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https://www.readbyqxmd.com/read/28214088/a-case-of-seropositive-autoimmune-autonomic-ganglionopathy-with-diffuse-esophageal-spasm
#1
Nobutoshi Morimoto, Sakuma Takahashi, Tomoki Inaba, Motonori Takamiya, Yasuhiko Kageyama, Mizuki Morimoto, Yoshiaki Takahashi, Hirotake Nishimura, Shunya Nakane, Koji Abe
Autoimmune autonomic ganglionopathy (AAG) is an immune-mediated disorder that leads to various autonomic failures associated with anti-ganglionic acetylcholine receptor antibodies (anti-gAChR-Abs). Diffuse esophageal spasm (DES) is an uncommon esophageal motility disorder. We herein report the case of a 68-year-old woman with DES as a partial symptom of AAG. She presented with chronic esophageal transit failure, constipation, and numbness of the hands and feet, Adie's pupil, thermal hypoalgesia, and decreased deep tendon reflexes...
February 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28213198/a-rare-presentation-of-an-enterogenous-cyst-as-an-intra-axial-pontine-lesion
#2
Tengfei Li, Xia Wu, Yuekang Zhang
A 56-year-old man was admitted to our hospital with intermittent right facial numbness for one year and walking instability for six months. Magnetic resonance imaging revealed an ovoid and well-demarcated intra-axial pontine lesion. Cyst fenestration and biopsy were carried out and the diagnosis of enterogenous cyst was made by MRI and pathologic findings. Preoperative symptoms resolved completely three months after surgery and no evidence of recurrence was found during 3 years of follow-up. Although total resection of enterogenous cysts is recommended, cyst fenestration may be useful if the cyst is adherent to vital neurovascular structures...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28212905/will-patients-perceive-a-numbing-spray-to-be-an-effective-method-of-anesthetizing-an-intravenous-site
#3
Pamela G Falotico, Linda Ryan
PURPOSE: The purpose of this study was to determine if patients would perceive a numbing spray to be an effective method of anesthetizing an intravenous (IV) site. DESIGN: A quasi-experimental design was used. METHODS: The first 50 patients were given no pain management strategy before their IV insertion, and the next 50 patients were given a numbing spray. FINDINGS: The hypothesis that pain scores reported from the numbing spray group would be less than pain scores reported from the non-numbing spray group was not supported...
February 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28205252/sensory-deficits-after-a-radial-nerve-injury
#4
Jayme Augusto Bertelli, Erica Cavalli, Vera Lúcia Mendes Lehn, Marcos Flávio Ghizoni
BACKGROUND: The aim of our study was to objectively test sensibility on the dorsal side of the hand in patients with radial nerve injury, to document deficits and to detect if surgery for sensory reconstruction is needed. METHODS: Nineteen patients of mean age 31 ± 10 years were examined at a mean of 26.4 ± 27.8 months post radial nerve injury. Sensory mechanical thresholds on the dorsal surface of the hand were evaluated using Semmes-Weinstein monofilaments...
February 16, 2017: Microsurgery
https://www.readbyqxmd.com/read/28202889/treatment-of-transthyretin-familial-amyloid-polyneuropathy-with-tafamidis-a-case-report
#5
Yoshimichi Miyazaki
INTRODUCTION: Familial amyloid polyneuropathy (FAP) is a rare hereditary disorder caused by mutations in the transthyretin (TTR) gene. Tafamidis is a TTR stabilizer able to prevent TTR tetramer dissociation, and several studies have demonstrated its safety and efficacy at slowing the progression of neuropathy in FAP caused by the TTR Val30Met mutation. However, nerve conduction study (NCS) and electromyography (EMG) results have yet to be reported in relation to FAP progression during tafamidis therapy...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28196783/symptom-cluster-trajectories-during-chemotherapy-in-breast-cancer-outpatients
#6
Hsin-Tien Hsu, Kuan-Chia Lin, Li-Min Wu, Chiung-Hui Juan, Ming-Feng Hou, Shiow-Li Hwang, Yi Liu, Marylin J Dodd
CONTEXT: Breast cancer patients often experience multiple symptoms and substantial discomfort. Some symptoms may occur simultaneously and throughout the duration of chemotherapy treatment OBJECTIVES: The aim of this study was to investigate symptom severity and symptom cluster trajectories during chemotherapy in outpatients with breast cancer in Taiwan. METHODS: This prospective, longitudinal, repeated measures study administered a standardized questionnaire (M...
