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https://www.readbyqxmd.com/read/29677535/betulinic-acid-attenuates-dexamethasone-induced-oxidative-damage-through-the-jnk-p38-mapk-signaling-pathway-in-mice
#1
Lijuan Zhu, Xianglian Yi, Jing Zhao, Zhihang Yuan, Lixin Wen, Blazej Pozniak, Bozena Obminska-Mrukowicz, Yanan Tian, Zhuliang Tan, Jing Wu, Jine Yi
Dexamethasone (Dex), a potent anti-inflammatory/immunosuppressive agent, has been shown to induce oxidative stress. Betulinic acid (BA) is a pentacyclic lupane triterpene with a potent antioxidant activity. The aim of this study was to investigate the ameliorative effect and underlying mechanisms of BA on Dex-induced oxidative damage. Mice were pretreated with BA orally (0, 0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and then a single dose of Dex (25 mg/kg body weight) was administered intraperitoneally 8 h after the last administration of BA to induce oxidative stress...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677370/topical-ripasudil-suppresses-retinal-ganglion-cell-death-in-a-mouse-model-of-normal-tension-glaucoma
#2
Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Hiroki Sano, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura, Takayuki Harada
Purpose: To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods: Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 KO mice from 5 to 12 weeks old. Optical coherence tomography, multifocal electroretinograms, the measurement of intraocular pressure (IOP), and histopathology analyses were performed at 5, 8, and 12 weeks old...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677088/corrigendum-the-priming-effect-of-c5a-on-monocytes-is-predominantly-mediated-by-the-p38-mapk-pathway
#3
(no author information available yet)
No abstract text is available yet for this article.
April 19, 2018: Shock
https://www.readbyqxmd.com/read/29675422/elucidation-on-predominant-pathways-involved-in-the-differentiation-and-mineralization-of-odontoblast-like-cells-by-selective-blockade-of-mitogen-activated-protein-kinases
#4
Jia Tang, Takashi Saito
Aim: To analyze the effect of three mitogen-activated protein kinase (MAPK) inhibitors, namely, SB202190 (p38 inhibitor), SP600125 (JNK inhibitor), and PD98059 (ERK inhibitor) in Dex-stimulated MDPC-23 cell differentiation and mineralization. Methods: Experiment was divided into five groups, control (cells without Dex and inhibitors treatment), Dex (cells with Dex treatment but without inhibitors), Dex + SB202190, Dex + SP600125, and Dex + PD98059. Cell differentiation was assessed by alkaline phosphatase (ALP) activity assay and real time RT-PCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29673353/modulation-of-ovine-sbd-1-expression-by-saccharomyces-cerevisiae-in-ovine-ruminal-epithelial-cells
#5
Xin Jin, Man Zhang, Xue-Min Zhu, Yan-Ru Fan, Chen-Guang Du, Hua-Er Bao, Siri-Guleng Xu, Qiao-Zhen Tian, Yun-He Wang, Yin-Feng Yang
BACKGROUND: The ovine rumen is involved in host defense responses and acts as the immune interface with the environment. The ruminal mucosal epithelium plays an important role in innate immunity and secretes antimicrobial innate immune molecules that have bactericidal activity against a variety of pathogens. Defensins are cationic peptides that are produced by the mucosal epithelia and have broad-spectrum antimicrobial activity. Sheep β-defensin-1 (SBD-1) is one of the most important antibacterial peptides in the rumen...
April 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29673083/fine-particle-matter-disrupts-the-blood-testis-barrier-by-activating-tgf-%C3%AE-3-p38-mapk-pathway-and-decreasing-testosterone-secretion-in-rat
#6
Jianhui Liu, Lihua Ren, Jialiu Wei, Jin Zhang, Yupeng Zhu, Xiangyang Li, Li Jing, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Fine particle matter (PM) is correlated with male reproductive dysfunction in animals and humans, but the underlying mechanisms remain unknown. To investigate the toxic mechanism of PM, 32 male Sprague-Dawley (SD) rats were exposed to saline or PM2.5 with the doses of 1.8, 5.4, and 16.2 mg/kg.b.w. via intratracheal instillation, respectively, one time every 3 days, in total times for 30 days. Sperm concentration, hormone level, the expressions of BTB-associated protein and the mitogen-activated protein kinase (MAPK) pathway, tumor necrosis factor α and transforming growth factor β3 levels were detected...
