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https://www.readbyqxmd.com/read/28702179/pathological-correlations-between-traumatic-brain-injury-and-chronic-neurodegenerative-diseases
#1
REVIEW
Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez, Riyi Shi
Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is associated with a number of chronic neurological and neuropsychiatric sequelae including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, despite the high incidence of traumatic brain injuries and the established clinical correlation with neurodegeneration, the causative factors linking these processes have not yet been fully elucidated...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28653390/interventions-for-preventing-high-altitude-illness-part-1-commonly-used-classes-of-drugs
#2
REVIEW
Víctor H Nieto Estrada, Daniel Molano Franco, Roger David Medina, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude. In this review, the first in a series of three about preventive strategies for HAI, we assess the effectiveness of six of the most recommended classes of pharmacological interventions...
June 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28652215/histoplasma-capsulatum-in-the-bone-marrow-of-an-hiv-infected-patient
#3
Isaí Medina-Piñón, Pedro Hernández-Rodríguez, Silvia Estela Haces-Rodríguez, Luis Arturo Acosta-Calderón
No abstract text is available yet for this article.
June 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28621523/mussel-inspired-hyaluronic-acid-derivative-nanostructures-for-improved-tumor-targeting-and-penetration
#4
Song Yi Lee, Ju-Hwan Park, Seung-Hak Ko, Jae-Seong Shim, Dae-Duk Kim, Hyun-Jong Cho
An amphiphilic hyaluronic acid-ceramide-dopamine (HACE-d) conjugate was prepared, and HACE-d-based nanoparticles (NPs) including phloretin (as an inhibitor of glucose transporter (GLUT1)) were fabricated. Mussel-inspired property of d was introduced to HACE NPs, and it may improve tumor targetability and penetration in addition to passive (based on enhanced permeability and retention effect) and active (interaction between HA and CD44 receptor) tumor targeting effects. HACE-d/phloretin NPs with 279 nm mean diameter, ∼0...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28614438/pressure-ulcer-dressings-in-critical-patients-a-cost-analysis
#5
Dinara Raquel Araújo Silva, Sandra Marina Gonçalves Bezerra, Jéssica Pereira Costa, Maria Helena Barros Araújo Luz, Vanessa Caminha Aguiar Lopes, Lidya Tolstenko Nogueira
OBJECTIVE: To assess the direct cost of dressings in pressure ulcer treatment. METHOD: This was a descriptive observational study conducted at an intensive care unit in the Northeast region of Brazil, between November and December 2015. Data were gathered using the Pressure Ulcer Scale for Healing and a form to characterize and assess costs. Values in Brazilian reais (BRL) were converted into U.S. dollars at the exchange rate of USD 0.26/BRL. Univariate and bivariate analyses were conducted...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28585853/%C3%A2-podemos-integrar-la-asistencia-nutricional-en-los-distintos-niveles-asistenciales-la-experiencia-catalana-visi%C3%A3-n-del-cl%C3%A3-nico
#6
Rosa Burgos Peláez, Clara Joaquin Ortiz, Cristina Vaqué Crusellas
La desnutrición relacionada con la enfermedad es altamente prevalente en patologías que con mucha frecuencia conforman la complejidad asistencial. Los modelos sanitarios de atención a la complejidad deben incluir la detección y el abordaje de la desnutrición como elemento clave debido a su elevado impacto en la evolución del paciente y en el consumo de recursos sanitarios. Los pacientes desnutridos presentan más necesidad de hospitalización, mayor tasa de complicaciones, más mortalidad, más necesidad de recursos sociales al alta hospitalaria y una mayor frecuencia de reingresos hospitalarios...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28481626/retinal-hemorrhage-in-a-high-altitude-aid-post-volunteer-doctor-a-case-report
#7
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Nirajan Regmi, Sushil Pant
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Nirajan Regmi, and Sushil Pant. Retinal hemorrhage in a high-altitude aid post volunteer doctor: a case report. High Alt Med Biol 00:000-000, 2017.-High-altitude retinal hemorrhages (HARHs) are seen at altitudes more than 3000 m, are usually multiple, flame shaped, and adjacent to blood vessels. Development near the macula causes blurring of vision, otherwise, they are symptomless and self-limiting. They often develop during the first few days after ascent to high altitude and subjects often suffer from acute mountain sickness (AMS) or high-altitude cerebral edema (HACE)...
