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https://www.readbyqxmd.com/read/29924047/lumbar-spinal-canal-osteosarcoma-a-case-report
#1
De-Jian Chen, Qi Lai, Jianghao Zhu, Zongmiao Wan, Hucheng Liu, Min Dai, Runsheng Guo, Bin Zhang
RATIONALE: Osteosarcoma is a rare neoplasm in the lumbar spine. Although osteosarcoma can arise in any portion of the skeleton, it very rarely arises in the spinal canal, which accounts for <0.1% of all cases of adult sarcomas. Here, we describe a case of osteosarcoma arising in the L4-5 spinal canal. PATIENT CONCERNS: The present report describes the case of a 55-year-old female patient with osteosarcoma of the L4-5 spinal canal. DIAGNOSES: The patient was initially diagnosed with lumbar spinal stenosis and underwent lumbar fusion at a local hospital...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924024/systemic-lupus-erythematosus-with-guillian-barre-syndrome-a-case-report-and-literature-review
#2
Zhaoli Gao, Xianhua Li, Tao Peng, Zhao Hu, Jie Liu, Junhui Zhen, Yanxia Gao
INTRODUCTION: We report a case of systemic lupus erythematosus (SLE) with Guillian-Barre syndrome (GBS) as the first symptom. CASE PRESENTATION: A 30-year-old Chinese female with numbness and inductance of lower extremities 2 months previously. The electromyographic and cerebrospinal fluid findings supported inflammatory demyelinating disease, and the renal biopsy findings and rheumatoid-related results considered systemic lupus erythematosus. The patient received treatment with glucocorticoids and cyclophosphamide...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923987/ulcerative-colitis-with-guillain-barr%C3%A3-syndrome-a-case-report
#3
Zhengru Liu, Ke Zhou, Shan Tian, Weiguo Dong
RATIONALE: Ulcerative colitis is a chronic and recurrent inflammatory disease involving the intestine. It is reported that about 40% of patients with ulcerative colitis have extraintestinal manifestations, where as the literature on neurological involvement as extraintestinal manifestation is rather limited. Guillain-Barré syndrome is an abnormal immune-mediated and acute-acquired demyelinating disease that mainly affects the peripheral nervous system and often has a phenomenon of protein-cell separation of cerebrospinal fluid...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29921751/thoracic-outlet-syndrome-biomechanical-and-exercise-considerations
#4
REVIEW
Nicholas A Levine, Brandon R Rigby
Thoracic outlet syndrome (TOS) describes a group of disorders that are due to a dynamic compression of blood vessels or nerves, between the clavicle and first rib or cervical vertebral nerve roots. Individuals with TOS typically experience upper limb pain, numbness, tingling, or weakness that is exacerbated by shoulder or neck movement. The causes of TOS vary, and can include abrupt movements, hypertrophy of the neck musculature, and anatomical variations in which the brachial plexus roots pass through this musculature, edema, pregnancy, repeated overhead motions, the blockage of an artery or vein, or abnormal posture...
June 19, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29897291/isoniazid-induced-neuropathy-in-a-pre-pubertal-child
#5
Naman S Shetty, Ira Shah
Isoniazid (INH)-induced peripheral neuritis is not uncommonly reported in adults, especially those with malnutrition and alcoholism, but it is very rare in children. INH leads to peripheral neuritis by causing a deficiency in the serum level of pyridoxine which depends on the dose of INH, duration of treatment and the patient's nutritional and acetylator status. A 12-year-old girl developed tingling and numbness of the lower limbs after commencing anti-tuberculous therapy which included INH 10 mg/kg/day. The symptoms continued despite the dose being reduced to 5 mg/kg/day...
June 13, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29884976/acute-type-a-aortic-dissection-repair-in-an-octogenarian-with-achondroplasia-a-case-report
#6
Shuji Moriyama, Masahiko Hara, Yasushi Kaneko
BACKGROUND: Achondroplasia is an inherited disorder and the most common type of short-limbed dwarfism in human beings, affecting more than 250,000 individuals worldwide. To the best of our knowledge, no study has reported a correlation between achondroplasia and aortic dissection. Here, we report a rare case of acute type A aortic dissection repair in a patient with achondroplasia. CASE PRESENTATION: An 82-year-old Japanese female with achondroplasia was admitted to our hospital because of acute-onset severe chest pain migration to her back accompanied by numbness and pain in the right lower limb...
