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https://www.readbyqxmd.com/read/29341133/development-and-initial-validity-of-the-in-hand-manipulation-assessment
#1
Gabrielle Klymenko, Karen P Y Liu, Michelle Bissett, Kenneth N K Fong, Nandana Welage, Rebecca S M Wong
BACKGROUND/AIM: A review of the literature related to in-hand manipulation (IHM) revealed that there is no assessment which specifically measures this construct in the adult population. This study reports the face and content validity of an IHM assessment for adults with impaired hand function based on expert opinion. METHODS: The definition of IHM skills, assessment tasks and scoring methods identified from literature was discussed in a focus group (n = 4) to establish face validity...
January 17, 2018: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29336685/seroprevalence-of-q-fever-among-the-indigenous-people-orang-asli-of-peninsular-malaysia
#2
Chee-Sieng Khor, Nurul-Farhana Mohd-Rahim, Habibi Hassan, Josephine Rebecca Chandren, Siti-Sarah Nore, Jefree Johari, Shih-Keng Loong, Juraina Abd-Jamil, Jing-Jing Khoo, Hai-Yen Lee, Brian L Pike, Li Ping Wong, Yvonne Ai-Lian Lim, Keivan Zandi, Sazaly AbuBakar
Q fever is a disease caused by Coxiella burnetii. It is a disease of public health concern in many parts of the world. In this study, we described the seroprevalence of Q fever among selected populations of Orang Asli (OA), indigenous people, many of whom live within the forest fringe areas of Peninsular Malaysia. Serum samples were obtained from 887 OA participants from selected villages. Samples were analyzed for the presence of IgG antibodies reactive against C. burnetii by enzyme-linked immunosorbent assay...
January 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29317609/apolipoprotein-e-apoe-%C3%AE%C2%B54-and-cognitive-decline-over-the-adult-life-course
#3
Mark James Rawle, Daniel Davis, Rebecca Bendayan, Andrew Wong, Diana Kuh, Marcus Richards
We tested the association between APOE-ε4 and processing speed and memory between ages 43 and 69 in a population-based birth cohort. Analyses of processing speed (using a timed letter search task) and episodic memory (a 15-item word learning test) were conducted at ages 43, 53, 60-64 and 69 years using linear and multivariable regression, adjusting for gender and childhood cognition. Linear mixed models, with random intercepts and slopes, were conducted to test the association between APOE and the rate of decline in these cognitive scores from age 43 to 69...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29276668/evaluating-the-association-between-the-built-environment-and-primary-care-access-for-new-medicaid-enrollees-in-an-urban-environment-using-walk-and-transit-scores
#4
Krisda H Chaiyachati, Jeffrey K Hom, Rebecca A Hubbard, Charlene Wong, David Grande
Worse health outcomes among those living in poverty are due in part to lower rates of health insurance and barriers to care. As the Affordable Care Act reduced financial barriers, identifying persistent barriers to accessible health care continues to be important. We examined whether the built environment as reflected by Walk Score™ (a measure of walkability to neighborhood resources) and Transit Score™ (a measure of transit access) is associated with having a usual source of care among low-income adults, newly enrolled in Medicaid...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29275851/biocompatibility-and-osteogenic-calcification-potential-of-casein-phosphopeptide-amorphous-calcium-phosphate-fluoride
#5
Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds
INTRODUCTION: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and CPP-ACP with fluoride (CPP-ACFP) have been shown to provide bioavailable ions to promote mineralization. Hence, the aim of this study was to evaluate the materials' biocompatibility and osteogenic/calcification potential for endodontic applications. METHODS: Human and mouse osteoblast-like and fibroblast-like cell lines were incubated with 0.05%-3.0% w/v CPP-ACP and CPP-ACFP, and toxicity, proliferation, alkaline phosphatase, interleukin (IL)-1α, and IL-6 production, collagen type I, osteocalcin, and osteopontin production, and mineralization/calcification were determined...
