keyword
https://read.qxmd.com/read/38647029/strontium-silicon-calcium-releasing-hierarchically-structured-3d-printed-scaffolds-accelerate-osteochondral-defect-repair
#21
JOURNAL ARTICLE
Cheng Ji Li, Jeong-Hui Park, Gang Shi Jin, Nandin Mandakhbayar, Donghyeon Yeo, Jun Hee Lee, Jung-Hwan Lee, Hye Sung Kim, Hae-Won Kim
Articular cartilage defects are a global challenge, causing substantial disability. Repairing large defects is problematic, often exceeding cartilage's self-healing capacity and damaging bone structures. To tackle this problem, we develop a scaffold-mediated therapeutic ion delivery system. These scaffolds are constructed from poly(ε-caprolactone) and strontium (Sr)-doped bioactive nanoglasses (SrBGn), creating a unique hierarchical structure featuring macro-pores from 3D printing, micro-pores, and nano-topologies due to SrBGn integration...
April 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38647021/repurposing-of-antifungal-drug-flucytosine-flucytosine-cocrystals-for-anticancer-activity-against-prostate-cancer-targeting-apoptosis-and-inflammatory-signaling-pathways
#22
JOURNAL ARTICLE
Manimurugan Kanagavel, Rajan Marystella Sparjan Samuvel, Vaikundamoorthy Ramalingam, Sunil Kumar Nechipadappu
This study aimed to repurpose the antifungal drug flucytosine (FCN) for anticancer activity together with cocrystals of nutraceutical coformers sinapic acid (SNP) and syringic acid (SYA). The cocrystal screening experiments with SNP resulted in three cocrystal hydrate forms in which two are polymorphs, namely, FCN-SNP F-I and FCN-SNP F-II, and the third one with different stoichiometry in the asymmetric unit (1:2:1 ratio of FCN:SNP:H2 O, FCN-SNP F-III). Cocrystallization with SYA resulted in two hydrated cocrystal polymorphs, namely, FCN-SYA F-I and FCN-SYA F-II...
April 22, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38646942/neuronal-mechanisms-regulating-locomotion-in-adult-drosophila
#23
REVIEW
Swetha B M Gowda, Ayesha Banu, Sadam Hussain, Farhan Mohammad
The coordinated action of multiple leg joints and muscles is required even for the simplest movements. Understanding the neuronal circuits and mechanisms that generate precise movements is essential for comprehending the neuronal basis of the locomotion and to infer the neuronal mechanisms underlying several locomotor-related diseases. Drosophila melanogaster provides an excellent model system for investigating the neuronal circuits underlying motor behaviors due to its simple nervous system and genetic accessibility...
April 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38646925/rose-bengal-photodynamic-therapy-rb-pdt-modulates-the-inflammatory-response-in-lps-stimulated-human-corneal-fibroblasts-by-influencing-nf-%C3%AE%C2%BAb-and-p38-mapk-signaling-pathways
#24
JOURNAL ARTICLE
Ning Chai, Tanja Stachon, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry
PURPOSE: To investigate the effect of rose bengal photodynamic therapy on lipopolysaccharide-induced inflammation in human corneal fibroblasts. Furthermore, to analyze potential involvement of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways in this process. METHODS: Human corneal fibroblast cultures underwent 0-2.0 µg/mL lipopolysaccharide treatment, and 24 h later rose bengal photodynamic therapy (0.001% RB, 565 nm wavelength illumination, 0...
April 22, 2024: Current Eye Research
https://read.qxmd.com/read/38646919/mir-146a-mice-model-reveals-that-nf-%C3%AE%C2%BAb-inhibition-reverts-inflammation-driven-myelofibrosis-like-phenotype
#25
JOURNAL ARTICLE
Ernesto José Cuenca-Zamora, Pedro J Guijarro-Carrillo, María J López-Poveda, María Luz Morales, María Luisa Lozano, Rocío Gonzalez-Conejero, Constantino Martínez, Raúl Teruel-Montoya, Francisca Ferrer-Marín
Emerging evidence shows the crucial role of inflammation (particularly NF-κB pathway) in the development and progression of myelofibrosis (MF), becoming a promising therapeutic target. Furthermore, tailoring treatment with currently available JAK inhibitors (such as ruxolitinib or fedratinib) does not modify the natural history of the disease and has important limitations, including cytopenias. Since recent studies have highlighted the role of miR-146a, a negative regulator of the NF-κB pathway, in the pathogenesis of MF; here we used miR-146a-/- (KO) mice, a MF-like model lacking driver mutations, to investigate whether pharmacological inhibition of JAK/STAT and/or NF-κB pathways may reverse the myelofibrotic phenotype of these mice...
