keyword
https://read.qxmd.com/read/37982244/targeting-cyclin-dependent-kinases-in-rheumatoid-arthritis-and-psoriasis-a-review-of-current-evidence
#21
REVIEW
Marzena Staniszewska, Kajetan Kiełbowski, Klaudia Rusińska, Estera Bakinowska, Ewa Gromowska, Andrzej Pawlik
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with synovial proliferation and bone erosion, which leads to the structural and functional impairment of the joints. Immune cells, together with synoviocytes, induce a pro-inflammatory environment and novel treatment agents target inflammatory cytokines. Psoriasis is a chronic immune-mediated skin disease, and several cytokines are considered as typical mediators in the progression of the disease, including IL-23, IL-22, and IL-17, among others...
November 20, 2023: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/37905185/management-of-plaque-psoriasis-in-adults-clinical-utility-of-tapinarof-cream
#22
REVIEW
Riley K Spencer, Joy Q Jin, Kareem G Elhage, Mitchell S Davis, Wilson Liao, Tina Bhutani
Topical medications represent the most commonly used drugs in the treatment of psoriasis. However, topical steroids are mainly limited to short-term or intermittent use, and traditional non-steroidal topicals such as vitamin D analogues, topical calcineurin inhibitors, and topical retinoids are limited by low efficacy and poor local skin tolerability. Tapinarof (GSK2894512, DMVT-505) is a novel, topical aryl hydrocarbon receptor (AHR) agonist, which was recently approved by the FDA for the treatment of plaque psoriasis in adults...
2023: Psoriasis: Targets and Therapy
https://read.qxmd.com/read/37880231/single-atom-catalysts-based-catalytic-ros-clearance-for-efficient-psoriasis-treatment-and-relapse-prevention-via-restoring-esr1
#23
JOURNAL ARTICLE
Xiangyu Lu, Le Kuai, Fang Huang, Jingsi Jiang, Jiankun Song, Yiqiong Liu, Si Chen, Lijie Mao, Wei Peng, Ying Luo, Yongyong Li, Haiqing Dong, Bin Li, Jianlin Shi
Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN4 O2 -SACs) with broad-spectrum ROS scavenging capability can be used for psoriasis treatment and relapse prevention via related gene restoration. FeN4 O2 -SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, which are analogous to those of natural antioxidant enzymes, iron superoxide dismutase, human erythrocyte catalase, and ascorbate peroxidase...
October 25, 2023: Nature Communications
https://read.qxmd.com/read/37871808/identification-of-potential-biomarkers-and-infiltrating-immune-cells-from-scalp-psoriasis
#24
JOURNAL ARTICLE
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
BACKGROUND: Scalp psoriasis seriously affects the appearance and psychological status of patients. The aim of this study was to investigate the effect and potential mechanism of RPL9 and TIFA in scalp psoriasis, so as to provide a precise and effective way for the clinical treatment of scalp psoriasis. METHODS: The Gene Expression Omnibus (GEO) database was employed to download the GSE75343 dataset to search for differentially expressed genes (DEGs) in scalp psoriasis through Sangerbox...
January 30, 2024: Gene
https://read.qxmd.com/read/37837493/efficacy-of-av%C3%A3-ne-hydrotherapy-on-chronic-pruritus-in-patients-with-plaque-psoriasis
#25
JOURNAL ARTICLE
Marie-Dominique Thouvenin, Adeline Bacquey, Marine Babin, Fabrice Lestienne, Christophe Lauze, Eléonore Gravier, Diana Placintescu, Ariadna Ortiz-Brugués, Sonja Ständer
INTRODUCTION: Pruritus is a prevalent symptom, described as one of the most bothersome of psoriasis. Specific itch management remains a challenge, for which hydrotherapy could be used as adjunct care to medical treatment. Therefore, we assessed the immediate and longer-term benefit of 3 weeks of Avène thermal spring water hydrotherapy on chronic pruritus in patients in addition to their usual psoriasis and/or pruritus management. METHODS: Twenty-six patients suffering from chronic pruritus due to psoriasis were evaluated before and after 3 weeks of hydrotherapy with a 3 and 6 month follow-up...
