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https://www.readbyqxmd.com/read/29912573/association-of-tissue-inhibitor-of-metalloproteinase-2-with-non-alcoholic-fatty-liver-disease-in-metabolic-syndrome
#1
Saira Yasmeen, Unab Khan, Ghulam Mustafa Khan, Syeda Sadia Fatima
The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. High TIMP2 was seen in MetS group (145.28 ± 23.11 pg/ml) versus controls (19.06 ± 1.19 pg/ml; p < .001). Serum cholesterol, triglyceride, LDL-c and glucose levels were significantly higher in MetS subjects (p < ...
June 18, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29859935/exosomal-mir-93-promotes-proliferation-and-invasion-in-hepatocellular-carcinoma-by-directly-inhibiting-timp2-tp53inp1-cdkn1a
#2
Xiaofeng Xue, Xiaona Wang, Yubin Zhao, Rongkuan Hu, Lei Qin
Hepatocellular carcinoma (HCC) is a malignant cancer worldwide; lacking biomarkers for early prognostication contributes to its high lethality. Herein, we report a novel biomarker, exosome delivered miR-93, is up-regulated in HCC cell line media and serum samples of HCC patients. We measured the proliferation and invasion ability of HCC cell lines following exosomal miR-93 treatment. After prediction with online algorithms, we further confirmed that TP53INP1, TIMP2 and CDKN1A are direct targets of miR-93 by dual-luciferase reporter assay...
May 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29782915/new-insights-into-the-natural-course-of-knee-osteoarthritis-early-regulation-of-cytokines-and-growth-factors-with-emphasis-on-sex-dependent-angiogenesis-and-tissue-remodeling-a-pilot-study
#3
Kalle Kisand, Ann Tamm, Mare Lintrop, Agu Tamm
OBJECTIVE: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. METHODS: The pilot population study involved 60 middle-aged patients (mean age 50±7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP® ) technology was used to simultaneously assess 60 biomarkers...
May 18, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29778391/matrix-metalloproteinases-and-their-inhibitors-in-human-cumulus-and-granulosa-cells-as-biomarkers-for-oocyte-quality-estimation
#4
Alice Luddi, Martina Gori, Camilla Marrocco, Angela Capaldo, Valentina Pavone, Laura Bianchi, Letizia Boschi, Giuseppe Morgante, Paola Piomboni, Vincenzo de Leo
OBJECTIVE: To study the molecular profile of metalloproteinases and their tissue inhibitors in granulosa and cumulus cells in a subset of fertile and infertile women. DESIGN: Molecular study with granulosa and cumulus cells. SETTING: University hospital. PATIENT(S): Forty-four women undergoing assisted reproductive techniques for female infertility factor, with partners having a normal spermiogram and 15 normally fertile women with male partner affected by severe oligoasthenoteratozoospermia or nonobstructive azoospermia...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29763380/angiogenin-and-the-mmp9-timp2-axis-are-up-regulated-in-proangiogenic-decidual-nk-like-cells-from-patients-with-colorectal-cancer
#5
Antonino Bruno, Barbara Bassani, Davide Giuseppe D'Urso, Ilvana Pitaku, Elisa Cassinotti, Giuseppe Pelosi, Luigi Boni, Lorenzo Dominioni, Douglas M Noonan, Lorenzo Mortara, Adriana Albini
NK cells are effector lymphocytes involved in tumor immunosurveillance; however, in patients with solid malignancies, NK cells have compromised functions. We have previously reported that lung tumor-associated NK cells (TANKs; peripheral blood) and tumor-infiltrating NK cells (TINKs) show proangiogenic, decidual NK-like (dNK) phenotype. In this study, we functionally and molecularly investigated TINKs and TANKs from blood and tissue samples of patients with colorectal cancer (CRC), a neoplasm in which inflammation and angiogenesis have clinical relevance, and compared them to NK cells from controls and patients with nononcologic inflammatory bowel disease...
