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https://www.readbyqxmd.com/read/28094764/neuromorphic-meets-neuromechanics-part-ii-the-role-of-fusimotor-drive
#1
Kian Jalaleddini, Chuanxin Niu, Suraj Chakravarthi Raja, Won Joon Sohn, Gerald Loeb, Terence Sanger, Francisco Valero-Cuevas
OBJECTIVE: We studied the fundamentals of muscle afferentation by building a neuro-mechano-morphic system actuating a cadaveric finger. This system is a faithful implementation of the stretch reflex circuitry. It allowed the systematic exploration of the effects of different fusimotor drives to the muscle spindle on the closed-loop stretch reflex response. APPROACH: As in Part I of this work, sensory neurons conveyed proprioceptive information from muscle spindles (with static and dynamic fusimotor drive) to populations of ��-motor neurons (with recruitment and rate coding properties)...
January 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28093370/a-comparison-of-locomotor-therapy-interventions-partial-body-weight-supported-treadmill-lokomat%C3%A2-and-g-eo%C3%A2-training-in-persons-with-traumatic-brain-injury
#2
Alberto Esquenazi, Stella Lee, Amanda Wikoff, Andrew Packel, Theresa Toczylowski, John Feeley
BACKGROUND: Literature in the application of gait training techniques in persons with traumatic brain injury is limited. Current techniques require of multiple staff and are physically demanding. The use of a robotic locomotor training may provide improved training capacity for this population. OBJECTIVE: To examine the impact of three different modes of locomotor therapy on gait velocity and spatiotemporal symmetry using: an end effector robot (G-EO™); a robotic exoskeleton (Lokomat®) and manual assisted partial-body weight supported treadmill training (PBWSTT) in participants with traumatic brain injury...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28092566/wake-up-exoskeleton-to-assist-children-with-cerebral-palsy-design-and-preliminary-evaluation-in-level-walking
#3
Fabrizio Patane, Stefano Rossi, Fausto Del Sette, Juri Taborri, Paolo Cappa
This paper presents the modular design and control of a novel compliant lower limb multi-joint exoskeleton for the rehabilitation of ankle knee mobility and locomotion of pediatric patients with neurological diseases, such as Cerebral Palsy (CP). The device consists of an untethered powered knee-ankle-foot orthosis (KAFO), addressed as WAKE-up (Wearable Ankle Knee Exoskeleton), characterized by a position control and capable of operating synchronously and synergistically with the human musculoskeletal system...
January 11, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28079030/neuromusculoskeletal-model-self-calibration-for-on-line-sequential-bayesian-moment-estimation
#4
Diana Ruiz Bueno, Luis Montano
OBJECTIVE: Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabilitation therapy. Non self-calibration algorithms have been applied to these models. To the best of our knowledge, the algorithm proposed in this work is the first on-line calibration algorithm for muscle models that allows a generic model to be adjusted to different subjects in a few steps...
January 12, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28076454/a-broad-ph-range-and-processive-chitinase-from-a-metagenome-library
#5
S S Thimoteo, A Glogauer, H Faoro, E M de Souza, L F Huergo, B M Moerschbacher, F O Pedrosa
Chitinases are hydrolases that degrade chitin, a polymer of N-acetylglucosamine linked β(1-4) present in the exoskeleton of crustaceans, insects, nematodes and fungal cell walls. A metagenome fosmid library from a wastewater-contaminated soil was functionally screened for chitinase activity leading to the isolation and identification of a chitinase gene named metachi18A. The metachi18A gene was subcloned and overexpressed in Escherichia coli BL21 and the MetaChi18A chitinase was purified by affinity chromatography as a 6xHis-tagged fusion protein...
