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https://www.readbyqxmd.com/read/27899215/toxicology-in-international-drug-control-prioritizing-the-most-harmful-persistent-and-prevalent-substances
#1
Susan C Ifeagwu, Martin Raithelhuber, Conor Crean, Dimitri Gerostamoulos, Heesun Chung, Justice N Tettey
The nature of the global drugs market has evolved rapidly and has become more complex with the emergence of new psychoactive substances (NPS), some of which have been associated with increased abuse, hospital emergency admissions and sometimes fatalities. NPS are characterized by geographic heterogeneity, with some only transient in nature and others not satisfying the criteria for harm required for international control. Consequently, a pragmatic response of the international community is to prioritize the most harmful, persistent and prevalent substances for action - an objective, which is hampered by the paucity of data on harms...
November 20, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27895842/postoperative-outcome-of-caesarean-sections-and-other-major-emergency-obstetric-surgery-by-clinical-officers-and-medical-officers-in-malawi
#2
Garvey Chilopora, Caetano Pereira, Francis Kamwendo, Agnes Chimbiri, Eddie Malunga, Staffan Bergström
BACKGROUND: Clinical officers perform much of major emergency surgery in Malawi, in the absence of medical officers. The aim of this study was to validate the advantages and disadvantages of delegation of major obstetric surgery to non-doctors. METHODS: During a three month period, data from 2131 consecutive obstetric surgeries in 38 district hospitals in Malawi were collected prospectively. The interventions included caesarean sections alone and those that were combined with other interventions such as subtotal and total hysterectomy repair of uterine rupture and tubal ligation...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895136/recognition-and-management-of-resistant-hypertension
#3
REVIEW
Branko Braam, Sandra J Taler, Mahboob Rahman, Jennifer A Fillaus, Barbara A Greco, John P Forman, Efrain Reisin, Debbie L Cohen, Mohammad G Saklayen, S Susan Hedayati
Despite improvements in hypertension awareness and treatment, 30%-60% of hypertensive patients do not achieve BP targets and subsequently remain at risk for target organ damage. This therapeutic gap is particularly important to nephrologists, who frequently encounter treatment-resistant hypertension in patients with CKD. Data are limited on how best to treat patients with CKD and resistant hypertension, because patients with CKD have historically been excluded from hypertension treatment trials. First, we propose a consistent definition of resistant hypertension as BP levels confirmed by both in-office and out-of-office measurements that exceed appropriate targets while the patient is receiving treatment with at least three antihypertensive medications, including a diuretic, at dosages optimized to provide maximum benefit in the absence of intolerable side effects...
November 28, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27888173/association-between-job-stress-and-occupational-injuries-among-korean-firefighters-a-nationwide-cross-sectional-study
#4
Yeong-Kwang Kim, Yeon-Soon Ahn, KyooSang Kim, Jin-Ha Yoon, Jaehoon Roh
OBJECTIVE: We aimed to assess the nature of association between job stress and occupational injuries among firefighters in Korea. DESIGN: Cross-sectional study. SETTING: We conducted a nationwide survey using self-reported questionnaires in South Korea. PARTICIPANTS: A survey was conducted among 30 630 firefighters; 25 616 (83.6%) responded. Our study included firefighters who were 20-59 years old. Individuals with <12 months of current job experience and those with missing data were excluded; ultimately, 14 991 firefighters were analysed...
November 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27886436/factors-that-hinder-or-enable-maternal-health-strategies-to-reduce-delays-in-rural-and-pastoralist-areas-in-ethiopia
#5
Ruth Jackson, Fisaha Haile Tesfay, Tesfay Gebregzabher Gebrehiwot, Hagos Godefay
OBJECTIVES: To document factors that hinder or enable strategies to reduce the first and second delays of the Three Delays in rural and pastoralist areas in Ethiopia. METHODS: A key informant study was conducted with 44 Health Extension Workers in Afar Region, Kafa Zone (Southern Nation, Nationalities and Peoples' Region), and Adwa Woreda (Tigray Region). Health Extension Workers were trained to interview women and ask for stories about their recent experiences of birth...
