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https://www.readbyqxmd.com/read/29228445/the-protective-effect-and-its-mechanism-of-3-n-butylphthalide-pretreatment-on-cerebral-ischemia-reperfusion-injury-in-rats
#1
R-Y Yan, S-J Wang, G-T Yao, Z-G Liu, N Xiao
OBJECTIVE: To investigate the potential effect of 3-n-butylphthalide (NBP) pretreatment on the cerebral ischemia/reperfusion injury in rats and the relevant mechanism. MATERIALS AND METHODS: A total of 90 rats was divided into three groups: Sham operation group (Sham group), ischemia-reperfusion group (I-R group), and NBP pretreatment group (NBP group 75 mg·kg-1·d-1 gavage). Pre-treatment was given once a day within 1 week before establishing the rat model of cerebral ischemia-reperfusion injury...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228105/metformin-attenuates-susceptibility-to-inflammation-induced-preterm-birth-in-mice-with-higher-endocannabinoid-levels
#2
Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K Dey
Premature decidual senescence is a contributing factor to preterm birth. Fatty acid amide hydrolase mutant females (Faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (LPS) challenge due to enhanced decidual senescence; this is associated with MAPK p38 activation. Previous studies have shown that mammalian target of rapamycin complex 1 (mTORC1) contributes to decidual senescence and promotes the incidence of preterm birth. In the present study, we sought to attenuate premature decidual aging in Faah-/- females by targeting mTORC1 and p38 signaling pathways...
December 5, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29227823/lncrna-malat1-regulates-sepsis-induced-cardiac-inflammation-and-dysfunction-via-interaction-with-mir-125b-and-p38-mapk-nf%C3%AE%C2%BAb
#3
Hu Chen, Xiaoyun Wang, Xuetao Yan, Xiaoli Cheng, Xianghu He, Wenzhong Zheng
This study aimed to explore the role of MALAT1 in sepsis-induced cardiac inflammation and dysfunction. We constructed the rat sepsis models through cecal ligation and puncture (CLP). The cardiac function, including left ventricular peak pressure (LVPP), left ventricular end diastolic pressure (LVEDP) and maximum rate of rise/fall of left ventricle pressure (±dp/dtmax) as well as the contents of serum cardiac troponin I (CTn-I), creatine kinase (CK), and creative kinase isoenzyme MB (CK-MB) were detected after modeling...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29226878/asic1a-contributes-to-the-symptom-of-pain-in-a-rat-model-of-chronic-prostatitis
#4
Song Fan, Zong-Yao Hao, Li Zhang, Jun Zhou, Yi-Fei Zhang, Shen Tai, Xian-Sheng Zhang, Chao-Zhao Liang
This study aims to validate our hypothesis that acid-sensing ion channels (ASICs) may contribute to the symptom of pain in patients with chronic prostatitis (CP). We first established a CP rat model, then isolated the L5-S2 spinal dorsal horn neurons for further studies. ASIC1a was knocked down and its effects on the expression of neurogenic inflammation-related factors in the dorsal horn neurons of rat spinal cord were evaluated. The effect of ASIC1a on the Ca2+ ion concentration in the dorsal horn neurons of rat spinal cord was measured by the intracellular calcium ([Ca2+]i) intensity...
December 8, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29226424/activation-of-ep2-receptor-suppresses-poly-i-c-and-lps-mediated-inflammation-in-primary-microglia-and-organotypic-hippocampal-slice-cultures-contributing-role-for-mapks
#5
Nizar M Yousif, Antonio Carlos Pinheiro de Oliveira, Simone Brioschi, Michael Huell, Knut Biber, Bernd L Fiebich
Brain inflammation is a critical factor involved in neurodegeneration. Recently, the prostaglandin E2 (PGE2 ) downstream members were suggested to modulate neuroinflammatory responses accompanying neurodegenerative diseases. In this study, we investigated the protective effects of prostaglandin E2 receptor 2 (EP2 ) during TLR3 and TLR4-driven inflammatory response using in vitro primary microglia and ex vivo organotypic hippocampal slice cultures (OHSCs). Depletion of microglia from OHSCs differentially affected TLR3 and TLR4 receptor expression...