May 8, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28433745/hypoxia-augments-lps-induced-inflammation-and-triggers-high-altitude-cerebral-edema-in-mice
#8
Yanzhao Zhou, Xin Huang, Tong Zhao, Meng Qiao, Xingnan Zhao, Ming Zhao, Lun Xu, Yongqi Zhao, Liying Wu, Kuiwu Wu, Ruoli Chen, Ming Fan, Lingling Zhu
High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to and development of brain edema. In the present study, we investigated the inflammatory response and its roles in HACE in mice following high altitude hypoxic injury. We report that acute hypobaric hypoxia induced a slight inflammatory response or brain edema within 24h in mice...
April 20, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28421789/in%C3%AF-uencia-del-aceite-de-coco-en-enfermos-de-alzh%C3%A3-imer-a-nivel-cognitivo
#9
José Enrique De la Rubia Ortí, Carmen Sánchez Álvarez, Pablo Selvi Sabater, Alma María Bueno Cayo, Sandra Sancho Castillo, Mariano Julián Rochina, Iván Hu Yang
Introducción: la enfermedad de Alzheimer es a día de hoy la demencia neurodegenerativa con mayor prevalencia en el primer mundo. Este hecho, unido a la falta de tratamiento farmacológico que cure la enfermedad, hace que se estudien nuevas estrategias terapéuticas no farmacológicas como es la administración de nutrientes. En este sentido, destaca la posible influencia del aceite de coco como fuente energética alternativa, capaz de frenar la muerte neuronal que se produce de modo progresivo en esta enfermedad...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421781/aporte-de-hierro-y-zinc-bioaccesible-a-la-dieta-de-ni%C3%A3-os-hondure%C3%A3-os-menores-de-24-meses
#10
Lorena Fernández-Palacios, Gaspar Ros-Berruezo, Elsa Barrientos-Augustinus, Elizabeth Jirón de Caballero, Carmen Frontela-Saseta
Objetivo: en el presente estudio se han analizado 18 alimentos infantiles (10 elaborados con recetas tradicionales hondureñas y 8 papillas industriales comercializadas en ese país), que suponen la base de la alimentación de los lactantes hondureños excluida la leche materna y las fórmulas infantiles.Material y métodos: se determinó el contenido y bioacesiblidad (fracciones solubes y dializables) de Fe y Zn. Para ello se simuló una digestión in vitro gastrointestinal con una primera fase de digestión gástrica (con pepsina), seguida de una segunda fase de digestión intestinal (con pancreatina y sales biliares)...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28323589/preventing-high-altitude-cerebral-edema-in-rats-with-repurposed-anti-angiogenesis-pharmacotherapy
#11
Samantha Tarshis, Joanne Maltzahn, Zoe Loomis, David C Irwin
BACKGROUND: High altitude cerebral edema (HACE) is a fulminant, deadly, and yet still unpredictable brain disease. A new prophylactic treatment for HACE and its predecessor, acute mountain sickness (AMS), needs to be developed without the contraindications or adverse effect profiles of acetazolamide and dexamethasone. Since neovascularization signals are likely key contributors to HACE/AMS, our approach was to examine already existing anti-angiogenic drugs to inhibit potential initiating HACE pathway(s)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28317325/experimental-verification-of-advanced-collapsed-cone-engine-for-use-with-a-multichannel-vaginal-cylinder-applicator
#12
Brie Cawston-Grant, Hali Morrison, Geetha Menon, Ron S Sloboda
Model-based dose calculation algorithms have recently been incorporated into brachytherapy treatment planning systems, and their introduction requires critical evaluation before clinical implementation. Here, we present an experimental evaluation of Oncentra(®) Brachy Advanced Collapsed-cone Engine (ACE) for a multichannel vaginal cylinder (MCVC) applicator using radiochromic film. A uniform dose of 500 cGy was specified to the surface of the MCVC using the TG-43 dose formalism under two conditions: (a) with only the central channel loaded or (b) only the peripheral channels loaded...
March 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28285976/high-altitude-illness-in-pilgrims-after-rapid-ascent-to-4380%C3%A2-m
#13
Ken Zafren, Matiram Pun, Nirajan Regmi, Gobinda Bashyal, Bhuwan Acharya, Subarna Gautam, Sujan Jamarkattel, Shankar Raj Lamichhane, Suman Acharya, Buddha Basnyat
BACKGROUND: The goal of the study was to characterize high altitude illness in Nepali pilgrims. METHODS: We kept standardized records at the Himalayan Rescue Association (HRA) Temporary Health Camp at Gosainkund Lake (4380 m) in the Nepal Himalaya during the annual Janai Purnima Festival in 2014. Records included rate of ascent and Lake Louise Score (LLS). We defined High Altitude Headache (HAH) as headache alone or LLS = 2. Acute Mountain Sickness (AMS) was LLS≥3...
