keyword
https://read.qxmd.com/read/38505822/recent-progresses-in-neural-tissue-engineering-using-topographic-scaffolds
#1
REVIEW
Shanying Han, Xiaolong Zhao, Lin Cheng, Jiangang Fan
Neural tissue engineering as alternatives to recover damaged tissues and organs is getting more and more attention due to the lack of regeneration ability of natural tissue nervous system after injury. Particularly, topographic scaffolds are one of the critical elements to guide nerve orientation and reconnection with characteristics of mimic the natural extracellular matrix. This review focuses on scaffolds preparation technologies, topographical features, scaffolds-based encapsulations delivery strategies for neural tissue regeneration, biological functions on nerve cell guidance and regeneration, and applications of topographic scaffolds in vivo and in vitro...
2024: American Journal of Stem Cells
https://read.qxmd.com/read/38505172/oriented-graphene-oxide-scaffold-promotes-nerve-regeneration-in-vitro-and-in-vivo
#2
JOURNAL ARTICLE
Xu Zhou, Aolin Tang, Chengjie Xiong, Guoquan Zhang, Liangliang Huang, Feng Xu
BACKGROUND: Treating peripheral nerve injuries (PNI) with defects remains challenging in clinical practice. The commercial conduits have shown suboptimal nerve regeneration and functional recovery due to their basic tubular design without electroactive and oriented topographical cues. PURPOSE: To develop a new scaffold with oriented microstructure and electroactive Graphene oxide (GO) and investigate its' therapeutic effect on nerve regeneration in vitro and in vivo...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38412382/advanced-hollow-cathode-discharge-plasma-treatment-of-unique-bilayered-fibrous-nerve-guidance-conduits-for-enhanced-oriented-neurite-outgrowth
#3
JOURNAL ARTICLE
Sheida Aliakbarshirazi, Rouba Ghobeira, Mahtab Asadian, Mehrnoush Narimisa, Anton Nikiforov, Ives De Baere, Wim Van Paepegem, Nathalie De Geyter, Heidi Declercq, Rino Morent
Despite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic- co -glycolic acid (PLGA) was first carefully selected as base material to electrospin nanofibrous NGCs simulating the extracellular matrix...
February 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38399258/nano-topographically-guided-biomineralized-3d-printed-polycaprolactone-scaffolds-with-urine-derived-stem-cells-for-promoting-bone-regeneration
#4
JOURNAL ARTICLE
Fei Xing, Hui-Yuan Shen, Man Zhe, Kai Jiang, Jun Lei, Zhou Xiang, Ming Liu, Jia-Zhuang Xu, Zhong-Ming Li
Currently, biomineralization is widely used as a surface modification approach to obtain ideal material surfaces with complex hierarchical nanostructures, morphologies, unique biological functions, and categorized organizations. The fabrication of biomineralized coating for the surfaces of scaffolds, especially synthetic polymer scaffolds, can alter surface characteristics, provide a favorable microenvironment, release various bioactive substances, regulate the cellular behaviors of osteoblasts, and promote bone regeneration after implantation...
January 31, 2024: Pharmaceutics
https://read.qxmd.com/read/38378055/creek-systems-in-restored-coastal-wetlands-morphological-evolution-and-design-implications
#5
JOURNAL ARTICLE
C Chirol, N Pontee, S L Gallop, C E L Thompson, H Kassem, I D Haigh
Saltmarsh restoration such as managed realignment (MR) projects often include excavation of simplified tidal creek networks to improve drainage and marsh functioning, but their design is based on limited evidence. This paper compares the morphological evolution of creek networks in current MR projects in the UK with creek networks in natural saltmarshes, in order to provide improved guidance. The evolution of creek networks was monitored for 2-20 years post-breach at 10 MR sites across the UK by semi-automatically extracting 12 morphological creek parameters from lidar...
