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https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#1
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29144538/control-of-hemorrhage-through-the-osteotomy-gap-during-tibial-plateau-leveling-osteotomy-9-cases
#2
Luis Matres-Lorenzo, Aidan McAlinden, Antoine Bernardé, Fabrice Bernard
OBJECTIVE: To describe a new technique to control intraoperative hemorrhage during tibial plateau leveling osteotomy (TPLO) and report subsequent short-term and long-term complications. STUDY DESIGN: Retrospective case series. ANIMALS: Nine dogs with arterial hemorrhage during TPLO. METHODS: Medical records of dogs with hemorrhage controlled through the osteotomy gap of a TPLO were reviewed at 2 institutions over 8 years...
November 16, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29143952/-the-effect-of-mood-stabilising-drugs-on-cytokine-levels-in-bipolar-disorder-a-systematic-review
#3
S Van Den Ameele, L van Diermen, W Staels, V Coppens, G Dumont, B Sabbe, M Morrens
Veranderde cytokineconcentraties bij personen met een bipolaire stoornis ten opzichte van controle-personen suggereren een rol van het immuunsysteem in de pathofysiologie van bipolaire stoornis. Farmacotherapie is een belangrijke verstorende factor in klinisch onderzoek naar cytokineconcentraties.<br/> DOEL: Evalueren van cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis en van het effect van stemmingsstabiliserende geneesmiddelen op deze concentraties.<br/> METHODE: We doorzochten systematisch PubMed en Embase naar klinische studies die cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis beschrijven of het effect van een individueel stemmingsstabiliserend geneesmiddel op deze concentraties evalueren...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29143763/intellectual-functioning-in-offspring-of-parents-with-bipolar-disorder-a-review-of-the-literature
#4
REVIEW
Bonnie Klimes-Dougan, Jake Jeong, Kevin P Kennedy, Timothy A Allen
Impaired intellectual functioning is an important risk factor for the emergence of severe mental illness. Unlike many other forms of mental disorder however, the association between bipolar disorder and intellectual deficits is unclear. In this narrative review, we examine the current evidence on intellectual functioning in children and adolescents at risk for developing bipolar disorder. The results are based on 18 independent, peer-reviewed publications from 1980 to 2017 that met criteria for this study. The findings yielded no consistent evidence of lower or higher intellectual quotient (IQ) in offspring of parents diagnosed with bipolar disorder...
October 28, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29138173/cardiovascular-preventive-care-for-patients-with-serious-mental-illness
#5
Sarah Ritchie, Laura Muldoon
OBJECTIVE: To determine whether patients with serious mental illness (SMI) are receiving preventive care for cardiovascular disease at the same rate as those without SMI in an interprofessional practice with a mandate to care for persons with barriers to access to the health care system. DESIGN: Quality improvement exercise using a case-matched retrospective chart review. SETTING: Somerset West Community Health Centre in downtown Ottawa, Ont...
November 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29137156/digital-platforms-in-the-assessment-and-monitoring-of-patients-with-bipolar-disorder
#6
REVIEW
Arvind Rajagopalan, Pooja Shah, Melvyn W Zhang, Roger C Ho
This paper aims to review the application of digital platforms in the assessment and monitoring of patients with Bipolar Disorder (BPD). We will detail the current clinical criteria for the diagnosis of BPD and the tools available for patient assessment in the clinic setting. We will go on to highlight the difficulties in the assessment and monitoring of BPD patients in the clinical context. Finally, we will elaborate upon the impact that diital platforms have made, and have the potential to make, on healthcare, mental health, and specifically the management of BPD, before going on to evaluate the benefits and drawbacks of the use of such technology...
November 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29135565/pediatric-and-adolescent-anterior-shoulder-instability-clinical-management-of-first-time-dislocators
#7
Kenneth M Lin, Evan W James, Elad Spitzer, Peter D Fabricant
PURPOSE OF REVIEW: The purpose of this review is to discuss the epidemiology, pathoanatomy, diagnosis, and clinical management of pediatric and adolescent patients following a first-time shoulder dislocation. RECENT FINDINGS: Shoulder instability is becoming increasingly common as pediatric and adolescent patients engage in earlier organized sports competition. Recommended treatment following a first-time glenohumeral dislocation event in adolescents depends on several factors, but surgical stabilization is becoming more frequently performed...