June 8, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29883818/successfully-conservative-management-of-delayed-cervical-spondylodiscitis-with-epidural-abscess-caused-by-esophageal-diverticulitis-a-case-report-and-review-of-literature
#7
Jinwei Ying, Shishen Pei, Linghao Su, Tianyong Wen, You Lv, Dike Ruan
BACKGROUND: Cervical spondylodiscitis with spinal epidural abscess (SEA) is not a rare medical condition that usually requires urgent decompression of neural structures and stabilization of the spine followed by antibiotic therapy for prevention from severe neurological deficits. CASE DESCRIPTION: In this report, we present a 43-year-old male patient with the chief complaint of neck pain and intermittent fever accompanying by slight dysphagia. After two weeks, he felt mild and transient numbness on the left upper limb...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29881530/medical-uses-of-carthamus-tinctorius-l-safflower-a-comprehensive-review-from-traditional-medicine-to-modern-medicine
#8
REVIEW
Elahe Delshad, Mahdi Yousefi, Payam Sasannezhad, Hasan Rakhshandeh, Zahra Ayati
Background: Carthamus tinctorius L. , known as Kafesheh (Persian) and safflower (English) is vastly utilized in Traditional Medicine for various medical conditions, namely dysmenorrhea, amenorrhea, postpartum abdominal pain and mass, trauma and pain of joints. It is largely used for flavoring and coloring purposes among the local population. Recent reviews have addressed the uses of the plant in various ethnomedical systems. Objective: This review was an update to provide a summary on the botanical features, uses in Iranian folklore and modern medical applications of safflower...
April 2018: Electronic Physician
https://www.readbyqxmd.com/read/29851841/when-dysphoria-is-not-a-primary-mental-state-a-case-report-of-the-role-of-the-aromatic-l-aminoacid-decarboxylase
#9
Simona Portaro, Agnese Gugliandolo, Domenico Scionti, Simona Cammaroto, Rosa Morabito, Salvatore Leonardi, Filippo Fraggetta, Placido Bramanti, Emanuela Mazzon
RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. PATIENT CONCERNS: We report the case of a Caucasian 43-year-old woman heterozygous for p.Ser250Phe in DDC, encoding for AADC with a positive family history for behavioral problems...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29779881/failure-of-tafamidis-to-halt-progression-of-ala36pro-ttr-oculomeningovascular-amyloidosis
#10
Fabrizio Salvi, Roberto Volpe, Francesca Pastorelli, Andrea Bianchi, Alessandra Vella, Claudio Rapezzi, Mario Mascalchi
Oculomeningovascular amyloidosis is a variant of transthyretin (TTR) amyloidotic polyneuropathy, which is associated with blindness and brain ischemia, microhemorrages, and siderosis due to prominent production of the abnormal TTR in the eye and in the choroid plexuses. Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy and of early-stage cardiomyopathy. However, the ocular manifestations of amyloid deposition progressed despite tafamidis therapy in Val30Met TTR amyloidosis, and the effects of tafamidis on meningovascular amyloidosis are unknown...
May 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29764822/numb-chin-syndrome-an-ominous-sign-of-mandibular-metastasis
#11
Abdul Razak, Bee See Goh, Jothi Raamahlingam Rajaran, Abd Jabar Nazimi
A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29729524/dysregulation-of-nrxn1-by-mutant-mir8485-leads-to-calcium-overload-in-pre-synapses-inducing-neurodegeneration-in-multiple-sclerosis
#12
Yogita Kattimani, Avinash M Veerappa
OBJECTIVES: To identify Damaging mutations in microRNAs (miRNAs) and 3' untranslated regions (UTRs) of target genes to establish Multiple sclerosis (MS) disease pathway. METHODS: Female aged 16, with Relapsing Remitting Multiple sclerosis (RRMS) was reported with initial symptoms of blurred vision, severe immobility, upper and lower limb numbness and backache. Whole Exome Sequencing (WES) and disease pathway analysis was performed to identify mutations in miRNAs and UTRs...
April 9, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29718880/various-clinical-features-of-patients-with-anti-hu-associated-paraneoplastic-neurological-syndromes-an-observational-study
#13
Jia Li, Weihong Lin
To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were analyzed.The study enrolled 6 female and 3 male patients. Three patients presented with vertigo and 6 patients exhibited a depressed mood, numbness of the lower limbs, generalized pains, seizures, mental disturbances, and a temporary unilateral hand tremor on initial presentation...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29703151/clinical-features-and-risk-factors-of-neurological-involvement-in-sj%C3%A3-gren-s-syndrome
#14
Wenjing Ye, Siyan Chen, Xinshi Huang, Wei Qin, Ting Zhang, Xiaofang Zhu, Xiaochun Zhu, Chongxiang Lin, Xiaobing Wang
BACKGROUND: To investigated distinct manifestations of Sjögren's syndrome (SS) patients with neurological complications and the potential risk factors associated with neurological complications in SS, and to produce a disease evaluation and neurological involvement prediction for SS. METHODS: 566 patients who fulfilled the 2002 classification criteria for SS from the Rheumatology Department of the First Affiliated Hospital of Wenzhou Medical University were included in the cross-sectional study...