January 5, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28076349/mechanical-control-of-whole-body-shape-by-a-single-cuticular-protein-obstructor-e-in-drosophila-melanogaster
#6
Reiko Tajiri, Nobuhiro Ogawa, Haruhiko Fujiwara, Tetsuya Kojima
Body shapes are much more variable than body plans. One way to alter body shapes independently of body plans would be to mechanically deform bodies. To what extent body shapes are regulated physically, or molecules involved in physical control of morphogenesis, remain elusive. During fly metamorphosis, the cuticle (exoskeleton) covering the larval body contracts longitudinally and expands laterally to become the ellipsoidal pupal case (puparium). Here we show that Drosophila melanogaster Obstructor-E (Obst-E) is a protein constituent of the larval cuticle that confers the oriented contractility/expandability...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28074858/traces-of-an-ancient-immune-system-how-an-injured-arthropod-survived-465-million-years-ago
#7
Brigitte Schoenemann, Euan N K Clarkson, Magne Høyberget
This report of a severely injured trilobite from the Middle Ordovician (~465 Ma) accords with a number of similar observations of healed lesions observed in trilobites. The uniqueness of the specimen described here is that the character of the repair-mechanisms is reflected by the secondarily built structures, which form the new surface of the ruptured compound eye. Smooth, repaired areas inside the visual surface advert to a clotting principle, rather similar to those of today, and the way in which broken parts of the exoskeleton fused during restoration seem to simulate modern samples...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071705/digestive-and-appendicular-soft-parts-with-behavioural-implications-in-a-large-ordovician-trilobite-from-the-fezouata-lagerst%C3%A3-tte-morocco
#8
Juan C Gutiérrez-Marco, Diego C García-Bellido, Isabel Rábano, Artur A Sá
Trilobites were one of the most successful groups of marine arthropods during the Palaeozoic era, yet their soft-part anatomy is only known from a few exceptionally-preserved specimens found in a handful of localities from the Cambrian to the Devonian. This is because, even if the sclerotized appendages were not destroyed during early taphonomic stages, they are often overprinted by the three-dimensional, mineralised exoskeleton. Inferences about the ventral anatomy and behavioural activities of trilobites can also be derived from the ichnological record, which suggests that most Cruziana and Rusophycus trace fossils were possibly produced by the actions of trilobites...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069028/robot-aided-developmental-assessment-of-wrist-proprioception-in-children
#9
Francesca Marini, Valentina Squeri, Pietro Morasso, Claudio Campus, Jürgen Konczak, Lorenzo Masia
BACKGROUND: Several neurodevelopmental disorders and brain injuries in children have been associated with proprioceptive dysfunction that will negatively affect their movement. Unfortunately, there is lack of reliable and objective clinical examination protocols and our current knowledge of how proprioception evolves in typically developing children is still sparse. METHODS: Using a robotic exoskeleton, we investigated proprioceptive acuity of the wrist in a group of 49 typically developing healthy children (8-15 years), and a group of 40 young adults...
January 9, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28068293/a-hybrid-bmi-based-exoskeleton-for-paresis-emg-control-for-assisting-arm-movements
#10
Toshihiro Kawase, Takeshi Sakurada, Yasuharu Koike, Kenji Kansaku
OBJECTIVE: Brain-machine interface (BMI) technologies have succeeded in controlling robotic exoskeletons, enabling some paralyzed people to control their own arms and hands. We have developed an exoskeleton asynchronously controlled by EEG signals. In this study, to enable real-time control of the exoskeleton for paresis, we developed a hybrid system with EEG and EMG signals, and the EMG signals were used to estimate its joint angles. APPROACH: Eleven able-bodied subjects and two patients with upper cervical spinal cord injuries (SCIs) performed hand and arm movements, and the angles of the metacarpophalangeal (MP) joint of the index finger, wrist, and elbow were estimated from EMG signals using a formula that we derived to calculate joint angles from EMG signals, based on a musculoskeletal model...
January 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28008363/muscular-activity-and-physical-interaction-forces-during-lower-limb-exoskeleton-use
#11
Matthew Wilcox, Ashish Rathore, Dafne Zuleima Morgado Ramirez, Rui C V Loureiro, Tom Carlson
Spinal cord injury (SCI) typically manifests with a loss of sensorimotor control of the lower limbs. In order to overcome some of the disadvantages of chronic wheelchair use by such patients, robotic exoskeletons are an emerging technology that has the potential to transform the lives of patients. However, there are a number of points of contact between the robot and the user, which lead to interaction forces. In a recent study, the authors have shown that peak interaction forces are particularly prominent at the anterior aspect of the right leg...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27990245/feedback-error-learning-controller-for-functional-electrical-stimulation-assistance-in-a-hybrid-robotic-system-for-reaching-rehabilitation
#12
Francisco Resquín, Jose Gonzalez-Vargas, Jaime Ibáñez, Fernando Brunetti, José Luis Pons
Hybrid robotic systems represent a novel research field, where functional electrical stimulation (FES) is combined with a robotic device for rehabilitation of motor impairment. Under this approach, the design of robust FES controllers still remains an open challenge. In this work, we aimed at developing a learning FES controller to assist in the performance of reaching movements in a simple hybrid robotic system setting. We implemented a Feedback Error Learning (FEL) control strategy consisting of a feedback PID controller and a feedforward controller based on a neural network...