February 18, 2024: Science of the Total Environment
https://read.qxmd.com/read/38283983/multi-needle-blow-spinning-technique-for-fabricating-collagen-nanofibrous-nerve-guidance-conduit-with-scalable-productivity-and-high-performance
#6
JOURNAL ARTICLE
Chun-Yi Yang, Zhaohui Hou, Peilun Hu, Chengli Li, Zifan Li, Zekun Cheng, Shuhui Yang, Pengchao Ma, Zhe Meng, Hui Wu, Yongwei Pan, Zheng Cao, Xiumei Wang
Nerve guidance conduits (NGCs) have been widely accepted as a promising strategy for peripheral nerve regeneration. Fabricating ideal NGCs with good biocompatibility, biodegradability, permeability, appropriate mechanical properties (space maintenance, suturing performance, etc.), and oriented topographic cues is still current research focus. From the perspective of translation, the technique stability and scalability are also an important consideration for industrial production. Recently, blow-spinning technique shows great potentials in nanofibrous scaffolds fabrication, possessing high quality, high fiber production rates, low cost, ease of maintenance, and high reliability...
February 2024: Materials today. Bio
https://read.qxmd.com/read/38272110/a-stochastic-model-for-topographically-influenced-cell-migration
#7
JOURNAL ARTICLE
A J Mitchinson, M Pogson, G Czanner, D Conway, R R Wilkinson, M F Murphy, I Siekmann, S D Webb
Migrating cells traverse a range of topographic configurations presented by the native extracellular environment to conduct their physiologic functions. It is well documented cells can modulate their behaviour in response to different topographic features, finding promising applications in biomaterial and bioimplant design. It is useful, in these areas of research, to be able to predict which topographic arrangements could be used to promote certain patterns of migration prior to laboratory experimentation...
January 23, 2024: Journal of Theoretical Biology
https://read.qxmd.com/read/38226738/topographical-depth-reveals-contact-guidance-mechanism-distinct-from-focal-adhesion-confinement
#8
JOURNAL ARTICLE
Michael C Robitaille, Chunghwan Kim, Joseph A Christodoulides, Patrick J Calhoun, Wonmo Kang, Jinny Liu, Jeff M Byers, Marc P Raphael
Cellular response to the topography of their environment, known as contact guidance, is a crucial aspect to many biological processes yet remains poorly understood. A prevailing model to describe cellular contact guidance involves the lateral confinement of focal adhesions (FA) by topography as an underlying mechanism governing how cells can respond to topographical cues. However, it is not clear how this model is consistent with the well-documented depth-dependent contact guidance responses in the literature...
January 16, 2024: Cytoskeleton
https://read.qxmd.com/read/38224015/development-of-bdnf-ngf-ikvav-peptide-modified-and-gold-nanoparticle-conductive-pcl-plga-nerve-guidance-conduit-for-regeneration-of-the-rat-spinal-cord-injury
#9
JOURNAL ARTICLE
Ilyas Ozcicek, Nese Aysit, Zeynep Balcikanli, Nilufer Ulas Ayturk, Asel Aydeger, Gulsena Baydas, Mehmet Serif Aydin, Esra Altintas, Umit Can Erim
Spinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results in the current clinical treatments are leading scientists to innovative neural regenerative research. Advances in nanoscience and neural tissue engineering have opened new avenues for spinal cord injury (SCI) treatment. In order for designed nerve guidance conduit (NGC) to be functionally useful, it must have ideal scaffold properties and topographic features that promote the linear orientation of damaged axons...
January 15, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38223190/combined-fluorescence-lifetime-and-surface-topographical-imaging-of-biological-tissue
#10
JOURNAL ARTICLE
Charlotte Hopkinson, Andrew B Matheson, Neil Finlayson, Michael G Tanner, Ahsan R Akram, Robert K Henderson
In this work a combined fluorescence lifetime and surface topographical imaging system is demonstrated. Based around a 126 × 192 time resolved single photon avalanche diode (SPAD) array operating in time correlated single-photon counting (TCSPC) mode, both the fluorescence lifetime and time of flight (ToF) can be calculated on a pixel by pixel basis. Initial tests on fluorescent samples show it is able to provide 4 mm resolution in distance and 0.4 ns resolution in lifetime. This combined modality has potential biomedical applications such as surgical guidance, endoscopy, and diagnostic imaging...
