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Rebecca wong

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https://www.readbyqxmd.com/read/29127155/tumor-suppressor-tsc1-is-a-new-hsp90-co-chaperone-that-facilitates-folding-of-kinase-and-non-kinase-clients
#1
Mark R Woodford, Rebecca A Sager, Elijah Marris, Diana M Dunn, Adam R Blanden, Ryan L Murphy, Nicholas Rensing, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N Loh, David H Gutmann, Dimitra Bourboulia, Gennady Bratslavsky, Michael Wong, Mehdi Mollapour
The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise mechanism involved remains elusive. The molecular chaperone heat-shock protein 90 (Hsp90) is an essential component of the cellular homeostatic machinery in eukaryotes. Here, we show that Tsc1 is a new co-chaperone for Hsp90 that inhibits its ATPase activity. The C-terminal domain of Tsc1 (998-1,164 aa) forms a homodimer and binds to both protomers of the Hsp90 middle domain...
November 10, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29106896/the-rib-cage-reduces-intervertebral-disc-pressures-in-cadaveric-thoracic-spines-by-sharing-loading-under-applied-dynamic-moments
#2
Dennis E Anderson, Erin M Mannen, Rebecca Tromp, Benjamin M Wong, Hadley L Sis, Eileen S Cadel, Elizabeth A Friis, Mary L Bouxsein
The effects of the rib cage on thoracic spine loading are not well studied, but the rib cage may provide stability or share loads with the spine. Intervertebral disc pressure provides insight into spinal loading, but such measurements are lacking in the thoracic spine. Thus, our objective was to examine thoracic intradiscal pressures under applied pure moments, and to determine the effect of the rib cage on these pressures. Human cadaveric thoracic spine specimens were positioned upright in a testing machine, and Dynamic pure moments (0 to ±5 N·m) with a compressive follower load of 400 N were applied in axial rotation, flexion - extension, and lateral bending...
October 12, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29102555/school-disciplinary-style-and-adolescent-health
#3
Claudia Lau, Mitchell Wong, Rebecca Dudovitz
PURPOSE: Parenting style is strongly associated with adolescent health. However, little is known about how school disciplinary style relates to health. We categorized adolescents' perceptions of their schools as authoritative, authoritarian, permissive, or neglectful, and test whether perceived school disciplinary style is associated with health. METHODS: We analyze data from the RISE Up study (Reducing Health Inequities Through Social and Educational Change Follow-up), comprised of baseline (eighth grade) and 2-year follow-up surveys (10th grade) from 1,159 low-income minority adolescents in Los Angeles attending 157 schools...
November 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29102263/gender-and-age-make-no-difference-in-the-re-irradiation-of-painful-bone-metastases-a-secondary-analysis-of-the-ncic-ctg-sc-20-randomized-trial
#4
Ronald Chow, Keyue Ding, Vithusha Ganesh, Ralph M Meyer, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid, Manouk van Acht, Rinus Wanders, Scott Babington, William F Demas, Carolyn F Wilson, Rebecca K S Wong, Michael Brundage, Liting Zhu, Edward Chow
BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation. MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions...
October 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29102120/antimicrobial-resistance-in-clinical-escherichia-coli-isolated-from-companion-animals-in-australia
#5
Sugiyono Saputra, David Jordan, Tahlia Mitchell, Hui San Wong, Rebecca J Abraham, Amanda Kidsley, John Turnidge, Darren J Trott, Sam Abraham
Multidrug-resistant (MDR) Escherichia coli have become a major public health concern to both humans and animal health. While the frequency of antimicrobial resistance (AMR) in clinical E. coli is monitored regularly in human medicine, current frequency of AMR in companion animals remains unknown in Australia. In this study we conducted antimicrobial susceptibility testing (AST) and where possible, determined potential risk factors for MDR infection among 883 clinical Escherichia coli isolated from dogs (n=514), cats (n=341) and horses (n=28)...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29096336/differential-response-to-contact-based-stigma-reduction-programs-perceived-quality-and-personal-experience-matter
#6
Jennifer L Cerully, Rebecca L Collins, Eunice Wong, Rachana Seelam, Jennifer Yu
The aim of this study was to examine two under-studied factors integral to the theoretical underpinnings of contact-based mental illness stigma reduction programs: the quality of the contact and prior personal experience with persons with mental health problems. This study utilized pre- and post-survey data collected from 4122 individuals participating in a diverse set of contact-based educational programs implemented as part of California's statewide initiative to reduce mental illness stigma. Multi-level mixed regression models were used to determine whether pre-post changes in a variety of stigma-related measures varied depending on perceived quality of contact and prior personal experience with mental illness...
