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https://www.readbyqxmd.com/read/29907213/carbon-monoxide-attenuates-lipopolysaccharide-induced-lung-injury-by-mitofusin-proteins-via-p38-mapk-pathway
#1
Shu-An Dong, Yuan Zhang, Jian-Bo Yu, Xiang-Yun Li, Li-Rong Gong, Jia Shi, Yuan-Yuan Kang
BACKGROUND: The protective effects of carbon monoxide against the lipopolysaccharide (LPS)-induced lung injury were attributed to maintenance of mitochondrial dynamics, but the mechanisms remain unexplored. MATERIALS AND METHODS: Using a rat model of acute lung injury induced by LPS and the LPS attacking cell model, we investigated the effects of pretreatment of carbon monoxide molecule-2 (CORM-2) on the acute lung injury and expressions of mitofusin proteins that play a critical role in mitochondrial dynamics...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906814/magnoflorine-enhances-lps-activated-pro-inflammatory-responses-via-myd88-dependent-pathways-in-u937-macrophages
#2
Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Siti Mariam Abdul Wahab
Magnoflorine, a major bioactive metabolite isolated from Tinospora crispa, has been reported for its diverse biochemical and pharmacological properties. However, there is little report on its underlying mechanisms of action on immune responses, particularly on macrophage activation. In this study, we aimed to investigate the effects of magnoflorine, isolated from T. crispa on the pro-inflammatory mediators generation induced by LPS and the concomitant NF- κ B, MAPKs, and PI3K-Akt signaling pathways in U937 macrophages...
June 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29906743/costunolide-ameliorates-lipoteichoic-acid-induced-acute-lung-injury-via-attenuating-mapk-signaling-pathway
#3
Zhengxu Chen, Dan Zhang, Man Li, Baolong Wang
Lipoteichoic acid (LTA)-induced acute lung injury (ALI) is an experimental model for mimicking Gram-positive bacteria-induced pneumonia that is a refractory disease with lack of effective medicines. Here, we reported that costunolide, a sesquiterpene lactone, ameliorated LTA-induced ALI. Costunolide treatment reduced LTA-induced neutrophil lung infiltration, cytokine and chemokine production (TNF-α, IL-6 and KC), and pulmonary edema. In response to LTA challenge, treatment with costunolide resulted less iNOS expression and produced less inflammatory cytokines in bone marrow derived macrophages (BMDMs)...
June 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29906250/oxidant-sensor-cation-channel-trpm2-regulates-neutrophil-extracellular-trap-formation-and-protects-against-pneumoseptic-bacterial-infection
#4
Jitendra Kumar Tripathi, Atul Sharma, Pramod Sukumaran, Yuyang Sun, Bibhuti Bhusan Mishra, Brij Bhan Singh, Jyotika Sharma
Neutrophil extracellular trap (NET) formation constitutes an important extracellular antimicrobial function of neutrophils that plays a protective role in bacterial pneumonia. Formation of reactive oxygen species (ROS) such as highly diffusible hydrogen peroxide (H2 O2 ) is a hallmark of oxidative stress during inflammatory lung conditions including pneumonia. However, the impact of exogenous ROS on NET formation and the signaling pathway involved in the process is not completely understood. Here we demonstrate that the ROS-sensing, nonselective, calcium-permeable channel transient receptor potential melastatin 2 (TRPM2) is required for NET formation in response to exogenous H2 O2 ...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29904922/sideroxylin-callistemon-lanceolatus-suppressed-cell-proliferation-and-increased-apoptosis-in-ovarian-cancer-cells-accompanied-by-mitochondrial-dysfunction-the-generation-of-reactive-oxygen-species-and-an-increase-of-lipid-peroxidation
#5
Sunwoo Park, Whasun Lim, Wonsik Jeong, Fuller W Bazer, Dongho Lee, Gwonhwa Song
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells)...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29904407/the-cardioprotective-effects-of-secretory-leukocyte-protease-inhibitor-against-myocardial-ischemia-reperfusion-injury
#6
Eakkapote Prompunt, Jantira Sanit, Stephanie Barrère-Lemaire, Joel Nargeot, Hannah Noordali, Melanie Madhani, Sarawut Kumphune
Protease enzymes generated from injured cells and leukocytes are the primary cause of myocardial cell damage following ischemia/reperfusion (I/R). The inhibition of protease enzyme activity via the administration of particular drugs may reduce injury and potentially save patients' lives. The aim of the current study was to investigate the cardioprotective effects of treatment with recombinant human secretory leukocyte protease inhibitor (rhSLPI) on in vitro and ex vivo models of myocardial I/R injury. rhSLPI was applied to isolated adult rat ventricular myocytes (ARVMs) subjected to simulated I/R and to ex vivo murine hearts prior to I/R injury...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904032/phloretin-promotes-adipogenesis-via-mitogen-activated-protein-kinase-pathways-in-mouse-marrow-stromal-st2-cells
#7
Ayumu Takeno, Ippei Kanazawa, Masakazu Notsu, Ken-Ichiro Tanaka, Toshitsugu Sugimoto
Phloretin, a glucose transporter (GLUT) inhibitor, has pleiotropic effects. The present study examined the effects of phloretin on the commitment of marrow stromal cells to adipocytes, using the mouse marrow stromal cell line ST2. Oil red O staining showed that treatment with phloretin 10⁻100 µM promoted lipid accumulation. Real-time PCR showed that phloretin significantly increased the expression of adipogenic markers, including PPARγ, C/EBPα, fatty acid synthase, fatty acid-binding protein 4, and adiponectin...