May 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29753168/serum-timp1-and-timp2-concentration-in-patients-with-different-grades-of-meningioma
#6
Farhad Mashayekhi, Alia Saberi, Sohail Mashayekhi
OBJECTIVE: Meningiomas are common primary brain tumors that constitute about 13% of all intracranial tumors. Matrix metalloproteinase-9 (MMP-9) is able to degrade the extracellular matrix and basement membrane leading to cancer cell invasion and metastasis. MMPs are specifically inhibited by a family of small extracellular proteins known as the tissue inhibitors of metalloproteinases (TIMPs). The objective of this project was to evaluate serum concentration of TIMP-1 and TIMP-2 in patients with different grades of meningioma...
May 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29685765/uv-induced-dna-methyltransferase-1-promotes-hypermethylation-of-tissue-inhibitor-of-metalloproteinase-2-in-the-human-skin
#7
Ha-Young Kim, Dong Hun Lee, Mi Hee Shin, Hye Sun Shin, Min-Kyoung Kim, Jin Ho Chung
BACKGROUND: Ultraviolet (UV) radiation has been reported to influence epigenetic regulation by affecting the expression of genome regulators such as DNA methyltransferase 1 (DNMT1). DNMT1 is a "gene silencer," that is responsible for the maintenance of DNA methylation and contribution to de novo methylation. Implications of DNMT1's involvement in the expression of UV-induced proteins have been previously reported. OBJECTIVE: To investigate for changes in DNA methylation-associated gene expressions by UV and to analyze the role of DNA methylation in the suppression of TIMP2 in UV-irradiated human skin...
March 15, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29682908/tracking-disease-progression-non-invasively-in-duchenne-and-becker-muscular-dystrophies
#8
Pietro Spitali, Kristina Hettne, Roula Tsonaka, Mohammed Charrout, Janneke van den Bergen, Zaïda Koeks, Hermien E Kan, Melissa T Hooijmans, Andreas Roos, Volker Straub, Francesco Muntoni, Cristina Al-Khalili-Szigyarto, Marleen J A Koel-Simmelink, Charlotte E Teunissen, Hanns Lochmüller, Erik H Niks, Annemieke Aartsma-Rus
BACKGROUND: Analysis of muscle biopsies allowed to characterize the pathophysiological changes of Duchenne and Becker muscular dystrophies (D/BMD) leading to the clinical phenotype. Muscle tissue is often investigated during interventional dose finding studies to show in situ proof of concept and pharmacodynamics effect of the tested drug. Less invasive readouts are needed to objectively monitor patients' health status, muscle quality, and response to treatment. The identification of serum biomarkers correlating with clinical function and able to anticipate functional scales is particularly needed for personalized patient management and to support drug development programs...
April 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29673878/down-regulation-of-mir-373-increases-the-radiosensitivity-of-lung-cancer-cells-by-targeting-timp2
#9
Yinghua Guo, Yingxiao Jiang, Maozhong Sang, Chunli Xu
BACKGROUND: Radiotherapy is a widely used effective treatment for lung cancer in clinic. MicroRNAs (miRNAs) have been proved to play an important role in radiation response. This study aimed to explore the regulatory role and mechanism of miR-373 in lung cancer cell radiosensitivity. METHODS: qRT-PCR was used to analyze the expression of miR-373 in lung cancer tissues and cell lines. MiR-373 expression was overexpressed or knocked down by transfection with miR-373 mimic or inhibitor...
June 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29658596/microrna-616-promotes-the-progression-of-ovarian-cancer-by-targeting-timp2
#10
Zhongbo Chen, Jianqing Zhu, Yiming Zhu, Junjian Wang
MicroRNAs (miRNAs), a group of short (~20 nt) non‑coding RNAs, play critical roles in the development and progression of ovarian cancer (OC). The role of miR‑616, a recently identified cancer-associated miRNA, has never been examined in OC before. The present study demonstrated that the level of miR‑616 was increased in OC tissues. A high miR‑616 level was associated with poor tumor differentiation and advanced tumor-node-metastasis (TNM) stage. Survival analysis revealed that an elevated level of miR‑616 was associated with poor prognosis of OC patients as demonstrated by decreased overall survival (OS) and disease‑free survival (DFS)...
