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https://www.readbyqxmd.com/read/29677060/cerebral-small-vessel-but-not-large-vessel-disease-is-associated-with-impaired-cerebral-autoregulation-during-cardiopulmonary-bypass-a-retrospective-cohort-study
#1
Yohei Nomura, Roland Faegle, Daijiro Hori, Abbas Al-Qamari, Alexander J Nemeth, Rebecca Gottesman, Gayane Yenokyan, Charles Brown, Charles W Hogue
BACKGROUND: Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associated with impaired cerebral autoregulation during CPB. METHODS: A retrospective cohort analysis of data from 346 patients undergoing cardiac surgery with CPB enrolled in an ongoing prospectively randomized clinical trial of autoregulation monitoring were evaluated...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676693/intraoperative-evaluation-of-local-cerebral-hemodynamic-change-by-indocyanine-green-videoangiography-prediction-of-incidence-and-duration-of-postoperative-transient-neurological-events-in-patients-with-moyamoya-disease
#2
Kenji Uda, Yoshio Araki, Shinsuke Muraoka, Shinji Ota, Kentaro Wada, Kinya Yokoyama, Masahiro Nishihori, Takashi Izumi, Sho Okamoto, Toshihiko Wakabayashi
OBJECTIVE Transient neurological events (TNEs) occur frequently in the acute phase after direct bypass surgery for moyamoya disease (MMD), but there is currently no way to predict them. FlowInsight is a specialized software for analyzing indocyanine green (ICG) videoangiography taken with a surgical microscope. The purpose of this study was to investigate whether intraoperative evaluation of local hemodynamic changes around anastomotic sites using FlowInsight could predict the incidence and duration of TNEs...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676177/acetylcholine-induced-ciliary-beat-of-the-human-nasal-mucosa-is-regulated-by-the-pannexin-1-channel-and-purinergic-p2x-receptor
#3
Ba H Do, Toyoaki Ohbuchi, Tetsuro Wakasugi, Hiroki Koizumi, Mitsuru Yokoyama, Nobusuke Hohchi, Hideaki Suzuki
Background Airway mucociliary transport is an important function for the clearance of inhaled foreign particulates in the respiratory tract. The present study aimed at investigating the regulatory mechanism of acetylcholine (Ach)-induced ciliary beat of the human nasal mucosa in ex vivo. Methods The inferior turbinate mucosa was collected from patients with chronic hypertrophic rhinitis during endoscopic surgery. The mucosa was cut into thin strips, and ciliary movement was observed under a phase-contrast light microscope with a high-speed digital video camera...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29675754/influence-of-mp-29-02-on-ciliary-beat-frequency-in-human-epithelial-cells-in-vitro
#4
D Häussler, J U Sommer, A Nastev, C Aderhold, A Wenzel, B Kramer, B A Stuck, R Birk
PURPOSE: MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far. METHODS: MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope...
April 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29675474/brain-tumor-characterization-using-multibiometric-evaluation-of-mri
#5
Faris Durmo, Jimmy Lätt, Anna Rydelius, Silke Engelholm, Sara Kinhult, Krister Askaner, Elisabet Englund, Johan Bengzon, Markus Nilsson, Isabella M Björkman-Burtscher, Thomas Chenevert, Linda Knutsson, Pia C Sundgren
The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest...
March 2018: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29674415/noninvasive-assessment-of-hemodynamic-stress-distribution-after-indirect-revascularization-for-pediatric-moyamoya-vasculopathy
#6
D Tortora, M Severino, M Pacetti, G Morana, M M Mancardi, V Capra, A Cama, M Pavanello, A Rossi
BACKGROUND AND PURPOSE: Indirect revascularization surgery is an effective treatment in children with Moyamoya vasculopathy. In the present study, we hypothesized that DSC-PWI may reliably assess the evolution of CBF-related parameters after revascularization surgery, monitoring the outcome of surgical pediatric patients with Moyamoya vasculopathy. Thus, we aimed to evaluate differences in DSC-PWI parameters, including the hemodynamic stress distribution, in surgical and nonsurgical children with Moyamoya vasculopathy and to correlate them with long-term postoperative outcome...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29668713/alterations-in-the-coupling-functions-between-cerebral-oxyhaemoglobin-and-arterial-blood-pressure-signals-in-post-stroke-subjects
#7
Honglun Su, Congcong Huo, Bitian Wang, Wenhao Li, Gongcheng Xu, Qianying Liu, Zengyong Li
Cerebral autoregulation (CA) is the complex homeostatic regulatory relationship between blood pressure (BP) and cerebral blood flow (CBF). This study aimed to analyze the frequency-specific coupling function between cerebral oxyhemoglobin concentrations (delta [HbO2]) and mean arterial pressure (MAP) signals based on a model of coupled phase oscillators and dynamical Bayesian inference. Delta [HbO2] was measured by 24-channel near-infrared spectroscopy (NIRS) and arterial BP signals were obtained by simultaneous resting-state measurements in patients with stroke, that is, 9 with left hemiparesis (L-H group), 8 with right hemiparesis (R-H group), and 17 age-matched healthy individuals as control (healthy group)...
