keyword
https://read.qxmd.com/read/38490761/heterogeneity-of-outcome-measures-in-depression-trials-and-the-relevance-of-the-content-of-outcome-measures-to-patients-a-systematic-review
#1
REVIEW
Christopher Veal, Anneka Tomlinson, Andrea Cipriani, Samuel Bulteau, Chantal Henry, Chlöé Müh, Suzanne Touboul, Nikki De Waal, Hana Levy-Soussan, Toshi A Furukawa, Eiko I Fried, Viet-Thi Tran, Astrid Chevance
Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure (Hamilton Depression Rating Scale [HAMD]). Patients and clinicians matched each item within the 25 most frequently used measures with 80 previously identified domains of depression that matter to patients...
April 2024: Lancet Psychiatry
https://read.qxmd.com/read/38490647/advances-in-the-understanding-of-the-pathophysiology-of-schizophrenia-and-bipolar-disorder-through-induced-pluripotent-stem-cell-models
#2
REVIEW
Andrea Perrottelli, Francesco Flavio Marzocchi, Edoardo Caporusso, Giulia Maria Giordano, Luigi Giuliani, Antonio Melillo, Pasquale Pezzella, Paola Bucci, Armida Mucci, Silvana Galderisi
The pathophysiology of schizophrenia and bipolar disorder involves a complex interaction between genetic and environmental factors that begins in the early stages of neurodevelopment. Recent advancements in the field of induced pluripotent stem cells (iPSCs) offer a promising tool for understanding the neurobiological alterations involved in these disorders and, potentially, for developing new treatment options. In this review, we summarize the results of iPSC-based research on schizophrenia and bipolar disorder, showing disturbances in neurodevelopmental processes, imbalance in glutamatergic-GABAergic transmission and neuromorphological alterations...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38489628/occupation-dependent-particle-separation-in-one-dimensional-non-hermitian-lattices
#3
JOURNAL ARTICLE
Yi Qin, Linhu Li
We unveil an exotic phenomenon arising from the intricate interplay between non-Hermiticity and many-body physics, namely, an occupation-dependent particle separation for hardcore bosons in a one-dimensional lattice driven by unidirectional non-Hermitian pumping. Taking hardcore bosons as an example, we find that a pair of particles occupying the same unit cell exhibit an opposite non-Hermitian pumping direction to that of unpaired ones occupying different unit cells. By turning on an intracell interaction, many-body eigenstates split in their real energies, forming separable clusters in the complex energy plane with either left-, right-, or bipolar-types of non-Hermitian skin effect (NHSE)...
March 1, 2024: Physical Review Letters
https://read.qxmd.com/read/38487836/efficacy-and-tolerability-of-fda-approved-atypical-antipsychotics-for-the-treatment-of-bipolar-depression-a-systematic-review-and-network-meta-analysis
#4
REVIEW
Shaoli Li, Chenyue Xu, Shaohua Hu, Jianbo Lai
No abstract text is available yet for this article.
March 15, 2024: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/38485677/assessment-of-monitoring-and-management-practices-of-antipsychotic-induced-hyperprolactinemia-at-a-medical-city-in-riyadh-saudi-arabia-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Zahra Hussain Alshabeeb, Bashayr Alsuwayni, Omar Alshargi, Ahmed H Abdelazeem
BACKGROUND: Hyperprolactinemia is a commonly underestimated adverse effect of antipsychotic medications. There are still no consensus guidelines for the optimal monitoring and treatment strategies. OBJECTIVE: The aim of the study was to assess the monitoring and treatment practices of antipsychotic- induced hyperprolactinemia, in addition to the prevalence and risk factors associated with it. METHODS: A retrospective cohort observational study was conducted among patients attending the psychiatric clinics at an academic tertiary hospital in Riyadh, Saudi Arabia, from May 2020 until May 2021, by reviewing each patient's medical record for up to five years...