April 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29672953/astragalus-polysaccharides-exerts-anti-infective-activity-by-inducing-human-cathelicidin-antimicrobial-peptide-ll-37-in-respiratory-epithelial-cells
#7
Lin Zhao, Shuai Tan, Hai Zhang, Peng Liu, Yu-Zhu Tan, Jia-Chuan Li, Da Jia, Xiao-Fei Shen
Astragalus polysaccharides (APS), one of the major active components in Astragalus membranaceus, is an effective immunomodulator used in the treatment of immunological diseases in China. However, the anti-infective action and mechanism of APS is not fully known. In the present study, we found that APS induced the expression of human cathelicidin antimicrobial peptide LL-37, a key host anti-infective molecule, in both mRNA and protein levels in respiratory epithelial cells HBE16 and A549. Furthermore, the lysate and supernatant from APS-treated HBE16 cells both exhibited an obvious antibacterial action, which was partially neutralizated by LL-37 monoclonal antibody...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672044/andrographolide-antagonizes-tnf-%C3%AE-induced-il-8-via-inhibition-of-nadph-oxidase-ros-nf-%C3%AE%C2%BAb-and-src-mapks-ap-1-axis-in-human-colorectal-cancer-hct116-cells
#8
Miaomiao Yuan, Wei Meng, Wenzhen Liao, Sen Lian
Andrographis paniculata Nees is used as a functional food in Japan, Korea, India and China. Andrographolide, a naturally occurring phytochemical identified in Andrographis paniculata, has been discovered to present anti-inflammatory and anticancer activities. Highly expressed of interleukin (IL-8) has been detected in colorectal cancer and is implicated in angiogenesis. However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells. The present study was aimed to investigate the effects of andrographolide on TNF-α-induced IL-8 expression and its underlying mechanisms...
April 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29670094/loss-of-deptor-in-renal-tubules-protects-against-cisplatin-induced-acute-kidney-injury
#9
Caixia Wang, Huaiqian Dai, Zhi Xiong, Qiancheng Song, Zhipeng Zou, Mangmang Li, Jing Nie, Xiaochun Bai, Zhenguo Chen
DEP domain containing mTOR-interacting protein (DEPTOR) was originally identified as an in vivo dual inhibitor of mechanistic target of rapamycin (mTOR). It was recently reported to be involved in renal physiology and pathology in vitro; however, its detailed roles and mechanisms in vivo are completely unknown. We observed that DEPTOR expression in the kidney was markedly increased on day 3 after cisplatin treatment, at which time cell apoptosis peaked, implicating DEPTOR in cisplatin-induced acute kidney injury (AKI)...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29670085/a-trib2-p38-axis-controls-myeloid-leukaemia-cell-cycle-and-stress-response-signalling
#10
Mara Salomé, Aoife Magee, Krisha Yalla, Shahzya Chaudhury, Evgenia Sarrou, Ruaidhrí J Carmody, Karen Keeshan
Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. Both high and low Trib2 expression levels correlate with different types of cancer. Elevated Trib2 expression has oncogenic properties in both leukaemia and lung cancer dependent on interactions with proteasome machinery proteins and degradation of transcription factors. Here, we demonstrated that Trib2 deficiency conferred a growth and survival advantage both at steady state and in stress conditions in leukaemia cells...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29670075/the-novel-trail-receptor-agonist-apg350-exerts-superior-therapeutic-activity-in-pancreatic-cancer-cells
#11
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke, Anna Trauzold
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has raised attention as a novel anticancer therapeutic as it induces apoptosis preferentially in tumor cells. However, first-generation TRAIL-receptor agonists (TRAs), comprising recombinant TRAIL and agonistic receptor-specific antibodies, have not demonstrated anticancer activity in clinical studies. In fact, cancer cells are often resistant to conventional TRAs. Therefore, in addition to TRAIL-sensitizing strategies, next-generation TRAs with superior apoptotic activity are warranted...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29669778/factor-viia-induces-anti-inflammatory-signaling-via-epcr-and-par1
#12
Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T Esmon, L Vijaya Mohan Rao, Usha R Pendurthi
Recent studies show that endothelial cell protein C receptor (EPCR) interacts with diverse ligands, in addition to its known ligands protein C and activated protein C (APC). We showed in earlier studies that procoagulant clotting factor VIIa (FVIIa) binds EPCR and down-regulates EPCR-mediated anticoagulation and induces endothelial barrier protective effect. Here, we investigated the effect of FVIIa interaction with EPCR on endothelial cell inflammation and LPS-induced inflammatory responses in vivo. Treatment of endothelial cells with FVIIa suppressed TNFα- and LPS-induced expression of cellular adhesion molecules and adherence of monocytes to endothelial cells...
