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https://www.readbyqxmd.com/read/28642680/weight-bearing-over-ground-stepping-in-an-exoskeleton-with-non-invasive-spinal-cord-neuromodulation-after-motor-complete-paraplegia
#1
Parag Gad, Yury Gerasimenko, Sharon Zdunowski, Amanda Turner, Dimitry Sayenko, Daniel C Lu, V Reggie Edgerton
We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacological neuromodulation by buspirone. We also asked whether these neuromodulatory strategies could facilitate stepping assisted by an exoskeleton (EKSO, EKSO Bionics, CA) that is designed so that the subject can voluntarily complement the work being performed by the exoskeleton...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28642437/human-in-the-loop-optimization-of-exoskeleton-assistance-during-walking
#2
Juanjuan Zhang, Pieter Fiers, Kirby A Witte, Rachel W Jackson, Katherine L Poggensee, Christopher G Atkeson, Steven H Collins
Exoskeletons and active prostheses promise to enhance human mobility, but few have succeeded. Optimizing device characteristics on the basis of measured human performance could lead to improved designs. We have developed a method for identifying the exoskeleton assistance that minimizes human energy cost during walking. Optimized torque patterns from an exoskeleton worn on one ankle reduced metabolic energy consumption by 24.2 ± 7.4% compared to no torque. The approach was effective with exoskeletons worn on one or both ankles, during a variety of walking conditions, during running, and when optimizing muscle activity...
June 23, 2017: Science
https://www.readbyqxmd.com/read/28642394/fast-exoskeleton-optimization
#3
Philippe Malcolm, Samuel Galle, Dirk De Clercq
No abstract text is available yet for this article.
June 23, 2017: Science
https://www.readbyqxmd.com/read/28631994/gene-expression-and-morphogenesis-during-the-deposition-of-drosophila-wing-cuticle
#4
Paul N Adler
The exoskeleton of insects and other arthropods is a very versatile material that is characterized by a complex multilayer structure. In Sobala and Adler (2016) we analyzed the process of wing cuticle deposition by RNAseq and electron microscopy. In this extra view we discuss the unique aspects of the envelope the first and most outermost layer and the gene expression program seen at the end of cuticle deposition. We discussed the role of undulae in the deposition of cuticle and how the hydrophobicity of wing cuticle arises...
February 17, 2017: Fly
https://www.readbyqxmd.com/read/28630429/marine-diatoms-change-their-gene-expression-profile-when-exposed-to-microscale-turbulence-under-nutrient-replete-conditions
#5
Alberto Amato, Gianluca Dell'Aquila, Francesco Musacchia, Rossella Annunziata, Ari Ugarte, Nicolas Maillet, Alessandra Carbone, Maurizio Ribera d'Alcalà, Remo Sanges, Daniele Iudicone, Maria I Ferrante
Diatoms are a fundamental microalgal phylum that thrives in turbulent environments. Despite several experimental and numerical studies, if and how diatoms may profit from turbulence is still an open question. One of the leading arguments is that turbulence favours nutrient uptake. Morphological features, such as the absence of flagella, the presence of a rigid exoskeleton and the micrometre size would support the possible passive but beneficial role of turbulence on diatoms. We demonstrate that in fact diatoms actively respond to turbulence in non-limiting nutrient conditions...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629415/kaps-kinematic-assessment-of-passive-stretch-a-tool-to-assess-elbow-flexor-and-extensor-spasticity-after-stroke-using-a-robotic-exoskeleton
#6
Andrew Centen, Catherine R Lowrey, Stephen H Scott, Ting-Ting Yeh, George Mochizuki
BACKGROUND: Spasticity is a common sequela of stroke. Traditional assessment methods include relatively coarse scales that may not capture all characteristics of elevated muscle tone. Thus, the aim of this study was to develop a tool to quantitatively assess post-stroke spasticity in the upper extremity. METHODS: Ninety-six healthy individuals and 46 individuals with stroke participated in this study. The kinematic assessment of passive stretch (KAPS) protocol consisted of passive elbow stretch in flexion and extension across an 80° range in 5 movement durations...
June 19, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28629390/results-of-the-first-interim-analysis-of-the-rapper-ii-trial-in-patients-with-spinal-cord-injury-ambulation-and-functional-exercise-programs-in-the-rex-powered-walking-aid
#7
Nick Birch, Jon Graham, Tom Priestley, Chris Heywood, Mohamed Sakel, Angela Gall, Andrew Nunn, Nada Signal
BACKGROUND: The RAPPER II study investigates the feasibility, safety and acceptability of using the REX self-stabilising robotic exoskeleton in people with spinal cord injury (SCI) who are obligatory wheelchair users. Feasibility is assessed by the completion of transfer into the REX device, competency in achieving autonomous control and completion of upper body exercise in an upright position in the REX device. Safety is measured by the occurrence of serious adverse events. Device acceptability is assessed with a user questionnaire...
