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vein wall thickness

Judit R Hetthéssy, Anna-Mária Tőkés, Sándor Kérész, Petra Balla, Gabriella Dörnyei, Emil Monos, György L Nádasy
Objective To better understand factors that may play a role in the development of varicosities. Methods We induced combined flow-pressure disturbance in the saphenous system of the rat by performing chronic partial clipping of the main branch. Biomechanical and quantitative histological testing was undertaken. Results A rich microvenous network developed. Bloodflow decreased to 0.65 ± 0.18 µl/s (control side, 3.5 ± 1.4 µl/s) and pressure elevated to 6.8 ± 0.7 mmHg (control side, 2.3 ± 0...
January 1, 2017: Phlebology
Tomoyuki Nakano, Shunsuke Endo, Hideki Negishi, Shinichi Yamamoto
A 75-year-old man underwent thoracoscopic left upper lobectomy for primary lung cancer. Additional ligature plication to the left superior pulmonary vein with absorbable monofilament suture was performed after stapling with an endostapler. Postoperative bronchoscopy revealed penetration of the monofilament thread edge eviscerating across the wall of the left main bronchus. The edge was spontaneously absorbed with no adverse events. Penetration of a thick monofilament thread edge into mediastinal organs should be considered when the thread is located in the mediastinum...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
Emilie M Herzog, Alex J Eggink, Anniek Reijnierse, Martina A M Kerkhof, Ronald R de Krijger, Anton J M Roks, Irwin K M Reiss, Alex L Nigg, Paul H C Eilers, Eric A P Steegers, Régine P M Steegers-Theunissen
INTRODUCTION: Offspring exposed to preeclampsia (PE) show an increased risk of cardiovascular disease in adulthood. We hypothesize that this is mediated by a disturbed vascular development of the placenta, umbilical cord and fetus. Therefore, we investigated associations between early-onset PE (EOPE), late-onset PE (LOPE) and features of placental and newborn vascular health. METHODS: We performed a nested case-control study in The Rotterdam Periconceptional Cohort, including 30 PE pregnancies (15 EOPE, 15 LOPE) and 218 control pregnancies (164 uncomplicated controls, 54 complicated controls including 28 fetal growth restriction, 26 preterm birth) and assessed macroscopic and histomorphometric outcomes of the placenta and umbilical cord...
January 2017: Placenta
Marco Piola, Matthijs Ruiter, Riccardo Vismara, Valeria Mastrullo, Marco Agrifoglio, Marco Zanobini, Maurizio Pesce, Monica Soncini, Gianfranco Beniamino Fiore
After coronary artery bypass grafting, structural modifications of the saphenous vein wall lead to lumen narrowing in response to the altered hemodynamic conditions. Here we present the design of a novel ex vivo culture system conceived for mimicking central coronary artery hemodynamics, and we report the results of biomechanical stimulation experiments using human saphenous vein samples. The novel pulsatile system used an aortic-like pressure for forcing a time-dependent coronary-like resistance to obtain the corresponding coronary-like flow rate...
October 17, 2016: Annals of Biomedical Engineering
Katherine A Gallagher, Andrea T Obi, Megan A Elfline, Emily Hogikyan, Catherine E Luke, Samuel Henke, Dawn Coleman, Peter K Henke
OBJECTIVE: Macrophages are involved in venous thrombus (VT) resolution and vein wall remodeling. This study was undertaken to identify variations in macrophage phenotypes in thrombi and vein wall in multiple models of VT to clarify the natural history of macrophage polarization in clearance of VT. We also sought to demonstrate the feasibility of macrophage phenotyping in human VT. METHODS: Established murine models of VT were used to mimic the clinical spectrum of human VT (stasis and nonstasis models)...
October 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Wang Rongrong, Deng Li, Zhang Guangqing, Chen Xiaoyin, Bao Kun
Context • For patients undergoing hemodialysis, the native arteriovenous fistula (AVF) is the primary approach to vascular access (VA). VA failure is the main cause of morbidity and mortality in hemodialysis patients. It has been reported in recent studies that the primary failure rate can be as high as 50%. Objective • The study investigated the effects of iontophoretic administration of Salvia miltiorrhiza (SM) on the maturation of the AVF. Design • The study was a randomized, controlled trial. Setting • The study occurred in Guangdong Provincial Hospital of Traditional Chinese Medicine (Guangzhou, China)...
September 2016: Alternative Therapies in Health and Medicine
Sunday Tunji Oluleye, Bolutife Ayokunu Olusanya, Abiodun Moshood Adeoye
BACKGROUND: Earlier studies in Nigeria reported the rarity of retinal vascular changes in hypertensives. The aim of this study was to describe the various retinal vascular changes in the hypertensive patients of Nigeria. PATIENTS AND METHODS: Nine hundred and three hypertensive patients were studied. This study was approved by the ethical and research committee of the University of Ibadan and University College Hospital, Ibadan, Nigeria. Blood pressure and anthropometric measurements were measured...
