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https://www.readbyqxmd.com/read/29221135/silencing-of-bag3-inhibits-the-epithelial-mesenchymal-transition-in-human-cervical-cancer
#1
Fei Song, Geng Wang, Zhifang Ma, Yuebing Ma, Yingying Wang
Bcl2-associated athanogene 3 (BAG3) has been reported to be involved in aggressive progression of many tumors. In the present study, we examined the expression of BAG3 in human cervical cancer (CC) tissues and investigated the role of BAG3 in SiHa and HeLa cell growth, migration, and invasion. Here, we found that most of CC tissues highly expressed the protein and mRNA of BAG3, while their expression was obviously lower in paired normal tissues (all p<0.001). BAG3 expression was associated with FIGO stage and metastasis (all p<0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218693/non-catalytic-region-of-tyrosine-kinase-adaptor-protein-2-nck2-pathways-as-factor-promoting-aggressiveness-in-ovarian-cancer
#2
Mara Fanelli, Alessia Camperchioli, Lella Petrella, Marco Petrillo, Cinzia Baranello, Pina Baccaro, Carmela Paolillo, Ettore Capoluongo, Giovanni Scambia
BACKGROUND: In this study we investigated the function of the non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) and its correlation with ITGB1 and ITGB4 integrins in driving ovarian cancer (OvCa) aggressiveness. We also evaluated whether NCK2 may influence prognosis in OvCa patients. METHODS: Nanofluidic technology was used to analyze expression of NCK2 in 332 OvCa patients. To evaluate mRNA expression of NCK2, integrins and VEGFA in OvCa cell lines, qRT-PCR was performed...
December 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29215729/crosstalk-between-adipose-stem-cells-and-tendon-cells-reveals-a-temporal-regulation-of-tenogenesis-by-matrix-deposition-and-remodeling
#3
Raquel Costa-Almeida, Isabel Calejo, Rui L Reis, Manuela E Gomes
Tendon injuries constitute an unmet clinical challenge owing to the limited intrinsic regenerative ability of this tissue. Cell-based therapies aim at improving tendon healing through the delicate orchestration of tissue rebuilding and regain of function. Hence, human adipose-derived stem cells (hASCs) have been proposed as a promising cell source for boosting tendon regeneration. In this work, we investigated the influence of hASCs on native human tendon-derived cells (hTDCs) through the establishment of a direct contact co-culture system...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215703/design-synthesis-and-characterization-of-%C3%AE-%C3%AE-unsaturated-carboxylic-acid-and-its-urea-based-derivatives-that-explores-novel-epigenetic-modulators-in-human-non-small-cell-lung-cancer-a549-cell-line
#4
Anusha Chidambaram, S H Kavya, Ramesh Kumar Chidambaram, Rajasekaran Subbiah, John Marshal Jayaraj, Karthikeyan Muthusamy, Ravikumar Vilwanathan
Histone deacetylase inhibitors (HDACi) are a small molecule chemotherapeutics that target the chromatin remodeling through the regulation of histone and non-histone proteins. These inhibitors directed against HDAC enzymes have become an important therapeutic tool in oncology; consequently, scientific efforts have fortified the quest for newer and novel HDACi, which forces the design of structurally innovative HDACi. Various urea containing compounds exhibited admirable anticancer activity. On the basis of these observations, we design and synthesize HDAC specific blocker molecules which are specifically besieged towards class I, class II and class IV HDAC isoforms to enhance the structural assortment for HDACi...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29213215/cmtm5-is-downregulated-and-suppresses-tumour-growth-in-hepatocellular-carcinoma-through-regulating-pi3k-akt-signalling
#5
Gang Xu, Chengxue Dang
Background: Human chemokine like factor (CKLF)-like MAL and related proteins for vesicle trafficking transmembrane, domain-containing member 5 (CMTM5) has been shown to involved and may function as a tumour suppressor in tumorigenesis. The current study aimed to investigate the expression and function of CMTM5 in human hepatocellular carcinoma (HCC). Methods: CMTM5 expression was examined by immunohistochemistry, and its clinical significance was analysed in 76 HCC specimens...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29212855/t-cell-densities-in-brain-metastases-are-associated-with-patient-survival-times-and-diffusion-tensor-mri-changes
#6
Rasheed Zakaria, Angela Platt-Higgins, Nitika Rathi, Mark Radon, Sumit Das, Kumar Das, Maneesh Bhojak, Andrew Brodbelt, Emmanuel Chavredakis, Michael D Jenkinson, Philip S Rudland
Brain metastases are common and are usually detected by magnetic resonance imaging (MRI). Diffusion tensor imaging (DTI) is a derivative MRI technique which can detect disruption of white matter tracts in the brain. We have matched preoperative DTI with image-guided sampling of the brain-tumor interface in 26 patients during resection of a brain metastasis and assessed mean diffusivity (MD) and fractional anisotropy (FA). The tissue samples were analysed for vascularity, inflammatory cell infiltration, growth pattern, and tumor expression of proteins associated with growth or local invasion such as Ki67, S100A4, and MMP2, 9, and 13...
