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Omega 3 aging

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https://www.readbyqxmd.com/read/27894336/curcumin-and-long-chain-omega-3-polyunsaturated-fatty-acids-for-prevention-of-type-2-diabetes-cop-d-study-protocol-for-a-randomised-controlled-trial
#1
Rohith N Thota, Shamasunder H Acharya, Kylie A Abbott, Manohar L Garg
BACKGROUND: Lifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D...
November 29, 2016: Trials
https://www.readbyqxmd.com/read/27889806/a-comparative-assessment-of-arsenic-risks-and-the-nutritional-benefits-of-fish-consumption-in-kuwait-arsenic-versus-omega-3-fatty-acids
#2
Adnan Husain, Kurunthachalam Kannan, Hing Man Chan, Brian Laird, Hanan Al-Amiri, Basma Dashti, Anwar Sultan, Amani Al-Othman, Bedraya Mandekar
Inorganic and organic forms of arsenic (As), as well as omega-3 fatty acids were measured in 578 fish/seafood samples that belong to 15 species of commonly consumed seafood in Kuwait. Arsenic speciation data, with the toxicological profile of inorganic arsenic (iAs) and fish consumption rates were applied in a probabilistic risk assessment to estimate the risk from exposure to iAs. The nutritional benefits of omega-3-fatty acid levels in various species of fish were taken into consideration. Results showed that the mean daily intake of iAs through fish consumption among the Kuwaiti population was 0...
November 26, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27880928/determination-of-red-blood-cell-fatty-acid-profiles-rapid-and-high-confident-analysis-by-chemical-ionization-gas-chromatography-tandem-mass-spectrometry
#3
Yvonne Schober, Hans Günther Wahl, Harald Renz, Wolfgang Andreas Nockher
Cellular fatty acid (FA) profiles have been acknowledged as biomarkers in various human diseases. Nevertheless, common FA analysis by gas chromatography mass spectrometry (GC-MS) requires long analysis time. Hence, there is a need for feasible methods for high throughput analysis in clinical studies. FA was extracted from red blood cells (RBC) and derivatized to fatty acid methyl esters (FAME). A method using gas chromatography tandem mass spectrometry (GC-MS/MS) with ammonia-induced chemical ionization (CI) was developed for the analysis of FA profiles in human RBC...
November 13, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27876342/omega-3-fatty-acids-supplementation-improves-endothelial-function-and-arterial-stiffness-in-hypertensive-patients-with-hypertriglyceridemia-and-high-cardiovascular-risk
#4
Marcela A Casanova, Fernanda Medeiros, Michelle Trindade, Célia Cohen, Wille Oigman, Mario Fritsch Neves
Association between hypertriglyceridemia and cardiovascular (CV) disease is still controversial. The purpose of this study was to compare omega-3 and ciprofibrate effects on the vascular structure and function in low and high CV risk hypertensive patients with hypertriglyceridemia. Twenty-nine adults with triglycerides 150-499 mg/dL were divided into low (<7.5%) and high (≥7.5%) CV risk, randomized to receive omega-3 fatty acids 1800 mg/d or ciprofibrate 100 mg/d for 12 weeks. Treatment was switched after 8-week washout...
October 26, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27864687/omega-3-fatty-acid-epa-improves-regenerative-capacity-of-mouse-skeletal-muscle-cells-exposed-to-saturated-fat-and-inflammation
#5
Amarjit Saini, Adam P Sharples, Nasser Al-Shanti, Claire E Stewart
Sarcopenic obesity is characterised by high fat mass, low muscle mass and an elevated inflammatory environmental milieu. We therefore investigated the effects of elevated inflammatory cytokine TNF-α (aging/obesity) and saturated fatty acid, palmitate (obesity) on skeletal muscle cells in the presence/absence of EPA, a-3 polyunsaturated fatty acid with proposed anti-inflammatory, anti-obesity activities. In the present study we show that palmitate was lipotoxic, inducing high levels of cell death and blocking myotube formation...