November 25, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27884924/low-acuity-presentations-to-the-emergency-department-in-canada-exploring-the-alternative-attempts-to-avoid-presentation
#6
Lynette D Krebs, Scott W Kirkland, Rajiv Chetram, Taylor Nikel, Britt Voaklander, Alan Davidson, Bryn Holroyd, Cristina Villa-Roel, Katelynn Crick, Stephanie Couperthwaite, Chris Alexiu, Garnet Cummings, Brian H Rowe
OBJECTIVE: ED visits have been rising year on year worldwide. It has been suggested that some of these visits could be avoided if low-acuity patients had better primary care access. This study explored patients' efforts to avoid ED presentation and alternative care sought prior to presentation. METHODS: Consecutive adult patients presenting to three urban EDs in Edmonton, Canada, completed a questionnaire collecting demographics, actions attempted to avoid presentation and reasons for presentation...
November 24, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27881091/conducting-a-large-multi-site-survey-about-patients-views-on-broad-consent-challenges-and-solutions
#7
Maureen E Smith, Saskia C Sanderson, Kyle B Brothers, Melanie F Myers, Jennifer McCormick, Sharon Aufox, Martha J Shrubsole, Nanibaá A Garrison, Nathaniel D Mercaldo, Jonathan S Schildcrout, Ellen Wright Clayton, Armand H Matheny Antommaria, Melissa Basford, Murray Brilliant, John J Connolly, Stephanie M Fullerton, Carol R Horowitz, Gail P Jarvik, Dave Kaufman, Terri Kitchner, Rongling Li, Evette J Ludman, Catherine McCarty, Valerie McManus, Sarah Stallings, Janet L Williams, Ingrid A Holm
BACKGROUND: As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diverse and large populations of patients in a variety of health care settings will be important in order to successfully carry out such studies. One important topic is participants' views towards consent and data sharing, especially since the 2011 Advanced Notice of Proposed Rulemaking (ANPRM), and subsequently the 2015 Notice of Proposed Rulemaking (NPRM) were issued by the Department of Health and Human Services (HHS) and Office of Science and Technology Policy (OSTP)...
November 24, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27881057/recent-patents-on-heat-shock-proteins-targeting-antibodies
#8
João Fernandes, Pedro Alves
BACKGROUND: Heat shock proteins (Hsp) are major chaperone molecules that have recently emerged as cancer therapeutic targets owing to their involvement in tumor cell proliferation, differentiation, invasion and metastasis. High levels of extracellular Hsp90 and Hsp70 have been closely associated with a wide range of human cancers. Accumulating evidence suggests that the pharmacological inhibition of these molecules can play a pivotal role in non-surgical cancer treatment. Efforts have been taken to develop monoclonal antibodies (mAbs) and antibody fragments targeting extracellular Hsp90 and Hsp70, alone or conjugated with standard anticancer agents, to control several types of cancer, such as breast, colon, prostate or melanoma...
November 23, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27875247/comorbidity-prevalence-healthcare-utilization-and-expenditures-of-medicaid-enrolled-adults-with-autism-spectrum-disorders
#9
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi
A retrospective data analysis using 2000-2008 three state Medicaid Analytic eXtract was conducted to examine the prevalence and association of comorbidities (psychiatric and non-psychiatric) with healthcare utilization and expenditures of fee-for-service enrolled adults (22-64 years) with and without autism spectrum disorders (International Classification of Diseases, Ninth Revision-clinical modification code: 299.xx). Autism spectrum disorder cases were 1:3 matched to no autism spectrum disorder controls by age, gender, and race using propensity scores...
