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Cervical insufficiency

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https://www.readbyqxmd.com/read/28526877/magnetospinography-visualizes-electrophysiological-activity-in-the-cervical-spinal-cord
#1
Satoshi Sumiya, Shigenori Kawabata, Yuko Hoshino, Yoshiaki Adachi, Kensuke Sekihara, Shoji Tomizawa, Masaki Tomori, Senichi Ishii, Kyohei Sakaki, Dai Ukegawa, Shuta Ushio, Taishi Watanabe, Atsushi Okawa
Diagnosis of nervous system disease is greatly aided by functional assessments and imaging techniques that localize neural activity abnormalities. Electrophysiological methods are helpful but often insufficient to locate neural lesions precisely. One proposed noninvasive alternative is magnetoneurography (MNG); we have developed MNG of the spinal cord (magnetospinography, MSG). Using a 120-channel superconducting quantum interference device biomagnetometer system in a magnetically shielded room, cervical spinal cord evoked magnetic fields (SCEFs) were recorded after stimulation of the lower thoracic cord in healthy subjects and a patient with cervical spondylotic myelopathy and after median nerve stimulation in healthy subjects...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524247/comparison-of-adjuvant-therapy-for-node-positive-clinical-stage-ib-iib-cervical-cancer-systemic-chemotherapy-versus-pelvic-irradiation
#2
Koji Matsuo, Muneaki Shimada, Yoichi Aoki, Masaru Sakamoto, Nobuhiro Takeshima, Hisaya Fujiwara, Takashi Matsumoto, Mikio Mikami, Toru Sugiyama
This was a nation-wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB-IIB cervical cancer with pelvic and/or para-aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death and patterns of disease recurrence were compared based upon the adjuvant treatment pattern: whole pelvic radiotherapy alone (n=253), concurrent chemo-radiotherapy (CCRT, n=502), and chemotherapy alone (n=319). Women who received chemotherapy alone had similar recurrence (5-year rates, 36...
May 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28498058/endoscopic-endonasal-resection-of-the-odontoid-process-clinical-outcomes-in-34-adults
#3
Nathan T Zwagerman, Matthew J Tormenti, Zachary J Tempel, Eric W Wang, Carl H Snyderman, Juan C Fernandez-Miranda, Paul A Gardner
OBJECTIVE Treatment of odontoid disease from a ventral corridor has consisted of a transoral approach. More recently, the endoscopic endonasal approach (EEA) has been used to access odontoid pathology. METHODS A retrospective review was conducted of patients who underwent an EEA for odontoid pathology from 2004 to 2013. During our analysis, the mean follow-up duration was 42.6 months (range 1-80 months). Patient outcomes, complications, and postoperative swallowing function were assessed either by clinic visit or phone contact...
May 12, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28475391/the-role-of-predictive-vaginal-biomarkers-in-women-with-cervical-cerclage
#4
Tomi T Kanninen, Giovanni Sisti, Mariarosaria Di Tommaso, Vincenzo Berghella
Cervical cerclage is presently one of the primary methods of treatment for cervical insufficiency (CI). Identifying methods in order to selectively apply cerclage may allow us to further limit unnecessary procedures. In this regard, a limited number of inflammatory and extracellular matrix biomarkers measurable non-invasively at the level of the cervix have been examined. In this review we summarize the current research on the use of cervical biomarkers in predicting cerclage failure and propose potential objectives for future research...