June 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29903983/4-methoxyresveratrol-alleviated-age-induced-inflammation-via-rage-mediated-nf-%C3%AE%C2%BAb-and-nlrp3-inflammasome-pathway
#8
Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its anti-inflammation effects. In the present study, we sought to explore the protective role of 4′MR in AGEs-induced inflammatory model using RAW264.7 macrophages. 4′MR significantly inhibited gene expression of pro-inflammatory cytokines and chemokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1), as well as two typical pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)...
June 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29903060/bifunctional-supramolecular-hydrogel-alleviates-myocardial-ischemia-reperfusion-injury-by-inhibiting-autophagy-and-apoptosis
#9
Yi Deng, Guoqin Chen, Min Ye, Yingyan He, Zehua Li, Xianbao Wang, Caiwen Ou, Zhimou Yang, Minsheng Chen
Generally, nitric oxide (NO) is an important multi-functional cardioprotective soluble gas molecule. However, it may be detrimental when in excessive levels or combined with O2- a kind of reactive oxygen species (ROS)-to form ONOO-. The latter will rapidly decompose to highly reactive oxidant components. ROS will be abundantly produced during the ischemia/reperfusion (I/R) procedure. Therefore, an NO donor coupled with another antioxidant would be a more promising strategy for I/R treatment. In this study, we report on a novel self-assembly supramolecular hydrogel capable of constantly releasing both NO and curcumin (Cur) simultaneously, and we found that the combinational treatment of Cur and NO from the gel could efficiently reduce I/R injuries...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29902518/differential-effects-of-typical-and-atypical-antipsychotics-on-astroglial-cells-in-vitro
#10
Larissa Daniele Bobermin, Amanda da Silva, Diogo Onofre Souza, André Quincozes-Santos
Astrocytes are glial cells that are essential for the maintenance of central nervous system functions, modulating neurotransmitters, providing metabolic, trophic and antioxidant support, and producing a wide range of cytokines to modulate the inflammatory response. These cells can be targets for antipsychotics, medications used in the treatment of neuropsychiatric disorders. In this regard, several studies have shown that antipsychotics are able to modulate peripheral cytokine release, but their effects on astroglial inflammatory response need to be further investigated...
June 11, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29901206/protein-kinase-d1-regulates-hypoxic-metabolism-through-hif-1%C3%AE-and-glycolytic-enzymes-incancer-cells
#11
Jiao Chen, Bomiao Cui, Yaping Fan, Xiaoying Li, Qian Li, Yue Du, Yun Feng, Ping Zhang
Protein kinase D1 (PKD1), one of the protein kinase D (PKD) family members, plays a prominent role in multiple bio-behaviors of cancer cells. Low pH and hypoxia are unique characteristics of the tumor microenvironment. The aim of this study was to investigate the role and mechanism of PKD1 in regulating metabolism in the human tongue squamous cell carcinoma (TSCC) cell line SCC25 under a hypoxic condition, as well as growth and apoptosis. Here, we found that hypoxia not only induced the expression of HIF-1α, but also induced the expression and activation of PKD1...
