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https://www.readbyqxmd.com/read/29475100/new-thiazolidinedione-lpsf-gq-2-inhibits-nf%C3%AE%C2%BAb-and-mapk-activation-in-lps-induced-acute-lung-inflammation
#1
Laise Aline Martins Dos Santos, Gabriel Barros Rodrigues, Fernanda Virgínia Barreto Mota, Maria Eduarda Rocha de França, Karla Patrícia de Souza Barbosa, Wilma Helena de Oliveira, Sura Wanessa Santos Rocha, Deniele Bezerra Lós, Amanda Karolina Soares Silva, Teresinha Gonçalves da Silva, Christina Alves Peixoto
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as potential drugs for the treatment of ALI and ARDS due to their anti-inflammatory efficacy. The present study aims to evaluate the potential anti-inflammatory effects of new TZDs derivatives, LPSF/GQ-2 and LPSF/RA-4, on ALI induced by LPS...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#2
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475064/ursodeoxycholyl-lysophosphatidylethanolamide-negatively-regulates-tlr-mediated-lipopolysaccharide-response-in-human-thp-1-derived-macrophages
#3
Alzbeta Horvatova, Tanyarath Utaipan, Ann-Christin Otto, Yuling Zhang, Hongying Gan-Schreier, Petr Pavek, Anita Pathil, Wolfgang Stremmel, Walee Chamulitrat
The bile acid-phospholipid conjugate ursodeoxycholyl oleoyl-lysophophatidylethanolamide (UDCA-18:1LPE) is an anti-inflammatory and anti-fibrotic agent as previously shown in cultured hepatocytes and hepatic stellate cells as well as in in vivo models of liver injury. We hypothesize that UDCA-18:1LPE may directly inhibit the activation of immune cells. We found that UDCA-18:1LPE was capable of inhibiting the migration of phorbol ester-differentiated human THP-1 cells. We examined anti-inflammatory activity of UDCA-18:1LPE during activation of THP1-derived macrophages...
February 20, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29474583/ochratoxin-a-citrinin-and-deoxynivalenol-decrease-claudin-2-expression-in-mouse-rectum-cmt93-ii-cells
#4
Hideaki Nakayama, Norio Kitagawa, Takahito Otani, Hiroshi Iida, Hisashi Anan, Tetsuichiro Inai
Intestinal epithelial cells are the first targets of ingested mycotoxins, such as ochratoxin A, citrinin and deoxynivalenol. It has been reported that paracellular permeability regulated by tight junctions is modulated by several mycotoxins by reducing the expression of specific claudins and integral membrane proteins in cell-cell contacts, accompanied by increase in phosphorylation of mitogen-activated protein kinases, including extracellular signal-related kinase (ERK) 1/2, p38 and c-Jun NH2-terminal protein kinase...
February 21, 2018: Microscopy
https://www.readbyqxmd.com/read/29472645/a-single-extinction-based-treatment-with-a-kappa-opioid-receptor-agonist-elicits-a-long-term-reduction-in-cocaine-relapse
#5
Jasper A Heinsbroek, Amelia B Furbish, Jamie Peters
Kappa opioid receptor (KOR) agonists have known anti-addiction properties and can reduce drug seeking. Their potential for clinical use has largely been daunted by their aversive properties mediated through p38 MAPK signaling. Here we examined the therapeutic potential of the KOR agonist U50,488 (U50) to reduce cocaine seeking in a self-administration model. Following cocaine self-administration and 7 days of forced home-cage abstinence, rats were administered a single dose of U50 (5 mg/kg, i.p.) 30 min prior to the first extinction training session, wherein cocaine and the discrete cocaine-paired cues were no longer available...
