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https://www.readbyqxmd.com/read/29145157/bmscs-derived-mir-223-containing-exosomes-contribute-to-liver-protection-in-experimental-autoimmune-hepatitis
#1
Lu Chen, Feng-Bin Lu, Da-Zhi Chen, Jin-Lu Wu, En-de Hu, Lan-Man Xu, Ming-Hua Zheng, Hui Li, Yu Huang, Xiao-Ya Jin, Yue-Wen Gong, Zhuo Lin, Xiao-Dong Wang, Yong-Ping Chen
Autoimmune hepatitis is a chronic inflammatory disease in the liver with potential to the development of liver fibrosis. Recent evidences suggest that bone marrow derived mesenchymal stem cells (BMSCs) may exert its therapeutic activity through exosomes. Moreover, miR-223 is highly expressed in BMSCs and plays an important role in autoimmune diseases. Therefore, in this study, hepatoprotective role of BMSCs and miR-223 was investigated in both mice and hepatocytes. Liver antigen S100 was used to establish autoimmune hepatitis model in mice while LPS and ATP were used to establish cell injury model in hepatocyte...
November 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29141446/myocardial-reparative-functions-of-exosomes-from-mesenchymal-stem-cells-are-enhanced-by-hypoxia-treatment-of-the-cells-via-transferring-microrna-210-in-an-nsmase2-dependent-way
#2
Jinyun Zhu, Kai Lu, Ning Zhang, Yun Zhao, Qunchao Ma, Jian Shen, Yinuo Lin, Pingping Xiang, Yaoliang Tang, Xinyang Hu, Jinghai Chen, Wei Zhu, Keith A Webster, Jian'an Wang, Hong Yu
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (Exo(H)) are superior to those from normoxia-treated MSCs (Exo(N)) for myocardial repair. Mouse bone marrow-derived MSCs were cultured under hypoxia or normoxia for 24 h, and exosomes from conditioned media were intramyocardially injected into infarcted heart of C57BL/6 mouse. Exo(H) resulted in significantly higher survival, smaller scar size and better cardiac functions recovery...
November 16, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29134631/microbial-expansion-collision-dynamics-promote-cooperation-and-coexistence-on-surfaces
#3
Shuang Xu, J David Van Dyken
Microbes colonizing a surface often experience colony growth dynamics characterized by an initial phase of spatial clonal expansion followed by collision between neighboring colonies to form potentially genetically heterogeneous boundaries. For species with life cycles consisting of repeated surface colonization and dispersal, these spatially-explicit "expansion-collision dynamics" generate periodic transitions between two distinct selective regimes, "expansion competition" and "boundary competition", each one favoring a different growth strategy...
November 14, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29129930/an-unusual-endo-selective-c-h-hydroarylationof-norbornene-by-the-rh-i-catalyzed-reactionof-benzamides
#4
Kaname Shibata, Satoko Natsui, Mamoru Tobisu, Yoshiya Fukumoto, Naoto Chatani
Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-catalyzed reaction of aromatic amides. The addition of sterically bulky carboxylic acids enhances the endo-selectivity of the reaction. The results of deuterium-labeling experiments show that both the ortho-carbon and the ortho-hydrogen atoms of aromatic amides were attached to the same carbon atom of the norbornane skeleton in the hydroarylation product...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29127370/exosomal-mir-126-as-a-circulating-biomarker-in-non-small-cell-lung-cancer-regulating-cancer-progression
#5
Franco Grimolizzi, Federica Monaco, Francesca Leoni, Massimo Bracci, Sara Staffolani, Cristiana Bersaglieri, Simona Gaetani, Matteo Valentino, Monica Amati, Corrado Rubini, Franca Saccucci, Jiri Neuzil, Marco Tomasetti, Lory Santarelli
Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exosome and exosome-free serum fractions in non-small cell lung cancer (NSCLC) patients at early and advanced stages, and compared with healthy controls. Down-regulation of miR-126 was found in serum of advanced stage NSCLC patients...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125298/surface-initiated-ring-opening-metathesis-polymerization-of-dicyclopentadiene-from-the-vapor-phase
#6
Ian Njoroge, Paul A Kempler, Xuanli Deng, Steven T Arnold, G Kane Jennings
Surface-tethered polydicyclopentadiene (pDCPD) films were prepared on gold and silicon substrates via surface-initiated ring-opening polymerization (SI-ROMP) of dicyclopentadiene (DCPD). The films were grown utilizing monomer in both the vapor phase and the solution phase with the former process exhibiting rapid kinetics producing ∽ 400 nm thick pDCPD films in less than 1 min of polymerization. No significant differences in thickness were observed for films grown from monomer in the vapor phase with the different isomers (exo and endo) of DCPD...
