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aminoglycoside ototoxicity

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https://www.readbyqxmd.com/read/28155306/an-audiological-profile-of-patients-infected-with-multi-drug-resistant-tuberculosis-at-a-district-hospital-in-kwazulu-natal
#1
Delicia Appana, Lavanithum Joseph, Jessica Paken
BACKGROUND: The increased incidence of multi-drug-resistant tuberculosis (MDR-TB) and the consequent use of aminoglycosides with their ototoxic potential necessitate a better understanding of the audiological pattern of infected patients. OBJECTIVE: To describe the occurrence and nature of hearing loss in patients with MDR-TB receiving aminoglycosides over a period of 6 months. METHODS: Baseline and five consecutive monthly audiological assessments were conducted on 52 adults at a hospital in KwaZulu-Natal...
November 25, 2016: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28149894/finding-ways-to-solve-or-prevent-aminoglycoside-induced-ototoxicity
#2
COMMENT
Jin Li, Connie W Woo
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28145495/autophagic-flux-a-possible-mechanism-for-delayed-gentamicin-induced-ototoxicity
#3
Yeon Ju Kim, Chunjie Tian, Jangho Kim, Beomyong Shin, Oak-Sung Choo, You-Sun Kim, Yun-Hoon Choung
Aminoglycoside antibiotics including gentamicin (GM) induce delayed ototoxic effects such as hearing loss after long-term use, unlike the early-onset ototoxicity caused by cisplatin. The purpose of the study was to identify the mechanism of the delayed GM-induced ototoxicity by exploring the role of autophagy in vitro and in vivo. Treating HEI-OC1 auditory cells with GM led to a time-dependent increase of the autophagosome marker LC3-II, which was accompanied by cell death. In contrast, cisplatin and penicillin caused a rapid increase and had no effect on LC3-II levels, respectively...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077265/a-smart-aminoglycoside-hydrogel-with-tunable-gel-degradation-on-demand-drug-release-and-high-antibacterial-activity
#4
Jingjing Hu, Yanchun Quan, Yuping Lai, Zhao Zheng, Zhiqi Hu, Xinyu Wang, Tianjiao Dai, Qiang Zhang, Yiyun Cheng
Aminoglycosides are a family of critically important antibiotics for the treatment of serious infections including multidrug-resistant pathogens. However, clinical use of aminoglycoside antibiotics is compromised by bacterial biofilm formation at subinhibitory concentrations or adverse side effects such as ototoxicity and nephrotoxicity at high antibiotic doses. Preparation of aminoglycoside formulation that allows on-demand drug delivery is a solution to this sticky issue. Here, we designed a new type of aminoglycoside hydrogels by cross-linking oxidized polysaccharides such as dextran, carboxymethyl cellulose, alginate, and chondroitin using aminoglycosides as cross-linkers...
January 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28012509/changes-in-the-inner-ear-structures-in-cystic-fibrosis-patients
#5
Henrique F Pauna, Rafael C Monsanto, Natsuko Kurata, Michael M Paparella, Sebahattin Cureoglu
OBJECTIVE: Although prolonged use of antibiotics is very common in cystic fibrosis (CF) patients, no studies have assessed the changes in both cochlear and peripheral vestibular systems in this population. METHODS: We used human temporal bones to analyze the density of vestibular dark, transitional, and hair cells in specimens from CF patients who were exposed to several types of antibiotics, as compared with specimens from an age-matched control group with no history of ear disease or antibiotic use...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28002638/drug-induced-ototoxicity-mechanisms-pharmacogenetics-and-protective-strategies
#6
REVIEW
C Lanvers-Kaminsky, Ag Am Zehnhoff-Dinnesen, R Parfitt, G Ciarimboli
Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed...
