Kateryna Maksyutynska, Nicolette Stogios, Femin Prasad, Jashan Gill, Zaineb Hamza, Riddhita De, Emily Smith, Angelina Horta, Benjamin I Goldstein, Daphne Korczak, Ariel Graff-Guerrero, Margaret K Hahn, Sri Mahavir Agarwal
Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765)...
March 7, 2024: Psychological Medicine