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https://www.readbyqxmd.com/read/29529715/interventions-for-preventing-high-altitude-illness-part-2-less-commonly-used-drugs
#1
REVIEW
Alejandro Gonzalez Garay, Daniel Molano Franco, Víctor H Nieto Estrada, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of mainly cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (˜ 8200 feet). Acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude ascent. In this second review, in a series of three about preventive strategies for HAI, we assessed the effectiveness of five of the less commonly used classes of pharmacological interventions...
March 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29428576/ganglioside-gm1-protects-against-high-altitude-cerebral-edema-in-rats-by-suppressing-the-oxidative-stress-and-inflammatory-response-via-the-pi3k-akt-nrf2-pathway
#2
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
February 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29420523/del-romanticismo-y-la-ficci%C3%A3-n-a-la-realidad-dippel-galvani-aldini-y-%C3%A2-el-moderno-prometeo%C3%A2-breve-historia-del-impulso-nervioso
#3
Julio César López-Valdés
Mary Wollstonecraft Godwin (1797-1851), mejor conocida como Mary Shelley, con su visión romántica del mundo dio vida a una progenie interminable de historias en la literatura, y su escrito originó el mito del creador mortal que da vida a partir de la ciencia. Aunque parezca sorprendente, la historia ha llegado a considerarse un mito debido a los actos fundamentados en hechos de cierta forma «verídicos» que ayudaron a su origen, como fueron el galvanismo y el estudio del potencial eléctrico en los seres vivos llevados a cabo por dos italianos: Luigi Galvani y Giovanni Aldini...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29420515/preimpresiones-en-biomedicina-%C3%A2-alternativa-o-complemento-al-modelo-tradicional-de-publicaci%C3%A3-n
#4
Guillermo Aquino-Jarquin, Josefina de Monserrat Valencia-Reyes, Abraham Silva-Carmona, Javier Tadeo Granados-Riverón
La revisión por pares es un sistema que ha permitido el control de calidad de los manuscritos enviados para publicación en revistas científicas durante más de tres siglos. Sin embargo, debido a su relativa lentitud y otras desventajas, algunos investigadores (principalmente en las áreas de la física y las matemáticas) iniciaron hace algunas décadas la difusión electrónica de manuscritos aún no sometidos a una revista de publicación formal. La popularización de esta práctica condujo al establecimiento de repositorios permanentes como ArXiv, a los que es posible enviar preimpresiones de forma gratuita y que a la vez permiten la búsqueda y descarga de los trabajos que contienen sin cargo para el lector...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29202898/isolated-psychosis-during-exposure-to-very-high-and-extreme-altitude-characterisation-of-a-new-medical-entity
#5
Katharina Hüfner, Hermann Brugger, Eva Kuster, Franziska Dünsser, Agnieszka E Stawinoga, Rachel Turner, Iztok Tomazin, Barbara Sperner-Unterweger
BACKGROUND: Psychotic episodes during exposure to very high or extreme altitude have been frequently reported in mountain literature, but not systematically analysed and acknowledged as a distinct clinical entity. METHODS: Episodes reported above 3500 m altitude with possible psychosis were collected from the lay literature and provide the basis for this observational study. Dimensional criteria of the Diagnostic and Statistical Manual of Mental Disorders were used for psychosis, and the Lake Louise Scoring criteria for acute mountain sickness and high-altitude cerebral oedema (HACE)...
December 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29054452/mechanism-of-aquaporin-4-aqp-4-up-regulation-in-rat-cerebral-edema-under-hypobaric-hypoxia-and-the-preventative-effect-of-puerarin
#6
Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Shang He, Jingwen Chen, Chengbin Wang
AIM: We aim to investigate the mechanism of aquaporin 4 (AQP 4) up-regulation during high-altitude cerebral edema (HACE) in rats under hypobaric hypoxia and preventative effect of puerarin. METHODS: Rats were exposed to a hypobaric chamber with or without the preventative treatment of puerarin or dexamethasone. Morriz water maze was used to evaluate the spatial memory injury. HE staining and W/D ratio were used to evaluate edema injury. Rat astrocytes and microglia were co-cultured under the condition of hypoxia with the administration of p38 inhibitor, NF-κB inhibitor or puerarin...