May 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28469668/anesthetic-considerations-for-patients-with-acute-cervical-spinal-cord-injury
#5
REVIEW
Fang-Ping Bao, Hong-Gang Zhang, Sheng-Mei Zhu
Anesthesiologists work to prevent or minimize secondary injury of the nervous system and improve the outcome of medical procedures. To this end, anesthesiologists must have a thorough understanding of pathophysiology and optimize their skills and equipment to make an anesthesia plan. Anesthesiologists should conduct careful physical examinations of patients and consider neuroprotection at preoperative interviews, consider cervical spinal cord movement and compression during airway management, and suggest awake fiberoptic bronchoscope intubation for stable patients and direct laryngoscopy with manual in-line immobilization in emergency situations...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28467685/structural-alterations-in-tumor-draining-lymph-nodes-before-papillary-thyroid-carcinoma-metastasis
#6
Andrew M Hinson, Nicole A Massoll, Lee Ann Jolly, Brendan C Stack, Donald L Bodenner, Aime T Franco
BACKGROUND: The purpose of this study was to define and characterize the thyroid tumor-draining lymph nodes in genetically engineered mice harboring thyroid-specific expression of oncogenic Braf(V600E) with and without Pten insufficiency. METHODS: After intratumoral injection of methylene blue, the lymphatic drainage of the thyroid gland was visualized in real time. The thyroid gland/tumor was resected en bloc with the respiratory system for histological analysis...
May 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28465722/does-partial-coating-with-titanium-improve-the-radiographic-fusion-rate-of-empty-peek-cages-in-cervical-spine-surgery-a-comparative-analysis-of-clinical-data
#7
Andreas Kotsias, Sven Mularski, Björn Kühn, Michael Hanna, Olaf Suess
BACKGROUND: Anterior cervical diskectomy and fusion (ACDF) is a well-established surgical treatment. Several types of intervertebral spacers can be used, but there is increasing evidence that PEEK cages yield insufficient fusion and thus less clinical improvement. The study aim was to assess the outcomes of single-level ACDF with an empty PEEK cage partially coated with titanium. METHODS: This prospective multicenter single-arm clinical study collected follow-up data at 6, 12, and 18 months...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28465721/empty-polyetheretherketone-peek-cages-in-anterior-cervical-diskectomy-and-fusion-acdf-show-slow-radiographic-fusion-that-reduces-clinical-improvement-results-from-the-prospective-multicenter-pierce-peek-study
#8
Olaf Suess, Martin Schomaker, Mario Cabraja, Marco Danne, Theodoros Kombos, Michael Hanna
BACKGROUND: Anterior cervical diskectomy and fusion (ACDF) is a well-established surgical treatment for radiculopathy and myelopathy. Previous studies showed that empty PEEK cages have lower radiographic fusion rates, but the clinical relevance remains unclear. This paper's aim is to provide high-quality evidence on the outcomes of ACDF with empty PEEK cages and on the relevance of radiographic fusion for clinical outcomes. METHODS: This large prospective multicenter clinical trial performed single-level ACDF with empty PEEK cages on patients with cervical radiculopathy or myelopathy...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28464264/concurrent-chemoradiotherapy-with-or-without-surgery-for-patients-with-resectable-esophageal-cancer-an-analysis-of-the-national-cancer-data-base
#9
Kushal B Naik, Yuan Liu, Michael Goodman, Theresa W Gillespie, Allan Pickens, Seth D Force, Conor E Steuer, Taofeek K Owonikoko, Suresh S Ramalingam, Kristin Higgins, Jonathan J Beitler, Dong M Shin, Field F Willingham, Bassel El-Rayes, Jerome C Landry, Felix G Fernandez, Nabil F Saba
BACKGROUND: Patients with resectable esophageal cancer (rEC) are managed with either concurrent chemoradiotherapy followed by surgery (CRSx) or concurrent chemoradiotherapy alone (cCR). To the authors' knowledge, there is insufficient evidence comparing the overall survival of patients treated with these 2 options. METHODS: The National Cancer Data Base was queried for rEC cases diagnosed from 2003 through 2011. Patients with previous cancers, cervical rEC, clinical stage T1N0 disease, or metastasis were excluded...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28451511/autograft-versus-allograft-for-cervical-spinal-fusion-a-systematic-review
#10
REVIEW
Alexander Tuchman, Darrel S Brodke, Jim A Youssef, Hans-Jörg Meisel, Joseph R Dettori, Jong-Beom Park, S Tim Yoon, Jeffrey C Wang
STUDY DESIGN: Systematic review. OBJECTIVE: To compare the effectiveness and safety between iliac crest bone graft (ICBG), non-ICBG autologous bone, and allograft in cervical spine fusion. To avoid problems at the donor site, various allograft materials have been used as a substitute for autograft. However, there are still questions as to the comparative effectiveness and safety of cadaver allograft compared with autologous ICBG. METHODS: A systematic search of multiple major medical reference databases was conducted to identify studies evaluating spinal fusion in patients with cervical degenerative disk disease using ICBG compared with non-ICBG autograft or allograft or non-ICBG autograft compared with allograft in the cervical spine...