June 2018: Oncology Reports
https://www.readbyqxmd.com/read/29620263/tpx2-silencing-mediated-by-joint-action-of-microvesicles-and-ultrasonic-radiation-inhibits-the-migration-and-invasion-of-skov3-cells
#11
Dong Huang, Jianmin Chen, Cuiyu Yang, Minzhen Wang
Ovarian cancer, with its high morbidity, has one of the highest mortality rates among gynecological malignant tumors. Overexpression of targeting protein for Xklp2 (TPX2) has been identified in numerous malignant tumors. The present study sought to determine whether TPX2 silencing inhibited the growth and metastasis of ovarian cancer cells, and whether microvesicles‑ and ultrasonic radiation‑mediated small interfering (si)RNA‑TPX2 transfection may improve the therapeutic effect. The SKOV3 cell line, derived from papillary serous cytadenocarcinoma of the human ovary, was selected as a cell model...
June 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29567202/mating-induces-production-of-mmp2-in-the-llama-oviduct-analysis-of-mmp2-effect-on-semen
#12
Renato Zampini, Luciana M Sari, Martin E Argañaraz, Fernanda G Fumuso, Daniela E Barraza, María I Carretero, Silvana A Apichela
Ovulation of South American Camelids is induced by mating. After copulation, sperm are stored into the oviduct to be released near ovulation time. To study whether copulation induces matrix metalloproteinase-2 (MMP2) secretion in the oviduct, the occurrence of MMP2 in oviductal tissue and oviductal fluid (OF) from 24 h post-mated was compared with non-mated llama females. There was an incremental increase of MMP2 in the oviductal epithelial cells, and MMP2 activity in OF after copulation. Additionally, MMP2 activator (MMP14), inducer (EMMPRIN) and inhibitor (TIMP2) were present in the oviductal epithelial cells of both non-mated and post-mated females...
May 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29565489/high-expression-of-lncrna-gacat3-inhibits-invasion-and-metastasis-of-non-small-cell-lung-cancer-to-enhance-the-effect-of-radiotherapy
#13
X Yang, W Zhang, S-Q Cheng, R-L Yang
OBJECTIVE: To clarify the role of long non-coding RNA (lncRNA) GACAT3 in invasion and metastasis of non-small cell lung cancer (NSCLC) and its effect on radiotherapy. PATIENTS AND METHODS: The expression of GACAT3 and TIMP2 in cells and tissues of NSCLC were detected by quantitative Real-time PCR (qRT-PCR). The influence of GACAT3 on cell proliferation and the capacity of colony formation were estimated by MTT test and colony forming experiment respectively. Luciferase reporting assay was used to confirm the correlation between GACAT3 and TIMP2...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29544929/angiotensin-receptor-neprilysin-inhibition-provides-superior-cardioprotection-compared-to-angiotensin-converting-enzyme-inhibition-after-experimental-myocardial-infarction
#14
Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang
BACKGROUND: Angiotensin receptor neprilysin inhibitor (ARNi) enhances beneficial natriuretic peptides by inhibiting their breakdown through neprilysin. Although the first-in-class ARNi sacubitril/valsartan (LCZ696) reduced mortality and morbidity in heart failure (HF) with reduced ejection fraction (EF) compared to angiotensin converting enzyme inhibitor (ACEi), mechanistic data on ARNi are scarce. ARNi may be superior to ACEi in attenuating adverse cardiac remodeling and dysfunction post-myocardial infarction (MI)...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29541006/change-of-ranibizumab-induced-human-vitreous-protein-profile-in-patients-with-proliferative-diabetic-retinopathy-based-on-proteomics-analysis
#15
Chen Zou, Changjing Han, Minjie Zhao, Jingjing Yu, Lin Bai, Yuan Yao, Shuaixin Gao, Hui Cao, Zhi Zheng
Background: Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objective of this research is to observe change of protein profile induced by ranibizumab (an anti-VEGF agent) in vitreous humor from PDR patients and reveal the effects of anti-VEGF treatment on PDR. Methods: A proteomic method was used to identify differentially expressed proteins in vitreous humor...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29502979/amelioration-of-cavernosal-fibrosis-and-erectile-function-by-lysyl-oxidase-inhibition-in-a-rat-model-of-cavernous-nerve-injury