June 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901190/curcumin-suppresses-cardiac-fibroblasts-activities-by-regulating-the-proliferation-and-cell-cycle-via-the-inhibition-of-the-p38-mapk-erk-signaling-pathway
#12
Guanhua Fang, Shaoqin Chen, Qiuyu Huang, Liangwan Chen, Dongshan Liao
Cardiac fibrosis is a deleterious effect of many cardiovascular diseases. Previous studies have shown that curcumin has exhibited protective effects on cardiovascular diseases. The aim of the present study was to evaluate the effects of curcumin on the activity of human cardiac fibroblasts (CFs) and to elucidate the underlying mechanisms involved. Human CFs were incubated with or without curcumin (20 µmol/l) and transforming growth factor β1 (TGF‑β1; 10 ng/ml), and the expression of α‑smooth muscle actin (α‑SMA), collagen type Iα (COLA)‑1 and COLA3 was evaluated using reverse transcription‑quantitative polymerase chain reaction and western blot analysis...
June 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901107/autophagy-protects-bone-marrow-mesenchymal-stem-cells-from-palmitate%C3%A2-induced-apoptosis-through-the-ros%C3%A2-jnk-p38-mapk-signaling-pathways
#13
Yongyi Liu, Ning Wang, Shaokun Zhang, Qingwei Liang
In recent years, the association between saturated fatty acids (FA) and bone cells has received a high level of attention. Previous studies have shown that palmitate (PA), a common saturated FA, can cause apoptosis in bone marrow mesenchymal stem cells (BMSCs). However, whether PA can induce autophagy, an important intracellular protection mechanism that is closely associated with apoptosis, in BMSCs is still unknown; the association between autophagy and apoptosis is also unclear. The aim of the present study was to determine whether PA can induce autophagy in BMSCs...
May 30, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901090/il%C3%A2-1%C3%AE-and-tnf%C3%A2-%C3%AE-suppress-tgf%C3%A2-%C3%AE-%C3%A2-promoted-ngf-expression-in-periodontal-ligament%C3%A2-derived-fibroblasts-through-inactivation-of-tgf%C3%A2-%C3%AE-%C3%A2-induced-smad2-3%C3%A2-and-p38-mapk%C3%A2-mediated-signals
#14
Maiko Ohta, Naoyuki Chosa, Seiko Kyakumoto, Seiji Yokota, Naoto Okubo, Akira Nemoto, Masaharu Kamo, Shigeharu Joh, Kenichi Satoh, Akira Ishisaki
Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth factor (NGF), a neurotrophic factor, serves important roles in the regeneration of injured sensory neurons. In the present study, the effect of pro‑inflammatory cytokines, including interleukin 1β (IL‑1β) and tumor necrosis factor α (TNF‑α), on transforming growth factor β1 (TGF‑β1)‑induced NGF expression was evaluated in rat PDL‑derived SCDC2 cells...
June 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901082/liquiritin-suppresses-uvb%C3%A2-induced-skin-injury-through-prevention-of-inflammation-oxidative-stress-and-apoptosis-through-the-tlr4-myd88-nf%C3%A2-%C3%AE%C2%BAb-and-mapk-caspase-signaling-pathways
#15
Xiao-Qing Li, Li-Min Cai, Jing Liu, Yan-Li Ma, Ying-Hui Kong, He Li, Ming Jiang
Solar ultraviolet B (UVB) radiation is known to trigger inflammation, oxidative stress and apoptotic responses through various signaling pathways, which eventually lead to skin cancer. The present study investigated whether liquiritin suppresses UVB‑induced skin injury in vivo and in vitro using SKH‑1 hairless mice and HACAT cells, respectively. The animals were exposed to UVB irradiation (180 mJ/cm2) for 20 min, followed by liquiritin treatment. The findings indicated that UVB exposure resulted in the excessive release of pro‑inflammatory cytokines, including interleukin (IL)‑1β, tumor necrosis factor (TNF)‑α, IL‑18, IL‑6 and cyclooxygenase (COX)2, which were dependent on the toll‑like receptor (TLR)4/myeloid differentiation factor 88 (MyD88)/nuclear factor‑κB (NF‑κB) signaling pathway...