February 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28426125/cerclage-use-a-review-of-3-national-guidelines
#11
Jeffrey D Sperling, Joshua D Dahlke, Juan M Gonzalez
Importance: Preterm birth is a major contributor to perinatal morbidity and mortality. The most common intervention performed to improve perinatal outcomes for a woman experiencing cervical dilation in the second trimester without signs or symptoms of preterm labor is the cerclage. Objective: We sought to review and compare available national guidelines on cerclage use. Evidence Acquisition: We performed a descriptive review of 3 national guidelines on cerclage: The American Congress of Obstetricians and Gynecologists Practice Bulletin on "Cerclage for the Management of Cervical Insufficiency," Green-top Guideline from the Royal College of Obstetricians and Gynaecologists entitled "Cervical Cerclage," and the Society of Obstetricians and Gynaecologists of Canada Clinical Practice Bulletin entitled "Cervical Insufficiency and Cervical Cerclage...
April 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28422837/multilevel-cervical-disc-replacement-versus-multilevel-anterior-discectomy-and-fusion-a-meta-analysis
#12
REVIEW
Ting-Kui Wu, Bei-Yu Wang, Yang Meng, Chen Ding, Yi Yang, Ji-Gang Lou, Hao Liu
BACKGROUND: Cervical disc replacement (CDR) has been developed as an alternative surgical procedure to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical degenerative disc disease. However, patients with multilevel cervical degenerative disc disease (MCDDD) are common in our clinic. Multilevel CDR is less established compared with multilevel ACDF. This study aims to compare the outcomes and evaluate safety and efficacy of CDR versus ACDF for the treatment of MCDDD...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28407326/maternal-lactocrine-programming-of-porcine-reproductive-tract-development
#13
REVIEW
Carol A Bagnell, Teh-Yuan Ho, Ashley F George, Anne A Wiley, Dori J Miller, Frank F Bartol
The lactocrine hypothesis for maternal programming of female reproductive tract development is based on the idea that non-nutritive, milk-borne bioactive factors (MbFs), delivered from mother to offspring during nursing, play a role in determining the trajectory of development with long-term consequences in the adult. Porcine female reproductive tract development is completed postnatally, and the period during which maternal support of neonatal growth derives exclusively from colostrum/milk defines a window of opportunity for lactocrine programming of reproductive tissues...
April 13, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28406870/the-effect-of-acupressure-applied-to-point-li4-on-perceived-labor-pains
#14
Yasemin Hamlacı, Saadet Yazici
Controlling labor pain is one of the basic goals for caregivers during the birthing process. There are many pharmacological and nonpharmacological methods that are used for controlling pain and helping the mother to cope with pain and have a favorable labor. The study was planned as a randomized, controlled experimental study to detect the effect of acupressure applied to Point LI4 on perceived labor pains. The study sample comprised 88 pregnant women (44 acupressure group, 44 control group), who complied with the study guidelines, agreed with the conditions of the study, and signed the informed consent...
