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https://www.readbyqxmd.com/read/29679679/activation-of-cyclic-gmp-dependent-protein-kinase-blocks-alcohol-mediated-cell-death-and-calcium-disruption-in-cerebellar-granule-neurons
#1
Dimitrios E Kouzoukas, Ramesh C Bhalla, Nicholas J Pantazis
Alcohol during brain development leads to the widespread neuronal death observed in fetal alcohol spectrum disorders (FASD). In comparison, the mature brain is less vulnerable to alcohol. Studies into maturation-acquired alcohol resistance uncovered a protective mechanism that reduces alcohol-induced neuronal death through nitric oxide-cGMP-cyclic GMP-dependent protein kinase (NO-cGMP-cGK) signaling. However, the downstream processes underlying this neuroprotection remain unclear. Alcohol can disrupt levels of intracellular calcium ([Ca2+ ]i ) in vulnerable neuronal populations to trigger cell death in both in vivo and in vitro models of FASD...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29672868/fetal-cerebral-circulation-as-target-of-maternal-alcohol-consumption
#2
Anna N Bukiya, Alex M Dopico
Alcohol (ethanol) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the US. The etiology of FAS/FASD remains poorly understood...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29672865/dietary-iron-fortification-normalizes-fetal-hematology-hepcidin-and-iron-distribution-in-a-rat-model-of-prenatal-alcohol-exposure
#3
Shane M Huebner, Kaylee K Helfrich, Nipun Saini, Sharon E Blohowiak, Adrienne A Cheng, Pamela J Kling, Susan M Smith
BACKGROUND: Prenatal alcohol exposure (PAE) causes neurodevelopmental disability. Clinical and animal studies show gestational iron deficiency exacerbates PAE's behavioral and growth deficits. In rat, PAE manifests an inability to establish iron homeostasis, increasing hepcidin (maternal and fetal) and fetal liver iron while decreasing brain iron and promoting anemia. Here, we hypothesize dietary iron fortification during pregnancy may mitigate alcohol's disruption of fetal iron homeostasis...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29658509/-experimental-approaches-to-the-investigation-of-behavioral-disorders-associated-with-prenatal-alcohol-exposure
#4
E V Razumkina, P K Anokhin, T V Proskuryakova, I Yu Shamakina
Fetal alcohol spectrum disorders (FASD) is an umbrella term which covers a wide range of deficits in prenatal and postnatal growth, anatomy and CNS functions produced by prenatal alcohol exposure. The most severe form of FASD is fetal alcohol syndrome (FAS) characterized by additional specific craniofacial and brain malformations. Despite a high prevalence and extensive clinical studies, the fundamental mechanisms of FASD are still poorly understood. Thereby, experimental models, which allow better control for both socio-environmental and genetic factors, are critical to our understanding of FASD...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29623043/developmental-ethanol-exposure-causes-reduced-feeding-and-reveals-a-critical-role-for-neuropeptide-f-in-survival
#5
Amanda Guevara, Hillary Gates, Brianna Urbina, Rachael French
Food intake is necessary for survival, and natural reward circuitry has evolved to help ensure that animals ingest sufficient food to maintain development, growth, and survival. Drugs of abuse, including alcohol, co-opt the natural reward circuitry in the brain, and this is a major factor in the reinforcement of drug behaviors leading to addiction. At the junction of these two aspects of reward are alterations in feeding behavior due to alcohol consumption. In particular, developmental alcohol exposure (DAE) results in a collection of physical and neurobehavioral disorders collectively referred to as Fetal Alcohol Spectrum Disorder (FASD)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29602689/benefits-of-caseload-midwifery-to-prevent-fetal-alcohol-spectrum-disorder-a-discussion-paper
#6
Natasha Reid, Jenny Gamble, Debra K Creedy, Amy Finlay-Jones
BACKGROUND: Exposure to alcohol prenatally can result in a child being diagnosed with fetal alcohol spectrum disorder. Affected infants experience lifelong impairments that can involve, physical, cognitive, behavioural and emotional difficulties that impact on their functional capacity. Effective prevention of fetal alcohol spectrum disorder is critically needed in Australia. Reduction in the prevalence of this disorder will only be possible if we prevent alcohol consumption during pregnancy...