November 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29122192/physiological-consequences-of-using-an-upper-limb-exoskeleton-during-manual-handling-tasks
#7
Jean Theurel, Kevin Desbrosses, Terence Roux, Adriana Savescu
This study aimed to assess the physiological consequences of using an upper limb exoskeleton during manual handling task, as muscle activity, upper limb kinematics, postural balance and cardiac cost. Participants performed three tasks (load lifting (LIFT), carrying (WALK) and stacking-unstacking (STACK)) with (EXOS) and without (FREE) an exoskeleton. During LIFT and STACK, the activity of the deltoid anterior muscle was significantly lower for EXOS than for FREE. During LIFT, the activity of the triceps brachii (TB) and tibialis anterior muscles significantly increased for EXO...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29121558/high-performance-and-versatile-electrochemical-aptasensor-based-on-self-supported-nanoporous-gold-microelectrode-and-enzyme-induced-signal-amplification
#8
Lei Shi, Xiaojiao Rong, Yan Wang, Shiming Ding, Wanying Tang
Herein, novel and versatile electrochemical aptasensors were constructed on a self-supported nanoporous gold (np-Au) microelectrode, integrating with an exonuclease III (Exo III) induced signal amplification strategy. Self-supported np-Au microelectrode with 3D bicontinuous nanoporous structures possesses tremendously large specific area, clean surface, high stability and biocompatibility, bringing about significant advantages in both molecular recognition and signal response. As paradigms, two analytes of bisphenol A (BPA) and ochratoxin A (OTA) were selected to demonstrate the superiority and versatility of designed aptasensors...
November 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29121496/properties-of-two-fungal-endo-%C3%AE-1-3-galactanases-and-their-synergistic-action-with-an-exo-%C3%AE-1-3-galactanase-in-degrading-arabinogalactan-proteins
#9
Yoshihisa Yoshimi, Kaori Yaguchi, Satoshi Kaneko, Yoichi Tsumuraya, Toshihisa Kotake
Arabinogalactan-proteins (AGPs) are plant proteoglycans, which are widely encountered in the plant kingdom, usually localized on the cell surface. The carbohydrate moieties of AGPs consist of β-1,3-galactan main chains and β-1,6-galactan side chains, to which other auxiliary sugars are attached. To date, FvEn3GAL isolated from Flammulina velutipes is the sole β-1,3-galactanase acting on β-1,3-galactan in an endo-manner. Here we cloned two homologous genes, designated Af3G and NcEn3GAL, possibly encoding endo-β-1,3-galactanase from Aspergillus flavus and Neurospora crassa, respectively...
October 25, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29118851/targeted-metatranscriptomics-of-compost-derived-consortia-reveals-a-gh11-exerting-an-unusual-exo-1-4-%C3%AE-xylanase-activity
#10
Bruno L Mello, Anna M Alessi, Diego M Riaño-Pachón, Eduardo R deAzevedo, Francisco E G Guimarães, Melissa C Espirito Santo, Simon McQueen-Mason, Neil C Bruce, Igor Polikarpov
Background: Using globally abundant crop residues as a carbon source for energy generation and renewable chemicals production stand out as a promising solution to reduce current dependency on fossil fuels. In nature, such as in compost habitats, microbial communities efficiently degrade the available plant biomass using a diverse set of synergistic enzymes. However, deconstruction of lignocellulose remains a challenge for industry due to recalcitrant nature of the substrate and the inefficiency of the enzyme systems available, making the economic production of lignocellulosic biofuels difficult...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29117187/the-green-tea-modulates-large-intestinal-microbiome-and-exo-endogenous-metabolome-altered-through-chronic-uvb-exposure
#11
Eun Sung Jung, Hye Min Park, Seung Min Hyun, Jong Cheol Shon, Digar Singh, Kwang-Hyeon Liu, Tae Woong Whon, Jin-Woo Bae, Jae Sung Hwang, Choong Hwan Lee
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbiome-metabolome analysis to uncover the esoteric links between gut microbiome and exo/endogenous metabolome maneuvered in the large intestine of UVB-exposed mice subjected to dietary GTS. In UVB-exposed mice groups (UVB), class Bacilli and order Bifidobacteriales were observed as discriminant taxa with decreased lysophospholipid levels compared to the unexposed mice groups subjected to normal diet (NOR)...