November 18, 2016: Biogerontology
https://www.readbyqxmd.com/read/27819485/pilot-randomized-controlled-trial-of-omega-3-and-individual-family-psychoeducational-psychotherapy-for-children-and-adolescents-with-depression
#6
Mary A Fristad, Anthony T Vesco, Andrea S Young, K Zachary Healy, Elias S Nader, William Gardner, Adina M Seidenfeld, Hannah L Wolfson, L Eugene Arnold
The goal of this study is to evaluate feasibility and estimate effect sizes of omega-3 fatty acids (Ω3), individual-family psychoeducational psychotherapy (PEP), their combination, and moderating effects of maternal depression and psychosocial stressors in youth with depression. In a pilot 2 × 2 randomized controlled trial, 72 youth (ages 7-14; 57% Caucasian, 57% male) with major depression, dysthymia, or depression not otherwise specified were randomized to 12 weeks of Ω3, PEP+placebo, Ω3+PEP, or placebo...
November 7, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27797641/effect-of-omega-3-fatty-acids-dietary-supplementation-on-ocular-surface-and-tear-film-in-diabetic-patients-with-dry-eye
#7
Constantine D Georgakopoulos, Olga E Makri, Dionisios Pagoulatos, Panagiotis Vasilakis, Politimi Peristeropoulou, Vasiliki Kouli, Maria I Eliopoulou, Caterina Psachoulia
OBJECTIVE: The objective of this study was to investigate the effect of dietary supplementation with omega-3 fatty acids on ocular surface and tear film in patients with type 2 diabetes suffering from dry eye. METHODS: Thirty-six patients suffering from type 2 diabetes and moderate to severe dry eye syndrome were included in the study. Patients were assigned to receive omega-3 long-chain polyunsaturated fatty acids for 3 months. Tear film break-up time test, Schirmer-I test, and conjunctival impression cytology analysis were performed on all patients at baseline and after 1 and 3 months...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27790827/omega-3-fatty-acids-predict-recurrent-venous-thromboembolism-or-total-mortality-in-elderly-patients-with-acute-venous-thromboembolism
#8
Martin F Reiner, Simona Stivala, Andreas Limacher, Nicole R Bonetti, Marie Méan, Michael Egloff, Nicolas Rodondi, Drahomir Aujesky, Clemens von Schacky, Thomas F Lüscher, Giovanni G Camici, Jürg H Beer
BACKGROUND: The role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) remains unknown. OBJECTIVES: To investigated the association of n-3 FAs with recurrent VTE or total mortality at six months and three years. METHODS: N-3 FAs were assessed in 826 patients aged ≥65 years, categorized into low, medium, and high based on the 25(th) and 75(th) percentile. Mean follow up was 29 months. RESULTS: At six months, subjects with medium (adjusted hazard ratio [HR], 0...
October 28, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27777380/aging-dysregulates-d-and-e-series-resolvins-to-modulate-cardiosplenic-and-cardiorenal-network-following-myocardial-infarction
#9
Ganesh V Halade, Vasundhara Kain, Laurence M Black, Sumanth D Prabhu, Kevin A Ingle
Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC) and excess fatty acid (safflower oil; SO)-enriched diet for 2 months and were then subjected to MI surgery. Despite similar infarct areas and left ventricle (LV) dysfunction post-MI, splenic mass spectrometry data revealed higher levels of arachidonic acid (AA) derived pro-inflammatory metabolites in young-SO, but minimal formation of docosanoids, D- and E- series resolvins in SO-fed aged mice...