2018: PloS One
https://www.readbyqxmd.com/read/29668325/is-cushing-mechanism-a-dynamic-blood-pressure-stabilizing-system-insights-from-granger-causality-analysis-of-spontaneous-blood-pressure-and-cerebral-blood-flow
#8
Saqib Saleem, Paul D Teal, Connor A Howe, Michael M Tymko, Philip N Ainslie, Yu-Chieh Tzeng
Blood pressure regulation is widely recognised as being integral to the control of end-organ perfusion but it remains unclear whether end-organ perfusion also plays a role in driving changes in blood pressure (BP). A randomized and placebo controlled study design was followed to examine the feedback relationships between very-low-frequency fluctuations in BP and cerebral blood flow (CBF) in humans under placebo treatment and α1-adrenergic blockade. To determine the causal relations among haemodynamic variables, BP, middle cerebral artery blood velocity (MCAv), and end-tidal CO2 time-series were decimated, low-pass filtered (<0...
April 18, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29667328/insights-into-the-regulation-of-cbf-cold-signaling-in-plants
#9
REVIEW
Jingyan Liu, Yiting Shi, Shuhua Yang
Cold temperatures, a major abiotic stress, threaten the growth and development of plants worldwide. To cope with this adverse environmental cue, plants from temperate climates have evolved an array of sophisticated mechanisms to acclimate to cold periods, increasing their ability to tolerate freezing stress. Over the last decade, significant progress has been made in determining the molecular mechanisms underpinning cold acclimation following the identification of several pivotal components, including candidates for cold sensors, protein kinases, and transcription factors...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29666881/pathological-factors-contributing-to-crossed-cerebellar-diaschisis-in-cerebral-gliomas-a-study-combining-perfusion-diffusion-and-structural-mr-imaging
#10
Xiaoxue Liu, Jianrui Li, Qiang Xu, Dante Mantini, Peng Wang, Yuan Xie, Yifei Weng, Chiyuan Ma, Kangjian Sun, Zhiqiang Zhang, Guangming Lu
PURPOSE: To investigate imaging features of crossed cerebellar diaschisis (CCD) in cerebral gliomas, and its underlying pathophysiological mechanisms. METHODS: Thirty-three pre-surgical patients with cerebral gliomas and 33 healthy controls underwent arterial spin-labeling, diffusion tensor imaging, and high-resolution T1-weighted imaging using MRI, in order to estimate cerebral blood flow (CBF), white matter integrity, and lesion volume, respectively. Asymmetry indices of CBF in the cerebellum were used for evaluating the level of CCD in the patients...
April 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29663576/neuroprotection-by-post-stroke-administration-of-an-oral-formulation-of-angiotensin-1-7-in-ischemic-stroke
#11
Douglas M Bennion, Chad H Jones, Lauren L Donnangelo, Justin T Graham, Jacob D Isenberg, Alex N Dang, Vermali Rodriguez, Ruben D M Sinisterra, Frederico B Sousa, Robson A S Santos, Colin Sumners
NEW FINDINGS: What is the central question of this study? Angiotensin-(1-7) decreases cerebral infarct volume and improves neurological function when delivered centrally prior to and during ischemic stroke. Here, we assessed the neuroprotective effects of angiotensin-(1-7) when delivered orally post-stroke. What is the main finding and its importance? We show that oral delivery of angiotensin-(1-7) attenuates cerebral damage induced by middle cerebral artery occlusion in rats, without affecting blood pressure or cerebral blood flow...
