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Bisphosphonate necrosis

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https://www.readbyqxmd.com/read/29233701/in%C3%A2-vivo-effects-of-geranylgeraniol-on-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaws
#1
Filip Koneski, Danica Popovic-Monevska, Icko Gjorgoski, Jovanka Krajoska, Mirjana Popovska, Ilijana Muratovska, Boris Velickovski, Gordana Petrushevska, Vladimir Popovski
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a complication of the bisphosphonate (BP) treatment and its pathopysiology is still not fully understood. The existing preventive and treatment options require updates and more attention. Geranylgeraniol (GGOH) so far demonstrated an increased activity and viability of the cells previously treated with zoledronic acid (ZA). The aim of this study was to evaluate the in vivo effects of GGOH on the development of BRONJ...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29216909/which-measuring-site-in-ankylosing-spondylitis-is-best-to-detect-bone-loss-and-what-predicts-the-decline-results-from-a-5-year-prospective-study
#2
Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T Jacobsson, Helena Forsblad-d'Elia
BACKGROUND: Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine anterior-posterior (AP) projection may be difficult to interpret due to the ligamentous calcifications, and the lateral projection might be a better measuring site. Our objectives were to investigate BMD changes after 5 years at different measuring sites in patients with AS and to evaluate disease-related variables and medications as predictors for BMD changes...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29215680/effects-of-zoledronic-acid-in-experimental-periapical-lesions-in-rats-an-imaging-and-histological-analysis
#3
Talita Ribeiro Tenório de França, Flávia Maria de Moraes Ramos-Perez, Andrea Dos Anjos Pontual, Jurema Freire Lisboa de Castro, Paulo Rogério Ferreti Bonan, Danyel Elias da Cruz Perez
The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29112802/consensus-treatment-plans-for-chronic-nonbacterial-osteomyelitis-refractory-to-nonsteroidal-anti-inflammatory-drugs-and-or-with-active-spinal-lesions
#4
Yongdong Zhao, Eveline Y Wu, Melissa S Oliver, Ashley M Cooper, Matthew L Basiaga, Sheetal S Vora, Tzielan C Lee, Emily Fox, Gil Amarilyo, Sara M Stern, Jeffrey A Dvergsten, Kathleen A Haines, Kelly A Rouster-Stevens, Karen B Onel, Julie Cherian, Jonathan S Hausmann, Paivi Miettunen, Tania Cellucci, Farzana Nuruzzaman, Angela Taneja, Karyl S Barron, Matthew C Hollander, Sivia K Lapidus, Suzanne C Li, Seza Ozen, Hermann Girschick, Ronald M Laxer, Fatma Dedeoglu, Christian M Hedrich, Polly J Ferguson
OBJECTIVE: To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO) to enable comparative effectiveness treatment studies. METHODS: Virtual and face-to-face discussions and meetings were held within the CNO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29071028/successful-use-of-lower-level-laser-therapy-in-the-treatment-of-medication-related-osteonecrosis-of-the-jaw
#5
Gustavo Antonio Correa Momesso, Fábio Roberto de Souza Batista, Cecília Alves de Sousa, Valthierre Nunes de Lima, Tárik Ocon Braga Polo, Jaqueline Suemi Hassumi, Idelmo Rangel Garcia Júnior, Leonardo Perez Faverani
Case Presentation: This study aimed to report a case of medication related osteonecrosis of the jaw (MRONJ) of a 65-year-old female patient referred to the Oral and Maxillofacial Surgery team from Araçatuba Dental School, complaining about mobility of a previously dental implant placed on the posterior maxillary region. Clinical examination revealed an extensive necrosis area around the implant region. The patient reported bisphosphonate therapy with sodium alendronate for prevention of osteoporosis 5 years ago...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29063702/antiresorptive-treatment-associated-onj
#6
REVIEW
Evangelos Eleutherakis-Papaiakovou, Aristotelis Bamias
Osteonecrosis of the jaw (ONJ) is a severe complication of therapy with antiresorptive agents (e.g. bisphosphonates and denosumab), which are used to manage bone metastases from cancer, to reduce the incidence of skeletal-related events. Available data indicate that 0-27, 5% of patients exposed to antiresorptive agents may develop ONJ, depending on the number of infusions and the duration of therapy. Besides antiresorptive therapy, a number of risk factors for osteonecrosis have been identified. Oral surgical procedures, tooth extractions and infection to the jawbones are considered the main risk factors for developing ONJ, when receiving antiresorptive therapy...
November 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28977694/denosumab-related-osteonecrosis-of-the-jaw-a-retrospective-study
#7
Claire Egloff-Juras, Aurélie Gallois, Julia Salleron, Vincent Massard, Gilles Dolivet, Julie Guillet, Bérengère Phulpin
BACKGROUND: Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab-related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. METHODS: To that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded...
