keyword
MENU ▼
Read by QxMD icon Read
search

triazoles

keyword
https://www.readbyqxmd.com/read/28636973/amide-to-triazole-switch-vs-in-vivo-nep-inhibition-approaches-to-promote-radiopeptide-targeting-of-grpr-positive-tumors
#1
Theodosia Maina, Aikaterini Kaloudi, Ibai E Valverde, Thomas L Mindt, Berthold A Nock
INTRODUCTION: Radiolabeled bombesin (BBN)-analogs have been proposed for diagnosis and therapy of gastrin-releasing peptide receptor (GRPR)-expressing tumors, such as prostate, breast and lung cancer. Metabolic stability represents a crucial factor for the success of this approach by ensuring sufficient delivery of circulating radioligand to tumor sites. The amide-to-triazole switch on the backbone of DOTA-PEG4-[Nle(14)]BBN(7-14) (1) was reported to improve the in vitro stability of resulting (177)Lu-radioligands...
June 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28635308/combined-hqsar-topomer-comfa-homology-modeling-and-docking-studies-on-triazole-derivatives-as-sglt2-inhibitors
#2
Shuling Yu, Jintao Yuan, Yi Zhang, Shufang Gao, Ying Gan, Meng Han, Yuewen Chen, Qiaoqiao Zhou, Jiahua Shi
AIM: Sodium-glucose cotransporter 2 (SGLT2) is a promising target for diabetes therapy. We aimed to develop computational approaches to identify structural features for more potential SGLT2 inhibitors. MATERIALS & METHODS: In this work, 46 triazole derivatives as SGLT2 inhibitors were studied using a combination of several approaches, including hologram quantitative structure-activity relationships (HQSAR), topomer comparative molecular field analysis (CoMFA), homology modeling, and molecular docking...
June 21, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28635285/triazole-triazine-functionalized-mesoporous-silica-as-a-hybrid-material-support-for-palladium-nanocatalyst
#3
Ali Saad, Christian Vard, Manef Abderrabba, Mohamed Mehdi Chehimi
Noble and precious metal catalysts are sought for their remarkable efficiency in catalyzing numerous reactions in heterogeneous phase. However, they are costly and request the development of high surface area supports that favor their strong immobilization, dispersion and stability. Towards this end, mesoporous silica-based materials can be regarded as unique supports for nanometric-sized noble metal catalysts provided they are functionalized with appropriate ligands. In this work, mesoporous silica SBA-15 was prepared and modified with 3-azidopropyltriethoxysilane then clicked with alkyne derivatives of 1,3,5-triazines complex ligand...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28635283/piezoresistive-effect-in-the-fe-htrz-2-trz-bf4-spin-crossover-complex
#4
Andrei Diaconu, Simona-Lacramioara Lupu, Ionela Rusu, Ioan-Marian Risca, Lionel Salmon, Gabor Molnár, Azzedine Bousseksou, Philippe Demont, Aurelian Rotaru
We report on the effect of hydrostatic pressure on the electrical conductivity and dielectric permittivity of the [Fe(Htrz)2(trz)](BF4) (Htrz = 1H-1,2,4, triazole) spin crossover complex. Variable temperature and pressure broadband imped-ance spectrometry revealed a piezo-resistive effect of more than one order of magnitude for pressures as low as 500 bar, associated with a large pressure-induced hysteresis of 1700 bar. The origin of the piezo-resistive effect has been attributed to the pressure induced spin-state switching in the complex and the associated P,T phase diagram was determined...
June 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28634471/a-chitin-binding-protein-purified-from-moringa-oleifera-seeds-presents-anticandidal-activity-by-increasing-cell-membrane-permeability-and-reactive-oxygen-species-production
#5
João X S Neto, Mirella L Pereira, Jose T A Oliveira, Lady C B Rocha-Bezerra, Tiago D P Lopes, Helen P S Costa, Daniele O B Sousa, Bruno A M Rocha, Thalles B Grangeiro, José E C Freire, Ana Cristina O Monteiro-Moreira, Marina D P Lobo, Raimunda S N Brilhante, Ilka M Vasconcelos
Candida species are opportunistic pathogens that infect immunocompromised and/or immunosuppressed patients, particularly in hospital facilities, that besides representing a significant threat to health increase the risk of mortality. Apart from echinocandins and triazoles, which are well tolerated, most of the antifungal drugs used for candidiasis treatment can cause side effects and lead to the development of resistant strains. A promising alternative to the conventional treatments is the use of plant proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28634040/1-2-4-triazole-and-1-3-4-oxadiazole-analogues-synthesis-mo-studies-in-silico-molecular-docking-studies-antimalarial-as-dhfr-inhibitor-and-antimicrobial-activities
#6
Sampark S Thakkar, Parth Thakor, Hiren Doshi, Arabinda Ray
1,2,4-Triazole and 1,3,4-oxadiazole analogues are of interest due to their potential activity against microbial and malarial infections. In search of suitable antimicrobial and antimalarial compounds, we report here the synthesis, characterization and biological activities of 1,2,4-triazole and 1,3,4-oxadiazole analogues (SS 1-SS 10). The molecules were characterized by IR, mass, (1)H NMR, (13)C NMR and elemental analysis. The in vitro antimicrobial activity was investigated against pathogenic strains, the results were explained with the help of DFT and PM6 molecular orbital calculations...