December 11, 2017: Glia
https://www.readbyqxmd.com/read/29225311/inhibition-of-oxidative-stress-by-antioxidant-supplementation-does-not-limit-muscle-mitochondrial-biogenesis-or-endurance-capacity-in-rats
#6
Jae Cheol Kim, Gi Duck Park, Sang Hyun Kim
The objective of the present study was to analyze the activation and expression patterns of upstream and downstream factors of PGC-1α to determine whether antioxidant (AO) supplementation inhibits mitochondrial biogenesis in skeletal muscles as an adaptation to endurance training, as well as to analyze changes in endurance capacity based on such findings. For this objective, 24 male Sprague-Dawley (SD) rats were allocated into 4 groups (vehicle-sedentary, V-Sed; vehicle-exercise, V-EX; antioxidant-sedentary, AO-Sed; antioxidant-exercise, AO-EX) of 6 rats each...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29225190/scopolamine-induced-passive-avoidance-memory-retrieval-deficit-is-accompanied-with-hippocampal-mmp2-mmp-9-and-mapks-alteration
#7
Maryam Moosavi, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalami
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine is used to induce an animal model of amnesia. Howbeit the effect of scopolamine on memory retrieval is contradictory. This study aimed to assess the effect of scopolamine on passive avoidance memory retrieval...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29224011/glp-1-and-ghrelin-attenuate-high-glucose-high-lipid-induced-apoptosis-and-senescence-of-human-microvascular-endothelial-cells
#8
Pengzhi Liao, Dan Yang, Duan Liu, Yuehong Zheng
BACKGROUND/AIMS: GLP-1 and ghrelin are common appetite-regulating hormones. Both have multiple functions beyond metabolic regulation. However, the effects of GLP-1 and ghrelin on endothelial biology are not fully understood. Here, we investigate the roles of GLP-1 and ghrelin in microvascular endothelial apoptosis and senescence. METHODS: Human microvascular endothelial cells (HMECs) were exposed to high glucose/high lipid (HG/HL) conditions and treated with GLP-1 or ghrelin...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#9
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29222329/glutaminolysis-is-required-for-tgf-%C3%AE-1-induced-myofibroblast-differentiation-and-activation
#10
Karen Bernard, Naomi J Logsdon, Gloria A Benavides, Yan Sanders, Jianhua Zhang, Victor M Darley-Usmar, Victor J Thannickal
Myofibroblasts participate in physiological wound healing and pathological fibrosis.  Myofibroblast differentiation is characterized by the expression of alpha-smooth muscle actin (α-SMA) and extracellular matrix (ECM) proteins, and is dependent on metabolic reprogramming.  In this study, we explored the role of glutaminolysis and metabolites of the tricarboxylic acid cycle (TCA) in supporting myofibroblast differentiation.  Glutaminolysis converts glutamine (Gln) into alpha-ketoglutarate (α-KG), a critical intermediate in the TCA cycle...
December 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29221948/cnb-001-a-synthetic-pyrazole-derivative-of-curcumin-suppresses-lipopolysaccharide-induced-nitric-oxide-production-through-the-inhibition-of-nf-%C3%AE%C2%BAb-and-p38-mapk-pathways-in-microglia
#11
Tatsuhiro Akaishi, Kazuho Abe
CNB-001, a pyrazole derivative of curcumin, has been found to exert neuroprotective and memory-enhancing effects that may be effective for the treatment of Alzheimer's disease. Since aberrant activation of microglia is involved in the pathogenesis of Alzheimer's disease, the present study was undertaken to investigate the effect of CNB-001 on microglia-mediated inflammatory responses. In primary cultured rat microglia, CNB-001 (1-10µM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), and the potency of CNB-001 was stronger than curcumin...
December 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29218605/oxymatrine-sensitizes-the-hacat-cells-to-the-ifn-%C3%AE-pathway-and-downregulates-mdc-icam-1-and-socs1-by-activating-p38-jnk-and-akt
#12
Chun-Jie Gao, Pei-Jun Ding, Li-Li Yang, Xu-Feng He, Meng-Jiao Chen, Dong-Ming Wang, Yan-Xin Tian, Hui-Min Zhang
Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways...
December 7, 2017: Inflammation
https://www.readbyqxmd.com/read/29218112/triptolide-protects-podocytes-from-tgf-%C3%AE-induced-injury-by-preventing-mir-30-downregulation
#13
Qianqian Yang, Mengjie Sun, Ying Chen, Yuqiu Lu, Yuting Ye, Hui Song, Xiaodong Xu, Shaolin Shi, Jinquan Wang
Triptolide is known to have a strong anti-proteinuric effect through direct protection of podocytes from injury and is used to treat glomerular diseases. However, the mechanism underlying its protective effect on podocytes remains elusive. MiR-30 family has recently been shown to be essential for structural and functional homeostasis of podocytes but is downregulated by injurious factors, leading to podocyte injury. In the present study, we explore whether Triptolide protects podocytes through preventing miR-30 downregulation...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218075/il-32%C3%AE-a-recently-identified-anti-inflammatory-variant-of-il-32-and-its-preventive-role-in-various-disorders-and-tumor-suppressor-activity
#14
REVIEW
Muhammad Babar Khawar, Maryam Mukhtar, Muddasir Hassan Abbasi, Nadeem Sheikh
Interleukin-32 theta (IL-32θ) is newly identified isoform of IL-32 which plays a vital role in inflammatory responses. Like IL-32α and IL-32β, IL-32θ isoform acts as an intracellular inflammatory modulator. It results in reduction of IL-1β production by attenuating the expression of PU.1 and inhibition of monocytes differentiation into macrophages. IL-32θ hinders TNF-α expression by inhibiting p38 MAPK and inhibitor of κB (IκB) as well. It also reserved STAT3-ZEB1 pathway leading to the inhibition of epithelial-mesenchymal transition (EMT) and stemness...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217619/microrna-4331-promotes-tgev-induced-mitochondrial-damage-via-targeting-rb1-up-regulating-il1rap-and-activating-p38-mapk-pathway-in-vitro
#15
Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and up-regulate miR-4331 level. So miR-4331 may play an important regulatory role in the control of mitochondrial function. To explore the potential role of miR-4331 in mitochondrial damage, we adopted a strategy consisting of quantitative proteomic analysis of porcine kidney (PK-15) cells in response to miR-4331 and TGEV infection...