December 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/29212226/transcribed-ultraconserved-region-uc-63-promotes-resistance-to-docetaxel-through-regulation-of-androgen-receptor-signaling-in-prostate-cancer
#7
Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Akio Matsubara, Wataru Yasui
Docetaxel is the standard chemotherapy for metastatic castration-resistant prostate cancer (CRPC). However, nearly all patients ultimately become refractory due to the development of docetaxel resistance. The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis including prostate cancer (PC). In this study, we investigated the transcriptional levels of 26 representative T-UCRs and determined the regions that were differentially expressed in PC...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209140/role-of-matrix-metalloproteinase-2-9-mmp2-9-in-lead-induced-changes-in-an-in-vitro-blood-brain-barrier-model
#8
Xinqin Liu, Peng Su, Shanshan Meng, Michael Aschner, Yupeng Cao, Wenjing Luo, Gang Zheng, Mingchao Liu
Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but the detailed mechanisms are not fully understood. Matrix metalloproteinases (MMPs) are important components of extracellular matrix proteasome and can affect the remodeling and degradation of tight junction (TJ)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29207164/silencing-tgif-suppresses-migration-invasion-and-metastasis-of-mda%C3%A2-mb%C3%A2-231-human-breast-cancer-cells
#9
Yadong Wang, Li Li, Haiyu Wang, Jiangmin Li, Haiyan Yang
This study explored the potential role of TG-interacting factor (TGIF) in migration, invasion and metastasis of the human breast cancer cell line MDA‑MB‑231. Western blot assay, immunohistochemistry and qRT-PCR assays were applied to detect the expression of protein and mRNA. Wound healing assay, Transwell invasion assay and tail vein metastatic assay were performed to assess the migration, invasion and metastasis of stable TGIF-silenced MDA‑MB‑231 cell line in vitro and in vivo. The significantly higher frequency of TGIF high-expression was observed in metastatic breast cancer (62...
December 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29203302/immunomodulatory-effects-of-a-rationally-designed-peptide-mimetic-of-human-ifn%C3%AE-in-eae-model-of-multiple-sclerosis
#10
Mansour Poorebrahim, Matin Asghari, Mohammad Foad Abazari, Hassan Askari, Solmaz Sadeghi, Asghar Taheri-Kafrani, Mohammad Hossein Nasr-Esfahani, Pegah Ghoraeian, Maryam Nouri Aleagha, Seyed Shahriar Arab, Derek Kennedy, Alireza Montaseri, Mahsa Mehranfar, Nima Sanadgol
The efficiency of interferon beta (IFNβ)-based drugs is considerably limited due to their undesirable properties, especially high immunogenicity. In this study, for the first time we investigated the impact of a computationally designed peptide mimetic of IFNβ, called MSPEP27, in the animal model of MS. A peptide library was constructed using the Rosetta program based on the predominant IFNAR1-binding site of IFNβ. Molecular docking studies were carried out using ClusPro and HADDOCK tools. The GROMACS package was subsequently used for molecular dynamics (MD) simulations...