October 18, 2016: Aging
https://www.readbyqxmd.com/read/27775848/metabolic-profiling-of-fatty-liver-in-young-and-middle-aged-adults-cross-sectional-and-prospective-analyses-of-the-young-finns-study
#10
Jari E Kaikkonen, Peter Würtz, Emmi Suomela, Miia Lehtovirta, Antti J Kangas, Antti Jula, Vera Mikkilä, Jorma S A Viikari, Markus Juonala, Tapani Rönnemaa, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Pasi Soininen, Mika Ala-Korpela, Olli T Raitakari
: Non-alcoholic fatty liver is associated with obesity-related metabolic disturbances, but little is known about the metabolic perturbations preceding fatty liver disease. We performed comprehensive metabolic profiling to assess how circulating metabolites, such as lipoprotein lipids, fatty acids, amino acids and glycolysis-related metabolites, reflect the presence of and future risk for fatty liver in young adults. Sixty-eight lipids and metabolites were quantified by nuclear magnetic resonance metabolomics in the population-based Young Finns Study from serum collected in 2001 (n=1,575), 2007 (n=1,509) and 2011 (n=2,002)...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27774593/properties-of-the-dass-21-in-an-australian-community-adolescent-population
#11
T Shaw, M A Campbell, K C Runions, S R Zubrick
BACKGROUND: Although developed for adults, the Depression Anxiety Stress Scales-Short Version (DASS-21) has been used in many research studies with adolescent samples. Evidence as to the applicability of the DASS subscale scores to represent the distinct states of depression, anxiety, and stress as experienced by adolescents is mixed, and the age at which it may be possible to differentiate these 3 states using the DASS-21 has not yet been determined. OBJECTIVE: This study evaluated evidence for a multifactor structure in the DASS-21 in adolescents and the specificity of the 3 subscales for adolescents in general and at different ages...
October 23, 2016: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27765796/early-life-residence-fish-consumption-and-risk-of-breast-cancer
#12
Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Unnur Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B Harris, Lenore Launer, Lorelei A Mucci, Edward L Giovannucci, Hans-Olov Adami, Vilmundur Gudnason, Johanna E Torfadottir
BACKGROUND: Little is known about fish intake throughout the life course and the risk of breast cancer. METHODS: We used data on the first residence of 9,340 women born 1908-1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the AGES-Reykjavik Study (n = 2,882). RESULTS: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study...
October 10, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27756480/extremely-preterm-infants-receiving-standard-care-receive-very-low-levels-of-arachidonic-and-docosahexaenoic-acids
#13
L De Rooy, H Hamdallah, S C Dyall
BACKGROUND & AIMS: Adequate supply of arachidonic (ARA) and docosahexaenoic (DHA) acids is essential for brain development, and extremely preterm infants may be at risk of deficiency. Current levels of ARA and DHA given to extremely preterm infants and the amounts available for accretion have not been established, although recent evidence suggests DHA intake is at a level likely to lead to severe deficits. This study quantified the omega-6 and omega-3 polyunsaturated fatty acid (PUFA) intakes from all sources in the first six weeks of life of preterm infants in standard care...
October 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27753664/lipids-and-physical-function-in-older-adults
#14
Patricia Casas-Agustench, Antonio Cherubini, Cristina Andrés-Lacueva
PURPOSE OF REVIEW: Healthy aging is a public health priority. The maintenance of adequate physical function is recognized as a key element of healthy aging. In recent years, scientific evidence has increased concerning the ability of lipids, in particular omega 3 polyunsaturated fatty acids (n-3 PUFAs), to positively influence muscle and overall physical function in older patients. The article will critically review observational as well as intervention studies on this topic, and it will elucidate the potential biological mechanisms underlying the beneficial effects of n-3 PUFA on physical function...
October 20, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27751666/omega-3-fatty-acids-inflammatory-status-and-biochemical-markers-of-patients-with-systemic-lupus-erythematosus-a-pilot-study
#15
Mariane Curado Borges, Fabiana de Miranda Moura Dos Santos, Rosa Weiss Telles, Marcus Vinícius Melo de Andrade, Maria Isabel Toulson Davisson Correia, Cristina Costa Duarte Lanna
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group...