April 22, 2024: American Journal of Hematology
https://read.qxmd.com/read/38646899/strategies-and-techniques-for-preclinical-therapeutic-targeting-of-pi3kin-oncology-where-do-we-stand-in-2024
#26
REVIEW
Yanyan Liu, Qiu Sun, Xiawei Wei
INTRODUCTION: The phosphatidylinositol-3-kinase (PI3K) pathway is a crucial intracellular signaling pathway involved in cell growth, proliferation, survival, and metabolism, which is aberrant in almos<u>t</u> all types of cancer. Extensive research is dedicated to elucidating the mechanisms of action and developing PI3K inhibitors. However, only a small portion of the research has been successfully translated into clinical applications. AREAS COVERED: In this review, we present an overview of the pivotal role that the PI3K pathway plays in tumor development...
April 22, 2024: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/38646849/network-pharmacology-and-molecular-docking-based-strategy-for-predicting-anti-tumour-mechanism-of-linarin
#27
JOURNAL ARTICLE
Jun Wang, Jingjing Cheng
The aim was to explore the anti-tumour mechanism of linarin (LIN) based on network pharmacology and molecular docking. PharmMapper database and GeneCards database were used to screen anti-tumour related targets of LIN. Enrichment analysis of GO and KEGG was conducted to predict the key targets and pathways. At last, LIN was docked with the key targets. ESR1, ESR2, EGFR, AR, TGFBR2, F2, MAPK10, MAPK14, CDK2 and HSP90AA1 were identified as the key targets. The key pathways included pathways in cancer, prostate cancer, pancreatic cancer and breast cancer...
April 22, 2024: Natural Product Research
https://read.qxmd.com/read/38646792/regulatory-interactions-between-daptomycin-and-bacitracin-responsive-pathways-coordinate-the-cell-envelope-antibiotic-resistance-response-of-enterococcus-faecalis
#28
JOURNAL ARTICLE
Sali M Morris, Laura Wiens, Olivia Rose, Georg Fritz, Tim Rogers, Susanne Gebhard
Enterococcal infections frequently show high levels of antibiotic resistance, including to cell envelope-acting antibiotics like daptomycin (DAP). While we have a good understanding of the resistance mechanisms, less is known about the control of such resistance genes in enterococci. Previous work unveiled a bacitracin resistance network, comprised of the sensory ABC transporter SapAB, the two-component system (TCS) SapRS and the resistance ABC transporter RapAB. Interestingly, components of this system have recently been implicated in DAP resistance, a role usually regulated by the TCS LiaFSR...
April 22, 2024: Molecular Microbiology
https://read.qxmd.com/read/38646789/sodium-glucose-co-transporter-1-promotes-the-bio-functions-of-perivascular-preadipocytes-mediated-by-akt-mtor-p70s6k-signaling-pathway
#29
JOURNAL ARTICLE
Zhiquan Liu, Jiayu Wang, Peiqing Tian, Yixuan Liu, Liyun Xing, Caihua Fu, Xianwei Huang, Ping Liu
The influence of SGLT-1 on perivascular preadipocytes (PVPACs) and vascular remodeling is not well understood. This study aimed to elucidate the role and mechanism of SGLT-1-mediated PVPACs bioactivity. PVPACs were cultured in vitro and applied ex vivo to the carotid arteries of mice using a lentivirus-based thermosensitive in situ gel (TISG). The groups were treated with Lv-SGLT1 (lentiviral vector, overexpression), Lv-siSGLT1 (RNA interference, knockdown), or specific signaling pathway inhibitors. Assays were conducted to assess changes in cell proliferation, apoptosis, glucose uptake, adipogenic differentiation, and vascular remodeling in the PVPACs...
April 22, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38646654/the-hsp90-inhibitor-hvh-2930-exhibits-potent-efficacy-against-trastuzumab-resistant-her2-positive-breast-cancer
#30
JOURNAL ARTICLE
Minsu Park, Eunsun Jung, Jung Min Park, Soeun Park, Dongmi Ko, Juyeon Seo, Seongjae Kim, Kee Dal Nam, Yong Koo Kang, Lee Farrand, Van-Hai Hoang, Cong-Truong Nguyen, Minh Thanh La, Gibeom Nam, Hyun-Ju Park, Jihyae Ann, Jeewoo Lee, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo
Rationale: Resistance to targeted therapies like trastuzumab remains a critical challenge for HER2-positive breast cancer patients. Despite the progress of several N-terminal HSP90 inhibitors in clinical trials, none have achieved approval for clinical use, primarily due to issues such as induction of the heat shock response (HSR), off-target effects, and unfavorable toxicity profiles. We sought to examine the effects of HVH-2930, a novel C-terminal HSP90 inhibitor, in overcoming trastuzumab resistance. Methods: The effect of HVH-2930 on trastuzumab-sensitive and -resistant cell lines in vitro was evaluated in terms of cell viability, expression of HSP90 client proteins, and impact on cancer stem cells...