April 27, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29702268/vascular-entrapment-of-both-the-sciatic-and-pudendal-nerves-causing-persistent-sciatica-and-pudendal-neuralgia
#15
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (educative video) (Canadian Task force classification II). The university's Ethics Committee ruled that approval was not required for this video. SETTING: Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey. PATIENT: A 26-year-old patient who had failed medical therapy and presented with complaints of numbness and burning pain on the right side of her vagina and pain radiating to her lower limbs for a period of approximately 36 months...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29698962/subacute-combined-degeneration-a-retrospective-study-of-68-cases-with-short-term-follow-up
#16
Jie Cao, Zhu-Yi Su, Sha-Bei Xu, Chen-Chen Liu
PURPOSE: The study aimed to analyze the clinical characteristics, laboratory test results, neuroimaging findings, and outcomes in patients diagnosed with subacute combined degeneration (SCD). MATERIALS AND METHODS: A total of 68 patients with SCD who had been appropriately treated for no less than 6 months were included in our study. Histories, results of routine blood tests, biochemical indices, serum vitamin B12 levels, and spinal magnetic resonance imaging (MRI) findings from the patients were studied and analyzed...
April 26, 2018: European Neurology
https://www.readbyqxmd.com/read/29682122/surgical-treatment-of-a-left-axillary-arterial-aneurysm-with-marfan-syndrome-by-combining-two-skin-incisions
#17
Hiroshi Sato, Syuichi Naraoka
An axillary arterial aneurysm is a rare disorder, with few surgical cases reported to date. Here we report the case of a left axillary arterial aneurysm associated with Marfan syndrome. A 44-year-old female with Marfan syndrome presented with numbness of the left upper limb and a pulsatile mass on the left chest. A computed tomography scan revealed a highly enlarged and tortuous left axillary arterial aneurysm. We performed a graft replacement and resection of the aneurysm with two skin incisions. After the surgery, the blood flow to the patient's left upper limb was confirmed, and the neurological symptoms improved significantly...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29678713/posterior-fossa-epidural-hematomas-a-rare-but-serious-complication-of-occipito-cervical-fusion-surgery
#18
Chang Rong Zhu, Jianhua Wang, Dai Jianqiang, Kun Chen, Xia Hong
BACKGROUND: Posterior occipito-cervical fusion surgery is a commonly used surgical method to treat various craniovertebral junction pathologies. Though it is an effective method, there also have been some reports about complications of occipito-cervical fusion. However, there have been no reports about posterior fossa epidural hematomas after occipito-cervical fusion. CASE DESCRIPTION: A 44-year-old female was referred to our Hospital with a 6-month history of neck pain and numbness limbs for 2 months...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678710/pediatric-type-follicular-lymphoma-in-the-dura-a-case-report-and-literature-review
#19
Junya Yamaguchi, Seiichi Kato, Eri Iwata, Kosuke Aoki, Ryusuke Kabeya, Atsushi Natsume, Toshihiko Wakabayashi
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a relatively common tumor of the central nervous system. Although PCNSLs generally arise from the parenchyma, lymphomas arising primarily from the dura are termed dural lymphomas (DL). Mucosa-associated lymphoid tissue is the most unique histological feature of DL. Due to its rarity, clinical characteristics and treatments for DL have not been fully elucidated to date. CASE DESCRIPTION: A 31-year-old man with no past medical history presented with numbness in his left upper limb...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678429/intercostal-entrapment-of-clavicle-fracture-causing-a-pulseless-flaccid-upper-extremity
#20
Chase Kluemper, Tyler Koestner, Justin Cowart, Matt Higgins
Limb-threatening vascular compromise from an isolated closed clavicle fracture is exceedingly rare. We report a case of a posteriorly angulated, closed clavicle fracture segment causing right upper-extremity ischemia, numbness, and paresis caused by entrapment of the clavicle between the first and second ribs.
April 17, 2018: Journal of Hand Surgery
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