keyword
MENU ▼
Read by QxMD icon Read
search

HAPE

keyword
https://www.readbyqxmd.com/read/29097771/subclinical-pulmonary-dysfunction-contributes-to-high-altitude-pulmonary-edema-susceptibility-in-healthy-non-mountaineers
#1
Rajinder K Gupta, Poonam Soree, Koundinya Desiraju, Anurag Agrawal, Shashi Bala Singh
HAPE susceptible (HAPE-S, had HAPE episode in past) subjects may have subclinical cardio-pulmonary dysfunction. We compared the results of pulmonary function tests in 25 healthy HAPE-S non-mountaineers and 19 matched HAPE resistant (HAPE-R, no HAPE episode in past). Acute normobaric hypoxia (FIo2 0.12) was administered at sea level to confirm hypoxia intolerance in HAPE-S. Unlike HAPE-R, HAPE-S subjects had elevated baseline and post-hypoxia systolic pulmonary arterial pressures (20.9 ± 3 vs 27.3 ± 5 mm Hg during normoxia and 26...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28953687/association-between-regulator-of-telomere-elongation-helicase1-rtel1-gene-and-hape-risk-a-case-control-study
#2
Hao Rong, Xue He, Linhao Zhu, Xikai Zhu, Longli Kang, Li Wang, Yongjun He, Dongya Yuan, Tianbo Jin
High altitude pulmonary edema (HAPE) is a paradigm of pulmonary edema. Mutations in regulator of telomere elongation helicase1 (RTEL1) represent an important contributor to risk for pulmonary fibrosis. However, little information is found about the association between RTEL1 and HAPE risk. The present study was undertaken to tentatively explore the potential relation between single-nucleotide polymorphisms (SNPs) in RTEL1 and HAPE risk in Chinese Han population. A total of 265 HAPE patients and 303 healthy controls were included in our case-control study...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28910201/reentry-high-altitude-pulmonary-edema-in-the-himalayas
#3
Santosh Baniya, Christopher Holden, Buddha Basnyat
Baniya, Santosh, Christopher Holden, and Buddha Basnyat. Reentry high altitude pulmonary edema in the Himalayas. High Alt Med Biol. 16:000-000, 2017.-Reentry high altitude pulmonary edema (HAPE), a subset of HAPE, is a well recognized, life-threatening illness documented almost exclusively in the North and South Americans, who live at high altitude (>2500 m) and return to their homes after a brief sojourn of days to months at lower altitude. This phenomenon has not been reported in Sherpas or other people of Tibetan origin in Nepal or India...
September 14, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28876136/electron-microscopy-observation-of-human-pulmonary-ultrastructure-in-two-patients-with-high-altitude-pulmonary-edema
#4
Yunden Droma, Akane Kato, Takashi Ichiyama, Nobumitsu Kobayashi, Takayuki Honda, Takeshi Uehara, Masayuki Hanaoka
We examined the pulmonary ultrastructure in tissue from two patients with high-altitude pulmonary edema (HAPE) by electron microscopy. In one case, we found that neutrophils were trapped in pulmonary capillary lumen of alveolar-capillary wall and part of the cytoplasm of a neutrophil protruded and adhered to the capillary endothelium. There were several degranulated vacuoles in the cytoplasm of the neutrophil. The pulmonary capillary wall was deformed, thickened, and swollen and there was evidence of degeneration...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846035/high-altitude-pulmonary-edema-in-mountain-community-residents
#5
Christine Ebert-Santos
Ebert-Santos, Christine. High-altitude pulmonary edema in mountain community residents. High Alt Med Biol. 18:278-284, 2017.-High-altitude pulmonary edema (HAPE) affects lowlanders ascending quickly to elevations above 2440 m. Mountain resident children with no travel can sometimes develop HAPE as was observed over 30 years ago (Fasules et al., 1985). This is not well known and children instead are diagnosed as having pneumonia or asthma. In our clinic at 2800 m, we see children presenting with severe hypoxemia, clinical, and radiographic findings consistent with HAPE despite no recent travel...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28673745/high-altitude-pulmonary-edema-in-a-mining-worker-with-an-abnormal-rise-in-pulmonary-artery-pressure-in-response-to-acute-hypoxia-without-prior-history-of-high-altitude-pulmonary-edema
#6
Almaz Ch Akunov, Meerim A Sartmyrzaeva, Abdirashit M Maripov, Kubatbek Muratali Uulu, Argen T Mamazhakypov, Akylbek S Sydykov, Akpay Sh Sarybaev
High altitude pulmonary edema (HAPE) is a potentially life-threatening form of noncardiogenic pulmonary edema that may develop in otherwise healthy individuals upon ascent to high altitude. A constitutional susceptibility has been noted in some individuals, whereas others appear not to be susceptible at all. In our report, we present a case of HAPE triggered by concurrent respiratory tract infection and strenuous exercise in a mining worker with an abnormal rise in pulmonary artery pressure in response to acute hypoxia, without a prior history of HAPE during almost a year of commuting between high altitude and lowland areas...