November 11, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29134707/reproducibility-of-diagnostic-criteria-associated-with-atypical-breast-cytology
#8
J Weigner, I Zardawi, S Braye, P McElduff
OBJECTIVE: The aim of this project was to assess the interobserver and intraobserver variability when identifying cytological criteria, which were found to have a statistically significant association with C3 within a workplace environment. METHODS: Sixty C3 cases with known endpoints of malignant, benign proliferative or benign non-proliferative diagnoses were blindly and independently screened by seven experienced cytologists to identify previously reported statistically significant criteria associated with the C3 category...
November 14, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29132553/dysregulation-of-glucose-metabolism-since-young-adulthood-increases-the-risk-of-cardiovascular-diseases-in-patients-with-bipolar-disorder
#9
Pao-Huan Chen, Yen-Kuang Lin, Chi-Kang Chang, Shuo-Ju Chiang, Shang-Ying Tsai
Aging patients with bipolar disorder (BD) are at a high risk of cardiovascular diseases (CVDs). However, few studies have directly examined the association between metabolic risks and CVDs in patients with BD across the lifespan. Therefore, the aim of this study was to determine lifetime metabolic risk factors for CVDs in patients with BD. We recruited BD-I patients who were more than 50 years old and had had at least one psychiatric hospitalization. Patients who had a cardiologist-confirmed CVD diagnosis (ICD-9 code 401-414) were assigned to the case group...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29130059/inter-and-intra-individual-variation-in-emotional-complexity-methodological-considerations-and-theoretical-implications
#10
Anthony D Ong, Alex J Zautra, Patrick H Finan
The degree of relationship between positive and negative emotional states or emotional complexity is a topic of ongoing methodological and theoretical debate. At issue is whether positive and negative emotions are opposite ends of a bipolar continuum or independent dimensions in a bivariate distribution with little degree of overlap. In this review, we summarize a body of work suggesting that the distinction between positive and negative emotions varies both between and within individuals over time as a function of cognition and changes in informational demands, a perspective called the Dynamic Model of Affect (DMA)...
June 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29129507/the-use-of-polygenic-risk-scores-to-identify-phenotypes-associated-with-genetic-risk-of-schizophrenia-systematic-review
#11
REVIEW
Sumit Mistry, Judith R Harrison, Daniel J Smith, Valentina Escott-Price, Stanley Zammit
Studying the phenotypic manifestations of increased genetic liability for schizophrenia can increase our understanding of this disorder. Specifically, information from alleles identified in genome-wide association studies can be collapsed into a polygenic risk score (PRS) to explore how genetic risk is manifest within different samples. In this systematic review, we provide a comprehensive assessment of studies examining associations between schizophrenia PRS (SZ-PRS) and several phenotypic measures. We searched EMBASE, Medline and PsycINFO (from August 2009-14th March 2016) plus references of included studies, following PRISMA guidelines...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128376/radial-head-replacement-with-a-bipolar-system-an-average-10-year-follow-up
#12
Robert A Sershon, Timothy J Luchetti, Mark S Cohen, Robert W Wysocki
BACKGROUND: We report the long-term results of a cohort of patients after radial head replacement with a bipolar design and a smooth cementless stem at a mean follow-up of 10.4 years. METHODS: Of 17 possible patients from a previous minimum 2-year follow-up study, 16 were available for review. Patients were assessed using clinical and radiographic examination and with standardized outcome measures. Range of motion, stability, and radiographic evaluation of implant loosening and joint degeneration were assessed...
November 8, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29127487/towards-a-unified-understanding-of-lithium-action-in-basic-biology-and-its-significance-for-applied-biology
#13
REVIEW
Eric Jakobsson, Orlando Argüello-Miranda, See-Wing Chiu, Zeeshan Fazal, James Kruczek, Santiago Nunez-Corrales, Sagar Pandit, Laura Pritchet
Lithium has literally been everywhere forever, since it is one of the three elements created in the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from place to place, and has varied widely in specific regions over evolutionary and geologic time. The biological effects of lithium are many and varied. Based on experiments in which animals are deprived of lithium, lithium is an essential nutrient. At the other extreme, at lithium ingestion sufficient to raise blood concentration significantly over 1 mM/, lithium is acutely toxic...