May 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28632963/metal-ion-induced-in-situ-ligand-oxidation-for-self-assembled-clusters-from-bis-5-2-pyridine-2-yl-1-2-4-triazole-3-yl-methane-to-alcohol-or-ketone
#7
Wei-Quan Lin, Yuan-Yuan Peng, Lang Tong, Jian-Hua Jia, Jun-Liang Liu, Yan-Cong Chen, Wen-Bin Chen, Ming-Liang Tong
Hydrothermal reactions of metal nitrates and ligand bis(5-(pyridine-2-yl)-1,2,4-triazol-3-yl)methane (H2L1) on same condition gave three cluster compounds, {Cr2}, {Zn12} and {Fe8}. Notably, methylene group of H2L1 was in situ oxidized either to hydroxymethylated (L2-O)3- in the metallo-ring {Zn12} or to a rigid carbonylated (L3=O)2- in the screw-type {Fe8}. In light of comparative experiment results, NO3- was deduced to be of a catalytic role in ligand oxidation. Metal ions could be regarded as an "induced" tool for clusters generation in self-assembly process...
June 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28631487/chemoselective-nitrile-oxide-alkyne-1-3-dipolar-cycloaddition-reactions-from-nitroalkane-tethered-peptides
#8
Rahi M Reja, Sereena Sunny, Hosahudya N Gopi
Synthesis and incorporation of a new amino acid with a nitroalkane side chain into peptides, in situ transformation of a nitroalkane side chain into nitrile oxide, and chemoselective 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxide and different alkynes are reported. The nitroalkane-mediated nitrile oxide-alkyne cycloaddition was found to be orthogonal to the copper(I)-catalyzed azide-alkyne cycloaddition reaction. The combination of orthogonal nitrile oxide-alkyne and azide-alkyne cycloaddition reactions can be explored to tailor different 1,2,3-triazole and 3,5-isoxazoles, respectively, on the peptide backbone...
June 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/28630185/in-vivo-biomarker-analysis-of-intranasally-dosed-pc945-a-novel-antifungal-triazole-on-aspergillus-fumigatus-infection-in-immunocompromised-mice
#9
Genki Kimura, Takahiro Nakaoki, Thomas Colley, Garth Rapeport, Pete Strong, Kazuhiro Ito, Yasuo Kizawa
PC945 is a novel triazole optimised for lung delivery and the objective of this study is to determine the effects of intranasally dosed PC945 on Aspergillus fumigatus infection and associated biomarkers in immunocompromised mice. PC945, posaconazole or voriconazole was treated intranasally once daily on days 0 to 3 (early intervention) or days 1 to 3 (late intervention) post-infection in temporarily neutropenic A/J mice infected intranasally with A. fumigatus, and bronchoalveolar lavage fluid (BALF) and serum were collected on day 3...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28628279/acyclic-nucleoside-phosphonates-containing-9-deazahypoxanthine-and-a-5-membered-heterocycle-as-selective-inhibitors-of-plasmodial-6-oxopurine-phosphoribosyltransferases
#10
Martin Maxmilian Kaiser, Ondřej Baszczyňski, Dana Hocková, Lenka Poštová-Slavětínská, Martin Dračínský, Dianne T Keough, Luke W Guddat, Zlatko Janeba
Acyclic nucleoside phosphonates (ANPs) are an important class of therapeutic drugs that act as antiviral agents by inhibiting viral DNA polymerases and reverse transcriptases. ANPs containing a 6-oxopurine instead of 6-aminopurine or pyrimidine bases are inhibitors of the purine salvage enzyme, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase (HG[X]PRT). Such compounds, and their prodrugs, are able to arrest the growth of Plasmodium falciparum (Pf) in cell culture. A new series of ANPs has been synthesized and tested as inhibitors of human HGPRT, PfHGXPRT and Plasmodium vivax (Pv) HGPRT...