2024: Theranostics
https://read.qxmd.com/read/38646649/disturbed-flow-impairs-mertk-mediated-efferocytosis-in-aortic-endothelial-cells-during-atherosclerosis
#31
JOURNAL ARTICLE
Jinzi Wu, Shijie Liu, Oishani Banerjee, Hang Shi, Bingzhong Xue, Zufeng Ding
Background: MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for efferocytosis, a process for the clearance of apoptotic cells. MerTK is mainly expressed in macrophages and immature dendritic cells. There are very limited reports focused on MerTK biology in aortic endothelial cells (ECs). It remains unclear for the role of blood flow patterns in regulating MerTK-mediated efferocytosis in aortic ECs. This study was designed to investigate whether endothelial MerTK and EC efferocytosis respond to blood flow patterns during atherosclerosis...
2024: Theranostics
https://read.qxmd.com/read/38646644/hepatic-progenitor-cell-originated-ductular-reaction-facilitates-liver-fibrosis-through-activation-of-hedgehog-signaling
#32
JOURNAL ARTICLE
Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Jian Ping, Hua Zhang, Yongping Mu, Chenghai Liu, Chao-Po Lin, Jian Wu, Ping Liu, Jiamei Chen
Background: It is poorly understood what cellular types participate in ductular reaction (DR) and whether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study is to gain insights into the role of hepatic progenitor cell (HPC)-originated DR during fibrotic progression. Methods: DR in liver specimens of PBC, chronic HBV infection (CHB) or NAFLD, and four rodent fibrotic models by different pathogenic processes was evaluated. Gli1 expression was inhibited in rodent models or cell culture and organoid models by AAV-sh Gli1 or treating with GANT61...
2024: Theranostics
https://read.qxmd.com/read/38646639/il4-receptor-targeting-enables-nab-paclitaxel-to-enhance-reprogramming-of-m2-type-macrophages-into-m1-like-phenotype-via-ros-hmgb1-tlr4-axis-and-inhibition-of-tumor-growth-and-metastasis
#33
JOURNAL ARTICLE
Sri Murugan Poongkavithai Vadevoo, Yeoul Kang, Gowri Rangaswamy Gunassekaran, Seok-Min Lee, Min-Sung Park, Dong Gyun Jo, Sang-Kyun Kim, Ho Lee, Won Jong Kim, Byungheon Lee
Rationale: Nab-paclitaxel (Abx) is widely employed in malignant tumor therapy. In tumor cells and pro-tumoral M2-type macrophages, the IL4 receptor (IL4R) is upregulated. This study aimed to elucidate the selective delivery of Abx to M2-type macrophages by targeting IL4R and reprogramming them into an anti-tumoral M1-type. Methods: Abx was conjugated with the IL4R-binding IL4RPep-1 peptide using click chemistry (IL4R-Abx). Cellular internalization, macrophage reprogramming and signal pathways, and tumor growth and metastasis by IL4R-Abx were examined...