2016: International Journal of General Medicine
William W Adams, Jared J Stewart, Christopher M Cohu, Onno Muller, Barbara Demmig-Adams
Acclimatory adjustments of foliar vascular architecture, photosynthetic capacity, and transpiration rate in Arabidopsis thaliana ecotypes (Italian, Polish [Col-0], Swedish) were characterized in the context of habitat of origin. Temperatures of the habitat of origin decreased linearly with increasing habitat latitude, but habitat precipitation was greatest in Italy, lowest in Poland, and intermediate in Sweden. Plants of the three ecotypes raised under three different growth temperature regimes (low, moderate, and high) exhibited highest photosynthetic capacities, greatest leaf thickness, highest chlorophyll a/b ratio and levels of β-carotene, and greatest levels of wall ingrowths in phloem transfer cells, and, in the Col-0 and Swedish ecotypes, of phloem per minor vein in plants grown at the low temperature...
2016: Frontiers in Plant Science
Guoyang Sun, Fengqi Lu, Zhuiyang Zhang, Danping Wu, Jianming Ni, Xiaoping Wu, Rongrong Zhang, Hongbo Huang
OBJECTIVE: To establish rabbit VX2 colorectal cancer(CRC) model and to compare CT images with gross pathology in order to offer help for TNM staging in patients with CRC. METHODS: VX2 tumor pieces were implanted into colonic wall in 9 New Zealand white rabbits and rectal wall in 2 New Zealand white rabbits. Four weeks after inoculation, Ultravist(370 mg/ml) was injected through ear marginal vein with high pressure injector for stage 3 scanning of chest, abdomen and pelvis, and enhanced CT (collimation 0...
July 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Grigore Tinica, Cristina Luca Vartic, Veronica Mocanu, Dana Baran, Doina Butcovan
Coronary artery bypass graft (CABG) is a surgical procedure able to improve the blood supply to the myocardium. In the present study, the distal segments of grafts taken from the internal thoracic artery (ITA), radial artery (RA) and saphenous vein (SV) for use in aortocoronary bypass surgery were examined. The morphologies of the grafts were investigated in order to draw conclusions concerning their patency and viability. In addition, clinical and laboratory risk factors considered to be significant predictors of lesion severity in graft vessels used in CABGs were investigated...
August 2016: Experimental and Therapeutic Medicine
Steven K Burke, David Bunton, Karen Bingham, Emma Moss, Kimberly S Bland, Barry Starcher, Marco D Wong, F Nicholas Franano
Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT-201) is a recombinant human chymotrypsin-like elastase family member 1 (CELA1) shown to cleave the elastin component of elastic fibers, resulting in increased vessel diameter. The purpose of these current studies was to determine vein diameter, wall thickness, elastin content, and vonapanitase potency in veins used in a model of arteriovenous fistula (AVF) and in patients undergoing AVF creation for hemodialysis access to guide dose selection for human trials...
June 2016: Pharmacology Research & Perspectives
S A Huang, P Luo, Y C Wu, J G He, C Chen, W Lei
OBJECTIVE: To investigate expression changes and role of Gα11 protein in the processes of muscularization of non-muscular pulmonary arterioles and effect of sildenafil intervention in rats with pulmonary arterial hypertension (PAH). METHODS: Thirty SD rats were randomly divided into three groups, including normal control group, monocrotaline (MCT) group and sildenafil group; PAH model was prepared with 50 mg/kg MCT treatment for 4 weeks in the MCT group, and these rats were treated by 25 mg/kg sildenafil for 2 weeks after PAH formation in the sildenafil group, and the normal control group were treated with the equal amounts of physiological saline instead of monocrotaline; pulmonary artery pressure was measured with jugular vein catheterization; hematoxylin and eosin (HE) staining method was used to detect the pulmonary arteriolar morphology and vascular tissue parameters; expression of the target Gα11 protein, vascular smooth muscle marker osteopontin (OPN) and proliferation marker proliferating cell nuclear antigen (PCNA) was detected by Western blot...
June 14, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Moloy Das, Jonathan J Loveday, Gareth J Wynn, Sean Gomes, Yawer Saeed, Laura J Bonnett, Johan E P Waktare, Derick M Todd, Mark C S Hall, Richard L Snowdon, Simon Modi, Dhiraj Gupta
AIMS: Force-Time Integral (FTI) is commonly used as a marker of ablation lesion quality during pulmonary vein isolation (PVI), but does not incorporate power. Ablation Index (AI) is a novel lesion quality marker that utilizes contact force, time, and power in a weighted formula. Furthermore, only a single FTI target value has been suggested despite regional variation in left atrial wall thickness. We aimed to study AI's and FTI's relationships with PV reconnection at repeat electrophysiology study, and regional threshold values that predicted no reconnection...