June 19, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28628257/contrasting-gene-expression-programs-correspond-with-predator-induced-phenotypic-plasticity-within-and-across-generations-in-daphnia
#8
Nicole R Hales, Drew R Schield, Audra L Andrew, Daren C Card, Matthew R Walsh, Todd A Castoe
Research has shown that a change in environmental conditions can alter the expression of traits during development (i.e., 'within-generation phenotypic plasticity') as well as induce heritable phenotypic responses that persist for multiple generations (i.e., 'transgenerational plasticity'). It has long been assumed that shifts in gene expression are tightly linked to observed trait responses at the phenotypic level. Yet, the manner in which organisms couple within- and trans-generational plasticity at the molecular level is unclear...
June 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28623037/muscle-recruitment-and-coordination-with-an-ankle-exoskeleton
#9
Katherine M Steele, Rachel W Jackson, Benjamin R Shuman, Steven H Collins
Exoskeletons have the potential to assist and augment human performance. Understanding how users adapt their movement and neuromuscular control in response to external assistance is important to inform the design of these devices. The aim of this research was to evaluate changes in muscle recruitment and coordination for ten unimpaired individuals walking with an ankle exoskeleton. We evaluated changes in the activity of individual muscles, cocontraction levels, and synergistic patterns of muscle coordination with increasing exoskeleton work and torque...
May 18, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28621428/loss-of-thrombospondin-reveals-a-possible-role-for-the-extracellular-matrix-in-chordotonal-cap-cell-elongation
#10
Rina T Greenblatt Ben-El, Abeer Hassan, Adi Salzberg
In the Drosophila larva, major proprioceptive input is provided to the brain by sub-epidermal stretch receptors called chordotonal organs (ChO). Similarly to the body wall muscle that needs to be attached on both of its sides to the larval exoskeleton in order to generate movement, the sensory unit of a ChO must be stably anchored to the cuticle on both of its sides in order to sense the relative displacement of body parts. Through an RNAi screen we have identified thrombospondin (Tsp), a secreted calcium binding glycoprotein, as a critical component in the anchoring of ChOs to the cuticle...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28617577/imaging-with-mass-spectrometry-of-bacteria-on-the-exoskeletons-of-fungus-growing-ants
#11
Erin Gemperline, Heidi A Horn, Kellen DeLaney, Cameron R Currie, Lingjun Li
Mass spectrometry imaging is a powerful analytical technique for detecting and determining spatial distributions of molecules within a sample. Typically mass spectrometry imaging is limited to the analysis of thin tissue sections taken from the middle of a sample. In this work, we present a mass spectrometry imaging method for the detection of compounds produced by bacteria on the outside surface of ant exoskeletons in response to pathogen exposure. Fungus-growing ants have a specialized mutualism with Pseudonocardia, a bacterium that lives on the ants' exoskeleton and helps protect their fungal garden food source from harmful pathogens...
June 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28615493/optically-ambidextrous-circularly-polarized-reflection-from-the-chiral-cuticle-of-the-scarab-beetle-chrysina-resplendens
#12
Ewan D Finlayson, Luke T McDonald, Pete Vukusic
The evolution of structural colour mechanisms in biological systems has given rise to many interesting optical effects in animals and plants. The instance of the scarab beetle Chrysina resplendens is particularly distinctive. Its exoskeleton has a bright, golden appearance and reflects both right-handed and left-handed circularly polarized light concurrently. The chiral nanostructure responsible for these properties is a helicoid, in which birefringent dielectric planes are assembled with an incremental rotation...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28613178/biomechanical-reactions-of-exoskeleton-neurorehabilitation-robots-in-spastic-elbows-and-wrists
#13
Hyung Seok Nam, Sukgyu Koh, Yoon Jae Kim, Jaewon Beom, Woo Hyung Lee, Shi-Uk Lee, Sungwan Kim
Spasticity is an important factor in designing wearable and lightweight exoskeleton neurorehabilitation robots. The proposed study evaluates biomechanical reactions of an exoskeleton robot to spasticity and establishes relevant guidelines for robot design. A two-axis exoskeleton robot is used to evaluate a group of 20 patients post-stroke with spastic elbow and/or wrist joints. All subjects are given isokinetic movements at various angular velocities within the capable range of motion for both joints. The resistance torque and corresponding angular position at each joint are recorded continuously...