October 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29092899/are-objective-measures-of-physical-capability-related-to-accelerated-epigenetic-age-findings-from-a-british-birth-cohort
#7
Andrew J Simpkin, Rachel Cooper, Laura D Howe, Caroline L Relton, George Davey Smith, Andrew Teschendorff, Martin Widschwendter, Andrew Wong, Diana Kuh, Rebecca Hardy
OBJECTIVES: Our aim was to investigate the association of epigenetic age and physical capability in later life. Having a higher epigenetic than chronological age (known as age acceleration (AA)) has been found to be associated with an increased rate of mortality. Similarly, physical capability has been proposed as a marker of ageing due to its consistent associations with mortality. SETTING: The MRC National Survey of Health and Development (NSHD) cohort study. PARTICIPANTS: We used data from 790 women from the NSHD who had DNA methylation data available...
November 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29059430/genome-wide-association-study-to-identify-susceptibility-loci-that-modify-radiation-related-risk-for-breast-cancer-after-childhood-cancer
#8
MULTICENTER STUDY
Lindsay M Morton, Joshua N Sampson, Gregory T Armstrong, Ting-Huei Chen, Melissa M Hudson, Eric Karlins, Casey L Dagnall, Shengchao Alfred Li, Carmen L Wilson, Deo Kumar Srivastava, Wei Liu, Guolian Kang, Kevin C Oeffinger, Tara O Henderson, Chaya S Moskowitz, Todd M Gibson, Diana M Merino, Jeannette R Wong, Sue Hammond, Joseph P Neglia, Lucie M Turcotte, Jeremy Miller, Laura Bowen, William A Wheeler, Wendy M Leisenring, John A Whitton, Laurie Burdette, Charles Chung, Belynda D Hicks, Kristine Jones, Mitchell J Machiela, Aurelie Vogt, Zhaoming Wang, Meredith Yeager, Geoffrey Neale, Matthew Lear, Louise C Strong, Yutaka Yasui, Marilyn Stovall, Rita E Weathers, Susan A Smith, Rebecca Howell, Stella M Davies, Gretchen A Radloff, Kenan Onel, Amy Berrington de González, Peter D Inskip, Preetha Rajaraman, Joseph F Fraumeni, Smita Bhatia, Stephen J Chanock, Margaret A Tucker, Leslie L Robison
Background: Childhood cancer survivors treated with chest-directed radiotherapy have substantially elevated risk for developing breast cancer. Although genetic susceptibility to breast cancer in the general population is well studied, large-scale evaluation of breast cancer susceptibility after chest-directed radiotherapy for childhood cancer is lacking. Methods: We conducted a genome-wide association study of breast cancer in female survivors of childhood cancer, pooling two cohorts with detailed treatment data and systematic, long-term follow-up: the Childhood Cancer Survivor Study and St...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29056476/array-based-sequencing-of-filaggrin-gene-for-comprehensive-detection-of-disease-associated-variants
#9
X F Colin C Wong, Simon L I J Denil, Jia Nee Foo, Huijia Chen, Angeline Su Ling Tay, Rebecca L Haines, Mark B Y Tang, W H Irwin McLean, Aileen Sandilands, Frances J D Smith, E Birgitte Lane, Jianjun Liu, John E A Common
Comprehensive sequencing of FLG is a challenging endeavour. We have developed a method using array-based amplicon PCR and NGS for a robust and cost efficient method to analyze this major atopic dermatitis risk factor.
October 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28979910/interdisciplinary-and-inter-institutional-differences-in-learning-preferences-among-malaysian-medical-and-health-sciences-students
#10
Rebecca S Y Wong, Heng Loke Siow, Vinoth Kumarasamy, Nazrila Shaherah Fadhlullah Suhaimi
INTRODUCTION: The learner-centred approach in medical and health sciences education makes the study of learning preferences relevant and important. This study aimed to investigate the interdisciplinary, inter-institutional, gender and racial differences in the preferred learning styles among Malaysian medical and health sciences students in three Malaysian universities, namely SEGi University (SEGi), University of Malaya (UM) and Universiti Tunku Abdul Rahman (UTAR). It also investigated the differences in the preferred learning styles of these students between high achievers and non-high achievers...