December 21, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29251003/the-physiology-and-toxicology-of-acute-inhalation-phosphine-poisoning-in-conscious-male-rats
#6
Benjamin Wong, Rebecca Lewandowski, Justin Tressler, Katherine Sherman, Jaclynn Andres, Jennifer Devorak, Cristin Rothwell, Tracey Hamilton, Heidi Hoard-Fruchey, Alfred M Sciuto
Phosphine (PH3) is a toxidrome-spanning chemical that is widely used as an insecticide and rodenticide. Exposure to PH3 causes a host of target organ and systemic effects, including oxidative stress, cardiopulmonary toxicity, seizure-like activity and overall metabolic disturbance. A custom dynamic inhalation gas exposure system was designed for the whole-body exposure of conscious male Sprague-Dawley rats (250-350 g) to PH3. An integrated plethysmography system was used to collect respiratory parameters in real-time before, during and after PH3 exposure...
December 18, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29248399/palliative-chemoradiotherapy-versus-radiotherapy-alone-for-dysphagia-in-advanced-oesophageal-cancer-a-multicentre-randomised-controlled-trial-trog-03-01
#7
Michael G Penniment, Paolo B De Ieso, Jennifer A Harvey, Sonya Stephens, Heather-Jane Au, Christopher J O'Callaghan, Andrew Kneebone, Samuel Y Ngan, Iain G Ward, Rajarshi Roy, Jennifer G Smith, Tirath Nijjar, James J Biagi, Liam A Mulroy, Rebecca Wong
BACKGROUND: A short course of radiotherapy is commonly prescribed for palliative relief of malignant dysphagia in patients with incurable oesophageal cancer. We compared chemoradiotherapy with radiotherapy alone for dysphagia relief in the palliative setting. METHODS: This multicentre randomised controlled trial included patients with advanced or metastatic oesophageal cancer who were randomly assigned (1:1) through a computer-generated adaptive biased coin design to either palliative chemoradiotherapy or radiotherapy alone for treatment of malignant dysphagia at 22 hospitals in Australia, Canada, New Zealand, and the UK...
December 13, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29247777/determining-risk-of-barrett-s-esophagus-and-esophageal-adenocarcinoma-based-on-epidemiologic-factors-and-genetic-variants
#8
Jing Dong, Matthew F Buas, Puya Gharahkhani, Bradley J Kendall, Lynn Onstad, Shanshan Zhao, Lesley A Anderson, Anna H Wu, Weimin Ye, Nigel C Bird, Leslie Bernstein, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Paul D Pharoah, Harvey A Risch, Prasad G Iyer, Brian J Reid, Laura J Hardie, Jesper Lagergren, Nicholas J Shaheen, Douglas A Corley, Rebecca C Fitzgerald, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
BACKGROUND & AIMS: We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic factors. METHODS: We used pooled data from 3288 patients with BE, 2511 patients with EAC, and 2177 individuals without either (controls) from participants in the international Barrett's and EAC consortium as well as the United Kingdom's BE gene study and stomach and esophageal cancer study. We collected data on 23 genetic variants associated with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by summing the risk allele counts for the variants weighted by their natural log-transformed effect estimates (odds ratios) extracted from genome-wide association studies...
December 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29234568/long-term-quality-of-life-of-retroperitoneal-sarcoma-patients-treated-with-pre-operative-radiotherapy-and-surgery
#9
Philip Wong, Zahra Kassam, Amanda N Springer, Rebecca Gladdy, Peter Chung, Jolie Ringash, Charles Catton
PURPOSE: Retroperitoneal sarcomas (RPS) are connective tissue cancers that are often large and anatomically in close proximity to critical and radiation-sensitive normal structures and organs within the abdomen and pelvis. The management of RPS may include preoperative radiotherapy (RT) and surgery. We aimed to examine how treatment-related toxicities affect patient quality of life (QOL).  Methods and materials: Within two prospective cohort studies, 48 RPS patients who were treated with preoperative RT from 1998-2012 were recruited and assessed for QOL (EORTC-QLQ-C30) and to determine toxicities potentially related to RT and surgery (graded using CTCAE V...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29221684/ex-vivo-flush-of-the-limb-allograft-reduces-inflammatory-burden-prior-to-transplantation
#10
Kavit R Amin, Alexandra L Ball, Chandanpreet Chhina, Rebecca J Edge, John P Stone, William R Critchley, Jason K Wong, James E Fildes
BACKGROUND: Passenger leucocytes and inflammatory debris transferred from the donor limb to the recipient can induce allorecognition, which activates the host immune response. This is the first study to evaluate whether the transfer of this inflammatory burden can be reduced via post-preservation flush prior to revascularisation, and whether this is influenced by ischaemia. METHODS: Bilateral forelimbs from the same pig were procured and infused with preservation flush and stored on ice...
