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Cervical insufficiency

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https://www.readbyqxmd.com/read/29142797/cervical-funneling-potential-pitfall-of-point-of-care-pelvic-ultrasound
#1
Lori A Stolz, Richard Amini, Elaine H Situ-LaCasse, Faryal Shareef, Heather A Reed, Srikar Adhikari
Though point-of-care ultrasound applications continue to expand, there are findings that are not within the scope of emergency ultrasound. It is important for emergency physicians to be aware of incidental findings that can be identified on comprehensive ultrasounds performed by other imaging departments in order to fully understand the limitations of bedside ultrasound. In this case, a gravid patient presented to the emergency department with pelvic cramping and vaginal bleeding. Point-of-care transabdominal pelvic ultrasound examination was performed and demonstrated cervical funneling...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29142619/the-formation-of-extragraft-bone-bridging-after-anterior-cervical-discectomy-and-fusion-a-finite-element-analysis
#2
Shin Won Kwon, Chi Heon Kim, Chun Kee Chung, Tae Hyun Park, Su Heon Woo, Sung-Jae Lee, Seung Heon Yang
Objective: In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29142158/computed-tomography-magnetic-resonance-imaging-and-a-novel-surgical-approach-of-atlanto-axial-instability-with-incongruence-in-dogs
#3
Mario Dolera, Luca Malfassi, Simone Pavesi, Sara Finesso, Giovanni Mazza, Silvia Marcarini, Massimo Sala, Nancy Carrara, Cristina Bianchi, Jennifer M Gambino
Atlanto-axial (AA) instability due to ligament insufficiency is a common cause of cervical spinal cord compression in toy breeds. However, in some dogs a difference in size between the atlas and the axis leads to joint incongruence that exacerbates AA subluxation and makes surgical treatment challenging. Twelve dogs with AA instability with incongruence were enrolled in a single institution prospective observational study. Computed tomography (CT) and magnetic resonance imaging (MRI) of the AA joint were compared to a retrospectively reviewed control group...
November 15, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29140150/radiotherapy-for-cervical-cancer-impact-on-the-vaginal-epithelium-and-sexual-function
#4
Alexandra Hofsjö, Karin Bergmark, Bo Blomgren, Helen Jahren, Nina Bohm-Starke
BACKGROUND: Women who have been treated for cervical cancer have persistent changes in their sexual function, which result in considerable distress. The aim of this study was to investigate the morphology of the vaginal epithelium in cervical cancer survivors treated with radiotherapy and its correlation to serum levels of sex steroid hormones and sexual function. MATERIAL AND METHODS: We included 34 patients treated for cervical cancer with radiotherapy and 37 healthy age-matched control women scheduled for benign gynecological surgery...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29116935/outcomes-of-physical-examination-indicated-cerclage-in-twin-pregnancies-with-acute-cervical-insufficiency-compared-to-singleton-pregnancies
#5
Jee Yoon Park, Soo-Hyun Cho, Se Jeong Jeon, Song Yi Kook, Hyunsoo Park, Kyung Joon Oh, Joon-Seok Hong
OBJECTIVES: To compare pregnancy outcomes of physical examination-indicated cerclage in twin pregnancies with acute cervical insufficiency with that of singletons. METHODS: This retrospective cohort study included 88 consecutive women (17 twins and 71 singletons) who had undergone physical examination-indicated cerclage because of acute cervical insufficiency (defined as painless cervical dilation with (1) prolapsed and/or visible membranes at the external cervical os on speculum examination and (2) a functional cervical length of zero on transvaginal ultrasound) between 160/7 and 236/7 weeks...