October 14, 2023: Dermatology and Therapy
https://read.qxmd.com/read/37797168/transcutaneous-immunotherapy-for-rnai-a-cascade-responsive-decomposable-nanocomplex-based-on-polyphenol-mediated-framework-nucleic-acid-in-psoriasis
#26
JOURNAL ARTICLE
Mei Zhang, Xin Qin, Yang Gao, Jiale Liang, Dexuan Xiao, Xiaolin Zhang, Mi Zhou, Yunfeng Lin
Skin is the first barrier against external threats, and skin immune dysfunction leads to multiple diseases. Psoriasis is an inflammatory, chronic, common, immune-related skin disease that affects more than 125 million people worldwide. RNA interference (RNAi) therapy is superior to traditional therapies, but rapid degradation and poor cell uptake are the greatest obstacles to its clinical transformation. The transdermal delivery of siRNA and controllable assembly/disassembly of nanodrug delivery systems can maximize the therapeutic effect...
October 5, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37751291/dimethyl-fumarate-modulates-the-dystrophic-disease-program-following-short-term-treatment
#27
JOURNAL ARTICLE
Cara A Timpani, Stephanie Kourakis, Danielle A Debruin, Dean G Campelj, Nancy Pompeani, Narges Dargahi, Angelo Patrick R Bautista, Ryan M Bagaric, Elya J Ritenis, Lauren Sahakian, Didier Debrincat, Nicole Stupka, Patricia Hafner, Peter G Arthur, Jessica R Terrill, Vasso Apostolopoulos, Judy B De Haan, Nuri Gueven, Dirk Fischer, Emma Rybalka
New medicines are urgently required to treat the fatal neuromuscular disease, Duchenne muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small molecule nuclear erythroid 2-related factor 2 (Nrf2) activator with current clinical utility in the treatment of multiple sclerosis and psoriasis that could be effective for DMD and rapidly translatable. Here, we tested two weeks of daily 100mg/kg DMF versus 5mg/kg standard care prednisone (PRED) treatment in juvenile mdx mice with early symptomatic DMD...
September 26, 2023: JCI Insight
https://read.qxmd.com/read/37746147/rationale-and-protocol-of-a-double-blind-randomized-placebo-controlled-trial-to-test-the-efficacy-safety-and-tolerability-of-dimethyl-fumarate-in-friedreich-ataxia-dmf-fa-201
#28
JOURNAL ARTICLE
Chiara Pane, Alberto Maria Marra, Ludovica Aliberti, Mario Campanile, Federica Coscetta, Giulia Crisci, Roberta D'Assante, Angela Marsili, Giorgia Puorro, Andrea Salzano, Antonio Cittadini, Francesco Saccà
INTRODUCTION: Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder that causes gait and limb ataxia, dysarthria, and impaired vibratory sense, with cardiomyopathy being the predominant cause of death. There is no approved therapy, which results in the use of symptomatic treatments and the chronic support of physiotherapy. Dimethyl fumarate (DMF) is a fumaric acid ester used for the treatment of psoriasis and Multiple Sclerosis (MS). It induces Nrf2 in vitro and in vivo , and it increases frataxin in FRDA patient lymphoblasts, in mouse models, and in MS treated patients...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37726967/cutaneous-findings-and-treatments-in-deficiency-of-interleukin-36-receptor-antagonist-ditra-a-review-of-the-literature
#29
REVIEW
Chiamaka L Okorie, Krithika Nayudu, Vinod E Nambudiri
Deficiency of the interleukin-36 receptor antagonist (DITRA) is a rare autoinflammatory disorder caused by mutations in the IL36RN gene. This mutation leads to a lack of functional interleukin-36 receptor antagonists (IL-36Ra), which results in an overactive immune system and chronic inflammation. Despite its rarity, numerous case series and individual reports in the literature emphasize the importance of recognizing and managing DITRA. Early identification of the cutaneous signs of DITRA is crucial for accurate diagnosis and timely administration of appropriate treatment...
September 19, 2023: Experimental Dermatology
https://read.qxmd.com/read/37719360/deciphering-the-mechanism-of-xijiao-dihuang-decoction-in-treating-psoriasis-by-network-pharmacology-and-experimental-validation
#30
JOURNAL ARTICLE
Yicheng Guo, Huiqun Gan, Shigui Xu, Guosheng Zeng, Lili Xiao, Zhijun Ding, Jie Zhu, Xinglong Xiong, Zhiyuan Fu
PURPOSE: This study aims to confirm the efficacy of Xijiao Dihuang decoction (XJDHT), a classic prescription, in treating psoriasis and to explore the potential therapeutic mechanism. METHODS: For pharmacodynamic analysis, a mouse model of imiquimod cream (IMQ)-induced psoriasis was constructed. Active ingredients and genes of XJDHT, as well as psoriasis-related targets, were obtained from public databases. Intersecting genes (IGEs) of XJDHT and psoriasis were collected by Venn Diagram...