December 21, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27942103/gentamicin-mediated-ototoxicity-and-nephrotoxicity-a-clinical-trial-study
#7
Parviz Saleh, Shamsi Abbasalizadeh, Saman Rezaeian, Mohammad Naghavi-Behzad, Reza Piri, Hojjat Hossein Pourfeizi
BACKGROUND: Aminoglycosides and mainly gentamicin are the most important antimicrobial agents. Two different methods of administration exist: Single and multiple doses. There has always been a controversy about the less harmful administration method, to minimize adverse effects of gentamicin - deafness and renal insufficiency. In this study, it was aimed to compare two different methods of administration to figure out the least harmful treatment method. MATERIALS AND METHODS: In a clinical study, eighty patients aged 12-55 years who were admitted with sepsis syndrome were included in the study; they were divided into two groups: The first group received single-dose treatment (5 mg/kg) whereas the second group was treated with multiple doses (1...
November 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27896487/natural-compounds-as-occult-ototoxins-ginkgo-biloba-flavonoids-moderately-damage-lateral-line-hair-cells
#8
Sarah Neveux, Nicole K Smith, Anna Roche, Bruce E Blough, Wimal Pathmasiri, Allison B Coffin
Several drugs, including aminoglycosides and platinum-based chemotherapy agents, are well known for their ototoxic properties. However, FDA-approved drugs are not routinely tested for ototoxicity, so their potential to affect hearing often goes unrecognized. This issue is further compounded for natural products, where there is a lack of FDA oversight and the manufacturer is solely responsible for ensuring the safety of their products. Natural products such as herbal supplements are easily accessible and commonly used in the practice of traditional eastern and alternative medicine...
November 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27868278/differences-in-vigibase%C3%A2-reporting-of-aminoglycoside-and-capreomycin-suspected-ototoxicity-during-tuberculosis-treatment
#9
Evans L Sagwa, Patrick C Souverein, Inês Ribeiro, Hubert G M Leufkens, Aukje K Mantel-Teeuwisse
PURPOSE: To evaluate the association between the use of streptomycin, amikacin, kanamycin and capreomycin in tuberculosis (TB) treatment and the pharmacovigilance reporting of ototoxicity (deafness or hearing loss, tinnitus and vertigo). Second, to analyze patient demographic and geographic factors that influence the reporting of ototoxicity in TB treatment. METHODS: A case/non-case disproportionality analysis of the VigiBase® individual case safety reports (ICSRs) of patients treated for TB using multidrug regimens that contain either of streptomycin, amikacin, kanamycin or capreomycin...
November 20, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27855522/melatonin-mitigates-neomycin-induced-hair-cell-injury-in-zebrafish
#10
Kyoung Ho Oh, Yoon Chan Rah, Kyu Ho Hwang, Seung Hoon Lee, Soon Young Kwon, Jae Hyung Cha, June Choi
CONTEXT: Ototoxicity due to medications, such as aminoglycosides, is irreversible, and free radicals in the inner ear are assumed to play a major role. Because melatonin has an antioxidant property, we hypothesize that it might mitigate hair cell injury by aminoglycosides. OBJECTIVE: The objective of this study was to evaluate whether melatonin has an alleviative effect on neomycin-induced hair cell injury in zebrafish (Danio rerio). METHODS: Various concentrations of melatonin were administered to 5-day post-fertilization zebrafish treated with 125 μM neomycin for 1 h...
November 18, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27832910/clinical-predictors-of-aminoglycoside-induced-ototoxicity-in-drug-resistant-tuberculosis-patients-on-intensive-therapy
#11
Olusola Ayodele Sogebi, Bolanle Olufunlola Adefuye, Stephen Oluwatosin Adebola, Susan Modupe Oladeji, Taiwo Olugbemiga Adedeji
OBJECTIVE: The study objectives were to determine the incidence of aminoglycoside-induced ototoxicity in institutionalized patients on intensive phase of therapy for drug-resistant Tuberculosis (DR Tb) and also to assess clinical factors which could predict the ototoxicity. METHODS: The study was a prospective analytical study among consecutive DR Tb patients who were admitted for intensive phase of therapy (of 4 months) at the DR-Tb center over a 12-month period...
