keyword
https://read.qxmd.com/read/38546949/compensatory-upregulation-of-mt2a-alleviates-neurogenic-intermittent-claudication-through-inhibiting-activated-p38-mapk-mediated-neuronal-apoptosis
#1
JOURNAL ARTICLE
Chenggang Wang, Zhanchao Wang, Ying Zi, Xuejian Dan, Jiahui Xu, Jingwei Zhao, Wei Xu, Zhourui Wu, Wei Liu, Bin Ma
Neurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal apoptosis. To explore the novel therapeutic target of NIC treatment, we constructed the rat model of NIC by cauda equina compression (CEC) method and collected dorsal root ganglion (DRG) tissues, a region responsible for sensory and motor function, for mRNA sequencing. Bioinformatic analysis of mRNA sequencing indicated that upregulated metallothionein 2A (MT2A), an apoptosis-regulating gene belonging to the metallothionein family, might participate in NIC progression...
March 28, 2024: Human Cell
https://read.qxmd.com/read/38546350/the-protective-effects-of-arctiin-in-asthma-by-attenuating-airway-inflammation-and-inhibiting-p38-nf-%C3%AE%C2%BAb-signaling
#2
JOURNAL ARTICLE
Lang Yuan, Chao Sun
Asthma is a common chronic inflammatory disease of the airways, which affects millions of people worldwide. Arctiin, a bioactive molecule derived from the traditional Chinese Burdock, has not been previously reported for its effects on asthma in infants. In this study, an asthma model was established in mice by stimulation with ovalbumin (OVA). Bronchoalveolar lavage (BALF) was collected from OVA-challenged mice and the cells were counted. Lung tissue was harvested for hematoxylin-eosin (HE) staining and measurement of Wet/Dry weight ratios...
March 27, 2024: Aging
https://read.qxmd.com/read/38545117/-acanthopanax-senticosus-improves-cognitive-impairment-in-alzheimer-s-disease-by-promoting-the-phosphorylation-of-the-mapk-signaling-pathway
#3
JOURNAL ARTICLE
Zhichun Zhang, Yonghui Wu, Dan Shi, Chanyu Jiang, Hengyan Cao, Fengyi Jiang, Xiaomin Bao, Yan Shen, Xiao Shi
BACKGROUND: Acanthopanax senticosus (AS) can improve sleep, enhance memory, and reduce fatigue and is considered as an effective drug for Alzheimer's disease (AD). The therapeutic effect and mechanism need to be further investigated. METHODS: To confirm the AS play efficacy in alleviating memory impairment in mice, 5×FAD transgenic mice were subjected to an open-field experiment and a novelty recognition experiment. Network pharmacology technique was used to analyze the information of key compounds and potential key targets of AS for the treatment of AD, molecular docking technique was applied to predict the binding ability of targets and compounds, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were also performed on the targets to derive the possible metabolic processes and pathway mechanisms of AS in treating AD...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544478/cutaneous-calcium-calmodulin-dependent-protein-kinase-ii-%C3%AE-positive-sympathetic-nerves-secreting-norepinephrine-dictate-psoriasis
#4
JOURNAL ARTICLE
Yafen Yu, Weiwei Chen, Bao Li, Zhuo Li, Yirui Wang, Yiwen Mao, Wencheng Fan, Yuanming Bai, Hongbo Hu, Qi Zhen, Liangdan Sun
Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It is found that cutaneous calcium/calmodulin-dependent protein kinase II-γ (CAMK2γ), expressed mainly in sympathetic nerves, is activated by stress and imiquimod in mouse skin. Camk2g-deficient mice exhibits attenuated imiquimod-induced psoriasis-like manifestations and skin inflammation. CaMK2γ regulates dermal γδT-cell interleukin-17 production in imiquimod-treated mice, dependent on norepinephrine production following cutaneous sympathetic nerve activation...
