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https://www.readbyqxmd.com/read/29909706/hyaluronic-acid-doxorubicin-nanoassembly-releasing-microspheres-for-the-transarterial-chemoembolization-of-a-liver-tumor
#1
Song Yi Lee, Jin Woo Choi, Jae-Young Lee, Dae-Duk Kim, Hyo-Cheol Kim, Hyun-Jong Cho
Doxorubicin (DOX)-loaded, hyaluronic acid-ceramide (HACE) nanoassembly-releasing poly(lactic-co-glycolic acid) (PLGA) microspheres (MSs) were developed for transarterial chemoembolization (TACE) therapy of liver cancer. DOX/HACE MSs with a mean diameter of 27 μm and a spherical shape were prepared based on the modified emulsification method. Their in vitro biodegradability in artificial biological fluids was observed. A more sustained drug release pattern was observed from DOX/HACE MS than from DOX MS at pH 7...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29902149/sarcoma-de-kaposi-en-paciente-con-diagn%C3%A3-stico-tard%C3%A3-o-de-vih-presentaci%C3%A3-n-de-un-caso-y-revisi%C3%A3-n
#2
María Belén Castaño, Débora Litvack, Ingrid Videla, Mónica Herrero, Susana Pereyra
El sarcoma de Kaposi es un tumor linfoangioproliferativo descripto por primera vez en el año 1872 por Moritz Kaposi. Hay cuatro variantes clínicas, la forma clásica, la endémica, la iatrogénica asociada a trasplante o inmunosupresión y la epidémica asociada a SIDA, de la cual se hará referencia en esta publicación. Se describe un paciente varón de 31 años, al cual durante la misma internación se hace el diagnóstico de SIDA y de sarcoma de Kaposi.
April 27, 2018: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/29763853/text-mining-and-network-analysis-to-find-functional-associations-of-genes-in-high-altitude-diseases
#3
Balu Bhasuran, Devika Subramanian, Jeyakumar Natarajan
BACKGROUND AND OBJECTIVES: Travel to elevations above 2500 m is associated with the risk of developing one or more forms of acute altitude illness such as acute mountain sickness (AMS), high altitude cerebral edema (HACE) or high altitude pulmonary edema (HAPE). Our work aims to identify the functional association of genes involved in high altitude diseases. METHOD: In this work we identified the gene networks responsible for high altitude diseases by using the principle of gene co-occurrence statistics from literature and network analysis...
August 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29722317/exendin-4-inhibits-high-altitude-cerebral-edema-by-protecting-against-neurobiological-dysfunction
#4
Zhong-Lei Sun, Xian-Feng Jiang, Yuan-Chi Cheng, Ying-Fu Liu, Kai Yang, Shuang-Long Zhu, Xian-Bin Kong, Yue Tu, Ke-Feng Bian, Zhen-Lin Liu, Xu-Yi Chen
The anti-inflammatory and antioxidant effects of exendin-4 (Ex-4) have been reported previously. However, whether (Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema (HACE) remains poorly understood. In this study, two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000- or 7000-m above sea level (MASL) for 72 hours. An altitude of 7000 MASL with 72-hours of hypoxia was found to be the optimized experimental paradigm for establishing HACE models...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29529715/interventions-for-preventing-high-altitude-illness-part-2-less-commonly-used-drugs
#5
REVIEW
Alejandro Gonzalez Garay, Daniel Molano Franco, Víctor H Nieto Estrada, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of mainly cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (˜ 8200 feet). Acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude ascent. In this second review, in a series of three about preventive strategies for HAI, we assessed the effectiveness of five of the less commonly used classes of pharmacological interventions...