November 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29221171/proteogenomic-analysis-prioritises-functional-single-nucleotide-variants-in-cancer-samples
#11
Shiyong Ma, Ranjeeta Menon, Rebecca C Poulos, Jason W H Wong
Massively parallel DNA sequencing enables the detection of thousands of germline and somatic single nucleotide variants (SNVs) in cancer samples. The functional analysis of these mutations is often carried out through in silico predictions, with further downstream experimental validation rarely performed. Here, we examine the potential of using mass spectrometry-based proteomics data to further annotate the function of SNVs in cancer samples. RNA-seq and whole genome sequencing (WGS) data from Jurkat cells were used to construct a custom database of single amino acid variant (SAAV) containing peptides and identified over 1,000 such peptides in two Jurkat proteomics datasets...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205937/experience-with-an-abdominal-compression-band-for-radiotherapy-of-upper-abdominal-tumours
#12
Rebecca Van Gelder, Shelley Wong, Andrew Le, Alexander Podreka, Adam Briggs, Carol Haddad, Nicholas Hardcastle
INTRODUCTION: Radiotherapy outcomes are influenced by treatment delivery geometric accuracy and organ-at-risk dose. The location of abdominal structures such as the liver, kidneys and tumour volumes can be strongly influenced by respiratory motion. This increases geometric uncertainty and dose to organs-at-risk. One common method of minimising respiratory motion is abdominal compression (AC). METHODS: Fifteen patients being treated for radiotherapy to upper abdominal tumours were analysed...
December 5, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29196773/effects-of-contact-based-mental-illness-stigma-reduction-programs-age-gender-and-asian-latino-and-white-american-differences
#13
Eunice C Wong, Rebecca L Collins, Jennifer L Cerully, Jennifer W Yu, Rachana Seelam
PURPOSE: Mental illness stigma disproportionately affects help seeking among youth, men, and ethnic minorities. As part of a comprehensive statewide initiative to reduce mental illness stigma and discrimination in California, a broad set of contact-based educational programs were widely disseminated. This study examined whether the effects of contact-based educational programs varied depending on the age, gender, and race-ethnicity of participants. METHODS: Participants (N = 4122) attended a contact-based educational program that was delivered as part of the statewide initiative to reduce mental illness stigma and discrimination...
December 2, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29188483/minimal-clinically-important-differences-in-the-eortc-qlq-c30-and-brief-pain-inventory-in-patients-undergoing-re-irradiation-for-painful-bone-metastases
#14
Srinivas Raman, Keyue Ding, Edward Chow, Ralph M Meyer, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid, Rick Haas, Ruud Wiggenraad, Scott Babington, William F Demas, Carolyn F Wilson, Rebecca K S Wong, Liting Zhu, Michael Brundage
PURPOSE: The EORTC QLQ-C30 and the Brief Pain Inventory (BPI) are validated tools for measuring quality of life (QOL) and the impact of pain in patients with advanced cancer. Interpretation of these instrument scores can be challenging and it is difficult to know what numerical changes translate to clinically significant impact in patients' lives. To address this issue, our study sought to establish the minimal clinically important differences (MCID) for these two instruments in a prospective cohort of patients with advanced cancer and painful bone metastases...