March 28, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38543164/anti-inflammatory-effect-of-columbianadin-against-d-galactose-induced-liver-injury-in-vivo-via-the-jak2-stat3-and-jak2-p38-nf-%C3%AE%C2%BAb-pathways
#5
JOURNAL ARTICLE
Zhe Ma, Lin Peng, Yaoyao Sheng, Wenhui Chu, Yongqian Fu
Angelicae pubescentis radix (APR) has been traditionally used for thousands of years in China to treat rheumatoid arthritis (RA), an autoimmune disorder. As the main active coumarin of APR, columbianadin (CBN) exhibits a significant anti-inflammatory effect in vitro. However, the anti-inflammatory activity and underlying mechanism of CBN in vivo remain unclear. This work aimed to elucidate the anti-inflammatory activity of CBN in vivo and its related signaling pathways in a D-Gal-induced liver injury mouse model...
March 15, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543095/exploring-the-mechanism-of-salvianolic-acid-b-against-myocardial-ischemia-reperfusion-injury-based-on-network-pharmacology
#6
JOURNAL ARTICLE
Qianping Mao, Chongyu Shao, Huifen Zhou, Li Yu, Yida Bao, Yali Zhao, Jiehong Yang, Haitong Wan
This study aimed to explore the mechanisms through which salvianolic acid B (Sal-B) exerts its effects during myocardial ischemia-reperfusion injury (MI/RI), aiming to demonstrate the potential pharmacological characteristics of Sal-B in the management of coronary heart disease. First, Sal-B-related targets and MI/RI-related genes were compiled from public databases. Subsequent functional enrichment analyses using the protein-protein interaction (PPI) network, gene ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) predicted the core targets and approaches by which Sal-B counters MI/RI...
February 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542228/inhibitor-trapping-in-kinases
#7
JOURNAL ARTICLE
Danislav S Spassov, Mariyana Atanasova, Irini Doytchinova
Recently, we identified a novel mechanism of enzyme inhibition in N-myristoyltransferases (NMTs), which we have named 'inhibitor trapping'. Inhibitor trapping occurs when the protein captures the small molecule within its structural confines, thereby preventing its free dissociation and resulting in a dramatic increase in inhibitor affinity and potency. Here, we demonstrate that inhibitor trapping also occurs in the kinases. Remarkably, the drug imatinib, which has revolutionized targeted cancer therapy, is entrapped in the structure of the Abl kinase...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542139/regulation-of-stat1-and-stat4-expression-by-growth-factor-and-interferon-supplementation-in-sj%C3%A3-gren-s-syndrome-cell-culture-models
#8
JOURNAL ARTICLE
Jean-Luc C Mougeot, Thomas E Thornburg, Braxton D Noll, Michael T Brennan, Farah Bahrani Mougeot
Our goal was to investigate the effects of epidermal growth factor (EGF) and interferons (IFNs) on signal transducer and activator of transcription STAT1 and STAT4 mRNA and active phosphorylated protein expression in Sjögren's syndrome cell culture models. iSGECs (immortalized salivary gland epithelial cells) and A253 cells were treated with EGF, IFN-alpha, -beta, -gamma, or mitogen-activated protein kinase p38 alpha (p38-MAPK) inhibitor for 0-24-48-72 h. STAT1 and STAT4 mRNA expression was quantified by qRT-PCR...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38540076/dietary-zn-deficiency-inhibits-cell-proliferation-via-the-gpr39-mediated-suppression-of-the-pi3k-akt-mtor-signaling-pathway-in-the-jejunum-of-broilers
#9
JOURNAL ARTICLE
Yangyang Hu, Ke Yang, Weiyun Zhang, Mengxiao Xue, Tingting Li, Shengchen Wang, Xiaoyan Cui, Liyang Zhang, Yun Hu, Xugang Luo
A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell proliferation of broilers. For this study, a total of 112 chickens (21 days old) were randomly divided into two treatments (seven replicate cages per treatment, eight chickens per replicate cage): the control group (CON) and the Zn deficiency group...