January 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38167425/development-and-evolution-of-thalamocortical-connectivity
#11
REVIEW
Zoltán Molnár, Kenneth Y Kwan
Conscious perception in mammals depends on precise circuit connectivity between cerebral cortex and thalamus; the evolution and development of these structures are closely linked. During the wiring of reciprocal thalamus-cortex connections, thalamocortical axons (TCAs) first navigate forebrain regions that had undergone substantial evolutionary modifications. In particular, the organization of the pallial-subpallial boundary (PSPB) diverged significantly between mammals, reptiles, and birds. In mammals, transient cell populations in internal capsule and early corticofugal projections from subplate neurons closely interact with TCAs to guide pathfinding through ventral forebrain and PSPB crossing...
January 2, 2024: Cold Spring Harbor Perspectives in Biology
https://read.qxmd.com/read/38099607/regulated-behavior-in-living-cells-with-highly-aligned-configurations-on-nanowrinkled-graphene-oxide-substrates-deep-learning-based-on-interplay-of-cellular-contact-guidance
#12
JOURNAL ARTICLE
Rowoon Park, Moon Sung Kang, Gyeonghwa Heo, Yong Cheol Shin, Dong-Wook Han, Suck Won Hong
Micro-/nanotopographical cues have emerged as a practical and promising strategy for controlling cell fate and reprogramming, which play a key role as biophysical regulators in diverse cellular processes and behaviors. Extracellular biophysical factors can trigger intracellular physiological signaling via mechanotransduction and promote cellular responses such as cell adhesion, migration, proliferation, gene/protein expression, and differentiation. Here, we engineered a highly ordered nanowrinkled graphene oxide (GO) surface via the mechanical deformation of an ultrathin GO film on an elastomeric substrate to observe specific cellular responses based on surface-mediated topographical cues...
December 15, 2023: ACS Nano
https://read.qxmd.com/read/38066191/hs27-fibroblast-response-to-contact-guidance-cues
#13
JOURNAL ARTICLE
C Kim, M Robitaille, J Christodoulides, Y Ng, M Raphael, W Kang
Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge and groove widths and groove depth ([Formula: see text], respectively). However, experimental studies that independently quantify the effect of the individual dimensions as well as their coupling on cellular function are still limited. In this work, we perform extensive parametric studies in the dimensional space-well beyond the previously studied range in the literature-to explore topographical effects on morphology and migration of Hs27 fibroblasts via static and dynamic analyses of live cell images...
December 7, 2023: Scientific Reports
https://read.qxmd.com/read/38036172/topographical-systematization-of-human-placenta-model-for-training-in-microneurosurgery
#14
JOURNAL ARTICLE
Rene Alejandro Apaza-Tintaya, Luis Ángel Jiménez Canache, Felipe Pereira Salvagni, Luis Gustavo Biondi Soares, Edgar David Tenelema Aguaisa, Alexander Feliciano Vilcahuamán Paitán, Raphael Wuo-Silva, Feres Chaddad-Neto
BACKGROUND: Neurosurgical training continuously seeks innovative methods to enhance the acquisition of essential technical skills for neurosurgeons worldwide. While various training models have been employed, few truly replicate real-life conditions optimally. Human placenta is a good model for neurosurgical microsurgery training due to its anatomical similarities to neurovascular structures. Placental vessels exhibit a branching pattern and caliber comparable to intracranial vessels, making them suitable for practicing microsurgical techniques...
November 28, 2023: World Neurosurgery
https://read.qxmd.com/read/37952493/topographic-anatomy-and-intraoperative-usg-guided-foreign-bodies-extraction-of-neglected-molotov-cocktail-victim-a-rare-case-report
#15
Muhammad Ade Junaidi, Fajar Defian Putra, Marcel Prasetyo, Aryo Winartomo, Chintya Mutiara Sari
INTRODUCTION AND SIGNIFICANCE: Foreign body implantation resulting from explosive devices is an extraordinary occurrence that often leads to substantial morbidity among the affected individuals. Explosions caused by such devices generate a rapidly propagating blast wave emanating from the point of detonation. This study aims to present a case involving a patient who experienced multiple foreign body implantations as a consequence of a bomb explosion. CASE PRESENTATION: A 41-year-old male presented with a history of multiple foreign bodies retained within his body for the past 22 years, originating from a homemade explosive device...