January 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/28763079/-medical-movement-in-mexico-to-50-years-open-file
#7
José Luis Sandoval-Gutiérrez
Gutiérrez-Samperio hace una excelente narrativa del movimiento denominado «blanco» hace medio siglo, encabezado por médicos y otros trabajadores de salud, principalmente enfermeras. Es importante revisar los logros y limitaciones que dicho fenómeno alcanzó. Por ejemplo, actualmente el residente que cursa una especialidad cuenta con un reconocimiento institucional, universitario y de profesiones al término de su formación, además de tener una beca económica (probablemente insuficiente) y días de vacaciones programados...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28702179/pathological-correlations-between-traumatic-brain-injury-and-chronic-neurodegenerative-diseases
#8
REVIEW
Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez, Riyi Shi
Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is associated with a number of chronic neurological and neuropsychiatric sequelae including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, despite the high incidence of traumatic brain injuries and the established clinical correlation with neurodegeneration, the causative factors linking these processes have not yet been fully elucidated...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28653390/interventions-for-preventing-high-altitude-illness-part-1-commonly-used-classes-of-drugs
#9
REVIEW
Víctor H Nieto Estrada, Daniel Molano Franco, Roger David Medina, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude. In this review, the first in a series of three about preventive strategies for HAI, we assess the effectiveness of six of the most recommended classes of pharmacological interventions...
June 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28652215/histoplasma-capsulatum-in-the-bone-marrow-of-an-hiv-infected-patient
#10
Isaí Medina-Piñón, Pedro Hernández-Rodríguez, Silvia Estela Haces-Rodríguez, Luis Arturo Acosta-Calderón
No abstract text is available yet for this article.
September 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28621523/mussel-inspired-hyaluronic-acid-derivative-nanostructures-for-improved-tumor-targeting-and-penetration
#11
Song Yi Lee, Ju-Hwan Park, Seung-Hak Ko, Jae-Seong Shim, Dae-Duk Kim, Hyun-Jong Cho
An amphiphilic hyaluronic acid-ceramide-dopamine (HACE-d) conjugate was prepared, and HACE-d-based nanoparticles (NPs) including phloretin (as an inhibitor of glucose transporter (GLUT1)) were fabricated. Mussel-inspired property of d was introduced to HACE NPs, and it may improve tumor targetability and penetration in addition to passive (based on enhanced permeability and retention effect) and active (interaction between HA and CD44 receptor) tumor targeting effects. HACE-d/phloretin NPs with 279 nm mean diameter, ∼0...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28614438/pressure-ulcer-dressings-in-critical-patients-a-cost-analysis
#12
Dinara Raquel Araújo Silva, Sandra Marina Gonçalves Bezerra, Jéssica Pereira Costa, Maria Helena Barros Araújo Luz, Vanessa Caminha Aguiar Lopes, Lidya Tolstenko Nogueira
OBJECTIVE: To assess the direct cost of dressings in pressure ulcer treatment. METHOD: This was a descriptive observational study conducted at an intensive care unit in the Northeast region of Brazil, between November and December 2015. Data were gathered using the Pressure Ulcer Scale for Healing and a form to characterize and assess costs. Values in Brazilian reais (BRL) were converted into U.S. dollars at the exchange rate of USD 0.26/BRL. Univariate and bivariate analyses were conducted...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28585853/%C3%A2-podemos-integrar-la-asistencia-nutricional-en-los-distintos-niveles-asistenciales-la-experiencia-catalana-visi%C3%A3-n-del-cl%C3%A3-nico
#13
Rosa Burgos Peláez, Clara Joaquin Ortiz, Cristina Vaqué Crusellas
La desnutrición relacionada con la enfermedad es altamente prevalente en patologías que con mucha frecuencia conforman la complejidad asistencial. Los modelos sanitarios de atención a la complejidad deben incluir la detección y el abordaje de la desnutrición como elemento clave debido a su elevado impacto en la evolución del paciente y en el consumo de recursos sanitarios. Los pacientes desnutridos presentan más necesidad de hospitalización, mayor tasa de complicaciones, más mortalidad, más necesidad de recursos sociales al alta hospitalaria y una mayor frecuencia de reingresos hospitalarios...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28481626/retinal-hemorrhage-in-a-high-altitude-aid-post-volunteer-doctor-a-case-report
#14
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Nirajan Regmi, Sushil Pant
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Nirajan Regmi, and Sushil Pant. Retinal hemorrhage in a high-altitude aid post volunteer doctor: a case report. High Alt Med Biol. 18: 285-287, 2017.-High-altitude retinal hemorrhages (HARHs) are seen at altitudes more than 3000 m, are usually multiple, flame shaped, and adjacent to blood vessels. Development near the macula causes blurring of vision, otherwise, they are symptomless and self-limiting. They often develop during the first few days after ascent to high altitude and subjects often suffer from acute mountain sickness (AMS) or high-altitude cerebral edema (HACE)...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28433745/hypoxia-augments-lps-induced-inflammation-and-triggers-high-altitude-cerebral-edema-in-mice
#15
Yanzhao Zhou, Xin Huang, Tong Zhao, Meng Qiao, Xingnan Zhao, Ming Zhao, Lun Xu, Yongqi Zhao, Liying Wu, Kuiwu Wu, Ruoli Chen, Ming Fan, Lingling Zhu
High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to and development of brain edema. In the present study, we investigated the inflammatory response and its roles in HACE in mice following high altitude hypoxic injury. We report that acute hypobaric hypoxia induced a slight inflammatory response or brain edema within 24h in mice...
