Leehe Peled-Avron, Hagar Gelbard Goren, Noa Brande-Eilat, Shirel Dorman-Ilan, Aviv Segev, Kfir Feffer, Hila Z Gvirts Problovski, Yechiel Levkovitz, Yael Barnea, Yael D Lewis, Rachel Tomer
BACKGROUND: Healthy individuals show subtle orienting bias, a phenomenon known as pseudoneglect, reflected in a tendency to direct greater attention toward one hemispace. Accumulating evidence indicates that this bias is an individual trait, and attention is preferentially directed contralaterally to the hemisphere with higher dopamine signaling. Administration of methylphenidate (MPH), a dopamine transporter inhibitor, was shown to normalize aberrant spatial attention bias in psychiatric and neurological patients, suggesting that the reduced orienting bias following administration of MPH reflects an asymmetric effect of the drug, increasing extracellular dopamine in the hemisphere with lower dopamine signaling...
March 15, 2021: Journal of Psychopharmacology