March 12, 2024: Current Drug Safety
https://read.qxmd.com/read/38481642/peripartum-cardiomyopathy-in-patients-with-psychiatric-disorders-successfully-treated-with-bromocriptine-two-case-reports
#6
Haruka Takanaka, Ryohei Ono, Hirotoshi Kato, Togo Iwahana, Tomoki Miyahara, Hidehisa Takahashi, Yasuhiko Hori, Kenichi Fukushima, Yoshio Kobayashi
UNLABELLED: Peripartum cardiomyopathy (PPCM) is a rare disorder in which left ventricular systolic dysfunction and heart failure symptoms occur during the peripartum period. Inhibition of prolactin secretion by bromocriptine mediates beneficial effects on cardiac function in PPCM. Mental disorders are also associated with the onset of PPCM. Psychiatric medications for mental disorders would affect serotonin production and tryptophan and dopamine metabolism, and they are associated with PPCM...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38475800/mental-health-interventions-for-individuals-with-serious-mental-illness-in-the-criminal-legal-system-a-systematic-review
#7
JOURNAL ARTICLE
Maji Hailemariam, Tatiana E Bustos, Barrett Wallace Montgomery, Garrett Brown, Gashaye Tefera, Rosemary Adaji, Brandon Taylor, Hiywote Eshetu, Clara Barajas, Rolando Barajas, Vanessa Najjar, Donovan Dennis, Jasmiyne Hudson, Julia W Felton, Jennifer E Johnson
BACKGROUND: Globally, individuals with mental illness get in contact with the law at a greater rate than the general population. The goal of this review was to identify and describe: (1) effectiveness of mental health interventions for individuals with serious mental illness (SMI) who have criminal legal involvement; (2) additional outcomes targeted by these interventions; (3) settings/contexts where interventions were delivered; and (4) barriers and facilitating factors for implementing these interventions...
March 12, 2024: BMC Psychiatry
https://read.qxmd.com/read/38475354/carbon-material-reinforced-polymer-composites-for-bipolar-plates-in-polymer-electrolyte-membrane-fuel-cells
#8
REVIEW
Alejandro Gomez-Sanchez, Víctor A Franco-Luján, Hilda M Alfaro-López, Laura Hernández-Sánchez, Heriberto Cruz-Martínez, Dora I Medina
Bipolar plates (BPs) are one of the most important components of polymer electrolyte membrane fuel cells (PEMFCs) because of their important role in gas and water management, electrical performance, and mechanical stability. Therefore, promising materials for use as BPs should meet several technical targets established by the United States Department of Energy (DOE). Thus far, in the literature, many materials have been reported for possible applications in BPs. Of these, polymer composites reinforced with carbon allotropes are one of the most prominent...
March 1, 2024: Polymers
https://read.qxmd.com/read/38472517/role-of-estrogen-in-sex-differences-in-memory-emotion-and-neuropsychiatric-disorders
#9
REVIEW
Javed Iqbal, Geng-Di Huang, Yan-Xue Xue, Mei Yang, Xiao-Jian Jia
Estrogen regulates a wide range of neuronal functions in the brain, such as dendritic spine formation, remodeling of synaptic plasticity, cognition, neurotransmission, and neurodevelopment. Estrogen interacts with intracellular estrogen receptors (ERs) and membrane-bound ERs to produce its effect via genomic and non-genomic pathways. Any alterations in these pathways affect the number, size, and shape of dendritic spines in neurons associated with psychiatric diseases. Increasing evidence suggests that estrogen fluctuation causes changes in dendritic spine density, morphology, and synapse numbers of excitatory and inhibitory neurons differently in males and females...