October 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28971007/evaluation-of-striatonigral-connectivity-using-probabilistic-tractography-in-parkinson-s-disease
#11
Frances Theisen, Rebecca Leda, Vincent Pozorski, Jennifer M Oh, Nagesh Adluru, Rachel Wong, Ozioma Okonkwo, Douglas C Dean, Barbara B Bendlin, Sterling C Johnson, Andrew L Alexander, Catherine L Gallagher
The cardinal movement abnormalities of Parkinson's disease (PD), including tremor, muscle rigidity, and reduced speed and frequency of movements, are caused by degeneration of dopaminergic neurons in the substantia nigra that project to the putamen, compromising information flow through frontal-subcortical circuits. Typically, the nigrostriatal pathway is more severely affected on the side of the brain opposite (contralateral) to the side of the body that manifests initial symptoms. Several studies have suggested that PD is also associated with changes in white matter microstructural integrity...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28967444/cyclic-testing-of-the-6-strand-tang-and-modified-lim-tsai-flexor-tendon-repair-techniques
#12
Gavrielle Hui-Ying Kang, Yoke-Rung Wong, Rebecca Qian-Ru Lim, Austin Mun-Kitt Loke, Shian-Chao Tay
PURPOSE: In this study, we compared the Tang repair technique with the 6-strand modified Lim-Tsai repair technique under cyclic testing conditions. METHODS: Twenty fresh-frozen porcine flexor tendons were randomized into 2 groups for repair with either the modified Lim-Tsai or the Tang technique using Supramid 4-0 core sutures and Ethilon 6-0 epitendinous running suture. The repaired tendons were subjected to 2 stage cyclic loading. The survival rate and gap formation at the repair site were recorded...
September 26, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28957990/adiposity-telomere-length-and-telomere-attrition-in-midlife-the-1946-british-birth-cohort
#13
Wahyu Wulaningsih, Diana Kuh, Andrew Wong, Rebecca Hardy
Background: Obesity has been linked with shorter telomere length, both of which have been implicated in ageing, but the impact of early life adiposity on telomere length is unclear. Methods: We included 2,479 participants from the MRC National Survey of Health and Development with measurements of body mass index (BMI), waist and hip circumference and leukocyte telomere length (LTL) at age 53, of whom 1,000 had second measurements at age 60-64. Relative LTL was measured with rt-PCR...
August 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28952914/tenecteplase-versus-alteplase-before-endovascular-thrombectomy-extend-ia-tnk-a-multicenter-randomized-controlled-study
#14
Bruce Cv Campbell, Peter J Mitchell, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Bernard Yan, Richard J Dowling, Steven J Bush, Helen M Dewey, Vincent Thijs, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y Wu, Darshan G Shah, Tissa Wijeratne, Timothy Ang, Ferdinand Miteff, Christopher Levi, Martin Krause, Timothy J Harrington, Kenneth C Faulder, Brendan S Steinfort, Peter Bailey, Henry Rice, Laetitia de Villiers, Rebecca Scroop, Wayne Collecutt, Andrew A Wong, Alan Coulthard, P A Barber, Ben McGuinness, Deborah Field, Henry Ma, Winston Chong, Ronil V Chandra, Christopher F Bladin, Helen Brown, Kendal Redmond, David Leggett, Geoffrey Cloud, Anoop Madan, Neil Mahant, Bill O'Brien, John Worthington, Geoffrey Parker, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis
Background and hypothesis Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5 h of ischemic stroke onset. However, alteplase only succeeds in reperfusing large vessel arterial occlusion prior to thrombectomy in a minority of patients. We hypothesized that tenecteplase is non-inferior to alteplase in achieving reperfusion at initial angiogram, when administered within 4.5 h of ischemic stroke onset, in patients planned to undergo endovascular therapy...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28950727/patient-reported-outcomes-after-radiation-therapy-for-bone-metastases-as-a-function-of-age-a-secondary-analysis-of-the-ncic-ctg-sc-twenty-three-randomized-trial
#15
Selina Chow, Keyue Ding, Bo Angela Wan, Michael Brundage, Ralph M Meyer, Abdenour Nabid, Pierre Chabot, Genevieve Coulombe, Shahida Ahmed, Joda Kuk, A Rashid Dar, Aamer Mahmud, Alysa Fairchild, Carolyn F Wilson, Jackson S Y Wu, Kristopher Dennis, Carlo DeAngelis, Rebecca K S Wong, Liting Zhu, Edward Chow
PURPOSE: To explore the age difference in response and patient-reported outcomes in patients with cancer having bone metastases undergoing palliative radiotherapy. METHODS: Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life (QOL) Bone Metastases module (QLQ-BM22), EORTC QOL Core-15-Palliative (QLQ-C15-PAL), and Dexamethasone Symptom Questionnaire (DSQ) before a single 8-Gy radiation treatment, on days 10 and 42 after treatment...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28941281/in-vitro-fracture-strength-and-patterns-in-root-filled-teeth-restored-with-different-base-materials
#16
Theo Chan, Selen Küçükkaya Eren, Rebecca Wong, Peter Parashos
BACKGROUND: There is little research on the effects of an intermediate base on the fracture strength of root filled teeth. This study compared the fracture strengths and patterns of root filled teeth restored with intermediate bases of GIC, ZPC, DCRC and Biodentine(®) under resin composite. METHODS: Standardised cavities were prepared in 100 extracted human maxillary and mandibular premolars, and root canal treatment was performed. The teeth were stratified and randomly allocated to five groups (n = 20): 1...