October 20, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27875053/pharmacological-reversal-agents-in-dental-practice-keys-to-patient-safety
#10
Mark Donaldson, Jason H Goodchild
Though uncommon, medical emergencies in the dental office are harrowing occurrences that can be the result of adverse drug reactions. Pharmacological antagonists have been developed for administration as reversal agents in emergency situations in which patients may have an untoward effect, typically caused by too much medication. Dental practitioners should be familiar with these agents to keep patients safe and help mitigate drug-induced medical emergencies. This article reviews the pharmacokinetic and pharmacodynamic principles of pharmacological antagonists; it emphasizes six specific reversal agents as they relate to the clinical practice of dentistry: naloxone, flumazenil, epinephrine, diphenhydramine, phentolamine, and atropine...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27870718/self-reported-preparedness-to-respond-to-mass-fatality-incidents-in-38-state-health-departments
#11
Jacqueline Merrill, Qi Zhi, Robyn R Gershon
CONTEXT: Public health departments play an important role in the preparation and response to mass fatality incidents (MFIs). OBJECTIVE: To describe MFI response capabilities of US state health departments. DESIGN: The data are part of a multisector cross-sectional study aimed at 5 sectors that comprise the US mass fatality infrastructure. Data were collected over a 6-week period via a self-administered, anonymous Web-based survey. SETTING: In 2014, a link to the survey was distributed via e-mail to health departments in 50 states and the District of Columbia...
January 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27865152/psychoactive-medications-and-disengagement-from-office-based-opioid-treatment-obot-with-buprenorphine
#12
Zoe M Weinstein, Debbie M Cheng, Emily Quinn, David Hui, Hyunjoong Kim, Gabriela Gryczynski, Jeffrey H Samet
BACKGROUND: The prevalence of psychoactive medications (PAMs) use in patients enrolled in Office Based Opioid Treatment (OBOT) and its association with engagement in this care is largely unknown. OBJECTIVE: To describe the use of PAMs, including those medications with emerging evidence of misuse ("emerging PAMs" - gabapentin, clonidine and promethazine) among patients on buprenorphine, and its association with disengagement from OBOT. METHODS: This is a retrospective cohort study of adults on buprenorphine from January 2002 to February 2014...
November 5, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27859257/does-spatial-access-to-primary-care-affect-emergency-department-utilization-for-nonemergent-conditions
#13
Jamie Fishman, Sara McLafferty, William Galanter
OBJECTIVE: To examine the contributions of individual- and neighborhood-level spatial access to care to the utilization of emergency departments (EDs) for preventable conditions through implementation of novel local spatial access measures. DATA SOURCES/STUDY SETTING: Emergency department admissions data are from four HealthLNK member hospitals in Chicago from 2007 to 2011. Primary care physician office and clinic locations were obtained from the American Medical Association and the City of Chicago...
November 17, 2016: Health Services Research
https://www.readbyqxmd.com/read/27859057/supplemental-insurance-and-racial-health-disparities-under-medicare-part-b
#14
Christopher S Brunt
OBJECTIVE: To assess the impact of preferences, socioeconomic status (SES), and supplemental insurance (SI) on racial/ethnic disparities in the probability and use of services at physicians' offices, hospitals, and emergency departments among Medicare beneficiaries enrolled in Part B. RESEARCH DESIGN AND SUBJECTS: This study includes black and white beneficiaries from the 2009-2011 panel of the Medicare Current Beneficiary Survey who were enrolled in Medicare Part B...
November 10, 2016: Health Services Research
https://www.readbyqxmd.com/read/27856211/patient-characteristics-and-healthcare-utilization-patterns-associated-with-unused-medications-among-medicare-patients
#15
Daniel D Maeng, Lou Ann Tom, Eric A Wright
OBJECTIVE: To examine what patient characteristics and healthcare utilization patterns are associated with the likelihood of having unused medications among elderly Medicare patients. DESIGN: Secondary data analysis combining insurance claims and phone survey data of Medicare Advantage members. SETTING: Regional health plan in Central Pennsylvania. PARTICIPANTS: 528 Medicare Advantage members (age 65 and older), who had Medicare Part D coverage through Geisinger Health Plan as of December 31, 2013, and completed the phone survey in May of 2014...
