Isabela A G Pereira, Camila S Freitas, Raquel S B Câmara, Marcelo M Jesus, Daniela P Lage, Grasiele S V Tavares, Tauane G Soyer, Fernanda F Ramos, Nícia P Soares, Samira S Santiago, Vívian T Martins, Danniele L Vale, Breno L Pimenta, Fernanda Ludolf, Fabrício M Oliveira, Mariana C Duarte, Miguel A Chávez-Fumagalli, Adilson V Costa, Denise U Gonçalves, Bruno M Roatt, Róbson R Teixeira, Eduardo A F Coelho
Treatment against leishmaniasis presents problems, mainly due to the toxicity of the drugs, high cost, and the emergence of resistant strains. A previous study showed that two vanillin-derived synthetic molecules, 3s [4-(2-hydroxy-3-(4-octyl-1H-1,2,3-triazol-1-yl)propoxy)-3-methoxybenzaldehyde] and 3t [4-(3-(4-decyl-1H-1,2,3-triazol-1-yl)-2-hydroxypropoxy)-3-methoxybenzaldehyde], presented antileishmanial activity against Leishmania infantum, L. amazonensis, and L. braziliensis species. In the present work, 3s and 3t were evaluated to treat L...
March 19, 2024: Experimental Parasitology