November 7, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27745736/evaluation-of-apramycin-activity-against-carbapenem-resistant-and-susceptible-strains-of-enterobacteriaceae
#12
Kenneth P Smith, James E Kirby
We evaluated activity of apramycin, a non-ototoxic/non-nephrotoxic aminocyclitol against 141 clinical Enterobacteriaceae isolates, 51% of which were non-susceptible to carbapenems (CRE). Among CRE, 70.8% were apramycin susceptible, which compared favorably to aminoglycosides in current clinical use. Our data suggest that apramycin deserves further investigation as a repurposed, anti-CRE therapeutic.
December 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27729156/analysis-of-genetic-and-non-genetic-risk-factors-for-cisplatin-ototoxicity-in-pediatric-patients
#13
Yüksel Olgun, Safiye Aktaş, Zekiye Altun, Günay Kırkım, Deniz Çakır Kızmazoğlu, Ayşe Pınar Erçetin, Banu Demir, Dilek İnce, Kamer Mutafoğlu, Bengü Demirağ, Hülya Ellidokuz, Nur Olgun, Enis Alpin Güneri
OBJECTIVE: The aim of this study was to analyse the genetic and non genetic risk factors for cisplatin ototoxicity. METHODS: This study was conducted on 72 children who received cisplatin based chemotherapy. Brock and Muenster classifications were used to evaluate ototoxicity seen in these children. 6 single nucleotide polymorphisms (SNP); ERCC1 rs 11615, GSTP1 rs1138272, GSTP1 rs1695, LRP2 rs 2075252, TPMT rs 12201199, COMT rs 9332377, were evaluated as genetic factors by real time PCR...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27638075/bilateral-vestibulopathy
#14
REVIEW
M Strupp, K Feil, M Dieterich, T Brandt
The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait that worsens in darkness and on uneven ground. There are typically no symptoms while sitting or lying under static conditions. A minority of patients also have movement-induced oscillopsia, in particular while walking. The diagnosis of BVP is based on a bilaterally reduced or absent function of the vestibulo-ocular reflex (VOR). This deficit is diagnosed for the high-frequency range of the angular VOR by a bilaterally pathologic bedside head impulse test (HIT) and for the low-frequency range by a bilaterally reduced or absent caloric response...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27631653/role-of-stat1-and-oxidative-stress-in-gentamicin-induced-hair-cell-death-in-organ-of-corti
#15
Peng Jiang, Amrita Ray, Leonard P Rybak, Michael J Brenner
RATIONALE: Oxidative stress plays a critical role in gentamicin-induced hair cell death. Previous work has implicated the cytoplasmic transcription factor signal transducer and activator of transcription 1 (STAT1) as a potential mediator of drug-induced ototoxicity, but role in aminoglycosides is largely unknown. This study investigated aminoglycosides-induced cell death, exploring contributions of reactive oxygen species and STAT1 pathway in injury and protection. METHODS: Neonatal murine organ of Corti explants from 2 to 3 day postnatal pups (n = 96) were treated with gentamicin at (4 μM, 50 μM) for 4 to 72 hours, with/without protectants...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27623314/synthesis-and-antiribosomal-activities-of-4-o-6-o-4%C3%A2-o-4-6-o-and-4%C3%A2-6%C3%A2-o-derivatives-in-the-kanamycin-series-indicate-differing-target-selectivity-patterns-between-the-4-5-and-4-6-series-of-disubstituted-2-deoxystreptamine-aminoglycoside-antibiotics
#16
Takayuki Kato, Guanyu Yang, Youjin Teo, Reda Juskeviciene, Déborah Perez-Fernandez, Harish M Shinde, Sumanth Salian, Bruno Bernet, Andrea Vasella, Erik C Böttger, David Crich
Chemistry for the efficient modification of the kanamycin class of 4,6-aminoglycosides at the 4'-position is presented. In all kanamycins but kanamycin B, 4'-O-alkylation is strongly detrimental to antiribosomal and antibacterial activity. Ethylation of kanamycin B at the 4″-position entails little loss of antiribosomal and antibacterial activity, but no increase of ribosomal selectivity. These results are contrasted with those for the 4,5-aminoglycosides, where 4'-O-alkylation of paromomycin causes only a minimal loss of activity but results in a significant increase in selectivity with a concomitant loss of ototoxicity...