December 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29201230/inhibition-of-penile-tunica-albuginea-myofibroblasts-activity-by-adipose-derived-stem-cells
#11
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. In the present study, the inhibitory effects and possible mechanism of ADSCs on the activation of MFs derived from rat penile tunica albuginea were investigated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29193730/the-3p14-2-tumour-suppressor-adamts9-is-inactivated-by-promoter-cpg-methylation-and-inhibits-tumour-cell-growth-in-breast-cancer
#12
Bianfei Shao, Yixiao Feng, Hongbin Zhang, Fang Yu, Qianqian Li, Cui Tan, Hongying Xu, Jianming Ying, Lili Li, Dejuan Yang, Weiyan Peng, Jun Tang, Shuman Li, Guosheng Ren, Qian Tao, Tingxiu Xiang
Chromosome region 3p12-14 is an important tumour suppressor gene (TSG) locus for multiple cancers. ADAMTS9, a member of the metalloprotease large family, has been identified as a candidate 3p14.2 TSG inactivated by aberrant promoter CpG methylation in several carcinomas, but little known about its expression and function in breast cancer. In this report, ADAMTS9 expression and methylation was analysed in breast cancer cell lines and tissue samples. ADAMTS9 RNA was significantly down-regulated in breast cancer cell lines (6/8)...
November 29, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29191629/effects-of-thc-on-human-amniotic-epithelial-cell-proliferation-and-migration
#13
J L Yao, Q Z He, M Liu, X W Chang, J T Wu, T Duan, K Wang
BACKGROUND: The deleterious effects of cannabis consumption for fertility and pregnancy outcome are recognized for years. The main psychoactive molecule of cannabis, Δ(9)-tetrahydrocannabinol (THC) is able to cross the placenta barrier and cause alterations in fetal growth, low birth weight and preterm labor. However, the effects of THC on the human placenta amnion are still unknown. METHODS: The distributions of CB1R and CB2R in human amnion tissues were observed by immunohistochemistry (IHC)...
November 27, 2017: Toxicology
https://www.readbyqxmd.com/read/29191012/tape-assisted-photolithographic-free-microfluidic-chip-tapmic-cell-patterning-for-tumor-metastasis-study
#14
Liang Zhao, Tengfei Guo, Lirong Wang, Yang Liu, Ganyu Chen, Hao Zhou, Meiqin Zhang
Cancer metastatic dissemination is a complex event during tumor progression which involves cell-cell, cell-matrix interactions. Micro-patterning of is one of the most efficient ways to study tumor development because it can tune the distribution of cells with spatial and temporal control. Extensive studies have shown that microfluidics can provide a feasible method for cell patterning. However, the current technique requires a microfabrication laboratory to manufacture the chip, which results in inaccessibility to researchers especially biologists who focus on the disclosing biological mechanisms rather than the methods...
November 30, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29190653/novel-molecular-imaging-ligands-targeting-matrix-metalloproteinases-2-and-9-for-imaging-of-unstable-atherosclerotic-plaques
#15
Nazanin Hakimzadeh, Victorine A Pinas, Ger Molenaar, Vivian de Waard, Esther Lutgens, Berthe L F van Eck-Smit, Kora de Bruin, Jan J Piek, Jos L H Eersels, Jan Booij, Hein J Verberne, Albert D Windhorst
Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel radiolabelled compound that can target gelatinase MMP subtypes (MMP2/9) with high selectivity and inhibitory potency. Inhibitory potencies of several halogenated analogues of MMP subtype-selective inhibitors (N-benzenesulfonyliminodiacetyl monohydroxamates and N-halophenoxy-benzenesulfonyl iminodiacetyl monohydroxamates) were in the nanomolar range for MMP2/9...