April 16, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29661900/increased-resting-cerebral-blood-flow-in-adult-fabry-disease-mri-arterial-spin-labeling-study
#12
Po Phyu, Aine Merwick, Indran Davagnanam, Fay Bolsover, Fatima Jichi, Claudia Wheeler-Kingshott, Xavier Golay, Deralynn Hughes, Lisa Cipolotti, Elaine Murphy, Robin H Lachmann, David John Werring
OBJECTIVE: To assess resting cerebral blood flow (CBF) in the whole-brain and cerebral white matter (WM) and gray matter (GM) of adults with Fabry disease (FD), using arterial spin labeling (ASL) MRI, and to investigate CBF correlations with WM hyperintensity (WMH) volume and the circulating biomarker lyso-Gb3. METHODS: This cross-sectional, case-control study included 25 patients with genetically confirmed FD and 18 age-matched healthy controls. We quantified resting CBF using Quantitative Signal Targeting With Alternating Radiofrequency Labeling of Arterial Regions (QUASAR) ASL MRI...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29660044/multimodal-neuroimaging-differences-in-nicotine-abstinent-vs-satiated-smokers
#13
Bader Chaarani, Philip A Spechler, Alexandra Ivanciu, Mitchell Snowe, Joshua P Nickerson, Stephen T Higgins, Hugh Garavan
Introduction: Research on cigarette smokers suggests cognitive and behavioral impairments. However, much remains unclear how the functional neurobiology of smokers is influenced by nicotine state. Therefore, we sought to determine which state, be it acute nicotine abstinence or satiety, would yield the most robust differences compared to non-smokers when assessing neurobiological markers of nicotine dependence. Methods: Smokers(N=15) and sociodemographically matched non-smokers(N=15) were scanned twice using a repeated-measures design...
April 6, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29658962/a-pilot-randomized-controlled-trial-of-a-new-supplementary-food-designed-to-enhance-cognitive-performance-during-prevention-and-treatment-of-malnutrition-in-childhood
#14
Susan B Roberts, Maria Angela Franceschini, Amy Krauss, Pei-Yi Lin, Augusto Braima de Sa, Raimundo Có, Salima Taylor, Carrie Brown, Oliver Chen, Elizabeth J Johnson, William Pruzensky, Nina Schlossman, Carlito Balé, Kuan-Cheng Tony Wu, Katherine Hagan, Edward Saltzman, Paul Muentener
Background: Cognitive impairment associated with childhood malnutrition and stunting is generally considered irreversible. Objective: The aim was to test a new nutritional supplement for the prevention and treatment of moderate-acute malnutrition (MAM) focused on enhancing cognitive performance. Methods: An 11-wk, village-randomized, controlled pilot trial was conducted in 78 children aged 1-3 or 5-7 y living in villages in Guinea-Bissau. The supplement contained 291 kcal/d for young children and 350 kcal/d for older children and included 5 nutrients and 2 flavan-3-ol-rich ingredients not present in current food-based recommendations for MAM...
November 2017: Current developments in nutrition
https://www.readbyqxmd.com/read/29656926/resting-state-cerebral-blood-flow-with-arterial-spin-labeling-mri-in-developing-human-brains
#15
Feng Liu, Yunsuo Duan, Bradley S Peterson, Iris Asllani, Fernando Zelaya, David Lythgoe, Alayar Kangarlu
The development of brain circuits is coupled with changes in neurovascular coupling, which refers to the close relationship between neural activity and cerebral blood flow (CBF). Studying the characteristics of CBF during resting state in developing brain can be a complementary way to understand the functional connectivity of the developing brain. Arterial spin labeling (ASL), as a noninvasive MR technique, is particularly attractive for studying cerebral perfusion in children and even newborns. We have collected pulsed ASL data in resting state for 47 healthy subjects from young children to adolescence (aged from 6 to 20 years old)...
March 24, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29653302/jembrana-disease-virus-vif-antagonizes-the-inhibition-of-bovine-apobec3-proteins-through-ubiquitin-mediate-protein-degradation
#16
Xing Su, Hong Wang, Xiaohong Zhou, Zhaolong Li, Baisong Zheng, Wenyan Zhang
Viral infectivity factor (Vif) encoded by lentiviruses is essential for viral replication and escaping from antiviral activity of host defensive factors APOBEC3. Jembrana disease virus (JDV) causes an acute disease syndrome with approximately 20% case fatality rate in Bali cattle. However, the interplay mechanism between JDV Vif and Bos taurus APOBEC3 (btA3) is poorly understood. In this study, we determined that JDV Vif recruits ElonginB, ElonginC(ELOB/C), Cul2 and RBX1 but without the need of CBF-β to form E3 ubiquitin ligase and induces the degradation of btA3 proteins...