November 10, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37862812/micro-nano-patterns-for-enhancing-differentiation-of-human-neural-stem-cells-and-fabrication-of-nerve-conduits-via-soft-lithography-and-3d-printing
#16
JOURNAL ARTICLE
Jagoda Litowczenko, Jacek K Wychowaniec, Karol Załęski, Łukasz Marczak, Charlotte J C Edwards-Gayle, Krzysztof Tadyszak, Barbara M Maciejewska
Topographical cues on materials can manipulate cellular fate, particularly for neural cells that respond well to such cues. Utilizing biomaterial surfaces with topographical features can effectively influence neuronal differentiation and promote neurite outgrowth. This is crucial for improving the regeneration of damaged neural tissue after injury. Here, we utilized groove patterns to create neural conduits that promote neural differentiation and axonal growth. We investigated the differentiation of human neural stem cells (NSCs) on silicon dioxide groove patterns with varying height-to-width/spacing ratios...
October 10, 2023: Biomater Adv
https://read.qxmd.com/read/37847181/4d-printed-nerve-conduit-with-in-situ-neurogenic-guidance-for-nerve-regeneration
#17
JOURNAL ARTICLE
Haitao Cui, Wei Zhu, Shida Miao, Kausik Sarkar, Lijie Grace Zhang
Nerve repair poses a significant challenge in the field of tissue regeneration. As a bioengineered therapeutic method, nerve conduits have been developed to address damaged nerve repair. However, despite their remarkable potential, it is still challenging to encompass complex physiologically microenvironmental cues (both biophysical and biochemical factors) to synergistically regulate stem cell differentiation within the implanted nerve conduits, especially in a facile manner. In this study, a neurogenic nerve conduit with self-actuated ability has been developed by in situ immobilization of neurogenic factors onto printed architectures with aligned microgrooves...
October 17, 2023: Tissue Engineering. Part A
https://read.qxmd.com/read/37750196/perspectives-on-the-novel-multifunctional-nerve-guidance-conduits-from-specific-regenerative-procedures-to-motor-function-rebuilding
#18
REVIEW
Weixian Zhou, Muhammad Saif Ur Rahman, Chengmei Sun, Shilin Li, Nuozi Zhang, Hao Chen, Charles C Han, Shanshan Xu, Ying Liu
Peripheral nerve injury potentially destroys the quality of life by inducing functional movement disorders and sensory capacity loss, which results in severe disability and substantial psychological, social, and financial burdens. Autologous nerve grafting has been commonly used as treatment in the clinic; however, its rare donor availability limits its application. A series of artificial nerve guidance conduits (NGC) with advanced architectures have also been proposed to promote injured peripheral nerve regeneration, which is a complicated process from axon sprouting to targeted muscle reinnervation...
September 26, 2023: Advanced Materials
https://read.qxmd.com/read/37693432/the-geometry-of-photopolymerized-topography-influences-neurite-pathfinding-by-directing-growth-cone-morphology-and-migration
#19
Joseph T Vecchi, Madeline Rhomberg, C Allan Guymon, Marlan R Hansen
Cochlear implants (CIs) provide auditory perception to those with profound sensorineural hearing loss: however, the quality of sound perceived by a CI user does not approximate natural hearing. This limitation is due in part to the large physical gap between the stimulating electrodes and their target neurons. Therefore, directing the controlled outgrowth of processes from spiral ganglion neurons (SGNs) into close proximity to the electrode array could provide significantly increased hearing function. For this objective to be properly designed and implemented, the ability and limits of SGN neurites to be guided must first be determined...
August 29, 2023: bioRxiv
https://read.qxmd.com/read/37663182/block-of-the-pericapsular-nerve-group-of-the-hip-with-and-without-ultrasound-guidance-comparative-cadaveric-study
#20
JOURNAL ARTICLE
Pedro Hamra, André Sanches Sau, Walter Ricioli Junior, Nayra Deise Dos Anjos Rabelo, Giancarlo Cavalli Polesello
Objective  To evaluate the technical reproducibility of a block of the pericapsular nerve group (PENG) of the hip aided or not by ultrasound in cadavers. Materials and Methods  The present is a randomized, descriptive, and comparative anatomical study on 40 hips from 2 cadaver groups. We compared the PENG block technique with the method with no ultrasound guidance. After injecting a methylene blue dye, we verified the dispersion and topographical staining of the anterior hip capsule through dissection...
August 2023: Revista Brasileira de Ortopedia
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