February 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28194181/simultaneous-left-ventricular-and-deep-vein-thrombi-caused-by-protein-c-deficiency
#7
Harufumi Maki, Motohiro Nishiyama, Motoaki Shirakawa
Protein C deficiency is a risk of venous thrombosis because of poor fibrinolytic activity. It remains controversial whether protein C deficiency causes arterial thrombosis. A 21-year-old woman was referred with a chief complaint of right leg pain and numbness. Contrast-enhanced computed tomography revealed a low-density mass in the left ventricle (LV), splenic infarction, and peripheral arterial obstructions in her right leg. Thrombosis extending from the renal vein to the inferior vena cava was also detected...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28187075/investigating-the-association-between-lower-extremity-and-low-back-symptoms-among-saskatchewan-farmers-using-the-standardized-nordic-questionnaire
#8
Samuel Kwaku Essien, Catherine Trask, James Dosman, Brenna Bath
STUDY DESIGN: Cross sectional survey OBJECTIVE.: To investigated the association between self-reported low back symptoms and symptoms in the hip, knee, and ankle in a high-risk occupational group SUMMARY OF BACKGROUND DATA.: Low back pain, with or without lower extremity referral, poses a major challenge to occupational productivity, especially in farming. Although low back symptoms can occur independent of lower extremity symptoms, anatomical positioning of nerves supplying the lower limbs means structural and physiological changes in the spine can lead to referred pain in the lower limbs, but the magnitude of the association between low back and lower extremity symptoms is unclear...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28186472/clinical-presentation-and-treatment-outcomes-of-spinal-epidural-arteriovenous-fistulas
#9
Deena M Nasr, Waleed Brinjikji, Michelle J Clarke, Giuseppe Lanzino
OBJECTIVE Spinal epidural arteriovenous fistulas (SEDAVFs) constitute a rare but treatable cause of vascular myelopathy and are a different subtype from the more common Type I spinal dural AVFs. The purpose of this study was to review a consecutive series of SEDAVFs from a single institution and report on the clinical presentations, functional status, and treatment outcomes. METHODS The authors identified all SEDAVFs treated at their institution from 2005 to 2015. SEDAVFs were defined as spinal AVFs in which the fistulous connection occurred in the epidural venous plexus...
February 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28183502/a-27-year-old-man-with-acute-severe-low-back-pain-and-bilateral-leg-swelling-that-prompted-renting-a-wheelchair-for-mobility
#10
John G Williams, Huy Phan, Helena R Winston, Randolph V Fugit, Bridget Graney, Brant Jamroz, Benjamin English, Edward D Chan
A 27-year-old man with OSA, posttraumatic stress disorder, and chronic mechanical back pain presented with a 3-day history of acute atraumatic worsening of his low back pain as well as right groin numbness that was exacerbated by walking. He also complained of bilateral leg "heaviness," pain, and swelling, all becoming so severe that he rented a wheelchair for mobility.
February 2017: Chest
https://www.readbyqxmd.com/read/28180093/a-case-of-delayed-radiation-myelopathy-of-the-thoracic-vertebrae-following-low-dose-radiation-therapy-for-metastatic-renal-cell-carcinoma
#11
Satoshi Nozaki, Taku Naiki, Shuzo Hamamoto, Ryosuke Ando, Keitaro Iida, Noriyasu Kawai, Kentaro Mizuno, Atsushi Okada, Yukihiro Umemoto, Takahiro Yasui
Delayed radiation myelopathy (DRM) is a rare disorder that rapidly leads to disabilities, and the median incubation period was reported to be about 2 years (from 6 months to a few years). In this report, we describe a 61-year-old woman who presented with rapid progressive numbness and weakness in both legs 22 months after palliative radiation therapy with 39 Gy in 3 Gy fractions. She was diagnosed with DRM of the thoracic vertebrae and was treated sequentially with corticosteroids, heparin, and hyperbaric oxygen therapy...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28170080/mesh-fixation-with-glue-versus-suture-for-chronic-pain-and-recurrence-in-lichtenstein-inguinal-hernioplasty
#12
REVIEW
Ping Sun, Xiang Cheng, Shichang Deng, Qinggang Hu, Yi Sun, Qichang Zheng
BACKGROUND: Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. OBJECTIVES: To determine whether tissue adhesives can reduce postoperative complications, especially chronic pain, with no increase in recurrence rate, compared with sutures for mesh fixation in Lichtenstein hernia repair...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28168238/numb-chin-syndrome-associated-with-vertical-root-fracture-and-odontogenic-infection
#13
John K Brooks, Kevin G Schwartz, Alvin S Ro, Chang-Ching D Lin
Numb chin syndrome (NCS) is a multifactorial neuropathic disorder associated with paresthesia to the chin, lip, and oral mucosa, particularly arising as a sequela to various dental-related procedures or infections in the mandible. Timely elucidation of the underlying etiology is of paramount importance as the presentation of NCS could serve as a harbinger of malignancy or metastatic disease. This report describes an unusual case of NCS developing synchronously with a vertical root fracture and odontogenic infection in a mandibular first molar...