March 9, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28244764/logros-y-retos-de-nutrici%C3%A3-n-hospitalaria-2016-2017
#14
José Manuel Moreno Villares, Gabriel Olveira Fuster
Un edificio no se construye sino ladrillo a ladrillo. Y antes de construir ya hubo quien roturó el terreno y asentó los cimientos. Y cuando la construcción esté terminada otros diseñarán los interiores, la amueblarán y harán que sea no un edificio sino una casa. Una revista científi ca se parece un poco a una construcción: se trabaja por fases, se precisa la colaboración de muchos, busca ser hogar de todos.Hace un año asumíamos el reto de continuar la tarea de la anterior Dirección de Nutrición Hospitalaria...
February 22, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28216300/boronic-acid-tethered-amphiphilic-hyaluronic-acid-derivative-based-nanoassemblies-for-tumor-targeting-and-penetration
#15
Jae Young Jeong, Eun-Hye Hong, Song Yi Lee, Jae-Young Lee, Jae-Hyoung Song, Seung-Hak Ko, Jae-Seong Shim, Sunghwa Choe, Dae-Duk Kim, Hyun-Jeong Ko, Hyun-Jong Cho
(3-Aminomethylphenyl)boronic acid (AMPB)-installed hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs), including manassantin B (MB), were fabricated for tumor-targeted delivery. The amine group of AMPB was conjugated to the carboxylic acid group of hyaluronic acid (HA) via amide bond formation, and synthesis was confirmed by spectroscopic methods. HACE-AMPB/MB NPs with a 239-nm mean diameter, narrow size distribution, negative zeta potential, and >90% drug encapsulation efficiency were fabricated...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28128652/extensive-microhemorrhages-of-the-cerebellar-peduncles-after-high-altitude-cerebral-edema
#16
Jacqueline Pichler Hefti, Philipp Hoigné-Perret, Raimund Kottke
Pichler Hefti, Jacqueline, Philipp Hoigné-Perret, and Raimund Kottke. Extensive microhemorrhages of the cerebellar peduncles after high-altitude cerebral edema. High Alt Med Biol 00:000-000, 2017.-Neuromagnetic resonance imaging (MRI) of subjects who suffered from high-altitude cerebral edema (HACE) typically shows cerebral microhemorrhages (MH) of the corpus callosum, in particular the splenium, and supratentorial white matter. This is a case report of a 43-year-old male, who suffered from unusually prolonged severe ataxia and amnesia after having been rescued during the ascent to Mount Everest at 6400 m...
January 27, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28000482/comparaci%C3%A3-n-entre-personas-con-malnutrici%C3%A3-n-por-exceso-con-y-sin-trastorno-por-atrac%C3%A3-n
#17
Neli Escandón-Nagel
Introducción: si bien el Trastorno por Atracón es un trastorno de la conducta alimentaria que  no se da exclusivamente en personas obesas, es más común en este grupo que en sujetos con normopeso, sin embargo no todas las personas con malnutrición por exceso presentan Trastorno por Atracón. Objetivo: identificar el conocimiento actual respecto a las diferencias y semejanzas existentes entre personas con malnutrición por exceso con y sin Trastorno por Atracón.Método: para lograr el objetivo anterior, se realizó una revisión de artículos científicos en torno al tema...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28000450/%C3%A2-estamos-dando-los-espa%C3%A3-oles-la-talla
#18
Federico Soriguer
Desde hace algún tiempo sabemos que la talla de las poblaciones es un buen instrumento para analizar la evolución socioeconómica, habiendo dejado de ser motivo de estudio solo por la biomedicina para serlo también por los economistas y sociólogos. Es lo que han hecho Martínez Carrión y cols., con el trabajo que aparece en este número de Nutrición Hospitalaria.
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27890034/do-patients-get-whacked-when-hospitals-get-haced
#19
Leonard A Mermel
No abstract text is available yet for this article.
February 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27799499/cervical-artery-dissection-at-high-altitude-an-overview-of-two-patients
#20
Shreeyukta Bhattarai, William Elson, Rashila Pradhan, Prativa Pandey
While altitude illness is common in the Himalayas, conditions unrelated to altitude illness also occur. High altitude cerebral oedema HACE is a global phenomenon of gradual onset affecting both cerebral hemispheres. We outline two cases of cervical artery dissection presenting with sudden onset of focal neurological symptoms at high altitude.
July 2016: Journal of Travel Medicine
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