March 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29428576/ganglioside-gm1-protects-against-high-altitude-cerebral-edema-in-rats-by-suppressing-the-oxidative-stress-and-inflammatory-response-via-the-pi3k-akt-nrf2-pathway
#6
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
March 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29420523/del-romanticismo-y-la-ficci%C3%A3-n-a-la-realidad-dippel-galvani-aldini-y-%C3%A2-el-moderno-prometeo%C3%A2-breve-historia-del-impulso-nervioso
#7
Julio César López-Valdés
Mary Wollstonecraft Godwin (1797-1851), mejor conocida como Mary Shelley, con su visión romántica del mundo dio vida a una progenie interminable de historias en la literatura, y su escrito originó el mito del creador mortal que da vida a partir de la ciencia. Aunque parezca sorprendente, la historia ha llegado a considerarse un mito debido a los actos fundamentados en hechos de cierta forma «verídicos» que ayudaron a su origen, como fueron el galvanismo y el estudio del potencial eléctrico en los seres vivos llevados a cabo por dos italianos: Luigi Galvani y Giovanni Aldini...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29420515/preimpresiones-en-biomedicina-%C3%A2-alternativa-o-complemento-al-modelo-tradicional-de-publicaci%C3%A3-n
#8
Guillermo Aquino-Jarquin, Josefina de Monserrat Valencia-Reyes, Abraham Silva-Carmona, Javier Tadeo Granados-Riverón
La revisión por pares es un sistema que ha permitido el control de calidad de los manuscritos enviados para publicación en revistas científicas durante más de tres siglos. Sin embargo, debido a su relativa lentitud y otras desventajas, algunos investigadores (principalmente en las áreas de la física y las matemáticas) iniciaron hace algunas décadas la difusión electrónica de manuscritos aún no sometidos a una revista de publicación formal. La popularización de esta práctica condujo al establecimiento de repositorios permanentes como ArXiv, a los que es posible enviar preimpresiones de forma gratuita y que a la vez permiten la búsqueda y descarga de los trabajos que contienen sin cargo para el lector...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29202898/isolated-psychosis-during-exposure-to-very-high-and-extreme-altitude-characterisation-of-a-new-medical-entity
#9
Katharina Hüfner, Hermann Brugger, Eva Kuster, Franziska Dünsser, Agnieszka E Stawinoga, Rachel Turner, Iztok Tomazin, Barbara Sperner-Unterweger
BACKGROUND: Psychotic episodes during exposure to very high or extreme altitude have been frequently reported in mountain literature, but not systematically analysed and acknowledged as a distinct clinical entity. METHODS: Episodes reported above 3500 m altitude with possible psychosis were collected from the lay literature and provide the basis for this observational study. Dimensional criteria of the Diagnostic and Statistical Manual of Mental Disorders were used for psychosis, and the Lake Louise Scoring criteria for acute mountain sickness and high-altitude cerebral oedema (HACE)...
December 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29054452/mechanism-of-aquaporin-4-aqp-4-up-regulation-in-rat-cerebral-edema-under-hypobaric-hypoxia-and-the-preventative-effect-of-puerarin
#10
Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Shang He, Jingwen Chen, Chengbin Wang
AIM: We aim to investigate the mechanism of aquaporin 4 (AQP 4) up-regulation during high-altitude cerebral edema (HACE) in rats under hypobaric hypoxia and preventative effect of puerarin. METHODS: Rats were exposed to a hypobaric chamber with or without the preventative treatment of puerarin or dexamethasone. Morriz water maze was used to evaluate the spatial memory injury. HE staining and W/D ratio were used to evaluate edema injury. Rat astrocytes and microglia were co-cultured under the condition of hypoxia with the administration of p38 inhibitor, NF-κB inhibitor or puerarin...
January 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/28763079/-medical-movement-in-mexico-to-50-years-open-file
#11
José Luis Sandoval-Gutiérrez
Gutiérrez-Samperio hace una excelente narrativa del movimiento denominado «blanco» hace medio siglo, encabezado por médicos y otros trabajadores de salud, principalmente enfermeras. Es importante revisar los logros y limitaciones que dicho fenómeno alcanzó. Por ejemplo, actualmente el residente que cursa una especialidad cuenta con un reconocimiento institucional, universitario y de profesiones al término de su formación, además de tener una beca económica (probablemente insuficiente) y días de vacaciones programados...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28702179/pathological-correlations-between-traumatic-brain-injury-and-chronic-neurodegenerative-diseases
#12
REVIEW
Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez, Riyi Shi
Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is associated with a number of chronic neurological and neuropsychiatric sequelae including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, despite the high incidence of traumatic brain injuries and the established clinical correlation with neurodegeneration, the causative factors linking these processes have not yet been fully elucidated...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28653390/interventions-for-preventing-high-altitude-illness-part-1-commonly-used-classes-of-drugs
#13
REVIEW
Víctor H Nieto Estrada, Daniel Molano Franco, Roger David Medina, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude. In this review, the first in a series of three about preventive strategies for HAI, we assess the effectiveness of six of the most recommended classes of pharmacological interventions...
June 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28652215/histoplasma-capsulatum-in-the-bone-marrow-of-an-hiv-infected-patient
#14
Isaí Medina-Piñón, Pedro Hernández-Rodríguez, Silvia Estela Haces-Rodríguez, Luis Arturo Acosta-Calderón
No abstract text is available yet for this article.