February 6, 2017: Quintessence International
https://www.readbyqxmd.com/read/28164268/a-comparison-of-ultrasound-guided-interscalene-and-supraclavicular-blocks-for-post-operative-analgesia-after-shoulder-surgery
#14
B G Kim, J U Han, J H Song, C Yang, B W Lee, J S Baek
BACKGROUND: In contrast to interscalene block, there was little information regarding the analgesic efficacy of supraclavicular block for shoulder surgery. This study aimed to compare the analgesic efficacy and side effects of interscalene and supraclavicular blocks for shoulder surgery. METHODS: Patients scheduled for shoulder surgery were assigned to receive either ultrasound-guided interscalene (n = 25) or supraclavicular block (n = 24) with 20 ml of 0.375% ropivacaine...
February 5, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28160856/vasculoprotective-and-vasodilatation-effects-of-herbal-formula-sahatsatara-and-piperine-in-spontaneously-hypertensive-rats
#15
Suksalin Booranasubkajorn, Sukit Huabprasert, Jantanee Wattanarangsan, Pruksa Chotitham, Pinpilai Jutasompakorn, Tawee Laohapand, Pravit Akarasereenont, Pinpat Tripatara
BACKGROUND: The herbal formula (Sahatsatara, STF), the Thai traditional poly-herbal recipe, has been used for treatment of muscle pain, anti-flatulence and numbness on hands and feet, with the caution when used in hypertensive patients. However, there is no scientific evidence to prove its effects on cardiovascular system. Piperine is the proposed major active compound in STF. It is shown to have antihypertensive effect in the L-NAME-induced endothelial dysfunction rats. PURPOSE: This study investigated the pharmacokinetics, mechanism of action, as well as the hemodynamic and vasoactive effect and toxicity of STF and piperine using spontaneously hypertensive rats (SHR) and normal Wistar rats (NWR)...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28157731/superficial-electrosurgery-to-numb-or-not-to-numb
#16
Omer Ibrahim, Kenneth A Arndt, Jeffrey S Dover
No abstract text is available yet for this article.
February 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157201/longitudinal-in-vivo-bioimaging-of-hepatocyte-transcription-factor-activity-following-cholestatic-liver-injury-in-mice
#17
Juliette M K M Delhove, Suzanne M K Buckley, Dany P Perocheau, Rajvinder Karda, Patrick Arbuthnot, Neil C Henderson, Simon N Waddington, Tristan R McKay
Molecular mechanisms regulating liver repair following cholestatic injury remain largely unknown. We have combined a mouse model of acute cholestatic liver injury, partial bile duct ligation (pBDL), with a novel longitudinal bioimaging methodology to quantify transcription factor activity during hepatic injury and repair. We administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassettes to neonatal mice enabling longitudinal TFAR profiling by continued bioimaging throughout the lives of the animals and following pBDL in adulthood...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28156643/pilot-study-of-minocycline-for-the-prevention-of-paclitaxel-associated-neuropathy-accru-ru221408i
#18
Travis J Dockter, Patricia J Zekan, Briant Fruth, Kathryn Jean Ruddy, Lauren E Ta, Todor Dentchev, Nguyet Le-Lindqwister, William M Sikov, Charles L Loprinzi
: 220 Background: Paclitaxel is associated with both an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Preliminary animal data suggest that minocycline may be effective for the prevention of chemotherapy-induced neurotoxicity. The purpose of this pilot study was to investigate the efficacy of minocycline for the prevention of CIPN and P-APS. METHODS: Patients with breast cancer were enrolled prior to initiating neoadjuvant or adjuvant weekly paclitaxel for 12 weeks...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156472/oncology-massage-impact-on-patient-with-cancer-and-caregiver-self-reported-symptoms-as-part-of-an-integrative-oncology-program-at-a-comprehensive-cancer-center
#19
Kathrin Milbury, Amy Spelman, Qi Wei, Pamela A Sumler, Curtiss M Beinhorn, Eduardo Bruera, Lorenzo Cohen
: 79 Background: Massage as a manual therapy has shown benefit for symptomatic relief in patients with cancer and their caregivers. We explored the impact of a single massage session on self-reported symptoms in an outpatient clinic at a comprehensive cancer center. METHODS: Patients and caregivers received oncology massage treatments (30 or 60-min duration) at our Integrative Medicine Center outpatient clinic from Sep 2012-Jan 2015. Participants completed a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale, 10 most severe) pre- and post-massage...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153862/the-cargo-protein-map17-pdzk1ip1-regulates-the-cancer-stem-cell-pool-activating-the-notch-pathway-by-abducting-numb
#20
Jose M Garcia-Heredia, Antonio Lucena-Cacace, Eva M Verdugo-Sivianes, Marco Perez, Amancio Carnero
Purpose Cancer stem cells (CSCs) are self-renewing tumor cells, with ability to generate the diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally controls stem cell physiology. CSCs are the origin of metastasis and highly resistant to therapy. Therefore the understanding of the CSC origin and deregulated pathways is important for tumor control. Experimental design We have included experiments in vitro, in cell lines and tumors of different origins...
February 2, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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