November 29, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29182402/individual-versus-interprofessional-team-performance-in-formulating-care-transition-plans-a-randomised-study-of-trainees-from-five-professional-groups
#15
Timothy W Farrell, Katherine P Supiano, Bob Wong, Marilyn K Luptak, Brenda Luther, Troy C Andersen, Rebecca Wilson, Frances Wilby, Rumei Yang, Ginette A Pepper, Cherie P Brunker
Health professions trainees' performance in teams is rarely evaluated, but increasingly important as the healthcare delivery systems in which they will practice move towards team-based care. Effective management of care transitions is an important aspect of interprofessional teamwork. This mixed-methods study used a crossover design to randomise health professions trainees to work as individuals and as teams to formulate written care transition plans. Experienced external raters assessed the quality of the written care transition plans as well as both the quality of team process and overall team performance...
November 28, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29170510/whole-blood-stabilization-for-the-microfluidic-isolation-and-molecular-characterization-of-circulating-tumor-cells
#16
Keith H K Wong, Shannon N Tessier, David T Miyamoto, Kathleen L Miller, Lauren D Bookstaver, Thomas R Carey, Cleo J Stannard, Vishal Thapar, Eric C Tai, Kevin D Vo, Erin S Emmons, Haley M Pleskow, Rebecca D Sandlin, Lecia V Sequist, David T Ting, Daniel A Haber, Shyamala Maheswaran, Shannon L Stott, Mehmet Toner
Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here we describe a method to preserve whole blood in its minimally altered state by combining hypothermic preservation with targeted strategies that counter cooling-induced platelet activation. Using this method, whole blood preserved for up to 72 h can be readily processed for microfluidic sorting without compromising CTC yield and viability...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29166337/detection-of-hepatitis-c-antibodies-without-viral-transmission-in-hepatitis-c-negative-recipients-receiving-kidneys-from-hepatitis-c-positive-donors-treated-with-direct-acting-anti-viral-therapy
#17
Neeru Agarwal, Rebecca J Davis, David M Gracey, Germaine Wong, Kathy Kable, Jeffrey K W Wong, Brian J Nankivell, Simone Strasser, Kate Wyburn
No abstract text is available yet for this article.
November 22, 2017: Transplantation
https://www.readbyqxmd.com/read/29156912/genetic-biomarkers-associated-with-pain-flare-and-dexamethasone-response-following-palliative-radiotherapy-in-patients-with-painful-bone-metastases
#18
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: In patients who receive palliative radiation therapy (RT) for painful bone metastases, 40% experience a transient increase in pain known as a pain flare. Prophylactic dexamethasone has been shown to reduce pain flare incidence to 25%. We aimed to identify DNA biomarkers associated with pain flare and dexamethasone response. METHODS: Daily pain levels were recorded by 81 patients who received a single 8 Gy RT for painful bone metastases, of which 50 also received prophylactic dexamethasone...
September 20, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156910/genetic-biomarkers-associated-with-changes-in-quality-of-life-and-pain-following-palliative-radiotherapy-in-patients-with-bone-metastases
#19
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: Patients with bone metastases undergoing palliative radiation therapy (RT) may experience changes in both the functional and symptomatic aspects of quality of life (QOL). The European Organization of Cancer Research and Treatment (EORTC) QOL Questionnaire Core-15 Palliative (QLQ-C15-PAL) is a validated questionnaire employed to assess QOL specifically in palliative patients. Our study aimed to identify single-nucleotide variant (SNV) genetic biomarkers associated with changes in QOL and pain...
September 28, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156909/genetic-biomarkers-associated-with-response-to-palliative-radiotherapy-in-patients-with-painful-bone-metastases
#20
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: Palliative radiotherapy (RT) is effective in patients with painful bone metastases. Genetic factors may identify subgroup of patients who responded to RT. To identify DNA biomarkers associated with response to palliative RT. METHODS: Patients who received a single 8 Gy dose of RT for painful bone metastases were categorised into responders (n=36), non-responders (NR) (n=71). Saliva samples were sequenced to identify single-nucleotide variants (SNVs) in genes with known disease-causing variants from inflammation, radiation response, and DNA damage pathways...
October 10, 2017: Annals of Palliative Medicine
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