February 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29472592/gsk3-is-a-negative-regulator-of-the-thermogenic-program-in-brown-adipocytes
#6
Lasse K Markussen, Sally Winther, Barton Wicksteed, Jacob B Hansen
Brown adipose tissue is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis. β-Adrenergic stimulation of brown adipocytes leads to an increase in oxygen consumption and induction of a thermogenic gene program that includes uncoupling protein 1 (Ucp1) and fibroblast growth factor 21 (Fgf21). In kinase inhibitor screens, we have identified glycogen synthase kinase 3 (GSK3) as a negative regulator of basal and β-adrenergically stimulated Fgf21 expression in cultured brown adipocytes...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29471675/alterations-in-nucleotide-binding-oligomerization-domain-2-expression-pathway-activation-and-cytokine-production-in-yao-syndrome
#7
Christine McDonald, Min Shen, Erin E Johnson, Amrita Kabi, Qingping Yao
Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease. Due to the recent identification of YAOS, the molecular mechanisms underlying its disease pathogenesis are unclear. With specific NOD2 variants as characteristic genotypic features of YAOS, our study examined NOD2 expression, transcript splicing, signaling pathway activation, and cytokine profiles in peripheral blood mononuclear cells (PBMCs) from 10 YAOS patients and six healthy individuals...
February 22, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29470830/strong-enhancement-by-igf1-r-antagonists-of-hepatocellular-carcinoma-cell-migration-inhibition-by-sorafenib-and-or-vitamin-k1
#8
Rosalba D'Alessandro, Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Caterina Messa, Aldo Cavallini, Brian Irving Carr
PURPOSE: Emerging evidence indicates that combining Sorafenib with vitamin K1 (VK1) may result in a synergistic inhibition of hepatocellular carcinoma (HCC) cell migration and proliferation. Despite this synergy, its benefits may be limited due to drug resistance resulting from cross-talk with the tumor microenvironment. Insulin-like growth factor-1 (IGF1) signaling acts as an important modulator of HCC cell growth, motility and drug resistance. Therefore, we aimed to explore the effects of Sorafenib in combination with VK1 and/or IGF1-R antagonists on HCC cells...
February 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29470443/structure-antiplatelet-activity-relationships-of-novel-ruthenium-ii-complexes-investigation-of-its-molecular-targets
#9
Chih-Hsuan Hsia, Thanasekaran Jayakumar, Joen-Rong Sheu, Shin-Yi Tsao, Marappan Velusamy, Chih-Wei Hsia, Duen-Suey Chou, Chao-Chien Chang, Chi-Li Chung, Themmila Khamrang, Kao-Chang Lin
The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven to be a positive approach to the prevention of thrombosis. Ruthenium complexes are fascinating for the development of new drugs, as they possess numerous chemical and biological properties. The present study aims to evaluate the structure-activity relationship (SAR) of newly synthesized ruthenium (II) complexes, TQ-1, TQ-2 and TQ-3 in agonists-induced washed human platelets. Silica gel column chromatography, aggregometry, immunoblotting, NMR, and X-ray analyses were performed in this study...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470442/phycocyanin-protects-against-uvb-induced-apoptosis-through-the-pkc-%C3%AE-%C3%AE-ii-nrf-2-ho-1-dependent-pathway-in-human-primary-skin-cells
#10
Ki Mo Kim, Joo Young Lee, A-Rang Im, Sungwook Chae
Phycocyanin (Pc) is one of the active pigment constituents of Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, the protective effects of Pc against ultraviolet-B (UVB)-induced primary skin cells damage are still undefined. In the present study, we investigated whether Pc prevented UVB-induced apoptotic cell death in human dermal fibroblasts (HDF) and human epidermal keratinocytes (HEK). Pc induced the transcription of heme oxygenase-1 (HO-1). Furthermore, Pc treatments resulted in a marked increase in nuclear factor erythroid-derived 2 (NF-E2)-like 2 (Nrf-2) nuclear translocation...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29468851/isolates-from-alpinia-officinarum-hance-attenuate-lps-induced-inflammation-in-hepg2-evidence-from-in-silico-and-in-vitro-studies
#11
Abdullah A Elgazar, Nabil M Selim, Nabil M Abdel-Hamid, Mohammed A El-Magd, Hala M El Hefnawy