April 18, 2018: Blood
https://www.readbyqxmd.com/read/29669336/clic1-promotes-the-progression-of-gastric-cancer-by-regulating-the-mapk-akt-pathways
#13
Bo-Pei Li, Yuan-Tian Mao, Zhen Wang, Ye-Yang Chen, Ye Wang, Chong-Yu Zhai, Bo Shi, Si-Yu Liu, Jin-Lu Liu, Jun-Qiang Chen
BACKGROUND/AIMS: Chloride intracellular channel 1 (CLIC1), which is a member of the chloride channel protein family, is associated with various human tumors. Recent studies have shown that CLIC1 is involved in the occurrence and development of gastric cancer (GC). However, the exact mechanism remains unclear in GC. METHODS: Effects of CLIC1 on the progression of GC in vivo and in vitro and the potential underlying mechanisms have been investigated by analysing 54 patients with GC, as well as human gastric cell lines SGC-7901 and MGC-803, utilizing proteomics, RT-PCR, Western blotting, flow cytometry, Cell invasion and migration assays and xenograft tumor models...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29667914/inactivation-of-map3k7-in-foxd1-expressing-cells-results-in-loss-of-mesangial-pdgfr%C3%AE-and-juvenile-kidney-scarring
#14
Michele J Karolak, Justin A Guay, Leif Oxburgh
Transforming growth factor beta (TGFβ) plays a central role in renal scarring, controlling extracellular matrix deposition by interstitial cells and mesangial cells. TGFβ signals through Smad and mitogen activated protein kinase (MAPK) pathways. To understand the role of MAPK in interstitial and mesangial cells, we genetically inactivated TGFβ-activated kinase 1 (Map3k7) using Foxd1+/cre. Embryonic kidney development was unperturbed in mutants, but spontaneous scarring of the kidney ensued during the first postnatal week, with retention of embryonic nephrogenic rests and accumulation of collagen IV in the mesangium...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29666854/casein-glycomacropeptide-hydrolysates-inhibit-pge2-production-and-cox2-expression-in-lps-stimulated-raw-264-7-macrophage-cells-via-akt-mediated-nf-%C3%AE%C2%BAb-and-mapk-pathways
#15
Tiange Li, Dongxiao Gao, Min Du, Xue Cheng, Xueying Mao
A casein glycomacropeptide hydrolysate (GMPH) was found to possess inhibitory activity against lipopolysaccharide (LPS)-induced inflammatory response in our previous study. In the current study, the inhibitory effect and the underlying molecular mechanism of GMPH on inflammatory response in LPS-stimulated RAW264.7 macrophages were further investigated. Results showed that GMPH significantly suppressed LPS-induced intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) production. GMPH reduced the production of prostaglandin E2 (PEG2) and the expression of cyclooxygenase-2 (COX-2) and cytosolic phospholipase A2 (cPLA2) in LPS-stimulated macrophages...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29665093/the-mapk-activator-protein-1-signaling-regulates-changes-in-lung-tissue-of-rat-exposed-to-hypobaric-hypoxia
#16
Mrinalini Singh, Seema Yadav, Meetul Kumar, Shweta Saxena, Deepika Saraswat, Anju Bansal, Shashi B Singh
This study reports the role of MAPKs (JNK, ERK, and p38), and activator protein-1 (AP-1) transcription factor in the hypobaric hypoxia induced change in lung tissue. Healthy male Sprague-Dawley rats were exposed to hypobaric hypoxia for 6, 12, 24, 48, 72, and 120 hr. Hypoxia resulted in significant increase in reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and decreased nitric oxide (NO), these act as signaling molecules for activation of MAPK and also contribute in development of vascular leakage (an indicator of pulmonary edema) as confirmed by histological studies...