November 8, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29115417/wnt-%C3%AE-%C3%A2-catenin-pathway-activation-and-silencing-of-the-apc-gene-in-hpv%C3%A2-positive-human-cervical-cancer%C3%A2-derived-cells
#6
Erick Ayala-Calvillo, Luis Humberto Mojica-Vázquez, Alejandro García-Carrancá, Leticia González-Maya
Although persistent infections with high‑risk human papilloma virus (HPV) constitute the most significant cofactor for the development of cervical cancer, they are insufficient on their own. Mutations or epigenetic inactivation of the tumor suppressor adenomatous polyposis coli (APC), the two acting as prominent oncogenic mechanisms in a number of types of cancer, are frequently associated with aberrant activation of the Wnt/β‑catenin pathway. According to these observations, it was hypothesized that APC alteration may lead to β‑catenin deregulation and the abnormal expression of direct targets of the Wnt pathway in HPV‑infected cervical cancer cells...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114306/combined-use-of-intraoperative-indocyanine-green-and-dynamic-angiography-in-rotational-vertebral-artery-occlusion
#7
Nauman Chaudhry, Brandon Gerard Gaynor, Sudheer Ambekar, Mohamed Samy Elhammady
Rotational vertebral artery occlusion (RVAO) is a well-documented surgically amenable cause of vertebrobasilar insufficiency. Traditionally, patients have been imaged using dynamic rotational angiography. We report a case of RVAO in which intraoperative indocyanine green angiography (ICGA) was used to confirm adequate surgical decompression of the VA. A 57-year-old female who presented with multiple episodes of syncope provoked by turning her head to the right. Rotational dynamic angiography revealed a dominant right VA that became occluded at the level of C5/6 with head rotation to the right...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113037/vitamin-d-and-vdr-in-gynecological-cancers-a-systematic-review
#8
REVIEW
Eileen Deuster, Udo Jeschke, Yao Ye, Sven Mahner, Bastian Czogalla
In recent years, a vast amount of studies have centered on the role of vitamin D in the pathogenesis of certain types of cancers such as breast, colorectal and lung cancer. Increasing evidence suggests that vitamin D and its receptor play a crucial role in the development of gynecological cancers. In this review, we systematically analyzed the effect of vitamin D and the vitamin D receptor on endometrial, ovarian, cervical, vulvar and vaginal cancer. Our literature research shows that vitamin D levels and vitamin-D-related pathways affect the risk of gynecological cancers...
November 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29093067/practice-guideline-cervical-and-ocular-vestibular-evoked-myogenic-potential-testing-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#9
Terry D Fife, James G Colebatch, Kevin A Kerber, Krister Brantberg, Michael Strupp, Hyung Lee, Mark F Walker, Eric Ashman, Jeffrey Fletcher, Brian Callaghan, David S Gloss
OBJECTIVE: To systematically review the evidence and make recommendations with regard to diagnostic utility of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively). Four questions were asked: Does cVEMP accurately identify superior canal dehiscence syndrome (SCDS)? Does oVEMP accurately identify SCDS? For suspected vestibular symptoms, does cVEMP/oVEMP accurately identify vestibular dysfunction related to the saccule/utricle? For vestibular symptoms, does cVEMP/oVEMP accurately and substantively aid diagnosis of any specific vestibular disorder besides SCDS? METHODS: The guideline panel identified and classified relevant published studies (January 1980-December 2016) according to the 2004 American Academy of Neurology process...
November 1, 2017: Neurology
https://www.readbyqxmd.com/read/29055558/pelvic-fractures-after-definitive-and-postoperative-radiotherapy-for-cervical-cancer-a-retrospective-analysis-of-risk-factors
#10
Kasumi Yamamoto, Shoji Nagao, Kazuhiro Suzuki, Ai Kogiku, Tokihiro Senda, Hiroko Yano, Miho Kitai, Takaya Shiozaki, Kazuko Matsuoka, Satoshi Yamaguchi
OBJECTIVES: This study clarified the incidence of and identified the risk factors for post-radiation pelvic insufficiency fractures (PIFs) in women who received postoperative definitive or adjuvant radiotherapy (RT) for cervical cancer. PATIENTS AND METHODS: The medical records and data of imaging studies, including computed tomography scan and magnetic resonance imaging, of women with cervical cancer who received external-beam RT for the entire pelvic area between January 2003 and December 2012 at our institution were reviewed...