In an attempt to connect the legacy of centuries of invaluable knowledge from traditional medicine and the current understanding to the molecular mechanism of diseases, we took the advantage of the emergence of in silico screening as a promising tool for identification of potential leads from libraries of natural products. Traditional Chinese Medicine database was subjected to structure based virtual screening for identification of anti-inflammatory compounds using the 3D crystal structure of p38 alpha mitogen activated protein kinase...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468753/f1012-2-inhibits-the-growth-of-triple-negative-breast-cancer-through-induction-of-cell-cycle-arrest-apoptosis-and-autophagy
#12
Shasha Tian, Yan Chen, Bo Yang, Chenghua Lou, Rui Zhu, Yaping Zhao, Huajun Zhao
Sesquiterpene lactones (SLs) are plant-derived constituents that have been proved to have potential antitumour activity. However, the intracellular molecular targets of SLs and the underlying molecular mechanisms have not been well elucidated. Here, we report that F1012-2, a novel SL active fraction, isolated from Eupatorium lindleyanum DC., can significantly inhibit the growth of triple-negative breast cancer (TNBC) cells (MDA-MB-231 and MDA-MB-468) but has no obvious inhibitory effect on the growth of human mammary epithelial cells (MCF-10A)...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29467907/tgfbr1-6a-is-a-potential-modifier-of-migration-and-invasion-in-colorectal-cancer-cells
#13
Rui Zhou, Ying Huang, Boran Cheng, Yulei Wang, Bin Xiong
Type 1 transforming growth factor β receptor (TGFBR1)*6A, a common hypomorphic variant of TGFBR1, may act as a susceptibility allele in colorectal cancer. However, the contribution of TGFBR1*6A to colorectal cancer development is largely unknown. To test the hypothesis that TGFBR1*6A promotes colorectal cancer invasion and metastasis via Smad-independent transforming growth factor-β (TGF-β) signaling, the effect of TGFBR1*6A on the invasion of colorectal cancer cells was assessed. pCMV5-TGFBR1*6A-HA plasmids were transfected into SW48 and DLD-1 cells by Lipofectamine-mediated DNA transfection...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467899/tnf-%C3%AE-promotes-colon-cancer-cell-migration-and-invasion-by-upregulating-trop-2
#14
Peng Zhao, Zhongtao Zhang
High levels of tumor-associated calcium signal transduction protein (TROP)-2 have been demonstrated to be strongly associated with tumor necrosis factor (TNF)-α levels in colon cancer. In the present study, the effect of TNF-α on the regulation of TROP-2 expression and its effect in colon cancer cell migration and invasion were investigated in vitro . TROP-2 protein levels were evaluated in HCT-116 human colon cancer cells cultured with various concentrations of TNF-α using western blot analysis. Changes in the migratory and invasive potential of the cells were evaluated using a wound healing and transwell assay, respectively...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467841/hepatoprotective-effect-of-methyl-ferulic-acid-against-carbon-tetrachloride-induced-acute-liver-injury-in-rats
#15
Chengfang Yang, Li Li, Zuheng Ma, Yujuan Zhong, Wenxiao Pang, Meili Xiong, Shuping Fang, Yongwen Li
The present study aimed to investigate the hepatoprotective effects of methyl ferulic acid (MFA) against oxidative stress and apoptosis in acute liver injury induced by carbon tetrachloride (CCl4 ) in rats, as well as the underlying mechanisms. Sprague Dawley rats were treated with CCl4 after oral administration of MFA (25, 50, and 100 mg/kg) or dimethyl diphenyl bicarboxylate (200 mg/kg) for 7 days. The hepatoprotective effects of MFA were determined by analyzing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities as well as changes of oxidant parameters...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467361/resveratrol-attenuates-cognitive-deficits-of-traumatic-brain-injury-by-activating-p38-signaling-in-the-brain
#16
Zhenhua Shi, Wusi Qiu, Guomin Xiao, Jun Cheng, Ning Zhang
BACKGROUND Traumatic brain injury (TBI) is characterized by cognitive deficits, which was associated with brain oxidative stress and apoptosis. Resveratrol (RSV) is an anti-apoptotic and anti-oxidative. This study aimed to investigate neuroprotective effects and involved molecular mechanisms in TBI. MATERIAL AND METHODS RSV and p38 inhibitor were administrated to TBI rats. Cognitive deficits were evaluated by Morris water maze assay. Reactive oxygen species (ROS) and apoptosis were detected in rat brains by fluorescent staining...