March 21, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539889/selenomethionine-alleviates-deoxynivalenol-induced-oxidative-injury-in-porcine-intestinal-epithelial-cells-independent-of-mapk-pathway-regulation
#10
JOURNAL ARTICLE
Zhouyin Huang, Haopeng Zhong, Ting Li, Zirui Wang, Xingping Chen, Tiande Zou, Jinming You, Jun Chen
Deoxynivalenol (DON) is a prevalent contaminant in feed and food, posing a serious threat to the health of both humans and animals. The pig stands as an ideal subject for the study of DON due to its recognition as the most susceptible animal to DON. In this study, the IPEC-J2 cells were utilized as an in vitro model to explore the potential of SeMet in alleviating the intestinal toxicity and oxidative injury in intestinal epithelial cells when exposed to DON. Cells were treated either with or without 4.0 μM SeMet, in combination with or without a simultaneous treatment with 0...
March 16, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38538669/mir-889-3p-targeting-bmpr2-promotes-the-development-of-retinoblastoma-via-jnk-mapk-erk-signaling
#11
JOURNAL ARTICLE
Yuan Gao, Pei Du
MicroRNAs (miRNAs) are vital regulators of tumor pathogenesis, including that of retinoblastoma (Rb). This study investigated the functions and mechanisms of action of miR-889-3p in Rb. BMPR2 and miR-889-3p levels were assessed by quantitative reverse transcription PCR (qRT-PCR) or western blotting. Through several cell function tests, the effects of miR-889-3p and BMPR2 on cell proliferation, migration, and JNK/MAPK/ERK signaling were evaluated. The interaction between miR-889-3p and BMPR2 was investigated using a luciferase reporter assay...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38537847/knockdown-of-mapk-p38-linked-genes-increases-the-susceptibility-of-chilo-suppressalis-larvae-to-various-transgenic-bt-rice-lines
#12
JOURNAL ARTICLE
Xurong Niu, Jialiang Jiang, Yajie Sun, J Joe Hull, Weihua Ma, Hongxia Hua, Yongjun Lin
Bacillus thuringiensis (Bt) toxins have provided exceptional control of agricultural insect pests, however, over reliance on the proteins would potentially contribute to the development of field tolerance. Developing new sustainable insect pest control methods that target the mechanisms underlying Bt tolerance can potentially support the Bt control paradigm while also providing insights into basic insect physiology. The MAPK p38 pathway is strongly associated with Bt tolerance in Chilo suppressalis, a major pest of rice...
March 25, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38536085/the-cryo-em-structure-of-ask1-reveals-an-asymmetric-architecture-allosterically-modulated-by-trx1
#13
JOURNAL ARTICLE
Karolina Honzejkova, Dalibor Kosek, Veronika Obsilova, Tomas Obsil
Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, cardiovascular, and neurodegenerative diseases, among others. However, our limited knowledge of the underlying structural mechanism of ASK1 regulation hampers our ability to target this member of the MAP3K protein family towards developing therapeutic interventions for these disorders...
March 27, 2024: ELife
https://read.qxmd.com/read/38534361/brain-derived-neurotrophic-factor-bdnf-enhances-osteogenesis-and-may-improve-bone-microarchitecture-in-an-ovariectomized-rat-model
#14
JOURNAL ARTICLE
Eugene J Park, Van-Long Truong, Woo-Sik Jeong, Woo-Kie Min
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of BDNF have not been fully understood. This study aimed to investigate the action of BDNF on the osteoblast differentiation in bone marrow stromal cells, and its influence on signaling pathways. In addition, to evaluate the clinical efficacy, an in vivo animal study was performed...
March 15, 2024: Cells
https://read.qxmd.com/read/38533556/ykl40-potentially-via-activating-the-p38-pathway-in-decreasing-atherosclerotic-plaque-stability
#15
JOURNAL ARTICLE
Chao Wang, Yandong Liu, Wei Huan, Jianjin Wu, Jie Jin, Sili Zou, Yu Chen, Lefeng Qu
No abstract text is available yet for this article.
