactate dehydrogenase (LDH) catalyzes the last step of glycolysis. Investigating the relationship between LDH and mortality is important to understand the effect of metabolic reprogramming on prognosis of patients with sepsis...
August 2018: Journal of Surgical Research
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