2023: Drug Design, Development and Therapy
https://read.qxmd.com/read/37717118/disentangling-the-complexity-of-psoriasis-in-the-post-genome-wide-association-era
#31
REVIEW
Charalabos Antonatos, Katerina Grafanaki, Sophia Georgiou, Evangelos Evangelou, Yiannis Vasilopoulos
In recent years, genome-wide association studies (GWAS) have been instrumental in unraveling the genetic architecture of complex diseases, including psoriasis. The application of large-scale GWA studies in psoriasis has illustrated several associated loci that participate in the cutaneous inflammation, however explaining a fraction of the disease heritability. With the advent of high-throughput sequencing technologies and functional genomics approaches, the post-GWAS era aims to unravel the functional mechanisms underlying the inter-individual variability in psoriasis patients...
September 16, 2023: Genes and Immunity
https://read.qxmd.com/read/37704911/successful-treatment-of-pityriasis-rubra-pilaris-with-risankizumab-in-children
#32
JOURNAL ARTICLE
Marta Kołt-Kamińska, Antonina Osińska, Ewa Kaznowska, Adam Reich
Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that affects men and women of all ages, including children. PRP is characterized by follicular and palmoplantar hyperkeratosis and salmon-colored scaling plaques. The exact pathogenesis of PRP is still unknown; most PRP cases are acquired, but some cases may show a familial occurrence, often associated with a mutation in the CARD14 gene. Due to the rarity of PRP, treatment recommendations are based mainly on case reports, small case series and expert opinions and still represent a major therapeutic challenge, especially in children...
September 13, 2023: Dermatology and Therapy
https://read.qxmd.com/read/37700026/gene-signature-from-cutaneous-autoimmune-diseases-provides-potential-immunotherapy-relevant-biomarkers-in-melanoma
#33
JOURNAL ARTICLE
Kyu-Hye Chun, Ye-Chan Park, Nahee Hwang, Bo Kyung Yoon, Jae-Woo Kim, Sungsoon Fang
Immune checkpoint inhibitors (ICIs) are promising agents for treating melanoma. Given that autoimmune skin diseases exhibit hyper immune reaction, investigation of immune cells from autoimmune skin disease is crucial to validate the effectiveness of ICIs in melanoma treatment. We employed multipanel markers to predict the response to immune checkpoint inhibitors by characterizing the gene expression signatures of skin immune cells in systemic lupus erythematosus (SLE), atopic dermatitis (AD), and psoriasis (PS)...
September 12, 2023: Scientific Reports
https://read.qxmd.com/read/37683783/hyaluronic-acid-engineered-gallic-acid-embedded-chitosan-nanoparticle-as-an-effective-delivery-system-for-treatment-of-psoriasis
#34
JOURNAL ARTICLE
Afsana Sheikh, Sahim Aziz Hazari, Nagashekhara Molugulu, Saad Ali Alshehri, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani
Psoriasis is a deleterious auto-immune disorder which seriously harms the patients physical and mental health. CD44 are found to be over-expressed on psoriatic lesions which are highly responsible for epidermal hyperproliferation and inflammation. Gallic acid (GA), a phenolic acid natural compound has potential inhibitory impact on pro-inflammatory transcription factors. However, the penetration across skin and availability is low when applied topically, making the treatment extremely challenging. Considering such factors, we developed GA loaded chitosan nanoparticles and modified with hyaluronic acid (HA) (HA@CS-GA NP) to assess the therapeutic potential against psoriasis...
September 6, 2023: Environmental Research
https://read.qxmd.com/read/37664450/comprehensive-analysis-to-identify-rh-family-c-glycoprotein-rhcg-as-the-causative-gene-for-psoriasis-and-search-for-alternative-treatment-modalities
#35
JOURNAL ARTICLE
Qian Zhang, Jia Liu, Dan Yao, Jian-Xin Shi, Yuan-Jie Liu, Yue-Gang Wei, Shun Guo
BACKGROUND: Psoriasis is a complex autoimmune disease. Frequent interactions between epidermal and immune cells are likely to be responsible for the strong heterogeneity of psoriasis. Therefore, our work aims to build on current knowledge and further search for new molecular mechanisms related to psoriasis pathogenesis in order to develop new targeted drugs. METHODS: Data from psoriasis samples were obtained from the Gene Expression Omnibus (GEO) database, and batch effects were corrected using the "Combat" algorithm in the "SVA" package...