October 9, 2015: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27556499/inhibition-of-arc-decreases-the-survival-of-hei-oc-1-cells-after-neomycin-damage-in-vitro
#17
Ming Guan, Qiaojun Fang, Zuhong He, Yong Li, Fuping Qian, Xiaoyun Qian, Ling Lu, Xiaoli Zhang, Dingding Liu, Jieyu Qi, Shasha Zhang, Mingliang Tang, Xia Gao, Renjie Chai
Hearing loss is a common sensory disorder mainly caused by the loss of hair cells (HCs). Noise, aging, and ototoxic drugs can all induce apoptosis in HCs. Apoptosis repressor with caspase recruitment domain(ARC) is a key factor in apoptosis that inhibits both intrinsic and extrinsic apoptosis pathways; however, there have been no reports on the role of ARC in HC loss in the inner ear. In this study, we used House Ear Institute Organ of Corti 1 (HEI-OC-1) cells, which is a cochlear hair-cell-like cell line, to investigate the role of ARC in aminoglycoside-induced HC loss...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27494904/amikacin-use-and-therapeutic-drug-monitoring-in-adults-do-dose-regimens-and-drug-exposures-affect-either-outcome-or-adverse-events-a-systematic-review
#18
REVIEW
Abi Jenkins, Alison H Thomson, Nicholas M Brown, Yvonne Semple, Christine Sluman, Alasdair MacGowan, Andrew M Lovering, Phil J Wiffen
OBJECTIVES: The objectives of this study were to identify the amikacin dosage regimens and drug concentrations consistent with good outcomes and to determine the drug exposures related to nephrotoxicity and ototoxicity. METHODS: A literature review was conducted in Medline, EMBASE and the Cochrane Central Register of Controlled Trials. Full journal articles reporting randomized controlled trials, controlled clinical trials, interrupted time series trials, and controlled before and after studies involving amikacin therapeutic drug monitoring (TDM) and dose adjustment were considered for inclusion...
October 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27486906/platinum-induced-hearing-loss-after-treatment-for-childhood-cancer
#19
REVIEW
Jorrit W van As, Henk van den Berg, Elvira C van Dalen
BACKGROUND: Platinum-based therapy, including cisplatin, carboplatin, oxaliplatin or a combination of these, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. There is a wide variation in the reported prevalence of platinum-induced ototoxicity and the associated risk factors. More insight into the prevalence of and risk factors for platinum-induced hearing loss is essential in order to develop less ototoxic treatment protocols for the future treatment of children with cancer and to develop adequate follow-up protocols for childhood cancer survivors treated with platinum-based therapy...
August 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27429949/audiological-evaluation-of-patients-taking-kanamycin-for-multidrug-resistant-tuberculosis
#20
Vishal Sharma, Sanjeev Bhagat, Bhimsain Verma, Ravinder Singh, Surinderpal Singh
INTRODUCTION: The incidence of multidrug resistant tuberculosis is increasing in developing countries. Aminoglycosides are an integral part of second-line drugs, however ototoxicity is a major limitation for their use. This study aims to determine the extent of hearing loss in patients taking one of the commonly prescribed drugs for Multidrug resistant tuberculosis (MDR-TB), Kanamycin, at a Government Medical College, Patiala, Punjab, India, which is a 1200 bed tertiary care hospital...
May 2016: Iranian Journal of Otorhinolaryngology
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