2024: Theranostics
https://read.qxmd.com/read/38646636/bibliometric-analysis-and-visualization-of-quorum-sensing-research-over-the-last-two-decade
#34
Xinghan Chen, Jiaqi Li, Ruohan Liao, Xiujun Shi, Yan Xing, Xuewen Xu, Haitao Xiao, Dongqin Xiao
BACKGROUND: Quorum sensing (QS) research stands as a pivotal and multifaceted domain within microbiology, holding profound implications across various scientific disciplines. This bibliometric analysis seeks to offer an extensive overview of QS research, covering the period from 2004 to 2023. It aims to elucidate the hotspots, trends, and the evolving dynamics within this research domain. METHODS: We conducted an exhaustive review of the literature, employing meticulous data curation from the Science Citation Index Extension (SCI-E) within the Web of Science (WOS) database...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38646628/biosynthetic-and-catabolic-pathways-control-amino-acid-%C3%AE-2-h-values-in-aerobic-heterotrophs
#35
JOURNAL ARTICLE
Shaelyn N Silverman, Reto S Wijker, Alex L Sessions
The hydrogen isotope ratios (δ2 HAA values) of amino acids in all organisms are substantially fractionated relative to growth water. In addition, they exhibit large variations within microbial biomass, animals, and human tissues, hinting at rich biochemical information encoded in such signals. In lipids, such δ2 H variations are thought to primarily reflect NADPH metabolism. Analogous biochemical controls for amino acids remain largely unknown, but must be elucidated to inform the interpretation of these measurements...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38646547/cortactin-dependent-control-of-par1b-regulated-epithelial-cell-polarity-in-helicobacter-infection
#36
JOURNAL ARTICLE
Irshad Sharafutdinov, Aileen Harrer, Mathias Müsken, Klemens Rottner, Heinrich Sticht, Christian Täger, Michael Naumann, Nicole Tegtmeyer, Steffen Backert
Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncoprotein CagA leading to loss of cell polarity, but the precise molecular mechanism is not fully clear. Here we discovered a novel function of the actin-binding protein cortactin in regulating Par1b, which forms a complex with cortactin and the tight junction protein zona occludens-1 (ZO-1)...
June 2024: Cell Insight
https://read.qxmd.com/read/38646545/exploring-the-role-of-cited-transcriptional-regulators-in-the-control-of-macrophage-polarization
#37
REVIEW
Derek A Wiggins, Jack N Maxwell, David E Nelson
Macrophages are tissue resident innate phagocytic cells that take on contrasting phenotypes, or polarization states, in response to the changing combination of microbial and cytokine signals at sites of infection. During the opening stages of an infection, macrophages adopt the proinflammatory, highly antimicrobial M1 state, later shifting to an anti-inflammatory, pro-tissue repair M2 state as the infection resolves. The changes in gene expression underlying these transitions are primarily governed by nuclear factor kappaB (NF-κB), Janus kinase (JAK)/signal transducer and activation of transcription (STAT), and hypoxia-inducible factor 1 (HIF1) transcription factors, the activity of which must be carefully controlled to ensure an effective yet spatially and temporally restricted inflammatory response...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38646543/effects-of-supplementing-coated-methionine-in-a-high-plant-protein-diet-on-growth-antioxidant-capacity-digestive-enzymes-activity-and-expression-of-tor-signaling-pathway-associated-genes-in-gibel-carp-carassius-auratus-gibelio
#38
JOURNAL ARTICLE
Yingying Du, Xiaowen Lin, Xianping Shao, Jianhua Zhao, Hong Xu, Clement R de Cruz, Qiyou Xu
This study explored the impacts of supplementation of different levels of coated methionine (Met) in a high-plant protein diet on growth, blood biochemistry, antioxidant capacity, digestive enzymes activity and expression of genes related to TOR signaling pathway in gibel carp ( Carassius auratus gibeilo). A high-plant protein diet was formulated and used as a basal diet and supplemented with five different levels of coated Met at 0.15, 0.30, 0.45, 0.60 and 0.75%, corresponding to final analyzed Met levels of 0...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38646539/pathways-and-molecules-for-overcoming-immunotolerance-in-metastatic-gastrointestinal-tumors
#39
REVIEW
Qixin Gan, Yue Li, Yuejun Li, Haifen Liu, Daochuan Chen, Lanxiang Liu, Churan Peng
Worldwide, gastrointestinal (GI) cancer is recognized as one of the leading malignancies diagnosed in both genders, with mortality largely attributed to metastatic dissemination. It has been identified that in GI cancer, a variety of signaling pathways and key molecules are modified, leading to the emergence of an immunotolerance phenotype. Such modifications are pivotal in the malignancy's evasion of immune detection. Thus, a thorough analysis of the pathways and molecules contributing to GI cancer's immunotolerance is vital for advancing our comprehension and propelling the creation of efficacious pharmacological treatments...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38646526/microglial-neuronal-crosstalk-in-chronic-viral-infection-through-mtor-spp1-opn-and-inflammasome-pathway-signaling
#40
REVIEW
Catalina Argandona Lopez, Amanda M Brown
HIV-infection of microglia and macrophages (MMs) induces neuronal injury and chronic release of inflammatory stimuli through direct and indirect molecular pathways. A large percentage of people with HIV-associated neurologic and psychiatric co-morbidities have high levels of circulating inflammatory molecules. Microglia, given their susceptibility to HIV infection and long-lived nature, are reservoirs for persistent infection. MMs and neurons possess the molecular machinery to detect pathogen nucleic acids and proteins to activate innate immune signals...
2024: Frontiers in Immunology
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