December 7, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29216316/correction-low-magnitude-high-frequency-vibration-promotes-adipogenic-differentiation-of-bone-marrow-stem-cells-via-p38-mapk-signal
#16
Qian Zhao, Yuezhi Lu, Xueqi Gan, Haiyang Yu
[This corrects the article DOI: 10.1371/journal.pone.0172954.].
2017: PloS One
https://www.readbyqxmd.com/read/29215790/inhibition-of-fucosylation-in-human-invasive-ductal-carcinoma-reduces-e-selectin-ligand-expression-cell-proliferation-and-erk1-2-and-p38-mapk-activation
#17
M A Carrascal, M Silva, J S Ramalho, C Pen, M Martins, C Pascoal, C Amaral, I Serrano, M J Oliveira, R Sackstein, P A Videira
Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role(s) in breast carcinogenesis is still unknown. Here, we aimed to define the contribution of the fucosylated structures, including sLeX/A , to cell adhesion, cell signaling and proliferation in invasive ductal carcinomas (IDC), the most frequent type of breast cancer...
December 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29215001/endomucin-inhibits-vegf-induced-endothelial-cell-migration-growth-and-morphogenesis-by-modulating-vegfr2-signaling
#18
Cindy Park-Windhol, Yin Shan Ng, Jinling Yang, Vincent Primo, Magali Saint-Geniez, Patricia A D'Amore
Angiogenesis is central to both normal and pathologic processes. Endothelial cells (ECs) express O-glycoproteins that are believed to play important roles in vascular development and stability. Endomucin-1 (EMCN) is a type I O-glycosylated, sialic-rich glycoprotein, specifically expressed by venous and capillary endothelium. Evidence has pointed to a potential role for EMCN in angiogenesis but it had not been directly investigated. In this study, we examined the role of EMCN in angiogenesis by modulating EMCN levels both in vivo and in vitro...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214724/cme-1-a-novel-polysaccharide-suppresses-inos-expression-in-lipopolysaccharide-stimulated-macrophages-through-ceramide-initiated-protein-phosphatase-2a-activation
#19
Joen-Rong Sheu, Zhih-Cherng Chen, Ming-Jen Hsu, Shwu-Huey Wang, Kuo-Wei Jung, Wei-Fan Wu, Szu-Han Pan, Ruei-Dun Teng, Chih-Hao Yang, Cheng-Ying Hsieh
CME-1, a novel water-soluble polysaccharide purified from Ophiocordyceps sinensis mycelia, has anti-oxidative, antithrombotic and antitumour properties. In this study, other major attributes of CME-1, namely anti-inflammatory and immunomodulatory properties, were investigated. Treating lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with CME-1 concentration-dependently suppressed nitric oxide formation and inducible nitric oxide synthase (iNOS) expression. In the CME-1-treated RAW 264.7 cells, LPS-induced IκBα degradation and the phosphorylation of p65, Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38, were reduced...
December 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29212817/casr-signaling-down-regulates-aqp2-expression-via-a-novel-microrna-pathway-in-pendrin-and-nacl-cotransporter-knockout-mice
#20
Marianna Ranieri, Kamyar Zahedi, Grazia Tamma, Mariangela Centrone, Annarita Di Mise, Manoocher Soleimani, Giovanna Valenti
High concentrations of urinary calcium counteract vasopressin action via the activation of the calcium-sensing receptor (CaSR) that is expressed in the luminal membrane of collecting duct cells, which impairs the trafficking of aquaporin-2 (AQP2). Pendrin/NaCl cotransporter double-knockout (dKO) mice display significant calcium wasting and develop severe volume depletion, despite increased circulating vasopressin levels. We hypothesized that the CaSR-mediated impairment of AQP2 expression/trafficking underlies vasopressin resistance in dKO mice...
December 6, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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