May 31, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Lars Walløe
Arterio-venous anastomoses (AVAs) are direct connections between small arteries and small veins. In humans they are numerous in the glabrous skin of the hands and feet. The AVAs are short vessel segments with a large inner diameter and a very thick muscular wall. They are densely innervated by adrenergic axons. When they are open, they provide a low-resistance connection between arteries and veins, shunting blood directly into the venous plexuses of the limbs. The AVAs play an important role in temperature regulation in humans in their thermoneutral zone, which for a naked resting human is about 26°C to 36°C, but lower when active and clothed...
January 2016: Temperature: Multidisciplinary Biomedical Journal
Kazuki Iso, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Kazumasa Sonoda, Rikitake Kogawa, Naoko Sasaki, Keiko Takahashi, Sayaka Kurokawa, Toshiko Nakai, Kimie Ohkubo, Atsushi Hirayama
PURPOSE: The usefulness of electrogram (EGM)-based information has been reported for assessing lesion transmurality during atrial fibrillation (AF) ablation, but the wall thickness of the pulmonary vein-left atrial (PV-LA) junction has not been considered. We conducted a study to evaluate the relation between PV-LA junction wall thickness and the presence of adenosine triphosphate (ATP)-provoked dormant PV conduction. METHODS: Eighteen AF patients underwent extensive encircling pulmonary vein isolation (EEPVI) with a target CF of >10 g...
September 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Xiaoxia Zhu, Lijuan Hou, Jian Zhang, Cijiang Yao, Ying Liu, Chao Zhang, Yachun Xu, Jiyu Cao
A growing body of epidemiological evidence has supported the association between maternal exposure to airborne fine particulate matter (PM2.5) during pregnancy and adverse pregnancy outcomes. However, the specific biological mechanisms implicated in the causes of adverse pregnancy outcomes are not well defined. In this study, a pregnant rat model of exposure to different doses of cooking oil fumes (COFs)-derived PM2.5 by tail intravenous injection in different pregnant stages was established. The results indicated that exposure to COFs-derived PM2...
August 2016: Environmental Science and Pollution Research International
Michael C Hsu, Charles N Weber, Mustafa A Mohammed, Terence P Gade, Stephen Hunt, Gregory J Nadolski, Timothy W I Clark
PURPOSE: To characterize thermal changes induced by rheolytic thrombectomy (RT) within an ex vivo venous model and evaluate resultant changes of endothelial and vessel wall injury. MATERIALS AND METHODS: Patent human saphenous vein segments without thrombus were mounted in an ex vivo perfusion system with a temperature probe apposed to the adventitial surface. RT was performed over a guide wire to facilitate device centering. Continuous RT was performed for 4 minutes with temperature recorded every 10 seconds...
June 2016: Journal of Vascular and Interventional Radiology: JVIR
Xiaofang Lu, Douglas L Miller, Chunyan Dou, Yiying I Zhu, Mario L Fabiilli, Gabe E Owens, Oliver D Kripfgans
Myocardial contrast echocardiography at enhanced therapeutic parameters may be a novel means of tissue reduction therapy, as for hypertrophic cardiomyopathy. Dahl/SS rats were anesthetized and treated with high-amplitude pulsed ultrasound guided by 10-MHz ultrasound images. Contrast microbubbles were infused via the tail vein during intermittent pulse-burst exposure at 4 MPa. A sham group, a low-impact group (group A, 5 cycle pulses with Gaussian modulation and 1:4 trigger for 5 min) and a high-impact group (group B, 10 cycle pulses with 4-ms square modulation and 1:8 trigger for 10 min) were tested...
July 2016: Ultrasound in Medicine & Biology
Akio Chikata, Takeshi Kato, Satoru Sakagami, Chieko Kato, Takahiro Saeki, Keiichi Kawai, Shin-Ichiro Takashima, Hisayoshi Murai, Soichiro Usui, Hiroshi Furusho, Shuichi Kaneko, Masayuki Takamura
BACKGROUND: Low contact force and force-time integral (FTI) during catheter ablation are associated with ineffective lesion formation, whereas excessively high contact force and FTI may increase the risk of complications. We sought to evaluate the optimal FTI for pulmonary vein (PV) isolation based on atrial wall thickness under the ablation line. METHODS AND RESULTS: Contact force parameters and FTI during anatomical ipsilateral PV isolation for atrial fibrillation and atrial wall thickness were assessed retrospectively in 59 consecutive patients for their first PV isolation procedure...
March 15, 2016: Journal of the American Heart Association
Ziyang Zhang, Luyun Hu, Wenpei Chen, Chenghao Zhou, Gang Gui, Baoqin Lin
BACKGROUND: Danhong huayu koufuye (DHK) has traditionally been used clinically for a long time in China. This study was to evaluate the effect of DHK in treating deep vein thrombosis (DVT) in rats and explore its possible mechanism. METHODS: Forty-eight Sprague-Dawley rats were divided into four groups, performed with incomplete inferior vena cava ligation to induce DVT, and orally administered with DHK (3.20 mg/kg/d), warfarin (2.00 mg/kg/d), or vehicle for 7 days...
April 2016: Journal of Surgical Research
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