April 20, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28421789/how-does-coconut-oil-affect-cognitive-performance-in-alzheimer-patients
#16
José Enrique De la Rubia Ortí, Carmen Sánchez Álvarez, Pablo Selvi Sabater, Alma María Bueno Cayo, Sandra Sancho Castillo, Mariano Julián Rochina, Iván Hu Yang
Introduction: Alzheimer’s disease is one of the most prevalent neurodegenerative dementia in developed world. This fact, coupled with the lack cure, makes new no pharmacological therapeutic strategies such as nutrient management to investigate. In this regard, it stresses the possible influence of coconut oil as alternative energy source capable of stopping the progressively neuronal death that occurs in this disease. Objectives: To assess the cognitive impact of coconut oil in Alzheimer’s patients, and specifically in orientation, language-building, fixing, calculation-concentration and memory areas...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421781/contribution-of-bioavailable-iron-and-zinc-to-the-diet-of-honduran-children-under-24-month
#17
Lorena Fernández-Palacios, Gaspar Ros-Berruezo, Elsa Barrientos-Augustinus, Elizabeth Jirón de Caballero, Carmen Frontela-Saseta
Objective: In the present study we analyzed 18 baby food (10 made from traditional Honduran recipes, and 8 industrial baby food sold in that country) involving the staple food of Honduran excluded infants breast milk and infant formulas. Material and methods: The content and bioaccesibility (soluble and dialysable fractions) of Fe and Zn were determined. For thisin vitro gastrointestinal digestion in a first phase of gastric digestion (pepsin) followed by a second phase of intestinal digestion (with pancreatin and bile salts) was simulated...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28323589/preventing-high-altitude-cerebral-edema-in-rats-with-repurposed-anti-angiogenesis-pharmacotherapy
#18
Samantha Tarshis, Joanne Maltzahn, Zoe Loomis, David C Irwin
BACKGROUND: High altitude cerebral edema (HACE) is a fulminant, deadly, and yet still unpredictable brain disease. A new prophylactic treatment for HACE and its predecessor, acute mountain sickness (AMS), needs to be developed without the contraindications or adverse effect profiles of acetazolamide and dexamethasone. Since neovascularization signals are likely key contributors to HACE/AMS, our approach was to examine already existing anti-angiogenic drugs to inhibit potential initiating HACE pathway(s)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28317325/experimental-verification-of-advanced-collapsed-cone-engine-for-use-with-a-multichannel-vaginal-cylinder-applicator
#19
Brie Cawston-Grant, Hali Morrison, Geetha Menon, Ron S Sloboda
Model-based dose calculation algorithms have recently been incorporated into brachytherapy treatment planning systems, and their introduction requires critical evaluation before clinical implementation. Here, we present an experimental evaluation of Oncentra(®) Brachy Advanced Collapsed-cone Engine (ACE) for a multichannel vaginal cylinder (MCVC) applicator using radiochromic film. A uniform dose of 500 cGy was specified to the surface of the MCVC using the TG-43 dose formalism under two conditions: (a) with only the central channel loaded or (b) only the peripheral channels loaded...
March 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28285976/high-altitude-illness-in-pilgrims-after-rapid-ascent-to-4380%C3%A2-m
#20
Ken Zafren, Matiram Pun, Nirajan Regmi, Gobinda Bashyal, Bhuwan Acharya, Subarna Gautam, Sujan Jamarkattel, Shankar Raj Lamichhane, Suman Acharya, Buddha Basnyat
BACKGROUND: The goal of the study was to characterize high altitude illness in Nepali pilgrims. METHODS: We kept standardized records at the Himalayan Rescue Association (HRA) Temporary Health Camp at Gosainkund Lake (4380 m) in the Nepal Himalaya during the annual Janai Purnima Festival in 2014. Records included rate of ascent and Lake Louise Score (LLS). We defined High Altitude Headache (HAH) as headache alone or LLS = 2. Acute Mountain Sickness (AMS) was LLS≥3...
March 2017: Travel Medicine and Infectious Disease
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