April 10, 2018: Virology
https://www.readbyqxmd.com/read/29643858/tobacco-transcription-factor-ntbhlh123-confers-tolerance-to-cold-stress-by-regulating-the-ntcbf-pathway-and-reactive-oxygen-species-homeostasis
#17
Qiang Zhao, Xiaohua Xiang, Dan Liu, Aiguo Yang, Yuanying Wang
Cold stress is a major environmental factor that impairs plant growth and development, geographic distribution, and crop productivity. The C-repeat binding factor (CBF) regulatory pathway has an essential role in response to cold stress. Here, we characterized a bHLH transcription factor from Nicotiana tabacum , NtbHLH123 , in response to cold stress (4°C). Overexpression of NtbHLH123 enhanced cold tolerance in transgenic tobacco plants. Based on yeast one-hybrid, chromatin immunoprecipitation PCR, and transient expression analysis assays, NtbHLH123 binds directly to the G-box/E-box motifs in the promoter of the NtCBF genes and positively regulates their expression...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29629959/baseline-cerebral-metabolic-rate-is-a-critical-determinant-of-the-cerebral-vasodilating-potency-of-volatile-anesthetic-agents
#18
John C Drummond
Halothane is commonly viewed as a more potent cerebral vasodilator than isoflurane. It was speculated that the lesser vasodilation caused by isoflurane might be the result of the greater reduction in cerebral metabolic rate (CMR) that it causes, and that the relative vasodilating potencies of halothane and isoflurane would be similar if the two agents were administered in a situation that precluded volatile-agent-induced depression of CMR. To test this hypothesis, cerebral blood flow (CBF) and the cerebral metabolic rate for oxygen (CMRO2) were measured in two groups of rabbits before and after the administration of 0...
April 9, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29627772/altered-cerebral-blood-flow-in-the-anterior-cingulate-cortex-is-associated-with-neuropathic-pain
#19
Keisuke Watanabe, Shigeki Hirano, Kazuho Kojima, Kengo Nagashima, Hiroki Mukai, Takatoshi Sato, Minoru Takemoto, Koji Matsumoto, Takashi Iimori, Sagiri Isose, Shigeki Omori, Kazumoto Shibuya, Yukari Sekiguchi, Minako Beppu, Hiroshi Amino, Tomoki Suichi, Koutaro Yokote, Takashi Uno, Satoshi Kuwabara, Sonoko Misawa
OBJECTIVE: To assess the cerebral blood flow (CBF) in patients with diabetic neuropathic pain, and its changes after duloxetine therapy. METHODS: Using iodine-123-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (IMP-SPECT), we performed a cross-sectional study of 44 patients with diabetes, and compared CBF in those with (n = 24) and without neuropathic pain (n = 20). In patients with neuropathic pain, we also longitudinally assessed changes in CBF 3 months after treatment with duloxetine...
April 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29627628/early-administration-of-hypertonic-hyperoncotic-hydroxyethyl-starch-hyperhes-improves-cerebral-blood-flow-and-outcome-after-experimental-subarachnoid-hemorrhage-in-rats
#20
Nadine Lilla, Christoph Rinne, Judith Weiland, Thomas Linsenmann, Thomas Westermaier
OBJECTIVE: Early cytotoxic brain edema may be one decisive factor which maintains a vicious of cerebral malperfusion after subarachnoid hemorrhage (SAH). In addition, endothelial cell swelling may be an independent factor restricting cerebral blood flow (CBF) in a very early stage after SAH. Immediate and aggressive treatment may be able to restore CBF in this critical period. MATERIALS AND METHODS: Male Sprague-Dawley rats were subjected to SAH by the endovascular filament model and treated by a bolus of hyperoncotic-hypertonic hydroxyethyl starch (HyperHES 4 ml/kg body weight) immediately after vessel perforation and 150 min later (n = 12) or by the same amount of normal saline (n = 9)...
April 5, 2018: World Neurosurgery
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