October 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29045834/a-latent-propriospinal-network-can-restore-diaphragm-function-after-high-cervical-spinal-cord-injury
#11
Jared M Cregg, Kevin A Chu, Lydia E Hager, Rachel S J Maggard, Daimen R Stoltz, Michaela Edmond, Warren J Alilain, Polyxeni Philippidou, Lynn T Landmesser, Jerry Silver
Spinal cord injury (SCI) above cervical level 4 disrupts descending axons from the medulla that innervate phrenic motor neurons, causing permanent paralysis of the diaphragm. Using an ex vivo preparation in neonatal mice, we have identified an excitatory spinal network that can direct phrenic motor bursting in the absence of medullary input. After complete cervical SCI, blockade of fast inhibitory synaptic transmission caused spontaneous, bilaterally coordinated phrenic bursting. Here, spinal cord glutamatergic neurons were both sufficient and necessary for the induction of phrenic bursts...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29040479/quality-of-life-following-esophagectomy-with-three-field-lymphadenectomy-for-carcinoma-focusing-on-its-relationship-to-vocal-cord-palsy
#12
M Baba, T Aikou, S Natsugoe, C Kusano, M Shimada, S Nakano, T Fukumoto, H Yoshinaka
To clarify the quality of life of patients who underwent esophagectomy for carcinoma by right thoracotomy, laparotomy and cervical anastomosis, 116 patients who were cancer free at the time of mailing a questionnaire were analyzed. A significant decrease in vital capacity for 3 years postoperatively, as well as in the percentage of ideal body weight, between 3 and 5 years were observed in 57 patients with three-field lymphadenectomy. Patients' quality of life undergoing three-field dissection was worse than those with less radical lymphadenectomy (59 cases) in terms of the performance status and difficulty in talking at 60 months or more postoperatively...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29033382/clinical-pathological-correlations-in-three-patients-with-fibrodysplasia-ossificans-progressiva
#13
Kelly L Wentworth, Katherine Bigay, Tea V Chan, Jennifer P Ho, Blanca M Morales, Joseph Connor, Erin Brooks, M Shahriar Salamat, Henry Charles Sanchez, Geoffrey Wool, Robert J Pignolo, Frederick S Kaplan, Edward C Hsiao
OBJECTIVE: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder in which heterotopic bone forms in the soft tissues. This often occurs in response to injury or inflammation, leading to joint immobilization and significant disability. There are currently no definitive treatment options for this devastating disease. Although the most dramatic phenotype in FOP is the episodic and progressive heterotopic ossification, patients report a number of symptoms that affect other organ systems...
October 13, 2017: Bone
https://www.readbyqxmd.com/read/29033106/current-options-for-mechanical-prevention-of-preterm-birth
#14
REVIEW
Rupsa C Boelig, Vincenzo Berghella
Cervical insufficiency can be defined by a combination of obstetric history, cervical dilation on exam, and/or short cervical length in women with prior preterm birth. Options for mechanical intervention include cerclage and pessary. There is evidence to support the benefit of a cervical cerclage in women with singleton gestations who have a diagnosis of cervical insufficiency either based on second trimester painless cervical dilatation leading to recurrent early preterm births, or a history of early spontaneous preterm birth and a second trimester transvaginal ultrasound short cervical length or cervical dilation on exam...