2023: Drug Design, Development and Therapy
https://read.qxmd.com/read/37653756/a-network-pharmacology-and-molecular-docking-investigation-on-the-mechanisms-of-shanyaotianhua-decoction-stt-as-a-therapy-for-psoriasis
#36
JOURNAL ARTICLE
Chen Yue, Jiahao Feng, Aili Gao
Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology involving environmental and genetic factors. Psoriasis patients often require long-term treatment. Shanyaotianua decoction (STT), a typical traditional Chinese medicine prescription, positively affects psoriasis, although its molecular targets remain unknown. To elucidate its molecular mechanisms, a combination of network pharmacology, bioinformatics analysis, and drug similarity comparisons were employed. Participants were separated into 3 groups: non-lesional (NL), lesions after medication (LM), and psoriasis lesion groups (LS)...
August 25, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37631238/gene-ontology-analysis-highlights-biological-processes-influencing-responsiveness-to-biological-therapy-in-psoriasis
#37
JOURNAL ARTICLE
Martina Krušič, Gregor Jezernik, Uroš Potočnik
Psoriasis is a chronic, immune-mediated and inflammatory skin disease. Although various biological drugs are available for psoriasis treatment, some patients have poor responses or do not respond to treatment. The aim of the present study was to highlight the molecular mechanism of responsiveness to current biological drugs for psoriasis treatment. To this end, we reviewed previously published articles that reported genes associated with treatment response to biological drugs in psoriasis, and gene ontology analysis was subsequently performed using the Cytoscape platform...
July 26, 2023: Pharmaceutics
https://read.qxmd.com/read/37621397/successful-secukinumab-therapy-in-plaque-psoriasis-is-associated-with-altered-gut-microbiota-and-related-functional-changes
#38
JOURNAL ARTICLE
Xueshan Du, Cong Yan, Shuzhen Kong, Delu Che, Bin Peng, Longfei Zhu, Songmei Geng, Kun Guo
INTRODUCTION: The role of gut microbiome dysbiosis in the pathogenesis of psoriasis has gained increasing attention in recent years. Secukinumab, targeting interleukin (IL)-17, has a promising efficacy in psoriasis treatment. However, it remains unclear the gut microbiota alteration and related functional changes caused by successful secukinumab therapy in psoriatic patients. METHODS: In our study, we compared the fecal microbiome profile between psoriatic patients after secukinumab successful treatment (AT) and the other two groups, psoriatic patients without therapy (BT) and healthy people (H), respectively, by using next-generation sequencing targeting 16S ribosomal RNA...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37609730/jak-stat-inhibitors-in-immune-mediated-diseases-an-overview
#39
REVIEW
Ruchi Jayesh Shah, Sneha Banerjee, Smriti Raychaudhuri, Siba P Raychaudhuri
For any biological response, transmission of extracellular signals to the nucleus is required for DNA transcription and gene expression. In that respect, cytokines/chemokines are well-known inflammatory agents which play a critical role in signalling pathways by activating the Janus kinase-signal transducers and activators of transcription (JAK-STAT) signalling proteins (Janus kinase-signal transducers and activators of transcription) which are a group of intracellular kinase molecules. Cytokines are a category of small proteins (∼5-25 kDa) that play a major role in cell signalling and are major drivers of an autoimmune response...
July 21, 2023: Indian Journal of Dermatology, Venereology and Leprology
https://read.qxmd.com/read/37578092/topical-application-of-topk-inhibitor-ots514-suppresses-psoriatic-progression-by-inducing-keratinocytes-cell-cycle-arrest-and-apoptosis
#40
JOURNAL ARTICLE
Fanfan Zeng, Hui Lu, Mengjun Wu, Chan Dai, Jianyu Li, Jinbiao Wang, Guoyun Hu
T-LAK cell-oriented protein kinase (TOPK) potently promotes malignant proliferation of tumour cells and is considered as a maker of tumour progression. Psoriasis is a common inflammatory skin disease characterized by abnormal proliferation of keratinocytes. However, the role of TOPK in psoriasis has not been well elucidated. This study aims to investigate the expression and role of TOPK in psoriasis, and the role of TOPK inhibitor in psoriasis attenuation. Gene Expression Omnibus datasets derived from psoriasis patients and psoriatic model mice were screened for analysis...
August 14, 2023: Experimental Dermatology
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