February 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29466693/acute-extracellular-matrix-inflammatory-and-mapk-response-to-lengthening-contractions-in-elderly-human-skeletal-muscle
#17
Jacob R Sorensen, Caitlin Skousen, Alex Holland, Kyle Williams, Robert D Hyldahl
To uncover potential factors that may be involved in the impaired regenerative capacity of aged skeletal muscle, we comprehensively assessed the molecular stress response following muscle damage in old and young individuals. 10 young (22.7 ± 2.25 yrs) and 8 physically active old (70.9 ± 7.5 yrs) subjects completed a bout of 300 lengthening contractions (LC), and muscle biopsies were taken pre-exercise and at 3, 24, and 72 h post-LC. Both age groups performed the same amount of work during LC, with the old group displaying a resistance to LC-induced fatigue during the exercise...
February 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29466417/epinephrine-modulates-na-k-atpase-activity-in-caco-2-cells-via-src-p38mapk-erk-and-pge2
#18
Layla El Moussawi, Mohamed Chakkour, Sawsan I Kreydiyyeh
Epinephrine, a key stress hormone, is known to affect ion transport in the colon. Stress has been associated with alterations in colonic functions leading to changes in water movements manifested as diarrhea or constipation. Colonic water movement is driven by the Na+-gradient created by the Na+/K+-ATPase. Whether epinephrine acts via an effect on the Na+/K+-ATPase hasn't been studied before. The aim of this work was to investigate the effect of epinephrine on the Na+/K+-ATPase and to elucidate the signaling pathway involved using CaCo-2 cells as a model...
2018: PloS One
https://www.readbyqxmd.com/read/29465363/inhibitory-effect-and-mechanism-of-1-25-dihydroxy-vitamin-d3-on-rankl-expression-in-fibroblast-like-synoviocytes-and-osteoclast-like-cell-formation-induced-by-il-22-in-rheumatoid-arthritis
#19
Hongyan Wen, Yang Liu, Jinchan Li, Dandan Wei, Dandan Liu, Fangfang Zhao
OBJECTIVES: To explore the inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 (l,25(OH)2D3) on receptor activator of nuclear factor-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLSs) and osteoclastogenesis induced by interleukin (IL)-22 in patients with rheumatoid arthritis (RA). METHODS: Fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLSs) were cultured and stimulated for RANKL expression with IL-22 in the absence or presence of various concentrations of l,25(OH)2D3, and JAK-2 inhibitor or p38 MAPK inhibitor at the optimised time point of IL-22 treatment...
February 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465317/neuroprotective-effects-of-silibinin-an-in-silico-and-in-vitro-study
#20
Valencia Fernandes, Dilip Sharma, Kiran Kalia, Vinod Tiwari
Astrogliosis is a key contributor for many neurological disorders involving apoptosis, neuroinflammation and subsequent neuronal death. Silibinin, a polyphenol isolated from milk thistle (Silybum marianum), has been shown to suppress the astrocyte activation in various neurodegenerative disorders and also exhibit a neuroprotective role in neuroinflammation-driven oxidative damage. In the present study, we found that treatment with silibinin significantly attenuates LPS- oxidative-nitrosative stress in C6 astrocytoma cells...
February 21, 2018: International Journal of Neuroscience
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