March 27, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29582069/global-prevalence-of-fetal-alcohol-spectrum-disorder-in-italy-reply
#7
Shannon Lange, Jürgen Rehm, Svetlana Popova
No abstract text is available yet for this article.
March 26, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29582047/global-prevalence-of-fetal-alcohol-spectrum-disorder-in-italy
#8
Simona Pichini, Roberta Pacifici, Francesco Paolo Busardò
No abstract text is available yet for this article.
March 26, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29581212/study-protocol-for-a-self-controlled-cluster-randomised-trial-of-the-alert-program-to-improve-self-regulation-and-executive-function-in-australian-aboriginal-children-with-fetal-alcohol-spectrum-disorder
#9
Bree Wagner, James P Fitzpatrick, Trevor G Mazzucchelli, Martyn Symons, Heather Carmichael Olson, Tracy Jirikowic, Donna Cross, Edie Wright, Emma Adams, Maureen Carter, Kaashifah Bruce, Jane Latimer
INTRODUCTION: While research highlights the benefits of early diagnosis and intervention for children with fetal alcohol spectrum disorders (FASD), there are limited data documenting effective interventions for Australian children living in remote communities. METHODS AND ANALYSIS: This self-controlled cluster randomised trial is evaluating the effectiveness of an 8-week Alert Program school curriculum for improving self-regulation and executive function in children living in remote Australian Aboriginal communities...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#10
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
March 20, 2018: Alcohol
https://www.readbyqxmd.com/read/29569352/have-we-done-enough-for-people-with-fetal-alcohol-spectrum-disorders
#11
Ilona Autti-Rämö
No abstract text is available yet for this article.
March 22, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29561633/drug-exposure-during-pregnancy-analytical-methods-and-toxicological-findings
#12
Marta Concheiro, Marilyn A Huestis
Drug use during pregnancy constitutes a major preventable worldwide public health issue. Birth defects, growth retardation and neurodevelopmental disorders are associated with tobacco, alcohol or drugs of abuse exposure during pregnancy. Besides these adverse health effects, drug use during pregnancy also raises legal and social concerns. Identification and quantification of drug markers in maternal and newborn biological samples offers objective evidence of exposure and complements maternal questionnaires...
March 21, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29555138/optimizing-an-ehealth-insomnia-intervention-for-children-with-neurodevelopmental-disorders-a-delphi-study
#13
Nicole Ali, Gabrielle Rigney, Shelly K Weiss, Cary A Brown, Evelyn Constantin, Roger Godbout, Ana Hanlon-Dearman, Osman Ipsiroglu, Graham J Reid, Sarah Shea, Isabel M Smith, Machiel Van der Loos, Penny V Corkum
Insomnia, which is related to daytime deficits and is a common problem for children with neurodevelopmental disorders (NDDs), is often successfully treated with behavioral strategies. However, there are barriers to accessing these treatments, and there has been little research examining what these interventions need to be usable and effective. The goal of this study was to gain consensus from experts in the field on the key components of an eHealth, parent-implemented, intervention program aimed at improving sleep in children with attention-deficit/hyperactivity disorder, autism spectrum disorder, cerebral palsy, and fetal alcohol spectrum disorder...
April 2018: Sleep Health
https://www.readbyqxmd.com/read/29551660/fetal-alcohol-spectrum-disorders-fasd-what-we-know-and-what-we-should-know-the-knowledge-of-german-health-professionals-and-parents
#14
Mirjam N Landgraf, Lucia Albers, Birte Rahmsdorf, Katharina Vill, Lucia Gerstl, Michaela Lippert, Florian Heinen
OBJECTIVE: The objective of our study was to evaluate the knowledge about fetal alcohol spectrum disorders (FASD) and the implementation of the German guideline for FASD among different professionals in the health and social system and among parents with children with FASD. METHODS: A questionnaire about FASD, containing 20 items, was sent by post to all children's hospitals (n = 287), all hospitals for child and adolescent psychiatry (n = 173), all social paediatric centres (n = 162), all neuropaediatricians (n = 129) and all youth welfare offices (n = 672) in Germany...