November 10, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29119926/-the-role-of-cxcr3-in-neurological-diseases
#14
Ya-Qun Zhou, Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xue-Rong Zhou, Cui Xing, Da-Wei Ye, Yu-Ke Tian
Neurological diseases have become an obvious challenge due to insufficient therapeutic intervention. Therefore, novel drugs for various neurological disorders are in desperate need. Recently, compelling evidence has demonstrated that chemokine receptor CXCR3, which is a G protein-coupled receptor in the CXC chemokine receptor family, may play a pivotal role in the development of neurological diseases. The expression level of CXCR3 in T cells was significantly elevated in several neurological diseases, suggesting a potential therapeutic role of CXCR3 antagonists...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29119914/obsessive-compulsive-disorder-with-comorbid-bipolar-disorders-clinical-features-and-treatment-implications
#15
Federico Mucci, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti, Giulio Perugi
BACKGROUND: Obsessive-compulsive disorder (OCD) symptoms within the context of a bipolar disorder (BD) have been described since the 19th century. Interestingly, the existence of a relevant overlap between the aforementioned psychiatric syndromes has been confirmed by a number of recent epidemiological and family studies. AIMS: The aim of the present paper is to review the clinical features and the therapeutic implications of the OCD-BD comorbidity. DISCUSSION: In the last two decades, the frequent association between OCD and BD has been earning a growing interest given its relevant nosological and therapeutic implications...
November 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29116664/unraveling-the-biology-of-bipolar-disorder-using-induced-pluripotent-stem-derived-neurons
#16
REVIEW
Nathaniel D Miller, John R Kelsoe
OBJECTIVES: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder...
November 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29112195/face-and-predictive-validity-of-the-clock%C3%AE-19-mouse-as-an-animal-model-for-bipolar-disorder-a-systematic-review
#17
REVIEW
M Kristensen, A A Nierenberg, S D Østergaard
Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (ClockΔ19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and ClockΔ19...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29108392/cauterization-of-ozurdex-wound-for-the-prevention-of-scleral-leakage-in-vitrectomized-eyes
#18
Claudio Furino, Nicola Recchimurzo, Francesco Boscia, Giovanni Alessio
PURPOSE: To study if cauterization of the scleroconjuctival wound secondary to intravitreal dexamethasone implant in vitrectomized eyes is effective to avoid scleral leakage and hypotony. METHODS: A total of 35 vitrectomized eyes of 35 consecutive patients with macular edema who underwent a single intravitreal dexamethasone implant injection in the operating room at the Eye Clinic of the University of Bari, Italy, from 2013 to 2017 were retrospectively reviewed...
October 31, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29108106/measurement-tools-for-assessment-of-older-age-bipolar-disorder-a-systematic-review-of-the-recent-global-literature
#19
Soham Rej, William Quayle, Brent P Forester, Annemiek Dols, Jennifer Gatchel, Peijun Chen, Sarah Gough, Rebecca Fox, Martha Sajatovic, Sergio A Strejilevich, Lisa T Eyler
OBJECTIVES: More than 50% of people with bipolar disorder will be age 60 years or older by 2030. There is a need for more data to guide assessment and treatment in older age bipolar disorder (OABD); however, interpretation of findings from small, single-site studies may not be generalizable and there are few large trials. As a step in the direction of coordinated large-scale OABD data collection, it is critical to identify which measurements are currently used and identify potential gaps in domains typically assessed...
November 6, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29102836/efficacy-and-tolerability-of-minocycline-for-depression-a-systematic-review-and-meta-analysis-of-clinical-trials
#20
REVIEW
Joshua D Rosenblat, Roger S McIntyre
BACKGROUND: Minocycline has been identified as a potential novel treatment for depression. The objective of the current review is to determine the overall antidepressant efficacy and tolerability of minocycline. METHODS: Completed and ongoing clinical trials of minocycline for depression (both bipolar and unipolar) published prior to September 12, 2017 were identified through searching relevant databases. Using a random-effects model, data from randomized controlled trials (RCTs) were pooled to determine the antidepressant effect size of minocycline compared to placebo...
October 28, 2017: Journal of Affective Disorders
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