June 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28627751/synthesis-of-gem-dinitromethylated-and-fluorodinitromethylated-derivatives-of-5-5-dinitro-bis-1-2-4-triazole-as-promising-high-energy-density-materials
#11
Qinghua Zhang, Shi Huang, Junjun Tian, Xiujuan Tian, Kangcai Wang
The gem-dinitromethylated and fluorodinitromethylated 5,5'-dinitro-3,3'-bis-1,2,4-triazole (DNBT) (2 and 3) along with seven ionic derivatives (4-9) were successfully synthesized and characterized by NMR and IR spectroscopies, elemental analysis, single crystal X-ray diffraction (XRD), and differential scanning calorimetry (DSC). XRD revealed that compounds 2 and 3 were crystallized in the monoclinic P21/n space group and compound 5 was crystallized in the monoclinic P21/c space group. The physicochemical properties for the as-synthesized compounds 2-9 were investigated and the results indicated that compounds 3, 6 and 7 exhibited a good balance between high energy and low sensitivity, indicating their promise as new high-energy-density materials (HEDMs)...
June 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28625801/clinical-features-antifungal-susceptibility-and-outcome-of-candida-guilliermondii-fungemia-an-experience-in-a-tertiary-hospital-in-mid-taiwan
#12
Ting-Yu Tseng, Tsung-Chia Chen, Cheng-Mao Ho, Po-Chang Lin, Chia-Huei Chou, Chia-Ta Tsai, Jen-Hsien Wang, Chih-Yu Chi, Mao-Wang Ho
BACKGROUNDS: Candida guilliermondii is rarely isolated from clinical specimen. C. guilliermondii fungemia is seldom reported in the literature. The aims of this study were to report the clinical features, antifungal susceptibility, and outcomes of patients with C. guilliermondii fungemia. METHODS: From 2003 to 2015, we retrospectively analyzed the clinical and laboratory data of patients with C. guilliermondii fungemia in a tertiary hospital in mid-Taiwan. We performed a multivariable logistic regression analysis to identify the risk factors of mortality...
May 17, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28625362/urotensin-core-mimics-that-modulate-the-biological-activity-of-urotensin-ii-related-peptide-but-not-urotensin-ii
#13
Martin Strack, Étienne Billard, David Chatenet, William D Lubell
A novel approach for the synthesis of head-to-tail cyclic peptides has been developed and used to prepare two mimics of the urotensin II-related peptide (URP) cyclic core. Mimics 1 and 2 (c[Trp-Lys-Tyr-Gly-ψ(triazole)-Gly] and c[Phe-Trp-Lys-Tyr-Gly-ψ(triazole)-Gly]) were respectively prepared using a combination of solid- and solution-phase synthesis. The silyl-based alkyne-modifying (SAM) linker enabled installation of C-terminal alkyne and N-terminal azide moieties onto linear peptide precursors, which underwent head-to-tail copper-catalyzed azide-alkyne cycloaddition (CuAAC) in solution...
May 31, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28622580/combating-breast-cancer-with-non-steroidal-aromatase-inhibitors-nsais-understanding-the-chemico-biological-interactions-through-comparative-sar-qsar-study
#14
REVIEW
Nilanjan Adhikari, Sk Abdul Amin, Achintya Saha, Tarun Jha
It is a challenging task to design target-specific and less toxic non-steroidal aromatase inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have been continuing for more than two decades to fight the dreaded estrogen-dependent breast cancer. In this article, different validated QSAR models are developed and analyzed to understand important physicochemical and structural parameters modulating the aromatase inhibitory activity of NSAIs. Physicochemical properties such as molar refractivity and dipole moment are found to be the most important parameters for controlling aromatase inhibition...
May 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28622429/synthesis-and-antigenic-evaluation-of-oligosaccharide-mimics-of-vi-antigen-from-salmonella-typhi
#15
Xinshan Ye, Gao-Lan Zhang, Lin Yang, Jingjing Zhu
Salmonella typhi is responsible for typhoid fever, which is a serious health threat in developing countries. As a virulent factor of Salmonella typhi, the purified Vi polysaccharide (Vi PS) has become an effective vaccine to combat typhoid fever. The chemical synthesis can provide homogeneous and well-defined molecules for the development of Vi-based vaccines. However, the synthesis of Vi oligosaccharides in high yields and with exclusive α-stereoselectivities remains very challenging. In this paper, a series of Vi pseudooligosaccharides, including pseudo tetra-, hexa-, and octa-saccharides were efficiently synthesized...