September 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28621523/mussel-inspired-hyaluronic-acid-derivative-nanostructures-for-improved-tumor-targeting-and-penetration
#15
Song Yi Lee, Ju-Hwan Park, Seung-Hak Ko, Jae-Seong Shim, Dae-Duk Kim, Hyun-Jong Cho
An amphiphilic hyaluronic acid-ceramide-dopamine (HACE-d) conjugate was prepared, and HACE-d-based nanoparticles (NPs) including phloretin (as an inhibitor of glucose transporter (GLUT1)) were fabricated. Mussel-inspired property of d was introduced to HACE NPs, and it may improve tumor targetability and penetration in addition to passive (based on enhanced permeability and retention effect) and active (interaction between HA and CD44 receptor) tumor targeting effects. HACE-d/phloretin NPs with 279 nm mean diameter, ∼0...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28614438/pressure-ulcer-dressings-in-critical-patients-a-cost-analysis
#16
Dinara Raquel Araújo Silva, Sandra Marina Gonçalves Bezerra, Jéssica Pereira Costa, Maria Helena Barros Araújo Luz, Vanessa Caminha Aguiar Lopes, Lidya Tolstenko Nogueira
OBJECTIVE: To assess the direct cost of dressings in pressure ulcer treatment. METHOD: This was a descriptive observational study conducted at an intensive care unit in the Northeast region of Brazil, between November and December 2015. Data were gathered using the Pressure Ulcer Scale for Healing and a form to characterize and assess costs. Values in Brazilian reais (BRL) were converted into U.S. dollars at the exchange rate of USD 0.26/BRL. Univariate and bivariate analyses were conducted...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28585853/is-the-integration-of-nutritional-care-in-the-different-assistance-levels-possible-the-catalan-experience-clinical-perspective
#17
REVIEW
Rosa Burgos Peláez, Clara Joaquin Ortiz, Cristina Vaqué Crusellas
Disease-related malnutrition is highly prevalent in pathologies commonly integrating care complexity. Healthcare models for complexity must include malnutrition detection and approaches, since it is a key factor which has great impact on the patient’s evolution and the consumption of healthcare resources. Malnourished patients present higher hospitalization, complication and mortality rates, higher demand of post-discharge social resources and higher hospital readmission frequency. Detecting malnutrition is necessary to implement a nutritional care program which might be used in any assistance level...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28481626/retinal-hemorrhage-in-a-high-altitude-aid-post-volunteer-doctor-a-case-report
#18
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Nirajan Regmi, Sushil Pant
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Nirajan Regmi, and Sushil Pant. Retinal hemorrhage in a high-altitude aid post volunteer doctor: a case report. High Alt Med Biol. 18: 285-287, 2017.-High-altitude retinal hemorrhages (HARHs) are seen at altitudes more than 3000 m, are usually multiple, flame shaped, and adjacent to blood vessels. Development near the macula causes blurring of vision, otherwise, they are symptomless and self-limiting. They often develop during the first few days after ascent to high altitude and subjects often suffer from acute mountain sickness (AMS) or high-altitude cerebral edema (HACE)...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28433745/hypoxia-augments-lps-induced-inflammation-and-triggers-high-altitude-cerebral-edema-in-mice
#19
Yanzhao Zhou, Xin Huang, Tong Zhao, Meng Qiao, Xingnan Zhao, Ming Zhao, Lun Xu, Yongqi Zhao, Liying Wu, Kuiwu Wu, Ruoli Chen, Ming Fan, Lingling Zhu
High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to and development of brain edema. In the present study, we investigated the inflammatory response and its roles in HACE in mice following high altitude hypoxic injury. We report that acute hypobaric hypoxia induced a slight inflammatory response or brain edema within 24h in mice...
August 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28421789/how-does-coconut-oil-affect-cognitive-performance-in-alzheimer-patients
#20
José Enrique De la Rubia Ortí, Carmen Sánchez Álvarez, Pablo Selvi Sabater, Alma María Bueno Cayo, Sandra Sancho Castillo, Mariano Julián Rochina, Iván Hu Yang
Introduction: Alzheimer’s disease is one of the most prevalent neurodegenerative dementia in developed world. This fact, coupled with the lack cure, makes new no pharmacological therapeutic strategies such as nutrient management to investigate. In this regard, it stresses the possible influence of coconut oil as alternative energy source capable of stopping the progressively neuronal death that occurs in this disease. Objectives: To assess the cognitive impact of coconut oil in Alzheimer’s patients, and specifically in orientation, language-building, fixing, calculation-concentration and memory areas...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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