June 30, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28653390/interventions-for-preventing-high-altitude-illness-part-1-commonly-used-classes-of-drugs
#7
REVIEW
Víctor H Nieto Estrada, Daniel Molano Franco, Roger David Medina, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude. In this review, the first in a series of three about preventive strategies for HAI, we assess the effectiveness of six of the most recommended classes of pharmacological interventions...
June 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28415562/genome-wide-association-study-of-high-altitude-pulmonary-edema-in-a-han-chinese-population
#8
Xun Li, Tianbo Jin, Mingxia Zhang, Hua Yang, Xuewen Huang, Xiaobo Zhou, Wenchao Huang, Lipeng Qin, Longli Kang, Ming Fan, Suzhi Li
A two-stage genome-wide association study (GWAS) was performed to identify and analyze genes and single nucleotide polymorphisms (SNPs) associated with high-altitude pulmonary edema (HAPE) in a Han Chinese patient population. In the first stage, DNA samples from 68 patients with recurrent HAPE were scanned using Affymetrix SNP Array 6.0 Chips, and allele frequencies were compared to those of 84 HapMap CHB samples to identify candidate SNPs. In the second stage, the 77 identified candidate SNPs were examined in an independent cohort of samples from 199 HAPE patients and 304 controls...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28398844/breathlessness-at-high-altitude-first-episode-of-bronchoconstriction-in-an-otherwise-healthy-sojourner
#9
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Sadichhya Lohani, Pratibha Phuyal, Buddha Basnyat
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Sadichhya Lohani, Pratibha Phuyal, and Buddha Basnyat. Breathlessness at high altitude: first episode of bronchoconstriction in an otherwise healthy sojourner. High Alt Med Biol.. 18:179-181, 2017-High-altitude illness is a collective term for less severe acute mountain sickness and more severe high-altitude pulmonary edema (HAPE) and high-altitude cerebral edema, which we can experience while traveling to high altitude. These get better when we get down to the lower altitudes...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28353602/association-between-genetic-polymorphism-of-telomere-associated-gene-acyp2-and-the-risk-of-hape-among-the-chinese-han-population-a-case-control-study
#10
Linhao Zhu, Lijun Liu, Xue He, Mengdan Yan, Jieli Du, Hua Yang, Yuan Zhang, Dongya Yuan, Tianbo Jin
High-altitude pulmonary edema (HAPE) is a hypoxia-induced, life-threatening, pulmonary edema, which is characterized by exaggerated pulmonary hypertension caused by stress failure. ACYP2 was found to associated with telomere length, the aim of this study was to identify whether ACYP2 polymorphisms increase or decrease HAPE risk in the Chinese Han individuals.In present study, we have genotyped 7 single-nucleotide polymorphisms (SNPs) in ACYP2 to determine the haplotypes in a case-control study with 265 HAPE patients and 303 healthy individuals...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28285976/high-altitude-illness-in-pilgrims-after-rapid-ascent-to-4380%C3%A2-m
#11
Ken Zafren, Matiram Pun, Nirajan Regmi, Gobinda Bashyal, Bhuwan Acharya, Subarna Gautam, Sujan Jamarkattel, Shankar Raj Lamichhane, Suman Acharya, Buddha Basnyat
BACKGROUND: The goal of the study was to characterize high altitude illness in Nepali pilgrims. METHODS: We kept standardized records at the Himalayan Rescue Association (HRA) Temporary Health Camp at Gosainkund Lake (4380 m) in the Nepal Himalaya during the annual Janai Purnima Festival in 2014. Records included rate of ascent and Lake Louise Score (LLS). We defined High Altitude Headache (HAH) as headache alone or LLS = 2. Acute Mountain Sickness (AMS) was LLS≥3...