2017: PloS One
https://www.readbyqxmd.com/read/29117078/prevalence-antimicrobial-susceptibility-and-clonal-diversity-of-pseudomonas-aeruginosa-in-chronic-wounds
#12
Fernanda Pessanha de Oliveira, Bruna Maiara Ferreira Barreto Pires, Keila de Cássia Ferreira de Almeida Silva, Bernadete Teixeira Ferreira de Carvalho, Lenise Arneiro Teixeira, Geraldo Renato de Paula, Beatriz Guitton Renaud Baptista de Oliveira
PURPOSE: Our purposes in this study were to (1) identify Pseudomonas aeruginosa strains collected from swabs of chronic wounds, (2) evaluate the susceptibility of P. aeruginosa strains to various antimicrobials, (3) detect the presence of virulence factors exoenzyme S (exoS) and exoenzyme U (exoU) in P. aeruginosa strains, and (4) evaluate wound colonization by P. aeruginosa via pulsed-field gel electrophoresis (PFGE). DESIGN: Descriptive research using a quantitative approach...
November 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29116802/co-oac-2-catalyzed-trifluoromethylation-and-c-3-selective-arylation-of-2-propargylamino-pyridines-via-a-6-endo-dig-cyclization
#13
Jianjun Li, Yifan Lei, Yang Yu, Cong Qin, Yiwei Fu, Hao Li, Wei Wang
A Co(OAc)2-catalyzed trifluoromethylation and subsequent C(3)-selective arylation of 2-(propargylamino)pyridines has been developed. A new 6-endo-dig cyclization involving an unprecedented C(3) selective arylation of the pyridines instead of a commonly observed 5-exo-dig cyclization with "N" is realized. Moreover, the study presents the first case of the installation of a trifluoromethyl group into electron-deficient azaarenes. The process delivers an efficient cascade approach to new trifluoromethylated 1,8-naphthyridine structures with a broad substrate scope...
November 8, 2017: Organic Letters
https://www.readbyqxmd.com/read/29115611/d%C3%A2-tagatose-inhibits-the-growth-and-biofilm-formation-of-streptococcus%C3%A2-mutans
#14
Khaleque Hasibul, Haruyuki Nakayama-Imaohji, Masahito Hashimoto, Hisashi Yamasaki, Takaaki Ogawa, Junpei Waki, Ayano Tada, Saori Yoneda, Masaaki Tokuda, Minoru Miyake, Tomomi Kuwahara
Dental caries is an important global health concern and Streptococcus mutans has been established as a major cariogenic bacterial species. Reports indicate that a rare sugar, D‑tagatose, is not easily catabolized by pathogenic bacteria. In the present study, the inhibitory effects of D‑tagatose on the growth and biofilm formation of S. mutans GS‑5 were examined. Monitoring S. mutans growth over a 24 h period revealed that D‑tagatose prolonged the lag phase without interfering with the final cell yield...
November 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114669/detection-of-single-nucleotide-polymorphism-by-measuring-extension-kinetics-with-t7-exonuclease-mediated-isothermal-amplification
#15
Miao Cui, Xianjin Xiao, Meiping Zhao, Bo Zheng
In this work, we measured the primer extension kinetics of the Klenow fragment (exo-) to achieve rapid detection of single nucleotide polymorphism (SNP). Both the matching and the single-base mismatching targets were used as the primer in the kinetic measurements to identify the single nucleotide polymorphism. By coupling with the T7 exonuclease-assisted target cycling process, we decreased the detection limit but still maintained a high discrimination factor. After the demonstration of a good discrimination ability with synthetic DNA strands, we applied the method to detect low abundance of epidermal growth factor receptor (EGFR) mutation in human genomic DNA, which was a biomarker of non-small cell lung cancer...
