Yafen Yu, Weiwei Chen, Bao Li, Zhuo Li, Yirui Wang, Yiwen Mao, Wencheng Fan, Yuanming Bai, Hongbo Hu, Qi Zhen, Liangdan Sun
Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It is found that cutaneous calcium/calmodulin-dependent protein kinase II-γ (CAMK2γ), expressed mainly in sympathetic nerves, is activated by stress and imiquimod in mouse skin. Camk2g-deficient mice exhibits attenuated imiquimod-induced psoriasis-like manifestations and skin inflammation. CaMK2γ regulates dermal γδT-cell interleukin-17 production in imiquimod-treated mice, dependent on norepinephrine production following cutaneous sympathetic nerve activation...
March 28, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)