June 5, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901077/apelin%C3%A2-13-attenuates-er-stress%C3%A2-associated-apoptosis-induced-by-mpp-in-sh%C3%A2-sy5y-cells
#16
Yunlu Jiang, Haiqing Liu, Bingyuan Ji, Zhengwen Wang, Chunmei Wang, Chunqing Yang, Yanyou Pan, Jing Chen, Baohua Cheng, Bo Bai
Apelin‑13, a neuropeptide that acts as a ligand for a putative receptor related to the angiotensin II type receptor, elicits neuroprotective effects in numerous neurological conditions, such as Huntington's disease and cerebral ischemia. Parkinson's disease (PD), one of the most prevalent neurodegenerative diseases, is caused by damage to neurons in the brain; however, the underlying mechanism remains unclear. The present study explored the effects of apelin‑13 on SH‑SY5Y human neuroblastoma cells treated with 1‑methyl‑4‑phenylpyridine (MPP+)...
June 5, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29899528/downregulation-of-hs6st2-by-mir-23b-3p-enhances-matrix-degradation-through-p38-mapk-pathway-in-osteoarthritis
#17
Yuanxu Guo, Zixin Min, Congshan Jiang, Wei Wang, Jidong Yan, Peng Xu, Ke Xu, Jing Xu, Mengyao Sun, Yitong Zhao, Safdar Hussain, Rui Zhang, Quancheng Wang, Yan Han, Fujun Zhang, Wenhua Zhu, Dongmin Li, Liesu Meng, Jian Sun, Shemin Lu
Osteoarthritis (OA) is the most common form of arthritis involving major structural changes of peripheral joints and local or systemic inflammation and in lack of therapeutic approaches because of complexity of underlying molecular basis. Our previous work showed that HS6ST2, an enzyme involved in the transfer of sulfate, is downregulated in cartilage tissues of OA patients compared with normal donors, but little is known about its regulatory mechanism. In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same patient...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29899409/phosphorylation-of-parkin-at-serine-131-by-p38-mapk-promotes-mitochondrial-dysfunction-and-neuronal-death-in-mutant-a53t-%C3%AE-synuclein-model-of-parkinson-s-disease
#18
Jialong Chen, Yixian Ren, Chen Gui, Menglan Zhao, Xian Wu, Kanmin Mao, Wenjun Li, Fei Zou
α-synuclein abnormal accumulation and mitochondria dysfunction are involved in the pathogenesis of Parkinson's disease. Selective autophagy of mitochondria (mitophagy) is a crucial component of the network controlling the mitochondrial homeostasis. However, the underlying mechanism that mutant α-synuclein induces mitochondrial abnormality through mitophagy impairment is not fully understood. Here, we showed that mutant A53T α-synuclein accumulation impaired mitochondrial function and Parkin-mediated mitophgy in α-synucleinA53T model...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29899110/differentiated-macrophages-acquire-a-pro-inflammatory-and-cell-death-resistant-phenotype-due-to-increasing-xiap-and-p38-mediated-inhibition-of-ripk1
#19
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A Alturki, Zoya Aamir, Emmanuelle Ametepe, Robert G Korneluk, Christopher Tiedje, Manoj B Menon, Matthias Gaestel, Scott McComb, Subash Sad
Monocytes differentiate into macrophages, which deactivate invading pathogens. Macrophages can be resistant to cell death mechanisms in some situations and the mechanisms involved are not clear. Here, using mouse immune cells, we investigated whether the differentiation of macrophages affects their susceptibility to cell death by the ripoptosome/necrosome pathways. We show that treatment of macrophages with a mimetic of second mitochondrial activator of caspases (SMAC) resulted in ripoptosome driven cell death that specifically depended on tumor necrosis factor α (TNFα) expression and the receptor-interacting serine/threonine protein kinase 1 (RipK1)-RipK3-caspase-8 interaction in activated and cycling macrophages...
June 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29896988/influence-of-hypothyroidism-on-testicular-mitochondrial-oxidative-stress-by-activating-the-p38-mitogen-activated-protein-kinase-and-c-jun-nh-2-terminal-kinase-signaling-pathways-in-rats
#20
X-R Chang, Y-L Yao, D Wang, H-T Ma, P-H Gou, C-Y Li, J-L Wang
Thyroid hormone deficiency can impair testicular function. However, knowledge of the effects of mitogen-activated protein kinase (MAPK) pathways on testicular mitochondrial oxidative damage induced by hypothyroidism is still rudimentary. This study aims to explore the possible mechanisms of testicular mitochondrial oxidative damage in hypothyroidism rats. Wistar male rats were randomly divided into control (C), low- (L), and high-hypothyroidism (H) groups (1 ml/100 g body weights (BWs)/day 0, 0.001% and 0.1% propylthiouracil, respectively) by intragastric gavage for 60 days...
January 1, 2018: Human & Experimental Toxicology
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