June 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28621402/microwave-assisted-synthesis-of-hybrid-heterocycles-as-potential-anticancer-agents
#16
Avula Srinivas, Malladi Sunitha, Kammachichu Raju, Banothu Ravinder, Siluveru Anusha, Thallapalli Rajasri, Pothuganti Swapna, Dupa Sushmitha, Deva Swaroopa, Gurala Nikitha, Chakunta Rao
In a one pot procedure, a series of novel hybrid heterocycles 6a-g and 7a-g were prepared by condensation of (3aS,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde 5 with mercapto acids and primary amines in the presence of ZnCl2 under both microwave irradiation and conventional heating conditions. Compound 5 was prepared from di-acetone D-mannose via a click reaction, primary acetonide deprotection and oxidative cleavage. Characterization of new compounds has been done by IR, NMR, MS and elemental analysis...
June 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28621400/study-on-the-equilibria-of-the-complex-formation-of-the-ion-pair-of-germanium-iv-with-4-nitrocatechol-and-1-4-diphenyl-3-phenylamino-1h-1-2-4-triazole
#17
Petya Racheva, Kirila Stojnova, Vidka Divarova, Vanya Lekova
The complex formation of the ion-pair formed between the anionic chelate of Ge(IV)-4-nitrocatechol (4-NC) and the cation of 1,4-diphenyl-3-(phenylamino)-1H-1,2,4-triazole (Nitron, Nt) in the liquid-liquid extraction system Ge(IV)-4-NC-Nt-H2O-CHCl3 was studied by spectrophotometry. The optimum extraction-spectrophotometric conditions for the complex formation were established. The validity of Beer's law was checked and some analytical characteristics of the system were calculated. The effect of co-existing ions and reagents on the process of complex formation was investigated...
June 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28619946/controlling-guest-conformation-for-efficient-purification-of-butadiene
#18
Pei-Qin Liao, Ning-Yu Huang, Wei-Xiong Zhang, Jie-Peng Zhang, Xiao-Ming Chen
Conventional adsorbents preferentially adsorb the small, high-polarity, and unsaturated 1,3-butadiene molecule over the other C4 hydrocarbons from which it must be separated. We show from single-crystal x-ray diffraction and computational simulation that a hydrophilic metal-organic framework, [Zn2(btm)2], where H2btm is bis(5-methyl-1H-1,2,4-triazol-3-yl)methane, has quasi-discrete pores that can induce conformational changes in the flexible guest molecules, weakening 1,3-butadiene adsorption through a large bending energy penalty...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28618988/synthesis-docking-and-anti-inflammatory-activity-of-triazole-amine-derivatives-as-potential-phosphodiesterase-4-inhibitors
#19
Ajmer Singh Grewal, Viney Lather, Deepti Pandita, Ruchi Dalal
BACKGROUND: Phosphodiesterase 4 (PDE4), one of the member of PDE superfamily catalyzes, the hydrolysis of cyclic adenosine monophosphate to adenosine monophosphate in pro-inflammatory and immunomodulatory cells leading to increased inflammatory processes. PDE4 has been reported as an attractive therapeutic target involved in various inflammatory disorders. OBJECTIVE: The present work was designed to synthesize and evaluate the anti-inflammatory activity of some new triazole amine derivatives as potential PDE4 inhibitors...
June 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28616429/evaluation-of-the-interaction-of-intravenous-and-oral-voriconazole-with-oral-cyclosporine-in-iranian-hsct-patients
#20
Hamidreza Taghvaye Masoumi, Molouk Hadjibabaie, Mohammad Vaezi, Ardeshir Ghavamzadeh
OBJECTIVE: Voriconazole as a triazole antifungal agent is widely used for prophylaxis or treatment of fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT). It can increase blood concentrations of other medications including cyclosporine A (CsA) which are substrates for cytochrome P450 3A4. The aim of this study was to evaluate comparatively the interaction between oral/intravenous (IV) voriconazole and oral CsA. METHODS: Twenty-nine recipients of allogeneic HSCT who had been already on a steady dose of CsA and were started on oral or IV voriconazole were evaluated in a prospective cohort study...
April 2017: Journal of Research in Pharmacy Practice
keyword
keyword
49915
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"