October 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28902603/the-utility-of-conservative-treatment-modalities-in-the-management-of-osteonecrosis
#8
Feroz Osmani, Savyasachi Thakkar, Jonathan Vigdorchik
INTRODUCTION: Osteonecrosis is an ischemic pathologic process associated with a number of conditions affecting a range of age groups. The problem faced in the management of osteonecrosis is whether conservative treatment is a viable and effective option for patients. In this systematic review, we investigated the efficacy of various nonoperative treatment modalities for hip and knee osteonecrosis, including pharmacological management and biophysical modalities. METHODS: We identified 16 studies based on electronic searches through the PubMed, Embase, CINAHL Plus, and Cochrane databases from January 2001 to November 2015...
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28871336/zoledronate-dysregulates-fatty-acid-metabolism-in-renal-tubular-epithelial-cells-to-induce-nephrotoxicity
#9
Lili Cheng, Mengmeng Ge, Zhou Lan, Zhilong Ma, Wenna Chi, Wenhua Kuang, Kun Sun, Xinbin Zhao, Ye Liu, Yaqian Feng, Yuedong Huang, Maoguo Luo, Liping Li, Bin Zhang, Xiaoyu Hu, Lina Xu, Xiaohui Liu, Yi Huo, Haiteng Deng, Jinliang Yang, Qiaoran Xi, Yonghui Zhang, Julie A Siegenthaler, Ligong Chen
Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and renal fibrosis when administered intravenously. There is speculation that zoledronate-induced nephrotoxicity may result from its pharmacological activity as an inhibitor of the mevalonate pathway but the molecular mechanisms are not fully understood. In this report, human proximal tubular HK-2 cells and mouse models were combined to dissect the molecular pathways underlying nephropathy caused by zoledronate treatments...
September 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28865081/chronic-treatment-with-zoledronic-acid-increases-inflammatory-markers-in-periodontium-of-rats
#10
Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
BACKGROUND: Bisphosphonates (BF) rise proinflammatory markers and irreversibly bind to bone. Chronically, BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was to evaluate whether the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. METHODS AND RESULTS: Chronically, infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70-day period to analyze periodontium of the first right inferior molar using histologic, histochemical (toluidine blue), and immunohistochemical (CD68, tumor necrosis factor-α (TNF-α), interleukin-1beta (IL-1β), inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-kB)) tests...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28803745/further-development-of-the-mronj-minipig-large-animal-model
#11
Sven Otto, Christoph Pautke, Olga Martin Jurado, Dirk Nehrbass, Martin J Stoddart, Michael Ehrenfeld, Stephan Zeiter
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious and potentially severe side effect of antiresorptive therapy with bisphosphonates or denosumab. Recently, a large animal minipig MRONJ model was introduced which led to early necrotic lesions in the majority of extraction sites after bisphosphonate administration. The aim of this project was to modify the preoperative cumulative bisphosphonate dose (zoledronate) and hereby firstly to demonstrate the reliability and reproducibility of the established model...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28751466/treatment-refractory-sternocostoclavicular-hyperostosis
#12
Ralph Yachoui, Mazen Kreidy, Brian J Parker
Sternocostoclavicular hyperostosis (SCCH) is an infrequent chronic inflammatory disorder of the axial skeleton of unknown origin. SCCH goes often unrecognized due to a low level of awareness for the disorder. It typically presents with relapsing and remitting pain in the shoulder, neck, and anterior chest wall area with occasional swelling and tenderness of the sternoclavicular area. The diagnosis is confirmed radiologically by sclerosis and hyperostosis of the sternoclavicular joints. There have been several reports in which intravenous bisphosphonates and tumor necrosis factor-inhibitors have shown reasonable efficacy in the treatment of this disorder...
June 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28728961/avascular-necrosis-of-the-femoral-head-in-patients-treated-for-leukaemia-assessment-of-the-need-for-a-diagnostic-protocol
#13
J Alguacil Pinel, P Vila Vives, M Salom Taverner
OBJECTIVE: To evaluate the incidence of avascular necrosis of the hip in leukaemia patients treated in our hospital with high doses of corticosteroids in order to evaluate the necessity for an early detection protocol. MATERIAL AND METHODS: Observational-descriptive and retrospective study from 2005 to 2016 of 253 patients diagnosed with paediatric leukaemia. Patients with musculoskeletal pathology were identified and patients with avascular necrosis were analysed...
July 17, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28655390/acute-granulomatous-interstitial-nephritis-and-acute-rejection-in-a-kidney-transplant-recipient-after-zoledronic-acid-therapy-a-case-report-and-review-of-the-literature
#14
Nuša Avguštin, Damjan Kovač, Nika Kojc, Gregor Mlinšek, Jelka Lindič
BACKGROUND: Acute granulomatous interstitial nephritis (AGIN) in native kidneys is most commonly linked to drugs. In allografts, it is a rare complication, and it occurs mostly with infections. CASE PRESENTATION: Our case report presents AGIN with simultaneous acute cellular rejections and acute tubular necrosis in a kidney transplant patient 2 weeks after intravenous application of zoledronic acid. A kidney biopsy showed signs of destructive AGIN with acute cellular rejection...