#16
Zhi-Hua Wan, Guo-Hao Li, Yong-Lian Guo, Wen-Zhou Li, Lin Chen, Yuan-Jie Zhang
BACKGROUND: Cavernous nerve injury (CNI) causes fibrosis and loss of smooth muscle cells (SMCs) in the corpus cavernosum and leads to erectile dysfunction, and lysyl oxidase (LOX) activation has been found to play an important role in fibrotic diseases. AIM: To evaluate the role of LOX in penile fibrosis after bilateral CNI (BCNI). METHODS: Rats underwent BCNI or a sham operation and were treated with vehicle or β-aminopropionitrile, a specific LOX activity inhibitor...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29491489/genome-wide-analysis-revealed-that-dznep-reduces-tubulointerstitial-fibrosis-via-down-regulation-of-pro-fibrotic-genes
#17
Imari Mimura, Yosuke Hirakawa, Yasuharu Kanki, Ryo Nakaki, Yutaka Suzuki, Tetsuhiro Tanaka, Hiroyuki Aburatani, Masaomi Nangaku
Tubulointerstitial fibrosis has been recently reported to be caused by the collapse of the epigenetic regulation of kidney diseases. We examined whether pharmacological inhibition of histone modification is effective against renal fibrosis. DZNep (3-deazaneplanocin A) was originally developed as an anti-cancer drug to inhibit the repressive histone mark, H3K27me3. We used a model of chronic tubulointerstitial fibrosis induced by unilateral ischaemia/reperfusion and administered DZNep intravenously to the mice for 8 weeks...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29486611/anti-elastase-and-anti-collagenase-potential-of-lactobacilli-exopolysaccharides-on-human-fibroblast
#18
Mahdieh Shirzad, Javad Hamedi, Elahe Motevaseli, Mohammad Hossein Modarressi
Polysaccharides could be used as biodegradable and biocompatible polymers for scaffolds and carriers matrix. Numerous algal, fungi and herbal polysaccharides can attenuate degradation of skin matrix by the inhibition of elastase, collagenase and matrix metalloproteinases (MMPs). In this study, we investigate anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides (LEPS) on normal human fibroblast. Among 60 Lactobacilli isolated from herbal plants and dairy products, selected LEPS showed high anti-collagenase (up to 100%), anti-elastase (up to 87%) and antioxidant activity (up to 60%)...
February 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29434787/expression-and-role-of-microrna-1271-in-the-pathogenesis-of-osteosarcoma
#19
Gongbiao Lu, Lin Du, Yi Guo, Baohua Xing, Jishou Lu, Yanchun Wei
The aim of the current study was to investigate the expression and role of microRNA (miR)-1271 in the pathogenesis of osteosarcoma, and the associated underlying mechanisms. Tissue samples from 45 patients with osteosarcoma were collected, while the 143B, MG-63 and U-2 OS osteosarcoma cell lines were also cultured. The expression levels of miR-1271 in the tissues and cells were detected with reverse transcription-quantitative polymerase chain reaction, and 143B osteosarcoma cells were subjected to miR-1271 manipulation...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432996/lncrna-let-inhibits-cell-viability-migration-and-emt-while-induces-apoptosis-by-up-regulation-of-timp2-in-human-granulosa-like-tumor-cell-line-kgn
#20
Qingfang Han, Wenke Zhang, Jinlai Meng, Li Ma, Aihua Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease characterized by hyperandrogenism, irregular menses, and polycystic ovaries. Several long non-coding RNAs (lncRNAs) are aberrantly expressed in PCOS patients; however, little is known about the effects of the lncRNA-low expression in tumor (lncRNA-LET) on PCOS. We aimed to explore the effects of lncRNA-LET on human granulosa-like tumor cell line, KGN. METHODS: Expression of lncRNA-LET in normal IOSE80 cells and granulosa cells was determined by qRT-PCR...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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