November 8, 2017: Analyst
https://www.readbyqxmd.com/read/29112686/interferon-regulatory-factor-1-priming-of-tumour-derived-exosomes-enhances-the-antitumour-immune-response
#16
Mu-Qing Yang, Qiang Du, Patrick R Varley, Julie Goswami, Zhihai Liang, Ronghua Wang, Hui Li, Donna B Stolz, David A Geller
BACKGROUND: Tumour-derived exosomes (TEXs) have a potential for application in cancer vaccines. Whether TEXs after induction by interferon regulatory factor 1 (IRF-1) are capable of enhancing the antitumour response remains to be determined. METHODS: Exosomes released by tumour cells infected with IRF-1-expressing adenovirus (IRF-1-Exo) or treated with interferon-γ (IFN-Exo) were isolated via ultracentrifugation. The IRF-1 target proteins IL-15Rα and MHC class I (MHC-I) were analysed by western blot...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29111730/one-pot-synthesis-of-%C3%AE-carbonyl-bicyclic-furans-via-a-sequential-diels-alder-5-exo-dig-cyclization-oxidation-reaction
#17
Khagendra B Hamal, Wesley A Chalifoux
A new one-pot approach to construct α-carbonyl bicyclic furans from easily accessible diynones is described. This reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethylaluminum chloride followed by a 5-exo-dig cyclization/oxidation reaction catalyzed by copper (II) chloride. This methodology generates α-carbonyl-functionalized dihydroisobenzofuran derivatives in good to excellent yields.
November 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29110666/development-of-real-time-recombinase-polymerase-amplification-assay-for-rapid-and-sensitive-detection-of-canine-parvovirus-2
#18
Yunyun Geng, Jianchang Wang, Libing Liu, Yan Lu, Ke Tan, Yan-Zhong Chang
BACKGROUND: Canine parvovirus 2, a linear single-stranded DNA virus belonging to the genus Parvovirus within the family Parvoviridae, is a highly contagious pathogen of domestic dogs and several wild canidae species. Early detection of canine parvovirus (CPV-2) is crucial to initiating appropriate outbreak control strategies. Recombinase polymerase amplification (RPA), a novel isothermal gene amplification technique, has been developed for the molecular detection of diverse pathogens...
November 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29103991/structural-basis-for-the-recognition-and-processing-of-dna-containing-bulky-lesions-by-the-mammalian-nucleotide-excision-repair-system
#19
Alexey N Evdokimov, Alexandra Yu Tsidulko, Alexander V Popov, Yury N Vorobiev, Alexander A Lomzov, Lyudmila S Koroleva, Vladimir N Silnikov, Irina O Petruseva, Olga I Lavrik
Mammalian nucleotide excision repair (NER) eliminates the broadest diversity of bulky lesions from DNA with wide specificity. However, the double incision efficiency for structurally different adducts can vary over several orders of magnitude. Therefore, great attention is drawn to the question of the relationship among structural properties of bulky DNA lesions and the rate of damage elimination. This paper studies the properties of several structurally diverse synthetic (model) DNAs containing bulky modifications...
November 2, 2017: DNA Repair
https://www.readbyqxmd.com/read/29103488/application-of-xanthan-gum-as-polysaccharide-in-tissue-engineering-a-review
#20
REVIEW
Anuj Kumar, Kummara Madhusudana Rao, Sung Soo Han
Xanthan gum is a microbial high molecular weight exo-polysaccharide produced by Xanthomonas bacteria (a Gram-negative bacteria genus that exhibits several different species) and it has widely been used as an additive in various industrial and biomedical applications such as food and food packaging, cosmetics, water-based paints, toiletries, petroleum, oil-recovery, construction and building materials, and drug delivery. Recently, it has shown great potential in issue engineering applications and a variety of modification methods have been employed to modify xanthan gum as polysaccharide for this purpose...
January 15, 2018: Carbohydrate Polymers
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