2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28587938/etidronate-down-regulates-toll-like-receptor-tlr-2-ligand-induced-proinflammatory-cytokine-production-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#15
Kentaro Hojo, Riyoko Tamai, Michiyo Kobayashi-Sakamoto, Yusuke Kiyoura
BACKGROUND: Etidronate is a non-nitrogen-containing bisphosphonate (non-NBP) used for anti-bone resorptive therapy as well as having inhibitory effects on atherosclerotic plaques. The present study examined the effects of etidronate on the production of proinflammatory cytokines and chemokines by the macrophage-like cell line, J774.1, incubated with Pam3Cys-Ser-(Lys)4 (Pam3CSK4, a Toll-like receptor (TLR) 2 agonist) and lipid A (a TLR4 agonist). METHODS: J774.1 cells and human monocytic THP-1 cells were pretreated with or without etidronate for 5min, and then incubated with or without Pam3CSK4 or lipid A for 24h...
March 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28566618/underlying-mechanisms-and-therapeutic-strategies-for-bisphosphonate-related-osteonecrosis-of-the-jaw-bronj
#16
Yasuo Endo, Hiroyuki Kumamoto, Masanori Nakamura, Shunji Sugawara, Teruko Takano-Yamamoto, Keiichi Sasaki, Tetsu Takahashi
Bisphosphonates (BPs), with a non-hydrolysable P-C-P structure, are cytotoxic analogues of pyrophosphate, bind strongly to bone, are taken into osteoclasts during bone-resorption and exhibit long-acting anti-bone-resorptive effects. Among the BPs, nitrogen-containing BPs (N-BPs) have far stronger anti-bone-resorptive effects than non-N-BPs. In addition to their pyrogenic and digestive-organ-injuring side effects, BP-related osteonecrosis of jaws (BRONJ), mostly caused by N-BPs, has been a serious concern since 2003...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28461645/treatment-response-and-longterm-outcomes-in-children-with-chronic-nonbacterial-osteomyelitis
#17
Anja Schnabel, Ursula Range, Gabriele Hahn, Reinhard Berner, Christian M Hedrich
OBJECTIVE: The autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO) covers a wide clinical spectrum, ranging from mild self-limited presentations to chronically active or recurrent courses, which are then referred to as chronic recurrent multifocal osteomyelitis (CRMO). Little is known about treatment options and longterm outcomes. We investigated treatment responses and outcomes in children with CNO. METHODS: A retrospective chart review was conducted in a tertiary referral center, covering 2004-2015...
July 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28401741/oral-alendronate-in-pediatric-chronic-recurrent-multifocal-osteomyelitis
#18
Daishi Hirano, Kosuke Chiba, Saya Yamada, Hiroyuki Ida
Chronic recurrent multifocal osteomyelitis (CRMO) primarily affects children and adolescents, and is characterized by episodic sterile osteomyelitis over several years. No definitive treatment is available. Non-steroidal anti-inflammatory drugs (NSAID) are common first-line agents, but provide limited improvement in bone pain and do not affect disease duration. Several agents are utilized in the case of non-response to NSAID, including corticosteroids, methotrexate, and tumor necrosis factor-blocking agents...
April 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28401420/an-update-on-the-pathogenesis-and-treatment-of-chronic-recurrent-multifocal-osteomyelitis-in-children
#19
REVIEW
Andrea Taddio, Floriana Zennaro, Serena Pastore, Rolando Cimaz
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic non-bacterial osteomyelitis (CNO), is a rare inflammatory disorder that primarily affects children. It is characterized by pain, local bone expansion, and radiological findings suggestive of osteomyelitis, usually at multiple sites. CRMO predominantly affects the metaphyses of long bones, but involvement of the clavicle or mandible are suggestive of the diagnosis. CRMO is a diagnosis of exclusion, and its pathogenesis remains unknown. Differential diagnosis includes infection, malignancies, benign bone tumors, metabolic disorders, and other autoinflammatory disorders...
June 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28365078/macrophage-and-osteoclast-polarization-in-bisphosphonate-associated-necrosis-and-osteoradionecrosis
#20
Falk Wehrhan, Patrick Moebius, Kerstin Amann, Jutta Ries, Raimund Preidl, Friedrich W Neukam, Manuel Weber
PURPOSE: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a complication of antiresorptive therapy with nitrogen-containing bisphosphonates (BP). With various suggestions as to pathogenesis, the etiology of BRONJ is not sufficiently understood. Osteoclasts and their precursors, that is, macrophages, are the main target cells of BP. BP can repolarize regeneration- and healing-associated M2 macrophages towards the tissue destructive M1-type. The current study aims to elucidate differences in macrophage and osteoclast polarization in BRONJ, osteoradionecrosis (ORN) and healthy control specimens...
March 1, 2017: Journal of Cranio-maxillo-facial Surgery
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