March 26, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38529191/antibacterial-activity-of-cinnamon-essential-oil-and-its-main-component-of-cinnamaldehyde-and-the-underlying-mechanism
#16
JOURNAL ARTICLE
Chengjie Shu, Ling Ge, Zhuohang Li, Bin Chen, Shengliang Liao, Lu Lu, Qinlin Wu, Xinyi Jiang, Yuhan An, Zongde Wang, Man Qu
Background: Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial mechanisms, especially the in vivo antibacterial mechanisms, remain elusive. Methods: In this study, we utilized the in vivo assessment system of Caenorhabditis elegans ( C...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38527573/anti-inflammatory-effects-and-related-mechanisms-in-vitro-and-in-vivo-of-hedychium-coccineum-rhizome-essential-oil
#17
JOURNAL ARTICLE
Minyi Tian, Dan Xie, Yi Hong, Furong Ding, Xia Wu, Dongxin Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Hedychium coccineum rhizome is an anti-inflammatory ethnomedicine used to remedy inflammation-related swelling and bronchial asthma. AIM OF THE STUDY: The study aimed to analyze the phytochemical constituents of H. coccineum rhizome essential oil (EO) and evaluate its in vitro and in vivo anti-inflammatory effects and underlying mechanisms. MATERIALS AND METHODS: Phytochemical constituents of H. coccineum rhizome EO were analyzed using GC-FID/MS...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38527438/demethylzeylasteral-t-96-alleviates-allergic-asthma-via-inhibiting-mapk-erk-and-nf-%C3%AE%C2%BAb-pathway
#18
JOURNAL ARTICLE
Jianan Huang, Hui Cai, Xiaofen Ye, Ge Zhang, Ling Ye, Chunxin Yang, Jian Wang, Meiling Jin
INTRODUCTION: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma. METHODS: The OVA-induced asthmatic mice were administered by gavage with T-96 (0.1 mg/10 g, 0.3 mg/10 g, or 0.6 mg/10 g) 1 h before each challenge. The airway hyperresponsiveness was assessed, pathological changes were evaluated by HE and PAS staining, and expressions of Th2 cytokines were determined by PCR and ELISA...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38525537/substance-p-promotes-tgf-%C3%AE-induced-collagen-synthesis-in-human-corneal-fibroblasts
#19
JOURNAL ARTICLE
Koji Sugioka, Teruo Nishida, Junko Murakami, Motoki Itahashi, Mai Yunoki, Shunji Kusaka
Corneal fibroblasts maintain homeostasis of the corneal stroma by mediating the synthesis and degradation of extracellular collagen, and these actions are promoted by transforming growth factor-β (TGF-β) and interleukin-1b (IL-1β), respectively. The cornea is densely innervated with sensory nerve fibers that are not only responsible for sensation but also required for physiological processes such as tear secretion and wound healing. Loss or dysfunction of corneal nerves thus impairs corneal epithelial wound healing and can lead to neurotrophic keratopathy...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38523594/rack1-mediated-ferroptosis-affects-hindgut-development-in-rats-with-anorectal-malformations-spatial-transcriptome-insights
#20
JOURNAL ARTICLE
Chen-Yi Wang, Mu-Yu Li, Si-Ying Li, Xiao-Gao Wei, Nai-Xuan Dong, Shu-Ting Liu, Zheng-Wei Yuan, Bo Li, Agostino Pierro, Xiao-Bing Tang, Yu-Zuo Bai
Anorectal malformation (ARM), a common congenital anomaly of the digestive tract, is a result of insufficient elongation of the urorectal septum. The cytoplasmic protein Receptor of Activated C-Kinase 1 (Rack1) is involved in embryonic neural development; however, its role in embryonic digestive tract development and ARM formation is unexplored. Our study explored the hindgut development and cell death mechanisms in ARM-affected rats using spatial transcriptome analysis. We induced ARM in rats by administering ethylenethiourea via gavage on gestational day (GD) 10...
March 25, 2024: Cell Proliferation
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