March 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28257713/hmox1-promoter-microsatellite-polymorphism-is-not-associated-with-high-altitude-pulmonary-edema-in-han-chinese
#12
Xue-Feng Cao, Lan Ma, Shang Ma, Jin Xu, Ri-Li Ge
OBJECTIVE: To investigate the relationship between microsatellite polymorphism in the Heme oxygenase-1 (HMOX1) gene promoter and high-altitude pulmonary edema (HAPE) in Han Chinese. METHODS: Eighty-three construction workers who developed HAPE 2 to 7 days after arrival at Yushu (3800 m) in Qinghai, China, and 145 matched healthy subjects were included in this study. The amplification and labeling of the polymerase chain reaction products for capillary electrophoresis were performed to identify HMOX1 genotype frequency...
March 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28242600/the-susceptibility-gene-screening-in-a-chinese-high-altitude-pulmonary-edema-family-by-whole-exome-sequencing
#13
Ying-zhong Yang, Ya-ping Wang, Jin Xu, Ri-li Ge
High-altitude pulmonary edema (HAPE) is one of idiopathic mountain sicknesses that occur in healthy lowlanders when they quickly ascend to altitudes exceeding 2500 m above sea levels within 1-7 days. Growing evidence suggests that genetics plays an important role in the risk of HAPE. In this study, we recruited a Chinese HAPE family and screened genetic variations in the 7 family members (including 6 family members with a medical history of HAPE and the propositus's mother) by whole-exome sequencing. The results showed 18 genetic variations (9 SNVs and 9 Indels) were related to HAPE...
February 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28212552/association-between-single-nucleotide-polymorphisms-in-adrb2-gnb3-and-gstp1-genes-and-high-altitude-pulmonary-edema-hape-in-the-chinese-han-population
#14
Yongjun He, Lijun Liu, Pengcheng Xu, Na He, Dongya Yuan, Longli Kang, Tianbo Jin
High altitude pulmonary edema (HAPE) occurs mainly under conditions such as high altitude, rapid ascent, or hypoxia. Previous studies suggest that ADRB2, GNB3, TH, and GSTP1 polymorphisms are associated with various lung diseases. We evaluated whether those polymorphisms are associated with the risk of HAPE in a Chinese Han population. ADRB2, GNB3, TH and GSTP1 polymorphisms were genotyped using a Sequenom MassARRAY. Logistic regression, adjusted for age and gender, was used to evaluate the association between the genotypes and the risk of HAPE by computing odds ratios (ORs) and 95% confidence intervals (95% CIs)...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057815/susceptibility-to-high-altitude-pulmonary-edema-is-associated-with-a-more-uniform-distribution-of-regional-specific-ventilation
#15
Michael D Patz, Rui C Sá, Chantal Darquenne, Ann R Elliott, Amran K Asadi, Rebecca J Theilmann, David J Dubowitz, Erik R Swenson, G Kim Prisk, Susan R Hopkins
High-altitude pulmonary edema (HAPE) is a potentially fatal condition affecting high-altitude sojourners. The biggest predictor of HAPE development is a history of prior HAPE. Magnetic resonance imaging (MRI) shows that HAPE-susceptible (with a history of HAPE), but not HAPE-resistant (with a history of repeated ascents without illness) individuals develop greater heterogeneity of regional pulmonary perfusion breathing hypoxic gas (O2 = 12.5%), consistent with uneven hypoxic pulmonary vasoconstriction (HPV)...