June 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28611573/simultaneous-and-continuous-estimation-of-shoulder-and-elbow-kinematics-from-surface-emg-signals
#14
Qin Zhang, Runfeng Liu, Wenbin Chen, Caihua Xiong
In this paper, we present a simultaneous and continuous kinematics estimation method for multiple DoFs across shoulder and elbow joint. Although simultaneous and continuous kinematics estimation from surface electromyography (EMG) is a feasible way to achieve natural and intuitive human-machine interaction, few works investigated multi-DoF estimation across the significant joints of upper limb, shoulder and elbow joints. This paper evaluates the feasibility to estimate 4-DoF kinematics at shoulder and elbow during coordinated arm movements...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28606862/pathogenicity-profile-of-vibrio-parahaemolyticus-in-farmed-pacific-white-shrimp-penaeus-vannamei
#15
R Ananda Raja, R Sridhar, C Balachandran, A Palanisammi, S Ramesh, K Nagarajan
A pathobiological study was conducted using Vibrio parahaemolyticus (VP) strain isolated from vibriosis affected shrimp (Penaeus vannamei) farms in Kancheepuram and Thiruvallur districts of Tamil Nadu during August 2014 to February 2015. The isolate was identified based on the morphological, physiological, biochemical and molecular characters. LD50 value with intramuscular injection was determined as 2.6 × 10(4) cfu/shrimp and sequential pathology was studied giving 6.1 × 10(3) cfu/shrimp (LD25). Total plate count (TPC) and total Vibrio count (TVC) in water, pond sediment, haemolymph, muscle, HP and gut were found significantly (P < 0...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28606179/modifying-upper-limb-inter-joint-coordination-in-healthy-subjects-by-training-with-a-robotic-exoskeleton
#16
Tommaso Proietti, Emmanuel Guigon, Agnès Roby-Brami, Nathanaël Jarrassé
BACKGROUND: The possibility to modify the usually pathological patterns of coordination of the upper-limb in stroke survivors remains a central issue and an open question for neurorehabilitation. Despite robot-led physical training could potentially improve the motor recovery of hemiparetic patients, most of the state-of-the-art studies addressing motor control learning, with artificial virtual force fields, only focused on the end-effector kinematic adaptation, by using planar devices...
June 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28597335/effect-of-endoskeleton-stent-graft-design-on-pulse-wave-velocity-in-patients-undergoing-endovascular-repair-of-the-aortic-arch
#17
Daijiro Hori, Kei Akiyoshi, Koichi Yuri, Satoshi Nishi, Takao Nonaka, Takahiro Yamamoto, Yusuke Imamura, Harunobu Matsumoto, Naoyuki Kimura, Atsushi Yamaguchi
PURPOSE: Pulse wave velocity (PWV), which measures vascular stiffness, is a powerful predictor of cardiovascular event. Treatment of aneurysms with endovascular prosthesis has been reported to increase PWV. The purpose of this study was to evaluate whether an endoskeleton stent graft design has less effect on PWV than the exoskeleton stent graft design. METHODS: Between July 2008 and September 2016, 74 patients underwent endovascular treatment of aortic arch aneurysm in our institution...
June 8, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28597018/robotic-devices-and-brain-machine-interfaces-for-hand-rehabilitation-post-stroke
#18
Alistair C McConnell, Renan C Moioli, Fabricio L Brasil, Marta Vallejo, David W Corne, Patricia A Vargas, Adam A Stokes
OBJECTIVE: To review the state of the art of robotic-aided hand physiotherapy for post-stroke rehabilitation, including the use of brain-machine interfaces. Each patient has a unique clinical history and, in response to personalized treatment needs, research into individualized and at-home treatment options has expanded rapidly in recent years. This has resulted in the development of many devices and design strategies for use in stroke rehabilitation. METHODS: The development progression of robotic-aided hand physiotherapy devices and brain-machine interface systems is outlined, focussing on those with mechanisms and control strategies designed to improve recovery outcomes of the hand post-stroke...
June 8, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28587252/multi-axis-force-sensor-for-human-robot-interaction-sensing-in-a-rehabilitation-robotic-device
#19
Victor Grosu, Svetlana Grosu, Bram Vanderborght, Dirk Lefeber, Carlos Rodriguez-Guerrero
Human-robot interaction sensing is a compulsory feature in modern robotic systems where direct contact or close collaboration is desired. Rehabilitation and assistive robotics are fields where interaction forces are required for both safety and increased control performance of the device with a more comfortable experience for the user. In order to provide an efficient interaction feedback between the user and rehabilitation device, high performance sensing units are demanded. This work introduces a novel design of a multi-axis force sensor dedicated for measuring pelvis interaction forces in a rehabilitation exoskeleton device...
June 5, 2017: Sensors
https://www.readbyqxmd.com/read/28582886/design-of-a-wearable-cable-driven-upper-limb-exoskeleton-based-on-epicyclic-gear-trains-structure
#20
Feiyun Xiao, Yongsheng Gao, Yong Wang, Yanhe Zhu, Jie Zhao
BACKGROUND: Many countries, including Japan, Italy, and China are experiencing demographic shifts as their populations age. Some basic activities of daily living (ADLs) are difficult for elderly people to complete independently due to declines in motor function. OBJECTIVE: In this paper, a 6-DOF wearable cable-driven upper limb exoskeleton (CABexo) based on epicyclic gear trains structure is proposed. METHODS: The main structure of the exoskeleton system is composed of three epicyclic gear train sections...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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