June 13, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/27974830/stress-physiology-and-weapon-integrity-of-intertidal-mantis-shrimp-under-future-ocean-conditions
#13
Maya S deVries, Summer J Webb, Jenny Tu, Esther Cory, Victoria Morgan, Robert L Sah, Dimitri D Deheyn, Jennifer R A Taylor
Calcified marine organisms typically experience increased oxidative stress and changes in mineralization in response to ocean acidification and warming conditions. These effects could hinder the potency of animal weapons, such as the mantis shrimp's raptorial appendage. The mechanical properties of this calcified weapon enable extremely powerful punches to be delivered to prey and aggressors. We examined oxidative stress and exoskeleton structure, mineral content, and mechanical properties of the raptorial appendage and the carapace under long-term ocean acidification and warming conditions...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27973679/effect-on-body-composition-and-bone-mineral-density-of-walking-with-a-robotic-exoskeleton-in-adults-with-chronic-spinal-cord-injury
#14
Antony D Karelis, Lívia Pinheiro Carvalho, Manuel Jose Castillo, Dany H Gagnon, Mylène Aubertin-Leheudre
OBJECTIVE: To examine the effect on body composition and bone mineral density of locomotor training using a robotic exoskeleton in individuals with spinal cord injury. STUDY DESIGN: Interventional study. SUBJECTS/METHODS: Five adults with a non-progressive traumatic complete sensorimotor spinal cord injury who were using a wheelchair as a primary mode of mobility. Participants performed a personalized 6-week progressive locomotor training programme using a robotic exoskeleton 3 times/week for up to 60 min...
December 14, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27942236/letter-to-the-editor-regarding-clinical-effectiveness-and-safety-of-powered-exoskeleton-assisted-walking-in-patients-with-spinal-cord-injury-systematic-review-with-meta-analysis
#15
COMMENT
Marcel P Dijkers, Katherine G Akers, Sujay S Galen, Diane E Patzer, Phuong T Vu
No abstract text is available yet for this article.
2016: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/27941863/coze-is-a-member-of-the-mrecd-complex-that-directs-cell-elongation-in-streptococcus-pneumoniae
#16
Andrew K Fenton, Lamya El Mortaji, Derek T C Lau, David Z Rudner, Thomas G Bernhardt
Most bacterial cells are surrounded by a peptidoglycan cell wall that is essential for their integrity. The major synthases of this exoskeleton are called penicillin-binding proteins (PBPs)(1,2). Surprisingly little is known about how cells control these enzymes, given their importance as drug targets. In the model Gram-negative bacterium Escherichia coli, outer membrane lipoproteins are critical activators of the class A PBPs (aPBPs)(3,4), bifunctional synthases capable of polymerizing and crosslinking peptidoglycan to build the exoskeletal matrix(1)...
December 12, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27939172/stable-bipedal-walking-with-a-swing-leg-protraction-strategy
#17
Pranav A Bhounsule, Ali Zamani
In bipedal locomotion, swing-leg protraction and retraction refer to the forward and backward motion, respectively, of the swing-leg before touchdown. Past studies have shown that swing-leg retraction strategy can lead to stable walking. We show that swing-leg protraction can also lead to stable walking. We use a simple 2D model of passive dynamic walking but with the addition of an actuator between the legs. We use the actuator to do full correction of the disturbance in a single step (a one-step dead-beat control)...
January 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27935089/the-mechanisms-of-nickel-toxicity-in-aquatic-environments-an-adverse-outcome-pathway-aop-analysis
#18
Kevin V Brix, Christian E Schlekat, Emily R Garman
Current ecological risk assessment and water quality regulation for nickel (Ni) use mechanistically-based, predictive tools such as Biotic Ligand Models (BLMs). However, despite many detailed studies, the precise mechanism(s) of Ni toxicity to aquatic organisms remains elusive. This uncertainty in the mechanism(s) of action for Ni has led to concern over the use of tools like the BLM in some regulatory settings. To begin addressing this knowledge gap, we used an Adverse Outcome Pathway (AOP) analysis, the first AOP for a metal, to identify multiple potential mechanisms of Ni toxicity and their interactions to freshwater aquatic organisms...
December 9, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27928968/rationale-for-assessing-safety-and-efficacy-of-drug-candidates-alone-and-in-combination-with-medical-devices-the-case-study-of-spinalontm
#19
Pierre A Guertin
The aim of this review is to describe the rationale and main underlying reasons for undertaking, during clinical development, the study of drug candidates used separately and/or in combination with other technologies. To ease comprehension, reference will be made to the case of SpinalonTM, a new fixed-dose combination (FDC) product composed of levodopa/carbidopa/buspirone. This drug is capable of triggering, within minutes after a single administration orally, 45 minute- episodes of basic involuntary 'reflex' walking in paraplegic animals...
December 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27918413/a-brain-machine-interface-based-on-erd-ers-for-an-upper-limb-exoskeleton-control
#20
Zhichuan Tang, Shouqian Sun, Sanyuan Zhang, Yumiao Chen, Chao Li, Shi Chen
To recognize the user's motion intention, brain-machine interfaces (BMI) usually decode movements from cortical activity to control exoskeletons and neuroprostheses for daily activities. The aim of this paper is to investigate whether self-induced variations of the electroencephalogram (EEG) can be useful as control signals for an upper-limb exoskeleton developed by us. A BMI based on event-related desynchronization/synchronization (ERD/ERS) is proposed. In the decoder-training phase, we investigate the offline classification performance of left versus right hand and left hand versus both feet by using motor execution (ME) or motor imagery (MI)...
December 2, 2016: Sensors
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