March 12, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38472341/techniques-for-registration-of-myoelectric-activity-of-women-s-pelvic-floor-muscles-a-scoping-review
#10
REVIEW
Josepha Karinne de Oliveira Ferro, Andrea Lemos, Alessandra Carolina de Santana Chagas, Alexa Alves de Moraes, Ana Izabela Sobral de Oliveira-Souza, Daniella Araújo de Oliveira
INTRODUCTION AND HYPOTHESIS: Surface electromyography is commonly applied to measure the electrophysiological activity of the neuromuscular system. However, there is no consensus regarding the best protocol to assess pelvic floor muscles. METHODS: A scoping literature review was carried out in six databases, using MeSH descriptors. It included studies with electromyographic assessment in adult women presenting or not with pelvic floor dysfunction. The results were presented in categories to contribute to the development of a protocol considering the most used parameters for non-invasive assessment of myoelectric activity of pelvic floor muscles...
March 12, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38471512/risperidone-induced-leukoneutropenia-evidence-from-a-positive-rechallenge-and-review-of-the-literature
#11
REVIEW
Dhouha Sahnoun, Ahlem Ghanmi, Soumaya Gazzeh, Bochra Saguem, Raoudha Slim, Jaafar Nakhli, Chaker Ben Salem
Antipsychotics can cause hematologic disorders, and they can have life-threatening consequences. Risperidone, less commonly associated with hematologic adverse effects, is an atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder and irritability associated with autism. While risperidone primarily affects the central nervous system, it can have some hematologic adverse effects, although these are relatively rare. It is crucial to note that these side effects are not common, and most people taking risperidone do not experience hematologic disorders...
March 2024: Pharmacopsychiatry
https://read.qxmd.com/read/38470559/biomarkers-of-bipolar-disorder-in-late-life-an-evidence-based-systematic-review
#12
REVIEW
R Chancel, J Lopez-Castroman, E Baca-Garcia, R Mateos Alvarez, Ph Courtet, I Conejero
PURPOSE OF REVIEW: Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and "Aged, 80 and over". Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers...
March 12, 2024: Current Psychiatry Reports
https://read.qxmd.com/read/38468398/complexity-of-patients-with-mental-healthcare-needs-cared-for-by-mental-health-clinical-pharmacist-practitioners-in-veterans-affairs
#13
JOURNAL ARTICLE
Guneet K Jasuja, Joel I Reisman, Donald R Miller, Elayne D Ansara, Dana L Chiulli, Tera Moore, Heather L Ourth, Michael H Tran, Eric G Smith, Anthony P Morreale, Megan M McCullough
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: The complexity of patients with mental healthcare needs cared for by clinical pharmacists is not well delineated...
March 12, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38465894/long-acting-second-generation-injectable-antipsychotics-for-the-maintenance-treatment-of-bipolar-disorder-a-narrative-review
#14
REVIEW
Jean-Baptiste Belge, Bernard G C C Sabbe
INTRODUCTION: Non-adherence to medication significantly affects bipolar disorder outcomes. Long-Acting Injectable antipsychotics show promise by ensuring adherence and averting relapses. AREAS COVERED: This narrative review sought to evaluate the efficacy of second-generation injectable antipsychotics in bipolar disorder through searches in Embase, MEDLINE, and PsycInfo for randomized controlled trials and mirror-image studies.Risperidone and aripiprazole Long-Acting Injectables demonstrated effectiveness in preventing mood recurrences compared to placebos in adults with bipolar disorder...
March 11, 2024: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/38460088/prevention-of-suicidal-behavior-with-lithium-treatment-in-patients-with-recurrent-mood-disorders
#15
REVIEW
Leonardo Tondo, Ross J Baldessarini
Suicidal behavior is more prevalent in bipolar disorders than in other psychiatric illnesses. In the last thirty years evidence has emerged to indicate that long-term treatment of bipolar disorder patients with lithium may reduce risk of suicide and attempts, with possibly similar benefits in recurrent major depressive disorder. We review and update selected research literature on effects of lithium treatment in reducing suicidal behavior and consider proposals that higher levels of lithium in drinking water may be associated with lower suicide rates...