September 23, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28933790/is-it-time-to-retire-fragile-x-testing-as-a-first-tier-test-for-developmental-delay-intellectual-disability-and-autism-spectrum-disorder
#17
Sureni V Mullegama, Steven D Klein, Dzung C Nguyen, Arang Kim, Rebecca Signer, Michelle Fox, Naghmeh Dorrani, Andrea Hendershot, Rebecca Mardach, Robert Suddath, Katrina Dipple, Eric Vilain, Derek A Wong, Joshua L Deignan, Stephen D Cederbaum, Wayne W Grody, Julian A Martinez-Agosto
No abstract text is available yet for this article.
September 21, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28922373/dynein-light-chain-regulates-adaptive-and-innate-b-cell-development-by-distinctive-genetic-mechanisms
#18
Ashleigh King, Lingli Li, David M Wong, Rui Liu, Rebecca Bamford, Andreas Strasser, David M Tarlinton, Jörg Heierhorst
Mechanistic differences in the development and function of adaptive, high-affinity antibody-producing B-2 cells and innate-like, "natural" antibody-producing B-1a cells remain poorly understood. Here we show that the multi-functional dynein light chain (DYNLL1/LC8) plays important roles in the establishment of B-1a cells in the peritoneal cavity and in the ongoing development of B-2 lymphoid cells in the bone marrow of mice. Epistasis analyses indicate that Dynll1 regulates B-1a and early B-2 cell development in a single, linear pathway with its direct transcriptional activator ASCIZ (ATMIN/ZNF822), and that the two genes also have complementary functions during late B-2 cell development...
September 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28905358/prognosis-communication-in-late-life-disability-a-mixed-methods-study
#19
Theresa W Wong, Sean Lang-Brown, Rafael D Romo, Alvin Au-Yeung, Sei J Lee, Patricia J Moran, Jason Karlawish, Rebecca Sudore, Josephine Clayton, Alexander K Smith
IMPORTANCE: Long-term prognosis informs clinical and personal decisions for older adults with late-life disability. However, many clinicians worry that telling patients their prognosis may cause harm. OBJECTIVE: To explore the safety of and reactions to prognosis communication in late-life disability. DESIGN: Participants estimated their own life expectancy and were then presented their calculated life expectancy using a validated prognostic index...
November 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28879690/design-principles-for-lymphatic-drainage-of-fluid-and-solutes-from-collagen-scaffolds
#20
Rebecca L Thompson, Emily A Margolis, Tyler J Ryan, Brent J Coisman, Gavrielle M Price, Keith H K Wong, Joe Tien
In vivo, tissues are drained of excess fluid and macromolecules by the lymphatic vascular system. How to engineer artificial lymphatics that can provide equivalent drainage in biomaterials remains an open question. The current study elucidates design principles for engineered lymphatics, by comparing the rates of removal of fluid and solute through type I collagen gels that contain lymphatic vessels or unseeded channels, or through gels without channels. Surprisingly, no difference was found between the fluid drainage rates for gels that contained vessels or bare channels...
September 6, 2017: Journal of Biomedical Materials Research. Part A
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