March 2, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29550584/proceedings-of-the-2017-annual-meeting-of-the-fetal-alcohol-spectrum-disorders-study-group
#15
REVIEW
Jeffrey R Wozniak, Anna Y Klintsova, Derek A Hamilton, Sandra M Mooney
The 2017 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was titled "Prenatal alcohol exposure in the context of multiple factors affecting brain development." The theme was reflected in the interactions between members of the Teratology Society and the FASDSG this year. The first keynote speaker, Elaine Faustman, Ph.D., was a liaison between the societies and spoke about systems biology and the multiple genetic and environmental influences on development. The second keynote speaker, Rebecca Knickmeyer, Ph...
November 1, 2017: Alcohol
https://www.readbyqxmd.com/read/29548503/fetal-alcohol-spectrum-disorder-and-the-criminal-justice-system-a-systematic-literature-review
#16
REVIEW
Katherine Flannigan, Jacqueline Pei, Michelle Stewart, Alexandra Johnson
No abstract text is available yet for this article.
March 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29544375/obstetric-and-perinatal-outcomes-in-pregnancies-with-isolated-fetal-congenital-heart-abnormalities
#17
Cathy Liu, Jade Lodge, Christopher Flatley, Alexander Gooi, Cameron Ward, Karen Eagleson, Sailesh Kumar
OBJECTIVE: To determine obstetric, intrapartum and perinatal outcomes for pregnancies with isolated fetal congenital heart defects (CHD). METHODS: This was a retrospective cohort study of women that delivered an infant with an isolated major CHD between January 2010 and April 2017 at a major Australian perinatal centre. The study cohort was compared with a cohort of women with infants without CHD. Cardiac abnormalities were broadly subdivided into the following five categories using the International Classification of Diseases Tenth Revision (ICD-10) as a guide - transposition of the great arteries (TGA), septal defects, right heart lesions (RHL), left heart lesions (LHL) and "other"...
March 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29544064/translating-to-the-community-t2c-a-protocol-paper-describing-the-development-of-canada-s-first-social-epigenetic-fasd-biobank
#18
Brenda Si Elias, Ana Hanlon-Dearman, Betty Head, Geoffrey G Hicks
Translating to the Community (T2C) is a social bio-repository designed to advance new diagnostic tools and realign community-clinical processes, with the aim to mitigate the short-and-long term impacts of Fetal Alcohol Spectrum Disorder (FASD), prenatal alcohol exposure, and its co-morbidities and behaviors. In this paper, we describe the evolution of this repository as a new translational partnership to advance a precision medicine approach to FASD. Key to its evolution was a partnership between academic researchers, Indigenous communities, families and a regional diagnostic clinic...
March 15, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29533680/copy-number-variation-in-fetal-alcohol-spectrum-disorder
#19
Mehdi Zarrei, Geoffrey G Hicks, James N Reynolds, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Molly Pind, Sylvia Lamoureux, John Wei, Zhouzhi Wang, Christian R Marshall, Richard F Wintle, Albert E Chudley, Stephen W Scherer
Fetal alcohol spectrum disorder (FASD) is characterized by a combination of neurological, developmental, and congenital defects that may occur as a consequence of prenatal alcohol exposure. Earlier reports showed that large chromosomal anomalies may link to FASD. Here, we examined the prevalence and types of copy number variations (CNVs) in FASD cases previously diagnosed by a multidisciplinary FASD team in sites across Canada. We genotyped 95 children with FASD and 87 age-matched, typically developing controls on the Illumina Human Omni2...
March 13, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29527911/alcohol-and-fetoplacental-vasoconstrictor-reactivity
#20
V Jakoubek, V Hampl
Alcohol abuse during pregnancy is a well-known factor in fetal morbidity, including smaller fetal size. We have shown that chronic hypoxia, considered the main pathogenetic factor in intrauterine growth restriction, elevates fetoplacental vascular resistance (and vasoconstrictor reactivity) and thus, presumably, reduces placental blood flow. We thus hypothesized that alcohol may affect the fetus - in addition to other mechanisms - by altering fetoplacental vascular resistance and/or reactivity. Using isolated, double-perfused rat placenta model, we found that maternal alcohol intake in the last third of gestation doubled the vasoconstrictor responses to angiotensin II but did not affect resting vascular resistance...
March 12, 2018: Physiological Research
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