May 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/28397052/pregnancy-outcomes-following-transvaginal-cerclage-for-cervical-insufficiency-results-from-a-single-center-retrospective-study
#15
Sheng Wang, Ying Wang, Ling Feng
To study maternal and perinatal outcomes after cervical cerclage in both singleton and twin pregnancies, we retrospectively reviewed women undergoing cervical cerclage for cervical insufficiency at Tongji Hospital, Wuhan, China from January 1, 2010 to July 31, 2015 to evaluate primary and secondary outcomes for subgroups with cervical length (CL) ≤15, >15 to <25, and ≥25 mm. Of 166 patients who underwent cervical cerclage, after exclusion of patients with missed abortion and continuing pregnancy, 141 patients (121 singleton and 20 twin pregnancies) were included in the analysis...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28374904/cervical-collagen-is-reduced-in-non-pregnant-women-with-a-history-of-cervical-insufficiency-and-a-short-cervix
#16
Iben Sundtoft, Jens Langhoff-Roos, Puk Sandager, Steffen Sommer, Niels Uldbjerg
INTRODUCTION: Preterm cervical shortening and cervical insufficiency may be caused by a constitutional weakness of the cervix. The aim of this study was to assess the cervical collagen concentration in non-pregnant women with a history of cervical insufficiency or a history of a short cervix in the second trimester of pregnancy. MATERIAL AND METHODS: In this case-control study we included non-pregnant women one year or more after pregnancy: 55 controls with a history of normal delivery; 27 women with a history of cervical insufficiency; and 10 women with a history of a short cervix (<5(th) percentile) and 10 women with a history of a long cervix (>95(th) percentile) at gestation weeks 18-20...
April 4, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28347539/a-novel-murine-model-of-marfan-syndrome-accelerates-aortopathy-and-cardiomyopathy
#17
Nicholas B Cavanaugh, Lan Qian, Nicole M Westergaard, William J Kutschke, Ella J Born, Joseph W Turek
BACKGROUND: Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. Although significant advances in the understanding of transforming growth factor beta signaling have led to promising therapeutic targets for the treatment of aortopathy, clinical studies have tempered this optimism. In particular, these studies suggest additional signaling pathways that play a significant role in disease progression...
March 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28332986/risk-factors-for-pelvic-insufficiency-fractures-in-locally-advanced-cervical-cancer-following-intensity-modulated-radiation-therapy
#18
Anne Ramlov, Erik Morre Pedersen, Lisbeth Røhl, Esben Worm, Lars Fokdal, Jacob Chr Lindegaard, Kari Tanderup
PURPOSE: To investigate the incidence of and risk factors for pelvic insufficiency fracture (PIF) after definitive chemoradiation therapy for locally advanced cervical cancer (LACC). METHODS AND MATERIALS: We analyzed 101 patients with LACC treated from 2008-2014. Patients received weekly cisplatin and underwent external beam radiation therapy with 45 Gy in 25 fractions (node-negative patients) or 50 Gy in 25 fractions with a simultaneous integrated boost of 60 Gy in 30 fractions (node-positive patients)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28322903/urologic-management-and-complications-in-spinal-cord-injury-patients-a-40-to-50-year-follow-up-study
#19
Yunliang Gao, Teresa Danforth, David A Ginsberg
OBJECTIVE: To assess the management and types of urologic complications in spinal cord injury (SCI) patients and to explore the risk factors for these complications. METHODS: A total of 43 SCI patients with a median follow-up of 45 (range 40-50) years were included in this retrospective study. All medical charts were reviewed for demographics, urologic complications, and bladder management. RESULTS: Recurrent urinary tract infection (UTI) was noted in all patients, with an average incidence of 6...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28300678/magnetic-resonance-imaging-of-internal-jugular-veins-in-multiple-sclerosis-inter-observer-agreement-and-comparison-with-doppler-ultrasound-examination
#20
S J Laukontaus, J Pekkola, J Numminen, T Kagayama, M Lepäntalo, M Färkkilä, S Atula, P Tienari, M Venermo
OBJECTIVES: Doppler ultrasound (US) has been widely used to evaluate the cervical venous system of multiple sclerosis (MS) patients according to the hypothesis of chronic cerebrospinal venous insufficiency (CCSVI) with contradictory results. Venous anatomy and pathology can be examined with less operator-dependent magnetic resonance imaging (MRI). DESIGN: To assess the inter-observer agreement in measuring internal jugular vein (IJV) cross-sectional area (CSA) in MR-images and to explore the agreement between US and MRI in the detection of calibres of ≤ 0...
March 11, 2017: Annals of Vascular Surgery
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