April 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27906598/managing-high-altitude-pulmonary-edema-with-oxygen-alone-results-of-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Uday Yanamandra, Velu Nair, Surinderpal Singh, Amul Gupta, Deepak Mulajkar, Sushma Yanamandra, Konchok Norgais, Ruchira Mukherjee, Vikrant Singh, Srinivasa A Bhattachar, Sagarika Patyal, Rajan Grewal, Bhushan Chopra
Yanamandra, Uday, Velu Nair, Surinderpal Singh, Amul Gupta, Deepak Mulajkar, Sushma Yanamandra, Konchok Norgais, Ruchira Mukherjee, Vikrant Singh, Srinivasa A. Bhattachar, Sagarika Patyal, and Rajan Grewal. High-altitude pulmonary edema management: Is anything other than oxygen required? Results of a randomized controlled trial. High Alt Med Biol. 17:294-299, 2016.-Treatment strategies for management of high-altitude pulmonary edema (HAPE) are mainly based on the observational studies with only two randomized controlled trials, thus the practice is very heterogeneous and individualized as per the choice of treating physician...
December 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27768392/pulmonary-embolism-masquerading-as-high-altitude-pulmonary-edema-at-high-altitude
#17
Prativa Pandey, Benu Lohani, Holly Murphy
Pandey, Prativa, Benu Lohani, and Holly Murphy. Pulmonary embolism masquerading as high altitude pulmonary edema at high altitude. High Alt Med Biol. 17:353-358, 2016.-Pulmonary embolism (PE) at high altitude is a rare entity that can masquerade as or occur in conjunction with high altitude pulmonary edema (HAPE) and can complicate the diagnosis and management. When HAPE cases do not improve rapidly with descent, other diagnoses, including PE, ought to be considered. From 2013 to 2015, we identified eight cases of PE among 303 patients with initial diagnosis of HAPE...
December 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27732943/angiotensin-ii-receptor-1-gene-variants-are-associated-with-high-altitude-pulmonary-edema-risk
#18
Tianbo Jin, Yongchao Ren, Xikai Zhu, Xun Li, Yongri Ouyang, Xue He, Zhiying Zhang, Yuan Zhang, Longli Kang, Dongya Yuan
Previous studies demonstrated that Angiotensin II Receptor 1 (AGTR1) may play an important role in the development of high-altitude pulmonary edema. We envisaged a role for AGTR1 gene variants in the pathogenesis of HAPE and investigated their potential associations with HAPE in a Han Chinese population. We genotyped seven AGTR1 polymorphisms in 267 patients with diagnosed HAPE and 304 controls and evaluated their association with risk of HAPE. Statistically significant associations were found for the single nucleotide polymorphisms (SNPs) rs275651 (p = 0...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27662354/lipid-subhyaloid-maculopathy-and-exposure-to-high-altitude
#19
Roberta Rosas Petrocinio, Elga Dias Gomes
BACKGROUND: High altitude retinopathy (HAR) includes a number of diseases related to high altitude such as acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE). High altitude retinopathy is mainly characterized by retinal hemorrhages, usually sparing the macular region, a condition specifically known as high altitude retinal hemorrhages (HARH). The pathogenesis of HARH is unclear. Many studies show that lack of oxygen causes an inadequate autoregulation of retinal circulation, causing vascular incompetence...
2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27575244/high-altitude-pulmonary-edema-without-appropriate-action-progresses-to-right-ventricular-strain-a-case-study
#20
Logan Mills, Chris Harper, Sophie Rozwadowski, Chris Imray
Mills, Logan, Chris Harper, Sophie Rozwadowski, and Chris Imray. High altitude pulmonary edema without appropriate action progresses to right ventricular strain: A case study. High Alt Med Biol. 17:228-232, 2016.-A 24-year-old male developed high altitude pulmonary edema (HAPE) after three ascents to 4061 m over 3 days, sleeping each night at 2735 m. He complained of exertional dyspnea, dry cough, chest pain, fever, nausea, vertigo, and a severe frontal headache. Inappropriate continuation of ascent despite symptoms led to functional impairment and forced a return to the valley, but dyspnea persisted in addition to new orthopnea...
September 2016: High Altitude Medicine & Biology
keyword
keyword
49913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"