2017: PloS One
https://www.readbyqxmd.com/read/29190630/alpha-mangostin-suppresses-the-metastasis-of-human-renal-carcinoma-cells-by-targeting-mek-erk-expression-and-mmp-9-transcription-activity
#16
Chien-Min Chen, Shu-Ching Hsieh, Chia-Liang Lin, Yu-Syun Lin, Jen-Pi Tsai, Yi-Hsien Hsieh
BACKGROUND/AIMS: α-mangostin has anti-carcinogenic effects against several cancers. We investigated the molecular mechanism of this compound on the metastasis of human renal carcinoma cells. METHODS: Cell viability was measured using the MTT assay, and cell cycle distribution using flow cytometry. A Matrigel-based assay was used to measure in vitro cell migration and invasion. MAPK-related proteins and matrix metalloproteinase (MMP)-9 and MMP-2 expression were measured by western blotting, and MMP2/-9 activities were determined by gelatin zymography...
December 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29180881/curcumin-potentiates-the-potent-antitumor-activity-of-acnu-against-glioblastoma-by-suppressing-the-pi3k-akt-and-nf-%C3%AE%C2%BAb-cox-2-signaling-pathways
#17
Jun Zhao, Jiabin Zhu, Xiaoshu Lv, Jinshan Xing, Shuang Liu, Chen Chen, Yinghui Xu
Glioblastoma (GBM) is a highly invasive and challenging primary tumor of the central nervous system (CNS), and currently available treatments provide limited benefits to patients with this disease. Therefore, the development of novel therapeutic targets and effective treatment strategies is essential. Nimustine hydrochloride (ACNU) is widely used as the standard chemotherapeutic agent and is frequently administered together with other chemotherapeutic agents in clinical studies. Curcumin, a natural polyphenolic compound, could potentially be combined with chemotherapeutics for cancer treatment; however, there are no reports of studies where ACNU and curcumin were combined for GBM treatment, and the mechanisms underlying their activity remain poorly understood...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29173024/main-components-of-pomegranate-ellagic-acid-and-luteolin-inhibit-metastasis-of-ovarian-cancer-by-down-regulating-mmp2-and-mmp9
#18
Huidi Liu, Zheng Zeng, Siwen Wang, Ting Li, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Yongfang Liu, Wei Liu, Sijing Hu, Shan Gao, Miao Yu, Yingying Qi, Zhihang Shen, Hongyue Wang, Tingting Gao, Lingqin Dong, Randal N Johnston, Shu-Lin Liu
Ovarian cancer is the third most common cancer in the female reproductive organs and epithelial ovarian cancer has the highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) has been shown to inhibit the growth of several types of cancer other than ovarian cancer. In this study, we exposed the ovarian cancer cell line A2780 to PFJ and two of its components (ellagic acid and luteolin). MTT and wound healing assays demonstrated that all three treatments suppressed the proliferation and migration of the ovarian cancer cells...
November 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29163762/bmal1-facilitates-trophoblast-migration-and-invasion-via-sp1-dnmt1-dab2ip-pathway-in-recurrent-spontaneous-abortion
#19
Shang Li, Junyu Zhai, Jiansheng Liu, Yan Hong, Weixiu Zhao, Aimin Zhao, Kang Sun, Yanzhi Du, Zi-Jiang Chen
The underlying mechanism about rhythms and epigenetics leading to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be associated with risk of miscarriage. However, the functional role of BMAL1 in RSA is not fully understood. Previous study shows the descended expression of DNA 5'-cytosine-methyltransferases 1 (DNMT1) in the villous of early pregnancy loss...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29158883/the-role-of-protein-kinase-b-signaling-pathway-in-anti-cancer-effect-of-rolipram-on-glioblastoma-multiforme-an-in-vitro-study
#20
Sara Ramezani, Mahmoudreza Hadjighassem, Nasim Vousooghi, Mansour Parvaresh, Farshid Arbabi, Naser Amini, Mohammad Taghi Joghataei
Introduction: The mechanism of putative cytotoxicity of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone (rolipram), a specific phosphodiesterase-4 (PDE4) inhibitor, on glioblastoma multiforme (GBM) is almost unknown. This study aimed to investigate the role of protein kinase B (Akt) pathway in the cytotoxic effect of rolipram on human GBM U87 MG cell line and Tumor-Initiating Cells (TICs) isolated from patient's GBM specimen. Methods: TICs were characterized by using flow cytometry and quantitative real-time PCR...
July 2017: Basic and Clinical Neuroscience
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