November 9, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27855099/cluster-randomised-feasibility-trial-to-improve-the-control-of-hypertension-in-rural-india-chiri-a-study-protocol
#16
Michaela A Riddell, Rohina Joshi, Brian Oldenburg, Clara Chow, K R Thankappan, Ajay Mahal, Nihal Thomas, Velandai K Srikanth, Roger G Evans, Kartik Kalyanram, Kamakshi Kartik, Pallab K Maulik, Simin Arabshahi, R P Varma, Rama K Guggilla, Oduru Suresh, G K Mini, Fabrizio D'Esposito, Thirunavukkarasu Sathish, Mohammed Alim, Amanda G Thrift
INTRODUCTION: Hypertension is emerging in rural populations of India. Barriers to diagnosis and treatment of hypertension may differ regionally according to economic development. Our main objectives are to estimate the prevalence, awareness, treatment and control of hypertension in 3 diverse regions of rural India; identify barriers to diagnosis and treatment in each setting and evaluate the feasibility of a community-based intervention to improve control of hypertension. METHODS AND ANALYSIS: This study includes 4 main activities: (1) assessment of risk factors, quality of life, socioeconomic position and barriers to changes in lifestyle behaviours in ∼14 500 participants; (2) focus group discussions with individuals with hypertension and indepth interviews with healthcare providers, to identify barriers to control of hypertension; (3) use of a medicines-availability survey to determine the availability, affordability and accessibility of medicines and (4) trial of an intervention provided by Accredited Social Health Activists (ASHAs), comprising group-based education and support for individuals with hypertension to self-manage blood pressure...
October 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852324/development-of-a-prognostic-model-based-on-demographic-environmental-and-lifestyle-information-for-predicting-incidences-of-symptomatic-respiratory-or-gastrointestinal-infection-in-adult-office-workers
#17
Tapani Hovi, Jukka Ollgren, Jaason Haapakoski, Carita Savolainen-Kopra
BACKGROUND: Occurrence of respiratory tract infection (RTI) or gastrointestinal tract infection (GTI) is known to vary between individuals and may be a confounding factor in the analysis of the results of intervention trials. We aimed at developing a prognostic model for predicting individual incidences of RTI and GTI on the basis of data collected in a hand-hygiene intervention trial among adult office workers, and comprising a prior-to-onset questionnaire on potential infection-risk factors and weekly electronic follow-up reports on occurrence of symptoms of, and on exposures to RTI or GTI...
November 16, 2016: Trials
https://www.readbyqxmd.com/read/27849750/106-real-time-assessment-of-u-s-health-system-stress-during-the-2015-16-influenza-season-pulse-program
#18
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847005/epidemiology-of-multidrug-resistant-extensively-drug-resistant-and-totally-drug-resistant-tuberculosis-in-middle-east-countries
#19
REVIEW
Mohanad M Ahmed, Ali A Velayati, Suhad H Mohammed
The 2015 represent the deadline for the global tuberculosis (TB) targets set through the Millennium Development Goals (MDG). From 2016 and onward, new goals were set to end the global TB epidemic via implementing new campaign entitled "the End TB Strategy". The major hurdle to end TB epidemic in several parts of the world is the emergence and spread of drug resistant Mycobacterium tuberculosis (MTB) strains. The better understanding of the actual global burden of drug resistant tuberculosis would feed into better implementing the End TB Strategy...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27843008/annual-and-seasonal-trends-in-ambulatory-visits-for-pediatric-concussion-in-ontario-between-2003-and-2013
#20
Roger L Zemek, Anne M Grool, Daniel Rodriguez Duque, Carol DeMatteo, Linda Rothman, Eric I Benchimol, Astrid Guttmann, Alison K Macpherson
OBJECTIVE: To investigate annual and seasonal trends in physician office and emergency department (ED) visit rates for pediatric concussion in Ontario between 2003 and 2013. STUDY DESIGN: A retrospective, population-based study was conducted using linked health administrative data from all concussion-related visits to ED and physician office by children aged 5 through 18 years. Time series analysis was used to assess whether periodic components exist in the monthly number of concussion-related visits...
November 11, 2016: Journal of Pediatrics
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