March 9, 2024: International Journal of Bipolar Disorders
https://read.qxmd.com/read/38458216/promoting-good-mental-health-over-the-menopause-transition
#16
REVIEW
Lydia Brown, Myra S Hunter, Rong Chen, Carolyn J Crandall, Jennifer L Gordon, Gita D Mishra, Viktoria Rother, Hadine Joffe, Martha Hickey
The potential risk for mental health conditions over the menopause transition shapes women's expectations and informs putative physiological mechanisms regulating women's mental health. We review evidence from prospective studies reporting on associations between mental health conditions and the menopause transition. Major depressive disorder and the more prevalent subthreshold depressive symptoms are the most common conditions studied. We reviewed 12 prospective studies reporting depressive symptoms, major depressive disorder, or both over the menopause transition and found no compelling evidence for a universal increased risk for either condition...
March 9, 2024: Lancet
https://read.qxmd.com/read/38453827/steroid-induced-mania-in-a-patient-with-previously-well-controlled-organic-bipolar-1-like-affective-disorder-secondary-to-acquired-brain-injury-case-report-and-literature-review
#17
JOURNAL ARTICLE
Jacob D King, Thomas Elliott, Alexandra Pitman
Steroid-induced neuropsychiatric sequelae are common, and pose significant risks to people usually receiving glucocorticoids in the context of physical illness. Steroid-induced mania and hypomania are the most common of the acute complications, yet despite great progress in understandings in neurophysiology there are no recent studies which review the factors which might predict who will experience this severe complication, nor are there consensus guidelines on management. We report the unusual case of a woman in her 50s admitted to a psychiatric unit with steroid-induced mania despite compliance with two mood stabilisers, several days after the administration of a Dexamethasone and Docetaxel chemotherapy regime adjunctive to lumpectomy for breast cancer...
March 8, 2024: Discov Ment Health
https://read.qxmd.com/read/38450447/neurocognitive-correlates-of-metabolic-dysregulation-in-individuals-with-mood-disorders-a-systematic-review-and-meta-analysis
#18
REVIEW
Kateryna Maksyutynska, Nicolette Stogios, Femin Prasad, Jashan Gill, Zaineb Hamza, Riddhita De, Emily Smith, Angelina Horta, Benjamin I Goldstein, Daphne Korczak, Ariel Graff-Guerrero, Margaret K Hahn, Sri Mahavir Agarwal
Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765)...
March 7, 2024: Psychological Medicine
https://read.qxmd.com/read/38447356/neural-correlates-of-cognitive-behavioral-therapy-based-interventions-for-bipolar-disorder-a-scoping-review
#19
REVIEW
Francesca Girelli, Maria Gloria Rossetti, Cinzia Perlini, Marcella Bellani
Cognitive Behavioral Therapy (CBT) is among the gold-standard psychotherapeutic interventions for the treatment of psychiatric disorders, including bipolar disorder (BD). While the clinical response of CBT in patients with BD has been widely investigated, its neural correlates remain poorly explored. Therefore, this scoping review aimed to discuss neuroimaging studies on CBT-based interventions in bipolar populations. Particular attention has been paid to similarities and differences between studies to inform future research...
February 26, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38435916/a-scoping-review-is-yoga-an-effective-intervention-for-erectile-dysfunction-and-premature-ejaculation
#20
REVIEW
Subrahmanaya Bhat, Manoj K Pandey, Udayakumar K, Nikunj Gokani, T S Sathyanarayana Rao
There is increasing concern among both healthcare professionals and the general public about the long-term effectiveness and possible adverse effects of medicines used to treat premature ejaculation (PE) and erectile dysfunction (ED). There is also a growing recognition of the advantages of incorporating alternative or traditional approaches into healthcare systems. Yoga is gaining popularity globally and has emerged as a viable adjunct and alternative to add value to patient care and prevention of illnesses, which requires further investigation...
January 2024: Curēus
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