September 22, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27742581/oxidative-stress-predicts-depressive-symptom-changes-with-omega-3-fatty-acid-treatment-in-coronary-artery-disease-patients
#16
Graham Mazereeuw, Nathan Herrmann, Ana C Andreazza, Gustavo Scola, David W L Ma, Paul I Oh, Krista L Lanctôt
BACKGROUND: Antidepressant efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment in coronary artery disease (CAD) patients remains unpredictable. N-3 PUFA can mitigate oxidative stress, which is common in CAD and may contribute to depressive symptoms. This study investigated whether greater pre-treatment oxidative stress, measured by the ratios of late-stage lipid peroxidation markers (malondialdehyde [MDA], 4-hydroxy-2-nonenal [4-HNE], and 8-isoprostane [8-ISO]) to an early-stage marker (lipid hydroperoxides [LPH]), predicted n-3 PUFA antidepressant benefits in CAD...
October 11, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27741564/the-anatomy-of-caprine-female-urethra-and-characteristics-of-muscle-and-bone-marrow-derived-caprine-cells-for-autologous-cell-therapy-testing
#17
A Burdzinska, B Dybowski, W Zarychta-Wisniewska, A Kulesza, R Zagozdzon, Z Gajewski, L Paczek
Cell therapy is emerging as an alternative treatment of stress urinary incontinence. However, many aspects of the procedure require further optimization. A large animal model is needed to reliably test cell delivery methods. In this study we aim to determine suitability of the goat as an experimental animal for testing intraurethral autologous cell transplantation in terms of urethral anatomy and cell culture parameters. The experiments were performed in 12 mature/aged female goats. Isolated caprine muscle derived cells (MDC) were myogenic in vitro and mesenchymal stem cells (MSC) population was able to differentiate into adipo-, osteo- and chondrogenic lineages...
October 14, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27736219/impact-of-dietary-and-metabolic-risk-factors-on-cardiovascular-and-diabetes-mortality-in-south-asia-analysis-from-the-2010-global-burden-of-disease-study
#18
Mohammad Y Yakoob, Renata Micha, Shahab Khatibzadeh, Gitanjali M Singh, Peilin Shi, Habibul Ahsan, Nagalla Balakrishna, Ginnela N V Brahmam, Yu Chen, Ashkan Afshin, Saman Fahimi, Goodarz Danaei, John W Powles, Majid Ezzati, Dariush Mozaffarian
OBJECTIVES: To quantify cardiovascular disease and diabetes deaths attributable to dietary and metabolic risks by country, age, sex, and time in South Asian countries. METHODS: We used the 2010 Global Burden of Disease national surveys to characterize risk factor levels by age and sex. We derived etiological effects of risk factors-disease endpoints, by age, from meta-analyses. We defined optimal levels. We combined these inputs with cause-specific mortality rates to compute population-attributable fractions as a percentage of total cardiometabolic deaths...
October 13, 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27732912/the-proportion-of-total-c18-1-trans-fatty-acids-in-red-blood-cell-membranes-relates-to-carotid-plaque-prevalence
#19
Zoe Herreras, Montserrat Cofán, Marta Catalan, Carlos Calvo, Montserrat Pinyol, Antonio J Amor, Rosa Gilabert, Emilio Ros, Aleix Sala-Vila, Emilio Ortega
Consistent evidence supports the pro-atherogenic properties of dietary trans-fatty acids (TFAs). However, there are no clinical data on TFA intake and atheroma plaque. We cross sectionally investigated whether the proportion of total C18:1 TFA in red blood cells (RBCs), which mirrors dietary TFA intake, independently relates to carotid plaque prevalence in subjects with new-onset type 2 diabetes mellitus without prior cardiovascular disease (n=101, 56% men, mean age 61 years) and age- and sex-matched controls (n=96)...
September 7, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27701160/cognitive-impairment-is-associated-with-a-low-omega-3-index-in-the-elderly-results-from-the-kora-age-study
#20
Karoline Lukaschek, Clemens von Schacky, Johannes Kruse, Karl-Heinz Ladwig
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS: Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoic acid (omega-3 index) were measured in erythrocytes as a percentage of total fatty acids. The categories low (<5.7), intermediate (5.7-6.8), and high (>6...
2016: Dementia and Geriatric Cognitive Disorders
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