April 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29664174/up-regulated-cx43-phosphorylation-at-ser368-prolongs-qrs-duration-in-myocarditis
#17
Chunlian Zhong, He Chang, Yang Wu, Li Zhou, Yan Wang, Mingyan Wang, Peng Wu, Zhi Qi, Jun Zou
Prolongation of QRS duration in electrocardiogram is one of the risk factors for morbidity and mortality in many kinds of cardiac diseases. However, its molecular mechanism is unknown. In this study, utilizing experimental autoimmune myocarditis (EAM) as a disease model, we show that the prolongation of QRS duration is accompanied by elevated phosphorylation of connexin 43 (Cx43) at Ser368 (pS 368 Cx43). In cultured cells, inflammatory cytokine IL-1β activates p38 MAPK to up-regulate pS 368 Cx43 and impairs cell-to-cell communication...
April 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29663930/diffusion-tensor-imaging-evaluation-of-axonal-white-matter-remodeling-in-a-mouse-model-of-diabetic-stroke-treated-with-novel-p38-mapk-inhibitor-vcp979
#18
Yu Cai, Chunqiang Lu, Tingting Xu, Yuanyuan Ma, Shudan Min, Peter Scammells, Binghui Wang, Shenghong Ju
Type 2 diabetes mellitus (T2DM) is associated with severe axonal/white matter (WM) injury and poor functional outcomes following ischemic stroke. T2DM induces activation of p38 mitogen-activated protein kinases (MAPKs), which may be linked to the axonal/WM damage. In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. The novel p38 MAPK inhibitor, VCP979, significantly promoted axonal/WM remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29662304/chrysin-suppresses-proliferation-migration-and-invasion-in-glioblastoma-cell-lines-via-mediating-the-erk-nrf2-signaling-pathway
#19
Juan Wang, Handong Wang, Kangjian Sun, Xiaoliang Wang, Hao Pan, Jianhong Zhu, Xiangjun Ji, Xiang Li
Background: Chrysin, an active natural bioflavonoid, has been proven to protect against carcinogenesis. However, the role of chrysin in glioblastoma and the potential molecular mechanisms remain to be elucidated. In our previous study, we found that nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is highly expressed in a variety of glioblastoma cell lines associated with the mitogen-activated protein kinase (MAPK) pathway. The aim of this study was to evaluate the antitumor effects of chrysin in glioblastoma cells and how chrysin is related to the MAPK/Nrf2 signaling pathway...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29660434/the-beclomethasone-anti-inflammatory-effect-occurs-in-cell-mediator-dependent-manner-and-is-additively-enhanced-by-formoterol-nfkb-p38-pka-analysis
#20
Silvana Cianchetti, Cristina Cardini, Alessandro Corti, Marta Menegazzi, Elena Darra, Eleonora Ingrassia, Alfonso Pompella, Pierluigi Paggiaro
AIMS: Beclomethasone/formoterol (BDP/FOR) has been reported to be more effective than its separate components in airway disease control and in airway inflammation improvement. However, BDP/FOR effects on cytokine-induced inflammation in structural cells have not been described and whether these effects occur in a cell- and mediator-dependent manner has not been fully elucidated. We sought to evaluate BDP and/or FOR effects on endothelial ICAM-1, E-selectin, IL-8 and on bronchial epithelial ICAM-1 and IL-8...
April 13, 2018: Life Sciences
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