October 12, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/29017374/prevalence-of-sexually-transmitted-infections-and-their-risk-factors-among-female-sex-workers-in-isfahan-iran-a-cross-sectional-study
#15
Maryam Nasirian, Sina Kianersi, Shervin Ghaffari Hoseini, Nazila Kassaian, Majid Yaran, Parisa Shoaei, Behrooz Ataei, Reza Fadaei, Marjan Meshkati, Alireza Emami Naeini, Mojtaba Rostami Jalilian
OBJECTIVES: Female sex workers (FSWs) are at high risk of sexually transmitted infections (STIs) and form a core group to facilitate STI spreading. We aimed to estimate the prevalence of STIs among FSWs who attended Female Harm Reduction Center of Isfahan, Iran, and to determine the association between risky behaviors and STIs. STUDY DESIGN: In a cross-sectional study, 99 FSWs were recruited and interviewed about demographic characteristics and risky behaviors. A trained midwife examined FSWs for genital ulcer, abnormal vaginal discharge, and cervicitis...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28970457/pharmacists-attitudes-and-perceived-barriers-to-human-papillomavirus-hpv-vaccination-services
#16
Tessa J Hastings, Lindsey A Hohmann, Stuart J McFarland, Benjamin S Teeter, Salisa C Westrick
Use of non-traditional settings such as community pharmacies has been suggested to increase human papillomavirus (HPV) vaccination uptake and completion rates. The objectives of this study were to explore HPV vaccination services and strategies employed by pharmacies to increase HPV vaccine uptake, pharmacists' attitudes towards the HPV vaccine, and pharmacists' perceived barriers to providing HPV vaccination services in community pharmacies. A pre-piloted mail survey was sent to 350 randomly selected community pharmacies in Alabama in 2014...
August 7, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28948205/cervical-cancer-in-low-and-middle-income-countries-addressing-barriers-to-radiotherapy-delivery
#17
REVIEW
Anna W LaVigne, Scott A Triedman, Thomas C Randall, Edward L Trimble, Akila N Viswanathan
The global cervical cancer burden falls disproportionately upon women in low and middle-income countries. Insufficient infrastructure, lack of access to preventive HPV vaccines, screening, and treatment, as well as limited trained personnel and training opportunities, continue to impede efforts to reduce incidence and mortality in these nations. These hurdles have been substantial challenges to radiation delivery in particular, preventing treatment for a disease in which radiation is a cornerstone of curative therapy...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28929314/radiation-therapy-versus-surgery-for-patients-with-cervical-squamous-cell-carcinoma-who-have-undergone-neoadjuvant-chemotherapy-revisited
#18
Yu Furuta, Yukiharu Todo, Hiroyuki Yamazaki, Chisa Shimada, Sho Takeshita, Kazuhira Okamoto, Hidenori Kato
BACKGROUND: The therapeutic significance of neoadjuvant chemotherapy (NAC) followed by radiation therapy (RT) was negated during the early 1990s. Here, we compared post-NAC RT to surgery for chemo-sensitive cervical squamous cell carcinoma (SCC). METHODS: This study included 79 consecutive patients with cervical SCC who were treated by NAC followed by surgery (n = 49) or by definitive RT (n = 30). We compared characteristics and survival outcomes between the surgery and RT groups by their responses to NAC...
September 19, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28927217/surgical-technique-for-high-flow-internal-maxillary-artery-to-middle-cerebral-artery-bypass-using-a-superficial-temporal-artery-interposition-graft
#19
Xuequan Feng, Ali Tayebi Meybodi, Jordina Rincon-Torroella, Ivan H El-Sayed, Michael T Lawton, Arnau Benet
BACKGROUND: Extracranial-to-intracranial high-flow bypass often requires cranial, cervical, and graft site incisions. The internal maxillary artery (IMA) has been proposed as a donor to decrease invasiveness, but its length is insufficient for direct intracranial bypass. We report interposition of a superficial temporal artery (STA) graft for high-flow IMA to middle cerebral artery (MCA) bypass using a middle fossa approach. OBJECTIVE: To assess the feasibility of an IMA-STA graft-MCA bypass using a new middle fossa approach...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926726/fertility-and-pregnancy-outcomes-after-transvaginal-cervico-isthmic-cerclage
#20
Marie-Emmanuelle Neveu, Hervé Fernandez, Xavier Deffieux, Marie-Victoire Senat, Marie Houllier, Perrine Capmas
INTRODUCTION: Prematurity is the leading cause of neonatal morbidity and mortality. Cervical insufficiency seems to be the main risk factor. Treatment is cervical cerclage. In case of failure, a cervico-isthmic cerclage by Fernandez' technique, with the placement of a polypropylene sling by vaginal approach during the first trimester of pregnancy, has proven its effectiveness. The aim of our study is to report effectiveness of Fernandez' cervico-isthmic cerclage in subsequent pregnancies...
September 11, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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